Published in Cancer Res on January 26, 2010
Identifying multi-layer gene regulatory modules from multi-dimensional genomic data. Bioinformatics (2012) 1.11
BRCA1-Dependent Translational Regulation in Breast Cancer Cells. PLoS One (2013) 1.11
Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis. Nucleic Acids Res (2011) 1.02
Cyclin D1 determines estrogen signaling in the mammary gland in vivo. Mol Endocrinol (2013) 0.95
Contributions of Rad9 to tumorigenesis. J Cell Biochem (2012) 0.88
Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells. Oncotarget (2011) 0.85
Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation. BMC Cancer (2010) 0.80
Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression. Cancer Prev Res (Phila) (2011) 0.76
The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription. Oncotarget (2016) 0.75
Amphiregulin as a Novel Serum Marker of Puberty in Girls. J Pediatr Adolesc Gynecol (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (1994) 36.53
Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer (2004) 10.31
Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell (2002) 9.61
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A (2002) 8.57
Epidermal growth factor receptor (EGFR) signaling in cancer. Gene (2005) 6.04
Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A (2005) 5.37
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell (1999) 5.28
Transcriptional activation by BRCA1. Nature (1996) 3.64
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development (1999) 2.89
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (2005) 2.73
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants. Cancer Res (2006) 2.58
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet (1998) 2.55
BRCA1 is a component of the RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A (1997) 2.55
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol (2004) 2.46
Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci U S A (2003) 2.31
The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol Cell Biol (1990) 2.21
The role of BRCA1 in transcriptional regulation and cell cycle control. Oncogene (2006) 2.09
Direct DNA binding by Brca1. Proc Natl Acad Sci U S A (2001) 1.94
Factors associated with the mammalian RNA polymerase II holoenzyme. Nucleic Acids Res (1998) 1.93
Location of BRCA1 in human breast and ovarian cancer cells. Science (1996) 1.88
Molecular profiling of inflammatory breast cancer: identification of a poor-prognosis gene expression signature. Clin Cancer Res (2004) 1.77
Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. J Biol Chem (2006) 1.67
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair. Curr Opin Cell Biol (2003) 1.65
Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. Clin Cancer Res (1998) 1.54
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Oncogene (2003) 1.43
The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. Cell (1999) 1.40
Induction and expression of amphiregulin in human pancreatic cancer. Cancer Res (1994) 1.32
Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell (2006) 1.24
Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region. Oncogene (1998) 1.21
BRCA1 DNA-binding activity is stimulated by BARD1. Cancer Res (2006) 1.12
Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines. Endocrinology (1995) 1.11
Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity. Proc Natl Acad Sci U S A (1993) 1.10
Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas. Br J Cancer (1994) 1.09
Amphiregulin: a new growth factor in hepatocarcinogenesis. Cancer Lett (2007) 1.08
Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer. Cancer Res (1993) 1.03
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2007) 1.01
BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit. J Biol Chem (2003) 1.00
Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. Int J Oncol (2002) 0.98
Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner. Am J Physiol Cell Physiol (2005) 0.96
The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells. Carcinogenesis (2005) 0.95
Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 93 cases. Prostate (2004) 0.94
Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-epithelial interactions. J Pathol (2001) 0.92
The BRCA1 E3 ubiquitin ligase controls centrosome dynamics. Cell Cycle (2006) 0.90
The role of amphiregulin in breast cancer. Breast Cancer Res Treat (1995) 0.86
Genetic epidemiology of BRCA1. Cancer Biol Ther (2004) 0.86
Direct stimulation of transcription initiation by BRCA1 requires both its amino and carboxyl termini. J Biol Chem (2006) 0.85
Amphiregulin as a tumor promoter for oral squamous cell carcinoma: involvement of cyclooxygenase 2. Oral Oncol (2005) 0.84
Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet (2007) 4.69
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol (2004) 2.46
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet (2006) 2.03
Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems. Annu Rev Biophys (2010) 1.78
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair. Curr Opin Cell Biol (2003) 1.65
Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase. J Biol Chem (2005) 1.47
BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. J Biol Chem (2005) 1.46
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Oncogene (2003) 1.43
Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells. Genes Dev (2005) 1.42
The tumor suppressor protein p53 functions similarly to p63 and p73 in activating transcription in vitro. Cancer Biol Ther (2005) 1.42
Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination. Cancer Res (2010) 1.41
Direct DNA binding activity of the Fanconi anemia D2 protein. J Biol Chem (2005) 1.33
Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. Mol Cell Biol (2005) 1.33
Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. Cancer Res (2006) 1.32
Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage. Mol Cell (2009) 1.27
Weighted frequent gene co-expression network mining to identify genes involved in genome stability. PLoS Comput Biol (2012) 1.19
Substrates of the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther (2006) 1.18
BRCA1 regulates gamma-tubulin binding to centrosomes. Cancer Biol Ther (2007) 1.15
The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. Cancer Res (2002) 1.14
Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function. Cancer Res (2006) 1.13
BRCA1 DNA-binding activity is stimulated by BARD1. Cancer Res (2006) 1.12
Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation. Cancer Res (2007) 1.07
Elongation by RNA polymerase II on chromatin templates requires topoisomerase activity. Nucleic Acids Res (2003) 1.06
MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples. Bioinformatics (2013) 1.04
KIAA0101 interacts with BRCA1 and regulates centrosome number. Mol Cancer Res (2011) 1.04
Histone deacetylases 9 and 10 are required for homologous recombination. J Biol Chem (2011) 1.03
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2007) 1.01
Centrosome function in normal and tumor cells. J Cell Biochem (2006) 1.01
Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes. Nucleic Acids Res (2012) 0.98
BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein. Cancer Sci (2011) 0.96
Phosphorylation of histone H2A inhibits transcription on chromatin templates. J Biol Chem (2004) 0.96
Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther (2008) 0.93
DFI: gene feature discovery in RNA-seq experiments from multiple sources. BMC Genomics (2012) 0.90
Multiple mechanisms contribute to inhibit transcription in response to DNA damage. J Biol Chem (2008) 0.89
BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A (2013) 0.88
Analysis of BRCA1 variants in double-strand break repair by homologous recombination and single-strand annealing. Hum Mutat (2012) 0.88
BRCA1 control of steroid receptor ubiquitination. Sci STKE (2007) 0.85
Direct stimulation of transcription initiation by BRCA1 requires both its amino and carboxyl termini. J Biol Chem (2006) 0.85
PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells. PLoS One (2010) 0.84
Gene Co-expression analysis predicts genetic aberration loci associated with colon cancer metastasis. Int J Comput Biol Drug Des (2013) 0.83
Expression of an amino-terminal BRCA1 deletion mutant causes a dominant growth inhibition in MCF10A cells. Oncogene (2004) 0.82
Comparing multiple ChIP-sequencing experiments. J Bioinform Comput Biol (2011) 0.81
Transcription from the perspective of the DNA: twists and bumps in the road. Crit Rev Eukaryot Gene Expr (2003) 0.80
BRCA1/BARD1 E3 ubiquitin ligase can modify histones H2A and H2B in the nucleosome particle. J Biomol Struct Dyn (2010) 0.80
Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver. Pharmacogenet Genomics (2013) 0.79
Promoters active in interphase are bookmarked during mitosis by ubiquitination. Nucleic Acids Res (2012) 0.78