PubRank

Heinrich Sticht

Author PubWeight™ 107.97‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study. Lancet 2012 8.42
2 Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Am J Hum Genet 2007 2.74
3 Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins. Chem Biol 2006 2.08
4 Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. Am J Hum Genet 2009 1.71
5 AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine. J Mol Model 2005 1.69
6 Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression. Hum Mutat 2010 1.59
7 The interleukin-10 family of cytokines. Trends Immunol 2002 1.54
8 Human TBX1 missense mutations cause gain of function resulting in the same phenotype as 22q11.2 deletions. Am J Hum Genet 2007 1.51
9 MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and Golgi architecture as a central mechanism in growth regulation. Hum Mutat 2014 1.45
10 Severely incapacitating mutations in patients with extreme short stature identify RNA-processing endoribonuclease RMRP as an essential cell growth regulator. Am J Hum Genet 2005 1.40
11 The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. J Biol Chem 2004 1.38
12 Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6). Eur Heart J 2011 1.37
13 Dual selection pressure by drugs and HLA class I-restricted immune responses on human immunodeficiency virus type 1 protease. J Virol 2007 1.28
14 Mutations in IL36RN in patients with generalized pustular psoriasis. J Invest Dermatol 2013 1.17
15 Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck. Biochemistry 2002 1.17
16 B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies. PLoS Pathog 2011 1.16
17 Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex. J Gen Virol 2009 1.16
18 Estrogen and progesterone receptors: from molecular structures to clinical targets. Cell Mol Life Sci 2009 1.16
19 Novel mode of phosphorylation-triggered reorganization of the nuclear lamina during nuclear egress of human cytomegalovirus. J Biol Chem 2010 1.14
20 CD and NMR studies of prion protein (PrP) helix 1. Novel implications for its role in the PrPC-->PrPSc conversion process. J Biol Chem 2003 1.13
21 Variants in ASB10 are associated with open-angle glaucoma. Hum Mol Genet 2011 1.12
22 Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Neurogenetics 2009 1.10
23 A computational strategy for the prediction of functional linear peptide motifs in proteins. Bioinformatics 2007 1.07
24 Independent NF1 and PTPN11 mutations in a family with neurofibromatosis-Noonan syndrome. Am J Med Genet A 2009 1.07
25 Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I. Hum Mutat 2011 1.03
26 De novo mutations in the genome organizer CTCF cause intellectual disability. Am J Hum Genet 2013 1.01
27 A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition. J Physiol 2010 1.01
28 Analysis of the structure-activity relationship of four herpesviral UL97 subfamily protein kinases reveals partial but not full functional conservation. J Med Chem 2006 1.00
29 Profiling of WDR36 missense variants in German patients with glaucoma. Invest Ophthalmol Vis Sci 2008 1.00
30 A dual phenotype of periventricular nodular heterotopia and frontometaphyseal dysplasia in one patient caused by a single FLNA mutation leading to two functionally different aberrant transcripts. Am J Hum Genet 2004 1.00
31 Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme. Hum Mutat 2008 1.00
32 Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. Mol Genet Metab 2008 0.99
33 Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice. ACS Chem Neurosci 2010 0.98
34 Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity. Protein Sci 2005 0.97
35 Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet 2013 0.96
36 Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution. Nucleic Acids Res 2006 0.96
37 Binding, domain orientation, and dynamics of the Lck SH3-SH2 domain pair and comparison with other Src-family kinases. Biochemistry 2005 0.95
38 Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53. J Biol Chem 2012 0.94
39 Conformational switch upon phosphorylation: human CDK inhibitor p19INK4d between the native and partially folded state. ACS Chem Biol 2009 0.94
40 Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Genes Dev 2006 0.93
41 Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs. J Mol Biol 2006 0.93
