Published in Am J Physiol Cell Physiol on October 05, 2005
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev (2012) 2.24
Massive transcriptional start site analysis of human genes in hypoxia cells. Nucleic Acids Res (2009) 1.60
Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. J Neurosci (2009) 1.24
Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis. Mol Biol Cell (2010) 1.02
The role of amphiregulin in exemestane-resistant breast cancer cells: evidence of an autocrine loop. Cancer Res (2008) 0.95
cAMP-response element-binding protein (CREB) and NF-κB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. J Biol Chem (2013) 0.94
BRCA1 represses amphiregulin gene expression. Cancer Res (2010) 0.88
EGF-like ligands mediate progesterone's anti-apoptotic action on macaque granulosa cells. Biol Reprod (2013) 0.82
Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes. J Biol Chem (2013) 0.78
Hypoxia activates constitutive luciferase reporter constructs. Biochimie (2010) 0.76
AREG triggered EGFR activation confers in vivo crizotinib-resistance of EML4-ALK lung cancer and circumvention by EGFR inhibitors. Cancer Sci (2016) 0.76
CREB Negatively Regulates IGF2R Gene Expression and Downstream Pathways to Inhibit Hypoxia-Induced H9c2 Cardiomyoblast Cell Death. Int J Mol Sci (2015) 0.75
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci U S A (2006) 4.08
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest (2002) 4.05
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science (2003) 3.91
Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med (2003) 3.71
An overview of transcriptional regulation in response to toxicological insult. Arch Toxicol (2012) 3.12
Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation (2005) 2.99
The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology (2007) 2.87
Hypoxia-responsive transcription factors. Pflugers Arch (2005) 2.64
Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol (2010) 2.18
MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol Cell Biol (2011) 1.81
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2009) 1.78
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology (2010) 1.64
Rapid and simple comparison of messenger RNA levels using real-time PCR. Biol Proced Online (2006) 1.64
Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J (2006) 1.61
Regulation of oxygen distribution in tissues by endothelial nitric oxide. Circ Res (2009) 1.61
TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol (2004) 1.59
Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A (2003) 1.52
Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome. Am J Respir Crit Care Med (2006) 1.50
SEURAT-1 liver gold reference compounds: a mechanism-based review. Arch Toxicol (2014) 1.50
Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin. Cancer Res (2003) 1.48
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest (2011) 1.44
Role of VASP in reestablishment of epithelial tight junction assembly after Ca2+ switch. Am J Physiol Cell Physiol (2002) 1.43
PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells. Proc Natl Acad Sci U S A (2009) 1.38
The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia. J Biol Chem (2003) 1.33
Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production. J Biol Chem (2010) 1.33
Immunomodulatory impact of the A2A adenosine receptor on the profile of chemokines produced by neutrophils. FASEB J (2005) 1.32
Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog. Kidney Int (2003) 1.21
An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia. J Immunol (2010) 1.20
Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal. J Cell Sci (2005) 1.13
NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells. J Immunol (2010) 1.12
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc Natl Acad Sci U S A (2013) 1.12
Gremlin plays a key role in the pathogenesis of pulmonary hypertension. Circulation (2012) 1.11
Carbon dioxide-sensing in organisms and its implications for human disease. Cell Mol Life Sci (2013) 1.10
15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure. J Am Soc Nephrol (2002) 1.08
Targeting the HIF pathway in inflammation and immunity. Curr Opin Pharmacol (2013) 1.07
Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells. Glia (2005) 1.07
Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress. J Proteomics (2012) 1.06
c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia. Cancer Res (2004) 1.05
A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network. J Cell Sci (2013) 1.03
Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung. Am J Respir Crit Care Med (2008) 0.97
A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation. Biochem Biophys Res Commun (2007) 0.97
Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps. Antimicrob Agents Chemother (2012) 0.96
Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases. Arthritis Res Ther (2009) 0.95
Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia. J Biol Chem (2010) 0.95
Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor. J Immunol (2005) 0.94
Human neutrophils as a source of nociceptin: a novel link between pain and inflammation. Biochemistry (2003) 0.94
Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway. Antioxid Redox Signal (2009) 0.94
NFκB and HIF display synergistic behaviour during hypoxic inflammation. Cell Mol Life Sci (2011) 0.94
Hypoxia, innate immunity and infection in the lung. Respir Physiol Neurobiol (2010) 0.93
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock (2011) 0.93
The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis. FASEB J (2007) 0.93
Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils. Biochim Biophys Acta (2007) 0.93
Hydroxylases as therapeutic targets in inflammatory bowel disease. Lab Invest (2013) 0.92
Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling. J Biol Chem (2012) 0.92
Differential effects of hypoxic stress in alveolar epithelial cells and microvascular endothelial cells. Cell Physiol Biochem (2009) 0.92
Modulation of interferon-induced genes by lipoxin analogue in anti-glomerular basement membrane nephritis. J Am Soc Nephrol (2004) 0.90
Induction of the interleukin-2/15 receptor beta-chain by the EWS-WT1 translocation product. Oncogene (2002) 0.90
SUMO, hypoxia and the regulation of metabolism. Biochem Soc Trans (2008) 0.89
Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity. Toxicol In Vitro (2010) 0.89
Alterations in oxidative gene expression in equine skeletal muscle following exercise and training. Physiol Genomics (2009) 0.88
Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults. Biol Neonate (2006) 0.87
Delineation of the key aspects in the regulation of epithelial monolayer formation. Mol Cell Biol (2013) 0.87
Hydroxylase-dependent regulation of the NF-κB pathway. Biol Chem (2013) 0.86
Proteinase-activated receptor-2 up-regulation by Fcgamma-receptor activation in human neutrophils. FASEB J (2010) 0.86
Hypoxia-dependent regulation of inflammatory pathways in immune cells. J Clin Invest (2016) 0.86
Hypoxic regulation of NF-kappaB signaling. Methods Enzymol (2007) 0.85
Regulation of protein phosphatase 1gamma activity in hypoxia through increased interaction with NIPP1: implications for cellular metabolism. J Cell Physiol (2006) 0.85
Crystal-induced neutrophil activation: VIII. Immediate production of prostaglandin E2 mediated by constitutive cyclooxygenase 2 in human neutrophils stimulated by urate crystals. Arthritis Rheum (2003) 0.85
The impact of hypoxia on cell death pathways. Biochem Soc Trans (2013) 0.83
Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo. J Cell Mol Med (2012) 0.83
Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa. PLoS One (2013) 0.83
Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemia-reperfusion injury? Transplantation (2007) 0.82
The pronociceptive effect of proteinase-activated receptor-4 stimulation in rat knee joints is dependent on mast cell activation. Pain (2011) 0.82
Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture. Invest Ophthalmol Vis Sci (2012) 0.82
Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes. Toxicol In Vitro (2011) 0.82
Pro-inflammatory type-1 and anti-inflammatory type-2 macrophages differentially modulate cell survival and invasion of human bladder carcinoma T24 cells. Mol Immunol (2011) 0.81
Osteoblast retraction induced by adherent neutrophils promotes osteoclast bone resorption: implication for altered bone remodeling in chronic gout. Lab Invest (2011) 0.81
Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways. PLoS One (2009) 0.81
Recurrence of urothelial carcinoma of the bladder: a role for insulin-like growth factor-II loss of imprinting and cytoplasmic E-cadherin immunolocalization. Clin Cancer Res (2008) 0.81
Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha. J Interferon Cytokine Res (2005) 0.80
Nucleobindin co-localizes and associates with cyclooxygenase (COX)-2 in human neutrophils. PLoS One (2008) 0.80
Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique. Integr Biol (Camb) (2010) 0.80
Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity. Am J Pathol (2013) 0.80
Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea. FASEB J (2010) 0.79
Interleukin-19 as a translational indicator of renal injury. Arch Toxicol (2014) 0.79
Mitochondria, oxygen sensing, and the regulation of HIF-2alpha. Focus on "Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line". Am J Physiol Cell Physiol (2008) 0.79
Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange. Biochim Biophys Acta (2010) 0.79
Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expression. Exp Cell Res (2013) 0.78
Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion. Mol Cell Biochem (2012) 0.78
Characterization of the Na/HCO3(-) cotransport in human neutrophils. Cell Physiol Biochem (2014) 0.78