Published in Nat Genet on July 01, 2012
Clinical interpretation and implications of whole-genome sequencing. JAMA (2014) 7.24
Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature (2013) 2.24
Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. PLoS Biol (2013) 2.08
Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries. Arterioscler Thromb Vasc Biol (2015) 1.54
Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet (2015) 1.52
Candidate pathway-based genome-wide association studies identify novel associations of genomic variants in the complement system associated with coronary artery disease. Circ Cardiovasc Genet (2014) 1.45
Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles. BMC Genomics (2016) 1.39
Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. J Lipid Res (2013) 1.23
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet (2016) 1.08
Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genet (2014) 1.06
Genetics of coronary artery disease. Circulation (2013) 1.00
The IL-33-ST2L pathway is associated with coronary artery disease in a Chinese Han population. Am J Hum Genet (2013) 0.96
A Phylogenomic Approach Based on PCR Target Enrichment and High Throughput Sequencing: Resolving the Diversity within the South American Species of Bartsia L. (Orobanchaceae). PLoS One (2016) 0.96
Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. PLoS Genet (2013) 0.95
Dissecting the causal genetic mechanisms of coronary heart disease. Curr Atheroscler Rep (2014) 0.93
From genotype to phenotype in human atherosclerosis--recent findings. Curr Opin Lipidol (2013) 0.93
Genetic variants associated with myocardial infarction and the risk factors in Chinese population. PLoS One (2014) 0.92
Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update (2014) 0.90
Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort). J Am Coll Cardiol (2013) 0.88
Genetics of cardiovascular disease: Importance of sex and ethnicity. Atherosclerosis (2015) 0.88
A genome-wide search for linkage of estimated glomerular filtration rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND). PLoS One (2013) 0.87
Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. PLoS Genet (2015) 0.84
A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. Eur J Hum Genet (2014) 0.84
The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease. EMBO Mol Med (2016) 0.83
Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures. J Invest Dermatol (2015) 0.83
Genome-wide association study in Han Chinese identifies three novel loci for human height. Hum Genet (2013) 0.83
Cardiovascular research is thriving in China. Br J Pharmacol (2014) 0.83
Common Variants in Promoter of ADTRP Associate with Early-Onset Coronary Artery Disease in a Southern Han Chinese Population. PLoS One (2015) 0.82
Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells. BMC Neurosci (2012) 0.81
Interaction of type 2 diabetes mellitus with chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population. BMC Cardiovasc Disord (2014) 0.81
Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility. Int J Mol Sci (2015) 0.81
Genome-Wide Association Analysis for Blood Lipid Traits Measured in Three Pig Populations Reveals a Substantial Level of Genetic Heterogeneity. PLoS One (2015) 0.80
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1. Atherosclerosis (2016) 0.80
Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis (2015) 0.80
The rs12526453 Polymorphism in an Intron of the PHACTR1 Gene and Its Association with 5-Year Mortality of Patients with Myocardial Infarction. PLoS One (2015) 0.80
The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression. PLoS One (2015) 0.80
Association of single nucleotide polymorphism rs2076185 in chromosome 6P24.1 with premature coronary artery diseases in Chinese Han population. J Geriatr Cardiol (2016) 0.79
Genetics of Coronary Artery Disease in Taiwan: A Cardiometabochip Study by the Taichi Consortium. PLoS One (2016) 0.79
Large-scale gene-centric analysis identifies polymorphisms for resistant hypertension. J Am Heart Assoc (2014) 0.79
Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11. PLoS One (2015) 0.79
Genomic variant in CAV1 increases susceptibility to coronary artery disease and myocardial infarction. Atherosclerosis (2016) 0.79
From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. Circ Res (2016) 0.79
Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis. Data Brief (2016) 0.78
Calcium-ATPases: Gene disorders and dysregulation in cancer. Biochim Biophys Acta (2015) 0.78
Genomic Study of Cardiovascular Continuum Comorbidity. Acta Naturae (2015) 0.78
Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells. PLoS One (2014) 0.78
On the analysis of a repeated measure design in genome-wide association analysis. Int J Environ Res Public Health (2014) 0.77
Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits. Dis Model Mech (2017) 0.77
Enhanced expression of WD repeat-containing protein 35 via nuclear factor-kappa B activation in bupivacaine-treated Neuro2a cells. PLoS One (2014) 0.77
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice. J Lipid Res (2016) 0.76
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. Nat Commun (2016) 0.76
Genetic loci associated with nonobstructive coronary artery disease in Caucasian women. Physiol Genomics (2015) 0.76
NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study. Oncotarget (2016) 0.76
PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population. Int J Environ Res Public Health (2016) 0.75