42 Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. J Biol Chem 2003 0.93
43 Differential contribution of EF-hands to the Ca²⁺-dependent activation in the plant two-pore channel TPC1. Plant J 2011 0.93
44 Characterization of Lck-binding elements in the herpesviral regulatory Tip protein. Biochemistry 2004 0.91
45 Structure predictions and interaction studies indicate homology of separase N-terminal regulatory domains and Drosophila THR. Cell Cycle 2004 0.91
46 The transcription regulator RbsR represents a novel interaction partner of the phosphoprotein HPr-Ser46-P in Bacillus subtilis. FEBS J 2006 0.90
47 Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies. Protein Expr Purif 2002 0.90
48 Conformational stability of fibrillar amyloid-beta oligomers via protofilament pair formation - a systematic computational study. PLoS One 2013 0.88
49 Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations. Hum Genet 2014 0.88
50 A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinity. FEBS Lett 2007 0.87
51 Two isoforms of the protein kinase pUL97 of human cytomegalovirus are differentially regulated in their nuclear translocation. J Gen Virol 2010 0.87
52 Insights into amprenavir resistance in E35D HIV-1 protease mutation from molecular dynamics and binding free-energy calculations. J Mol Model 2006 0.86
53 The cyclin-dependent kinase ortholog pUL97 of human cytomegalovirus interacts with cyclins. Viruses 2013 0.85
54 Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes. Arch Biochem Biophys 2012 0.84
55 Amyloid-beta42 oligomer structures from fibrils: a systematic molecular dynamics study. J Phys Chem B 2010 0.84
56 Combining independent drug classes into superior, synergistically acting hybrid molecules. Angew Chem Int Ed Engl 2010 0.84
57 Mouse ApoM displays an unprecedented seven-stranded lipocalin fold: folding decoy or alternative native fold? J Mol Biol 2010 0.84
58 Structural insight into the giant Ca²⁺-binding adhesin SiiE: implications for the adhesion of Salmonella enterica to polarized epithelial cells. Structure 2013 0.84
59 The cytomegalovirus egress proteins pUL50 and pUL53 are translocated to the nuclear envelope through two distinct modes of nuclear import. J Gen Virol 2013 0.84
60 SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b. Biochem J 2011 0.83
61 Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. Circ Cardiovasc Genet 2014 0.83
62 Multiple modes of interaction between Lck and CD28. J Immunol 2005 0.83
63 Genotype-epigenotype-phenotype correlations in females with frontometaphyseal dysplasia. Am J Med Genet A 2006 0.83
64 Rational design of β-sheet ligands against Aβ42-induced toxicity. J Am Chem Soc 2011 0.83
65 Functional and structural relevance of conserved positively charged lysine residues in organic anion transporting polypeptide 1B3. Mol Pharmacol 2011 0.83
66 Small ubiquitin-related modifier (SUMO) pathway-mediated enhancement of human cytomegalovirus replication correlates with a recruitment of SUMO-1/3 proteins to viral replication compartments. J Gen Virol 2013 0.82
67 A new redox-dependent mechanism of MMP-1 activity control comprising reduced low-molecular-weight thiols and oxidizing radicals. J Mol Med (Berl) 2008 0.82
68 Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-α binding. J Gen Virol 2012 0.82
69 CD83 is a dimer: Comparative analysis of monomeric and dimeric isoforms. Biochem Biophys Res Commun 2005 0.82
70 Impact of the C-terminal disulfide bond on the folding and stability of onconase. Chembiochem 2010 0.82
71 Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability. Hum Mutat 2015 0.81
72 Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. Matrix Biol 2013 0.81
73 Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus. J Virol 2013 0.81
74 DNA binding by Corynebacterium glutamicum TetR-type transcription regulator AmtR. BMC Mol Biol 2009 0.81
75 Effects of the V82A and I54V mutations on the dynamics and ligand binding properties of HIV-1 protease. J Mol Model 2010 0.81
76 NDST1 missense mutations in autosomal recessive intellectual disability. Am J Med Genet A 2014 0.81
77 Effect of pathogenic mutations on the structure and dynamics of Alzheimer's A beta 42-amyloid oligomers. J Mol Model 2009 0.81
78 An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation. Cell Physiol Biochem 2012 0.81
