Published in Bioorg Med Chem on January 07, 2010
Improving physical properties via C-H oxidation: chemical and enzymatic approaches. Angew Chem Int Ed Engl (2014) 0.89
Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: synergistic effects with miltefosine. PLoS One (2014) 0.84
Disuccinyl betulin triggers metacaspase-dependent endonuclease G-mediated cell death in unicellular protozoan parasite Leishmania donovani. Antimicrob Agents Chemother (2014) 0.81
Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease. Bioorg Med Chem Lett (2011) 0.78
Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12). PLoS One (2014) 0.78
Screening and characterisation of antimicrobial properties of semisynthetic betulin derivatives. PLoS One (2014) 0.75
PCR diagnosis and characterization of Leishmania in local and imported clinical samples. Diagn Microbiol Infect Dis (2003) 5.32
Comparison of PCR assays for diagnosis of cutaneous leishmaniasis. J Clin Microbiol (2006) 2.26
Pharmacological properties of the ubiquitous natural product betulin. Eur J Pharm Sci (2006) 2.00
Microsatellite analysis reveals genetic structure of Leishmania tropica. Int J Parasitol (2005) 1.98
Identification and differentiation of Leishmania species in clinical samples by PCR amplification of the miniexon sequence and subsequent restriction fragment length polymorphism analysis. J Clin Microbiol (2003) 1.96
Modular multiantigen T cell epitope-enriched DNA vaccine against human leishmaniasis. Sci Transl Med (2014) 1.57
Outbreak of cutaneous leishmaniasis in northern Israel. J Infect Dis (2003) 1.57
Detection and identification of old world Leishmania by high resolution melt analysis. PLoS Negl Trop Dis (2010) 1.57
2-(3-aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: a new antileishmanial chemotype. J Med Chem (2008) 1.36
Practical approach for typing strains of Leishmania infantum by microsatellite analysis. J Clin Microbiol (2002) 1.33
Polymerase chain reaction using noninvasively obtained samples, for the detection of Leishmania infantum DNA in dogs. J Infect Dis (2004) 1.28
Leishmania tropica in rock hyraxes (Procavia capensis) in a focus of human cutaneous leishmaniasis. Am J Trop Med Hyg (2010) 1.25
Molecular diagnosis of Old World cutaneous leishmaniasis and species identification by use of a reverse line blot hybridization assay. J Clin Microbiol (2008) 1.18
Rapid fluorescent assay for screening drugs on Leishmania amastigotes. J Microbiol Methods (2008) 1.15
UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. Drug Metab Dispos (2008) 1.13
Rapid diagnosis of Old World Leishmaniasis by high-resolution melting analysis of the 7SL RNA gene. J Clin Microbiol (2010) 1.10
Multifarious characterization of leishmania tropica from a Judean desert focus, exposing intraspecific diversity and incriminating phlebotomus sergenti as its vector. Am J Trop Med Hyg (2004) 1.02
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. Anesth Analg (2006) 1.00
Epidemiology of visceral leishmaniasis in the Jenin District, West Bank: 1989-1998. Am J Trop Med Hyg (2002) 0.98
Treatment of cutaneous leishmaniasis with photodynamic therapy. Arch Dermatol (2003) 0.96
Leishmania tropica in northern Israel: a clinical overview of an emerging focus. J Am Acad Dermatol (2005) 0.94
Splenic immune responses during canine visceral leishmaniasis. Vet Res (2007) 0.94
Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L. Bioorg Med Chem (2008) 0.94
Leishmaniasis in Turkey: molecular characterization of Leishmania from human and canine clinical samples. Trop Med Int Health (2009) 0.94
Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9. Drug Metab Dispos (2011) 0.93
Betulin-derived compounds as inhibitors of alphavirus replication. J Nat Prod (2009) 0.91
Anti-leishmanial activity of betulin derivatives. J Antibiot (Tokyo) (2010) 0.91
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. J Am Soc Mass Spectrom (2005) 0.90
Population genetics of Leishmania infantum in Israel and the Palestinian Authority through microsatellite analysis. Microbes Infect (2009) 0.89
Solid-phase synthesis of 1,2,3-triazoles via 1,3-dipolar cycloaddition. J Comb Chem (2003) 0.89
Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation. Biochem Pharmacol (2007) 0.88
Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors. J Neurosci (2009) 0.87
Canine leishmaniosis and its relationship to human visceral leishmaniasis in Eastern Uzbekistan. Parasit Vectors (2011) 0.87
Identification of Babesia species infecting dogs using reverse line blot hybridization for six canine piroplasms, and evaluation of co-infection by other vector-borne pathogens. Vet Parasitol (2012) 0.87
Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines. Bioorg Med Chem Lett (2011) 0.86
Effect of pH and temperature on protein kinase release by Leishmania donovani. Int J Parasitol (2002) 0.86
Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae. Biochem Pharmacol (2010) 0.85
Solid-phase synthesis of amino acid derived N-unsubstituted pyrazoles via sydnones. Org Lett (2009) 0.85
Leishmania tropica infection in golden jackals and red foxes, Israel. Emerg Infect Dis (2010) 0.85
Identification of the molecular attributes required for aminoglycoside activity against Leishmania. Proc Natl Acad Sci U S A (2013) 0.85
Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17. J Med Chem (2006) 0.85
Determination of neutral carbohydrates by CZE with direct UV detection. Electrophoresis (2007) 0.85
