Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 3270550)

Published in Adv Bioinformatics on January 19, 2012

Authors

Kristin Kassler1, Julia Meier, Jutta Eichler, Heinrich Sticht

Author Affiliations

1: Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Fahrstraße 17, 91054 Erlangen, Germany.

Articles cited by this

VMD: visual molecular dynamics. J Mol Graph (1996) 117.02

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis (1997) 57.27

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics (2005) 34.83

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature (1985) 30.47

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature (1998) 24.69

Comparison of multiple Amber force fields and development of improved protein backbone parameters. Proteins (2006) 22.80

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell (1986) 22.26

Errors in protein structures. Nature (1996) 18.70

The SWISS-MODEL Repository and associated resources. Nucleic Acids Res (2008) 11.61

Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science (2010) 10.69

Recognition of errors in three-dimensional structures of proteins. Proteins (1993) 9.38

ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Nucleic Acids Res (2007) 9.16

Structure of a V3-containing HIV-1 gp120 core. Science (2005) 7.69

Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. Structure (2000) 5.57

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120. Proc Natl Acad Sci U S A (2004) 5.15

Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (1990) 4.81

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility. Proc Natl Acad Sci U S A (2009) 3.92

QMEAN: A comprehensive scoring function for model quality assessment. Proteins (2008) 3.90

Identification of the residues in human CD4 critical for the binding of HIV. Cell (1989) 3.71

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4. Nature (1988) 3.47

QMEAN server for protein model quality estimation. Nucleic Acids Res (2009) 3.39

The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure. J Exp Med (1992) 2.13

Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth. Structure (2005) 2.09

Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins. Chem Biol (2006) 2.08

Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis. Proc Natl Acad Sci U S A (1990) 1.99

Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes. Nat Biotechnol (2002) 1.95

HIV infection of primate lymphocytes and conservation of the CD4 receptor. Nature (1988) 1.84

Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein. J Mol Biol (2008) 1.14

Characterization of the major histocompatibility complex class II binding site on LAG-3 protein. Proc Natl Acad Sci U S A (1997) 1.14

Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. Structure (1994) 1.03

Anti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor. Expert Opin Investig Drugs (2005) 0.86

Synthetic mimetics of the CD4 binding site of HIV-1 gp120 for the design of immunogens. Angew Chem Int Ed Engl (2007) 0.84

Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human immunodeficiency virus. J Biol Chem (2000) 0.77

Comparative analysis of the gp120-binding area of murine and human CD4 molecules. J Acquir Immune Defic Syndr Hum Retrovirol (1997) 0.76

Articles by these authors

Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study. Lancet (2012) 8.42

Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Am J Hum Genet (2007) 2.74

Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins. Chem Biol (2006) 2.08

ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04

Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. Am J Hum Genet (2009) 1.71

AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine. J Mol Model (2005) 1.69

Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression. Hum Mutat (2010) 1.59

The interleukin-10 family of cytokines. Trends Immunol (2002) 1.54

Human TBX1 missense mutations cause gain of function resulting in the same phenotype as 22q11.2 deletions. Am J Hum Genet (2007) 1.51

MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and Golgi architecture as a central mechanism in growth regulation. Hum Mutat (2014) 1.45

Severely incapacitating mutations in patients with extreme short stature identify RNA-processing endoribonuclease RMRP as an essential cell growth regulator. Am J Hum Genet (2005) 1.40

The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. J Biol Chem (2004) 1.38

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6). Eur Heart J (2011) 1.37

Dual selection pressure by drugs and HLA class I-restricted immune responses on human immunodeficiency virus type 1 protease. J Virol (2007) 1.28

Mutations in IL36RN in patients with generalized pustular psoriasis. J Invest Dermatol (2013) 1.17

Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck. Biochemistry (2002) 1.17

B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies. PLoS Pathog (2011) 1.16

Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex. J Gen Virol (2009) 1.16

Estrogen and progesterone receptors: from molecular structures to clinical targets. Cell Mol Life Sci (2009) 1.16

Novel mode of phosphorylation-triggered reorganization of the nuclear lamina during nuclear egress of human cytomegalovirus. J Biol Chem (2010) 1.14