79 Rare large scale subdomain motions in prion protein can initiate aggregation. J Biomol Struct Dyn 2006 0.80
80 PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Mol Cell Neurosci 2008 0.80
81 A two-alpha-helix extra domain mediates the halophilic character of a plant-type ferredoxin from halophilic archaea. Biochemistry 2005 0.80
82 HIV-1 fusion is blocked through binding of GB Virus C E2-derived peptides to the HIV-1 gp41 disulfide loop [corrected]. PLoS One 2013 0.79
83 Mutations in herpes simplex virus gD protein affect receptor binding by different molecular mechanisms. J Mol Model 2014 0.79
84 Characterization of a single-chain variable fragment recognizing a linear epitope of aβ: a biotechnical tool for studies on Alzheimer's disease? PLoS One 2013 0.79
85 Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides. Adv Bioinformatics 2012 0.78
86 Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120. Beilstein J Org Chem 2012 0.78
87 Molecular modeling of the interleukin-19 receptor complex. Novel aspects of receptor recognition in the interleukin-10 cytokine family. J Mol Model 2004 0.78
88 A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect. Am J Physiol Lung Cell Mol Physiol 2012 0.78
89 Application of information theory to feature selection in protein docking. J Mol Model 2011 0.78
90 Molecular engineering of a secreted, highly homogeneous, and neurotoxic aβ dimer. ACS Chem Neurosci 2011 0.77
91 Premature osteoarthritis as presenting sign of type II collagenopathy: a case report and literature review. Semin Arthritis Rheum 2012 0.77
92 A protein-specifically adapted scoring function for the reranking of docking solutions. Proteins 2007 0.77
93 A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip. PLoS One 2012 0.77
94 Hybrid compounds: from simple combinations to nanomachines. BioDrugs 2012 0.77
95 Identification of the structural features that mediate binding specificity in the recognition of STAT proteins by dual-specificity phosphatases. J Biomol Struct Dyn 2012 0.77
96 Expression, purification, and structural analysis of intracellular C-termini from metabotropic glutamate receptors. Methods Enzymol 2013 0.77
97 Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors. FEBS Lett 2011 0.76
98 A comparative study of HIV-1 and HTLV-I protease structure and dynamics reveals a conserved residue interaction network. J Mol Model 2011 0.76
99 pH-dependent molecular dynamics of vesicular stomatitis virus glycoprotein G. Proteins 2012 0.76
100 Noncanonical NF-κB activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif. Sci Signal 2013 0.76
101 Effect of the SH3-SH2 domain linker sequence on the structure of Hck kinase. J Mol Model 2010 0.76
102 Insight into the phosphoryl transfer of the Escherichia coli glucose phosphotransferase system from QM/MM simulations. J Phys Chem B 2008 0.76
103 Binding properties of SUMO-interacting motifs (SIMs) in yeast. J Mol Model 2015 0.76
104 Erratum: Responsiveness of B cells is regulated by the hinge region of IgD. Nat Immunol 2015 0.75
105 The conformational stability of nonfibrillar amyloid-β peptide oligomers critically depends on the C-terminal peptide length. ACS Chem Neurosci 2014 0.75
106 Probing the Structure of the Escherichia coli Periplasmic Proteins HdeA and YmgD by Molecular Dynamics Simulations. J Phys Chem B 2016 0.75
107 Sequence-specific 1H, 13C and 15N resonance assignments of the SH3-SH2 domain pair from the human tyrosine kinase Lck. J Biomol NMR 2003 0.75
108 Biallelic SEMA3A defects cause a novel type of syndromic short stature. Am J Med Genet A 2013 0.75
109 Erratum: Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins. Sci Rep 2016 0.75
110 An information-theoretic classification of amino acids for the assessment of interfaces in protein-protein docking. J Mol Model 2013 0.75
111 Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity. J Biomol Struct Dyn 2013 0.75
112 Effects of histidine protonation and phosphorylation on histidine-containing phosphocarrier protein structure, dynamics, and physicochemical properties. Biochemistry 2007 0.75
113 Effect of HPr phosphorylation on structure, dynamics, and interactions in the course of transcriptional control. J Mol Model 2006 0.75
114 Thymosin β4 and tissue transglutaminase. Molecular characterization of cyclic thymosin β4. Protein J 2013 0.75