Leishmania major: effect of protein kinase A and phosphodiesterase activity on infectivity and proliferation of promastigotes. Exp Parasitol (2009) 0.84
The effect of amphotericin b derivatives on Leishmania and immune functions. J Parasitol (2005) 0.84
Serological survey with PCR validation for canine visceral leishmaniasis in northern Palestine. J Parasitol (2006) 0.84
(+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro. Int J Mol Sci (2013) 0.84
Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays. Anal Biochem (2006) 0.83
Interleukin-12 augments a Th1-type immune response manifested as lymphocyte proliferation and interferon gamma production in Leishmania infantum-infected dogs. Int J Parasitol (2004) 0.83
Current status and future prospects of C1 domain ligands as drug candidates. Curr Top Med Chem (2011) 0.83
UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin. Drug Metab Dispos (2012) 0.82
Polymorphism in the HASPB repeat region of East African Leishmania donovani strains. PLoS Negl Trop Dis (2013) 0.82
Total synthesis of bistramide A and its 36(Z) isomers: differential effect on cell division, differentiation, and apoptosis. Chemistry (2012) 0.82
Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma. PLoS One (2013) 0.82
Kinetoplast DNA heterogeneity among Leishmania infantum strains in central Israel and Palestine. Vet Parasitol (2008) 0.81
Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem (2009) 0.81
Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent. PLoS One (2013) 0.81
Asymptomatic visceral leishmaniasis, northern Israel. Emerg Infect Dis (2003) 0.81
Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors. J Neurochem (2005) 0.81
HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition. Eur J Pharm Sci (2010) 0.80
Visceral leishmaniasis in Israel, 1960-2000. Isr Med Assoc J (2004) 0.80
Leishmania tropica experimental infection in the rat using luciferase-transfected parasites. Vet Parasitol (2012) 0.80
A new insight into solid-state conformation of macrolide antibiotics. Bioorg Med Chem (2007) 0.80
Molecular cloning and characterization of two new isoforms of the protein kinase A catalytic subunit from the human parasite Leishmania. Gene (2002) 0.80
Molecular fingerprinting of Leishmania infantum strains following an outbreak of visceral leishmaniasis in central Israel. J Clin Microbiol (2005) 0.80
Benzo[cd]azulene skeleton: azulene, heptafulvene, and tropone derivatives. Org Lett (2009) 0.79
Enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan. Bioorg Chem (2008) 0.79
C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells. PLoS One (2011) 0.79
Tricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells. PLoS One (2013) 0.78
Quantitative computerized western blotting. Methods Mol Biol (2009) 0.78
Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease. Bioorg Med Chem Lett (2011) 0.78
Recent advances in 1,3-dipolar cycloaddition reactions on solid supports. Mol Divers (2005) 0.78
Identification of a secreted casein kinase 1 in Leishmania donovani: effect of protein over expression on parasite growth and virulence. PLoS One (2013) 0.78
Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17. Biol Chem (2006) 0.78
2-Arylpaullones are selective antitrypanosomal agents. Eur J Med Chem (2013) 0.78
Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. ChemMedChem (2011) 0.78
Polyketide derivatives active against Botrytis cinerea in Gerbera hybrida. Planta (2010) 0.78
Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae. J Med Chem (2010) 0.78
A new Heck reaction modification using ketone Mannich bases as enone precursors: parallel synthesis of anti-leishmanial chalcones. Bioorg Med Chem Lett (2008) 0.77
Synthesis and tautomerization of benzo[cd]azulen-3-ones. Org Lett (2011) 0.77
Microwave-assisted synthesis of imidazoles: reaction of p-toluenesulfonylmethyl isocyanide and polymer-bound imines. Bioorg Med Chem Lett (2005) 0.77
Solid-phase synthesis of pyrazolopyridines from polymer-bound alkyne and azomethine imines. J Comb Chem (2006) 0.77
Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives. J Med Chem (2007) 0.77
The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells. Pharmacol Res (2013) 0.76
Characterization of Leishmania (Leishmania) tropica axenic amastigotes. Acta Trop (2009) 0.76
Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth. Bioorg Med Chem Lett (2012) 0.76
Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug Metab Dispos (2009) 0.76
Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7. ChemMedChem (2007) 0.75
Eudismic analysis of tricyclic sesquiterpenoid alcohols: lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7. Bioorg Chem (2007) 0.75
Potent inhibitors of the human UDP-glucuronosyltransferase 2B7 derived from the sesquiterpenoid alcohol longifolol. ChemMedChem (2007) 0.75
Stereoselective aza Diels-Alder reaction on solid phase: a facile synthesis of hexahydrocinnoline derivatives. J Comb Chem (2007) 0.75
On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole. J Pharm Sci (2003) 0.75
The Diels-Alder reaction between deactivated dienes and electron-deficient dienophiles on solid support: stereoselective synthesis of hexahydro-1,3-dioxoisoindoles. J Comb Chem (2004) 0.75
Synthesis and characterization of hydroxylated mesocarb metabolites for doping control. Arch Pharm (Weinheim) (2009) 0.75