CD and NMR studies of prion protein (PrP) helix 1. Novel implications for its role in the PrPC-->PrPSc conversion process. J Biol Chem (2003) 1.13

Variants in ASB10 are associated with open-angle glaucoma. Hum Mol Genet (2011) 1.12

Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Neurogenetics (2009) 1.10

A computational strategy for the prediction of functional linear peptide motifs in proteins. Bioinformatics (2007) 1.07

Independent NF1 and PTPN11 mutations in a family with neurofibromatosis-Noonan syndrome. Am J Med Genet A (2009) 1.07

Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I. Hum Mutat (2011) 1.03

De novo mutations in the genome organizer CTCF cause intellectual disability. Am J Hum Genet (2013) 1.01

A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition. J Physiol (2010) 1.01

Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. Mol Biol Cell (2006) 1.00

A dual phenotype of periventricular nodular heterotopia and frontometaphyseal dysplasia in one patient caused by a single FLNA mutation leading to two functionally different aberrant transcripts. Am J Hum Genet (2004) 1.00

Analysis of the structure-activity relationship of four herpesviral UL97 subfamily protein kinases reveals partial but not full functional conservation. J Med Chem (2006) 1.00

Profiling of WDR36 missense variants in German patients with glaucoma. Invest Ophthalmol Vis Sci (2008) 1.00

Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme. Hum Mutat (2008) 1.00

Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. Mol Genet Metab (2008) 0.99

Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice. ACS Chem Neurosci (2010) 0.98

Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity. Protein Sci (2005) 0.97

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet (2013) 0.96

Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution. Nucleic Acids Res (2006) 0.96

Binding, domain orientation, and dynamics of the Lck SH3-SH2 domain pair and comparison with other Src-family kinases. Biochemistry (2005) 0.95

Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53. J Biol Chem (2012) 0.94

Conformational switch upon phosphorylation: human CDK inhibitor p19INK4d between the native and partially folded state. ACS Chem Biol (2009) 0.94

Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. J Virol (2009) 0.94

Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Genes Dev (2006) 0.93

Differential contribution of EF-hands to the Ca²⁺-dependent activation in the plant two-pore channel TPC1. Plant J (2011) 0.93

Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs. J Mol Biol (2006) 0.93

Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. J Biol Chem (2003) 0.93

Characterization of Lck-binding elements in the herpesviral regulatory Tip protein. Biochemistry (2004) 0.91

Structure predictions and interaction studies indicate homology of separase N-terminal regulatory domains and Drosophila THR. Cell Cycle (2004) 0.91

Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies. Protein Expr Purif (2002) 0.90

The transcription regulator RbsR represents a novel interaction partner of the phosphoprotein HPr-Ser46-P in Bacillus subtilis. FEBS J (2006) 0.90

Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display. J Virol (2006) 0.88

Conformational stability of fibrillar amyloid-beta oligomers via protofilament pair formation - a systematic computational study. PLoS One (2013) 0.88

The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3- exchanger DRA in rabbit small intestinal mucosa. Biochemistry (2005) 0.88

Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations. Hum Genet (2014) 0.88

A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinity. FEBS Lett (2007) 0.87

Two isoforms of the protein kinase pUL97 of human cytomegalovirus are differentially regulated in their nuclear translocation. J Gen Virol (2010) 0.87

Insights into amprenavir resistance in E35D HIV-1 protease mutation from molecular dynamics and binding free-energy calculations. J Mol Model (2006) 0.86

The cyclin-dependent kinase ortholog pUL97 of human cytomegalovirus interacts with cyclins. Viruses (2013) 0.85

Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes. Arch Biochem Biophys (2012) 0.84

Synthetic mimetics of the CD4 binding site of HIV-1 gp120 for the design of immunogens. Angew Chem Int Ed Engl (2007) 0.84

Amyloid-beta42 oligomer structures from fibrils: a systematic molecular dynamics study. J Phys Chem B (2010) 0.84

Combining independent drug classes into superior, synergistically acting hybrid molecules. Angew Chem Int Ed Engl (2010) 0.84

Mouse ApoM displays an unprecedented seven-stranded lipocalin fold: folding decoy or alternative native fold? J Mol Biol (2010) 0.84

