Published in J Immunol on April 01, 2005
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat Immunol (2011) 1.30
Regulation of PKC-θ function by phosphorylation in T cell receptor signaling. Front Immunol (2012) 1.06
PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors. Front Immunol (2012) 0.97
Signals and sequences that control CD28 localization to the central region of the immunological synapse. J Immunol (2008) 0.94
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Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study. Lancet (2012) 8.42
Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Am J Hum Genet (2007) 2.74
Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins. Chem Biol (2006) 2.08
Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. Am J Hum Genet (2009) 1.71
AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine. J Mol Model (2005) 1.69
Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression. Hum Mutat (2010) 1.59
The interleukin-10 family of cytokines. Trends Immunol (2002) 1.54
Human TBX1 missense mutations cause gain of function resulting in the same phenotype as 22q11.2 deletions. Am J Hum Genet (2007) 1.51
MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and Golgi architecture as a central mechanism in growth regulation. Hum Mutat (2014) 1.45
Severely incapacitating mutations in patients with extreme short stature identify RNA-processing endoribonuclease RMRP as an essential cell growth regulator. Am J Hum Genet (2005) 1.40
The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. J Biol Chem (2004) 1.38
Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6). Eur Heart J (2011) 1.37
Dual selection pressure by drugs and HLA class I-restricted immune responses on human immunodeficiency virus type 1 protease. J Virol (2007) 1.28
Mutations in IL36RN in patients with generalized pustular psoriasis. J Invest Dermatol (2013) 1.17
Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck. Biochemistry (2002) 1.17
B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies. PLoS Pathog (2011) 1.16
Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex. J Gen Virol (2009) 1.16
Estrogen and progesterone receptors: from molecular structures to clinical targets. Cell Mol Life Sci (2009) 1.16
Novel mode of phosphorylation-triggered reorganization of the nuclear lamina during nuclear egress of human cytomegalovirus. J Biol Chem (2010) 1.14
CD and NMR studies of prion protein (PrP) helix 1. Novel implications for its role in the PrPC-->PrPSc conversion process. J Biol Chem (2003) 1.13
Variants in ASB10 are associated with open-angle glaucoma. Hum Mol Genet (2011) 1.12
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Neurogenetics (2009) 1.10
A computational strategy for the prediction of functional linear peptide motifs in proteins. Bioinformatics (2007) 1.07
Independent NF1 and PTPN11 mutations in a family with neurofibromatosis-Noonan syndrome. Am J Med Genet A (2009) 1.07
Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I. Hum Mutat (2011) 1.03
De novo mutations in the genome organizer CTCF cause intellectual disability. Am J Hum Genet (2013) 1.01
A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition. J Physiol (2010) 1.01
Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme. Hum Mutat (2008) 1.00
A dual phenotype of periventricular nodular heterotopia and frontometaphyseal dysplasia in one patient caused by a single FLNA mutation leading to two functionally different aberrant transcripts. Am J Hum Genet (2004) 1.00
Profiling of WDR36 missense variants in German patients with glaucoma. Invest Ophthalmol Vis Sci (2008) 1.00
Analysis of the structure-activity relationship of four herpesviral UL97 subfamily protein kinases reveals partial but not full functional conservation. J Med Chem (2006) 1.00
Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. Mol Genet Metab (2008) 0.99
Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice. ACS Chem Neurosci (2010) 0.98
Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity. Protein Sci (2005) 0.97
Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet (2013) 0.96
Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution. Nucleic Acids Res (2006) 0.96
Binding, domain orientation, and dynamics of the Lck SH3-SH2 domain pair and comparison with other Src-family kinases. Biochemistry (2005) 0.95
Conformational switch upon phosphorylation: human CDK inhibitor p19INK4d between the native and partially folded state. ACS Chem Biol (2009) 0.94
Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53. J Biol Chem (2012) 0.94
Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Genes Dev (2006) 0.93
Differential contribution of EF-hands to the Ca²⁺-dependent activation in the plant two-pore channel TPC1. Plant J (2011) 0.93
Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. J Biol Chem (2003) 0.93
Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs. J Mol Biol (2006) 0.93
Structure predictions and interaction studies indicate homology of separase N-terminal regulatory domains and Drosophila THR. Cell Cycle (2004) 0.91
Characterization of Lck-binding elements in the herpesviral regulatory Tip protein. Biochemistry (2004) 0.91
The transcription regulator RbsR represents a novel interaction partner of the phosphoprotein HPr-Ser46-P in Bacillus subtilis. FEBS J (2006) 0.90
Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies. Protein Expr Purif (2002) 0.90
Conformational stability of fibrillar amyloid-beta oligomers via protofilament pair formation - a systematic computational study. PLoS One (2013) 0.88
Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations. Hum Genet (2014) 0.88