Association Between Apolipoprotein B XbaI Polymorphism and Coronary Heart Disease in Han Chinese Population: A Meta-Analysis. Genet Test Mol Biomarkers (2016) 0.75
Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease. Int J Mol Sci (2016) 0.75
Association of genetic polymorphisms on BTNL2 with susceptibility to and prognosis of dilated cardiomyopathy in a Chinese population. Int J Clin Exp Pathol (2015) 0.75
An integrated analysis tool for analyzing hybridization intensities and genotypes using new-generation population-optimized human arrays. BMC Genomics (2016) 0.75
Genomic Variant in IL-37 Confers A Significant Risk of Coronary Artery Disease. Sci Rep (2017) 0.75
ADAMTS7 locus confers high cross-race risk for development of coronary atheromatous plaque. Mol Genet Genomics (2015) 0.75
Exome Sequencing in a Family Identifies RECQL5 Mutation Resulting in Early Myocardial Infarction. Medicine (Baltimore) (2016) 0.75
Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females. Oncotarget (2017) 0.75
Association in a Chinese population of a genetic variation in the early B-cell factor 1 gene with coronary artery disease. BMC Cardiovasc Disord (2017) 0.75
Genetics of coronary artery disease - a clinician's perspective. Indian Heart J (2014) 0.75
Investigation of associations between ten polymorphisms and the risk of coronary artery disease in Southern Han Chinese. J Hum Genet (2016) 0.75
The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies. Br J Pharmacol (2015) 0.75
Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1. Mol Cell Biochem (2013) 0.75
Transcriptional Control of Cell Lineage Development in Epicardium-Derived Cells. J Dev Biol (2013) 0.75
Association of TERT polymorphisms and risk of coronary heart disease in a Chinese Han population. Oncotarget (2017) 0.75
Paleogenetic study on the 17th century Korean mummy with atherosclerotic cardiovascular disease. PLoS One (2017) 0.75
Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease. Sci Rep (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
The International HapMap Project. Nature (2003) 73.65
Genomic control for association studies. Biometrics (1999) 64.39
Population structure and eigenanalysis. PLoS Genet (2006) 37.21
Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation (2010) 30.07
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Genotype imputation. Annu Rev Genomics Hum Genet (2009) 18.64
Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol (2000) 16.47
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Major causes of death among men and women in China. N Engl J Med (2005) 11.80
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bull World Health Organ (1962) 10.43
Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation (1996) 7.29
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Prevalence of the metabolic syndrome and overweight among adults in China. Lancet (2005) 5.05
Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet (2005) 4.23
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet (2011) 4.04
Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation (2011) 2.48
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet (2011) 2.32
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet (2011) 2.27
Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. Hum Mol Genet (2011) 2.21
Tetratricopeptide repeat cochaperones in steroid receptor complexes. Cell Stress Chaperones (2004) 1.79
Genome-wide association study of coronary artery disease in the Japanese. Eur J Hum Genet (2011) 1.32
Associations of PLA2G7 gene polymorphisms with plasma lipoprotein-associated phospholipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis study. Hum Genet (2008) 1.17
Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. Arthritis Rheum (2010) 1.13
Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset. J Invest Dermatol (2011) 1.08
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res (2002) 1.05
The plasma membrane calcium ATPase and disease. Subcell Biochem (2007) 0.85
BTNL2 gene polymorphisms may be associated with susceptibility to Kawasaki disease and formation of coronary artery lesions in Taiwanese children. Eur J Pediatr (2009) 0.85
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol (2003) 84.79
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet (2011) 18.88
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. Proc Natl Acad Sci U S A (2002) 17.22
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Major causes of death among men and women in China. N Engl J Med (2005) 11.80
Widespread RNA and DNA sequence differences in the human transcriptome. Science (2011) 11.45
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet (2008) 10.52
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Testing for an unusual distribution of rare variants. PLoS Genet (2011) 9.28
Genome sequence of Aedes aegypti, a major arbovirus vector. Science (2007) 9.19
Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol (2003) 9.08
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
Apical and midventricular transient left ventricular dysfunction syndrome (tako-tsubo cardiomyopathy): frequency, mechanisms, and prognosis. Chest (2007) 8.08
Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol (2006) 8.05
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
Genome sequence and analysis of the tuber crop potato. Nature (2011) 7.77
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity (2008) 7.60
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59