Structural insight into the giant Ca²⁺-binding adhesin SiiE: implications for the adhesion of Salmonella enterica to polarized epithelial cells. Structure (2013) 0.84

The cytomegalovirus egress proteins pUL50 and pUL53 are translocated to the nuclear envelope through two distinct modes of nuclear import. J Gen Virol (2013) 0.84

SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b. Biochem J (2011) 0.83

Rational design of β-sheet ligands against Aβ42-induced toxicity. J Am Chem Soc (2011) 0.83

Multiple modes of interaction between Lck and CD28. J Immunol (2005) 0.83

Functional and structural relevance of conserved positively charged lysine residues in organic anion transporting polypeptide 1B3. Mol Pharmacol (2011) 0.83

Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. Circ Cardiovasc Genet (2014) 0.83

Genotype-epigenotype-phenotype correlations in females with frontometaphyseal dysplasia. Am J Med Genet A (2006) 0.83

Impact of the C-terminal disulfide bond on the folding and stability of onconase. Chembiochem (2010) 0.82

Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-α binding. J Gen Virol (2012) 0.82

CD83 is a dimer: Comparative analysis of monomeric and dimeric isoforms. Biochem Biophys Res Commun (2005) 0.82

A new redox-dependent mechanism of MMP-1 activity control comprising reduced low-molecular-weight thiols and oxidizing radicals. J Mol Med (Berl) (2008) 0.82

Small ubiquitin-related modifier (SUMO) pathway-mediated enhancement of human cytomegalovirus replication correlates with a recruitment of SUMO-1/3 proteins to viral replication compartments. J Gen Virol (2013) 0.82

Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3). PLoS One (2013) 0.81

NDST1 missense mutations in autosomal recessive intellectual disability. Am J Med Genet A (2014) 0.81

Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. Matrix Biol (2013) 0.81

An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation. Cell Physiol Biochem (2012) 0.81

Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability. Hum Mutat (2015) 0.81

Effect of pathogenic mutations on the structure and dynamics of Alzheimer's A beta 42-amyloid oligomers. J Mol Model (2009) 0.81

DNA binding by Corynebacterium glutamicum TetR-type transcription regulator AmtR. BMC Mol Biol (2009) 0.81

Effects of the V82A and I54V mutations on the dynamics and ligand binding properties of HIV-1 protease. J Mol Model (2010) 0.81

Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus. J Virol (2013) 0.81

PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Mol Cell Neurosci (2008) 0.80

A two-alpha-helix extra domain mediates the halophilic character of a plant-type ferredoxin from halophilic archaea. Biochemistry (2005) 0.80

A functionally selective synthetic mimic of the HIV-1 co-receptor CXCR4. Chemistry (2012) 0.80

A rationally designed synthetic mimic of the discontinuous CD4-binding site of HIV-1 gp120. J Recept Signal Transduct Res (2006) 0.80

Rare large scale subdomain motions in prion protein can initiate aggregation. J Biomol Struct Dyn (2006) 0.80

Solid-phase synthesis of structurally diverse scaffolded peptides for the mimicry of discontinuous protein binding sites. Protein Pept Lett (2003) 0.79

HIV-1 fusion is blocked through binding of GB Virus C E2-derived peptides to the HIV-1 gp41 disulfide loop [corrected]. PLoS One (2013) 0.79

Mutations in herpes simplex virus gD protein affect receptor binding by different molecular mechanisms. J Mol Model (2014) 0.79

Characterization of a single-chain variable fragment recognizing a linear epitope of aβ: a biotechnical tool for studies on Alzheimer's disease? PLoS One (2013) 0.79

Odd-skipped related genes regulate differentiation of embryonic limb mesenchyme and bone marrow mesenchymal stromal cells. Stem Cells Dev (2011) 0.79

Structure-based synthetic mimicry of discontinuous protein binding sites: inhibitors of the interaction of Mena EVH1 domain with proline-rich ligands. Chembiochem (2006) 0.78

Molecular modeling of the interleukin-19 receptor complex. Novel aspects of receptor recognition in the interleukin-10 cytokine family. J Mol Model (2004) 0.78

Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120. Beilstein J Org Chem (2012) 0.78