A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinity. FEBS Lett (2007) 0.87
Two isoforms of the protein kinase pUL97 of human cytomegalovirus are differentially regulated in their nuclear translocation. J Gen Virol (2010) 0.87
Insights into amprenavir resistance in E35D HIV-1 protease mutation from molecular dynamics and binding free-energy calculations. J Mol Model (2006) 0.86
The cyclin-dependent kinase ortholog pUL97 of human cytomegalovirus interacts with cyclins. Viruses (2013) 0.85
Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes. Arch Biochem Biophys (2012) 0.84
Combining independent drug classes into superior, synergistically acting hybrid molecules. Angew Chem Int Ed Engl (2010) 0.84
Amyloid-beta42 oligomer structures from fibrils: a systematic molecular dynamics study. J Phys Chem B (2010) 0.84
Structural insight into the giant Ca²⁺-binding adhesin SiiE: implications for the adhesion of Salmonella enterica to polarized epithelial cells. Structure (2013) 0.84
Mouse ApoM displays an unprecedented seven-stranded lipocalin fold: folding decoy or alternative native fold? J Mol Biol (2010) 0.84
The cytomegalovirus egress proteins pUL50 and pUL53 are translocated to the nuclear envelope through two distinct modes of nuclear import. J Gen Virol (2013) 0.84
SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b. Biochem J (2011) 0.83
Genotype-epigenotype-phenotype correlations in females with frontometaphyseal dysplasia. Am J Med Genet A (2006) 0.83
Rational design of β-sheet ligands against Aβ42-induced toxicity. J Am Chem Soc (2011) 0.83
Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. Circ Cardiovasc Genet (2014) 0.83
Functional and structural relevance of conserved positively charged lysine residues in organic anion transporting polypeptide 1B3. Mol Pharmacol (2011) 0.83
Impact of the C-terminal disulfide bond on the folding and stability of onconase. Chembiochem (2010) 0.82
Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-α binding. J Gen Virol (2012) 0.82
A new redox-dependent mechanism of MMP-1 activity control comprising reduced low-molecular-weight thiols and oxidizing radicals. J Mol Med (Berl) (2008) 0.82
CD83 is a dimer: Comparative analysis of monomeric and dimeric isoforms. Biochem Biophys Res Commun (2005) 0.82
Small ubiquitin-related modifier (SUMO) pathway-mediated enhancement of human cytomegalovirus replication correlates with a recruitment of SUMO-1/3 proteins to viral replication compartments. J Gen Virol (2013) 0.82
Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus. J Virol (2013) 0.81
NDST1 missense mutations in autosomal recessive intellectual disability. Am J Med Genet A (2014) 0.81
Effect of pathogenic mutations on the structure and dynamics of Alzheimer's A beta 42-amyloid oligomers. J Mol Model (2009) 0.81
An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation. Cell Physiol Biochem (2012) 0.81
Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability. Hum Mutat (2015) 0.81
DNA binding by Corynebacterium glutamicum TetR-type transcription regulator AmtR. BMC Mol Biol (2009) 0.81
Effects of the V82A and I54V mutations on the dynamics and ligand binding properties of HIV-1 protease. J Mol Model (2010) 0.81
Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. Matrix Biol (2013) 0.81
A two-alpha-helix extra domain mediates the halophilic character of a plant-type ferredoxin from halophilic archaea. Biochemistry (2005) 0.80
Rare large scale subdomain motions in prion protein can initiate aggregation. J Biomol Struct Dyn (2006) 0.80
PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Mol Cell Neurosci (2008) 0.80
Characterization of a single-chain variable fragment recognizing a linear epitope of aβ: a biotechnical tool for studies on Alzheimer's disease? PLoS One (2013) 0.79
HIV-1 fusion is blocked through binding of GB Virus C E2-derived peptides to the HIV-1 gp41 disulfide loop [corrected]. PLoS One (2013) 0.79
Mutations in herpes simplex virus gD protein affect receptor binding by different molecular mechanisms. J Mol Model (2014) 0.79
Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120. Beilstein J Org Chem (2012) 0.78
Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides. Adv Bioinformatics (2012) 0.78
Molecular modeling of the interleukin-19 receptor complex. Novel aspects of receptor recognition in the interleukin-10 cytokine family. J Mol Model (2004) 0.78
A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect. Am J Physiol Lung Cell Mol Physiol (2012) 0.78
Application of information theory to feature selection in protein docking. J Mol Model (2011) 0.78
Expression, purification, and structural analysis of intracellular C-termini from metabotropic glutamate receptors. Methods Enzymol (2013) 0.77
Molecular engineering of a secreted, highly homogeneous, and neurotoxic aβ dimer. ACS Chem Neurosci (2011) 0.77
A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip. PLoS One (2012) 0.77
Hybrid compounds: from simple combinations to nanomachines. BioDrugs (2012) 0.77
Identification of the structural features that mediate binding specificity in the recognition of STAT proteins by dual-specificity phosphatases. J Biomol Struct Dyn (2012) 0.77
A protein-specifically adapted scoring function for the reranking of docking solutions. Proteins (2007) 0.77
Premature osteoarthritis as presenting sign of type II collagenopathy: a case report and literature review. Semin Arthritis Rheum (2012) 0.77
pH-dependent molecular dynamics of vesicular stomatitis virus glycoprotein G. Proteins (2012) 0.76
Binding properties of SUMO-interacting motifs (SIMs) in yeast. J Mol Model (2015) 0.76
Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors. FEBS Lett (2011) 0.76