Published in Bioorg Med Chem on January 04, 2010
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol (2011) 5.96
Role of detection method in predicting breast cancer survival: analysis of randomized screening trials. J Natl Cancer Inst (2005) 4.01
Extra-embryonic function of Rb is essential for embryonic development and viability. Nature (2003) 3.92
Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol (2007) 3.54
Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther (2003) 3.34
Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations. J Invest Dermatol (2009) 2.94
Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. Eur J Med Chem (2006) 2.78
Is breast cancer survival improving? Cancer (2004) 2.73
Enamines as novel antibacterials and their structure-activity relationships. Eur J Med Chem (2007) 2.65
Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell (2010) 2.46
Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor. Nat Methods (2008) 2.44
Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials. Bioorg Med Chem (2007) 2.29
Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res (2004) 2.28
Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents. Bioorg Med Chem (2010) 2.25
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet (2002) 2.23
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17
Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis. FEBS J (2010) 2.13
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease. Bioorg Med Chem (2007) 2.13
Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J Am Chem Soc (2013) 1.90
A cytochrome C oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux. Science (2007) 1.84
DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. Mol Cell Biol (2006) 1.80
Response of a KIT-positive extra-abdominal fibromatosis to imatinib mesylate and KIT genetic analysis. J Natl Cancer Inst (2006) 1.80
Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A (2012) 1.80
Lifetime prevalence of mood and anxiety disorders in fragile X premutation carriers. J Clin Psychiatry (2010) 1.79
Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A (2003) 1.74
Effects of berberine on glucose metabolism in vitro. Metabolism (2002) 1.74
The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev (2010) 1.73
Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice. Front Neural Circuits (2010) 1.71
Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position. Eur J Med Chem (2006) 1.65
Synthesis, antiproliferative activity, and structure-activity relationships of 3-aryl-1H-quinolin-4-ones. ChemMedChem (2008) 1.64
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Mol Cell (2012) 1.63
Metronidazole-flavonoid derivatives as anti-Helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8 production by AGS cells. ChemMedChem (2007) 1.62
Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors. Eur J Med Chem (2010) 1.61
Enhanced radical scavenging activity by antioxidant-functionalized gold nanoparticles: a novel inspiration for development of new artificial antioxidants. Free Radic Biol Med (2007) 1.59
Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. Eur J Med Chem (2007) 1.57
Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells. Hum Mol Genet (2009) 1.54
Prognostic factors and treatment of patients with T-cell non-Hodgkin lymphoma: the M. D. Anderson Cancer Center experience. Cancer (2005) 1.53
Left atrial regional phasic strain, strain rate and velocity by speckle-tracking echocardiography: normal values and effects of aging in a large group of normal subjects. Int J Cardiol (2013) 1.52
Selective fluorescent probes for live-cell monitoring of sulphide. Nat Commun (2011) 1.51
Synthesis, antiproliferative evaluation, and structure-activity relationships of 3-arylquinolines. ChemMedChem (2008) 1.50
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. J Biol Chem (2003) 1.47
Characterizing the viscoelastic properties of thin hydrogel-based constructs for tissue engineering applications. J R Soc Interface (2005) 1.47
Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials. Bioorg Med Chem (2011) 1.44
Dyssynchronous pacing triggers endothelial-mesenchymal transition through heterogeneity of mechanical stretch in a canine model. Circ J (2014) 1.41
Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc Natl Acad Sci U S A (2007) 1.41
Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury. Stem Cells Dev (2009) 1.41
Plasma catecholamine release-inhibitory peptide catestatin in patients with essential hypertension. J Cardiovasc Med (Hagerstown) (2011) 1.41
Berberine stimulates glucose transport through a mechanism distinct from insulin. Metabolism (2007) 1.40
Treatment effects of selegiline transdermal system on symptoms of major depressive disorder: a meta-analysis of short-term, placebo-controlled, efficacy trials. Psychopharmacol Bull (2007) 1.40
Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors. Eur J Med Chem (2013) 1.40
Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice. Invest Ophthalmol Vis Sci (2004) 1.40
Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting. J Biol Chem (2001) 1.39
Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy. Cytometry A (2014) 1.38
Transcriptome analysis of early organogenesis in human embryos. Dev Cell (2010) 1.37
Glycine metabolism in animals and humans: implications for nutrition and health. Amino Acids (2013) 1.36
Bioluminescence imaging to monitor the in vivo distribution of administered mesenchymal stem cells in acute kidney injury. Am J Physiol Renal Physiol (2008) 1.36
Schiff base transition metal complexes as novel inhibitors of xanthine oxidase. Eur J Med Chem (2007) 1.36
Polymorphisms of KDR gene are associated with coronary heart disease. J Am Coll Cardiol (2007) 1.35
The public health impact of coccidioidomycosis in Arizona and California. Int J Environ Res Public Health (2011) 1.35
Development of the mammalian lymphatic vasculature. J Clin Invest (2014) 1.34
Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. Eur J Med Chem (2010) 1.33
Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors. Mol Cancer Res (2008) 1.31
Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma. Cancer (2004) 1.30
FLEXIBLE CULM 1 encoding a cinnamyl-alcohol dehydrogenase controls culm mechanical strength in rice. Plant Mol Biol (2008) 1.29
Carbon nanofibers prepared via electrospinning. Adv Mater (2012) 1.28
Optical coherence tomography: real-time imaging of bronchial airways microstructure and detection of inflammatory/neoplastic morphologic changes. Clin Cancer Res (2006) 1.27
The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach. Mol Cell Proteomics (2008) 1.27
Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals. Proc Natl Acad Sci U S A (2005) 1.26
Characterization of the complete mitochondrial genome of the giant silkworm moth, Eriogyna pyretorum (Lepidoptera: Saturniidae). Int J Biol Sci (2009) 1.24
Synthesis and antiproliferative activity of indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line. Eur J Med Chem (2010) 1.23
Change in tumor cellularity of breast carcinoma after neoadjuvant chemotherapy as a variable in the pathologic assessment of response. Cancer (2004) 1.22
Gab2-mediated signaling promotes melanoma metastasis. Am J Pathol (2009) 1.21
Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives. Bioorg Med Chem (2008) 1.20
The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors. Eur J Med Chem (2010) 1.20
Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens. Int J Dev Biol (2004) 1.20
PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. Cancer Res (2002) 1.20
CD44 expression is associated with increased survival in node-negative invasive breast carcinoma. Clin Cancer Res (2005) 1.19
Identification of pax6-dependent gene regulatory networks in the mouse lens. PLoS One (2009) 1.19
Synthesis, molecular modeling and biological evaluation of chalcone thiosemicarbazide derivatives as novel anticancer agents. Eur J Med Chem (2011) 1.18
Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents. Eur J Med Chem (2009) 1.17
Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents. Bioorg Med Chem Lett (2011) 1.14
Synthesis, molecular docking and biological evaluation of metronidazole derivatives as potent Helicobacter pylori urease inhibitors. Bioorg Med Chem (2009) 1.14
Synthesis and cytotoxic evaluation of a series of genistein derivatives. Chem Biodivers (2006) 1.14
A functional nitric oxide reductase model. Proc Natl Acad Sci U S A (2008) 1.14
Functional interactions between alternatively spliced forms of Pax6 in crystallin gene regulation and in haploinsufficiency. Nucleic Acids Res (2004) 1.14
Synthesis of resveratrol analogues, and evaluation of their cytotoxic and xanthine oxidase inhibitory activities. Chem Biodivers (2008) 1.13
Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Proc Natl Acad Sci U S A (2010) 1.12
CD25 expression is correlated with histological grade and response to denileukin diftitox in cutaneous T-cell lymphoma. J Invest Dermatol (2006) 1.12
JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription. J Cell Biochem (2011) 1.12
Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones. Eur J Med Chem (2011) 1.12
Synthesis and antimicrobial activities of 7-O-modified genistein derivatives. Eur J Med Chem (2007) 1.10
Dietary requirements of "nutritionally non-essential amino acids" by animals and humans. Amino Acids (2012) 1.09
Predictive value of serum CEA, CA19-9 and CA72.4 in early diagnosis of recurrence after radical resection of gastric cancer. Hepatogastroenterology (2012) 1.09
Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype. Dev Dyn (2008) 1.08
Ordered mesoporous black TiO(2) as highly efficient hydrogen evolution photocatalyst. J Am Chem Soc (2014) 1.08
High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma. J Clin Oncol (2005) 1.08
Identification of the transmembrane metal binding site in Cu+-transporting PIB-type ATPases. J Biol Chem (2004) 1.08
Curcumin and its formulations: potential anti-cancer agents. Anticancer Agents Med Chem (2012) 1.08
Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes. J Endocrinol (2008) 1.08