Bradley E Bernstein

Author PubWeight™ 442.10‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007 65.18
2 Model-based analysis of ChIP-Seq (MACS). Genome Biol 2008 51.63
3 Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 2009 35.48
4 Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 2008 30.29
5 In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007 28.24
6 Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 2011 24.37
7 Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A 2009 20.66
8 Initial genome sequencing and analysis of multiple myeloma. Nature 2011 17.28
9 Dissecting direct reprogramming through integrative genomic analysis. Nature 2008 16.47
10 Active genes are tri-methylated at K4 of histone H3. Nature 2002 15.68
11 Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet 2008 11.17
12 ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res 2012 9.13
13 Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet 2010 7.39
14 Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol 2010 7.00
15 Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science 2009 6.07
16 Charting a dynamic DNA methylation landscape of the human genome. Nature 2013 5.80
17 Signaling network model of chromatin. Cell 2002 4.87
18 Jarid2 and PRC2, partners in regulating gene expression. Genes Dev 2010 4.65
19 Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell 2013 3.83
20 Locus-specific editing of histone modifications at endogenous enhancers. Nat Biotechnol 2013 3.82
21 Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol 2006 3.54
22 Epigenetic reprogramming in cancer. Science 2013 3.47
23 Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell 2003 3.47
24 Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A 2014 3.35
25 Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell 2011 3.20
26 Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell Stem Cell 2011 3.16
27 Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell 2009 3.05
28 A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell 2012 3.04
29 Genomic distribution and inter-sample variation of non-CpG methylation across human cell types. PLoS Genet 2011 2.98
30 Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol 2013 2.89
31 GC-rich sequence elements recruit PRC2 in mammalian ES cells. PLoS Genet 2010 2.86
32 The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012 2.78
33 Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors. Nat Methods 2010 2.71
34 Transcriptional and epigenetic dynamics during specification of human embryonic stem cells. Cell 2013 2.64
35 ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 2012 2.42
36 Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell 2011 2.30
37 Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature 2012 2.28
38 Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA. Nat Methods 2009 2.26
39 Development and validation of a T7 based linear amplification for genomic DNA. BMC Genomics 2003 2.23
40 DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell 2012 2.20
41 Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A 2011 2.16
42 SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing. Dev Cell 2013 1.97
43 Digital transcriptome profiling from attomole-level RNA samples. Genome Res 2010 1.83
44 Chromatin state maps: new technologies, new insights. Curr Opin Genet Dev 2008 1.77
45 Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq. Nat Protoc 2011 1.74
46 Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med 2013 1.71
47 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A 2011 1.59
48 EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas. PLoS One 2011 1.49
49 In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites. Nucleic Acids Res 2013 1.46
50 Molecular biology. Genetic events that shape the cancer epigenome. Science 2012 1.44
51 Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet 2012 1.40
52 An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. Cell Rep 2013 1.35
53 Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network. Cell Stem Cell 2010 1.34
54 H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions. Genome Biol 2012 1.33
55 Developmental biology. Pluripotent chromatin state. Science 2009 1.24
56 Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev 2012 1.24
57 Genome-wide analysis of histone modifications by ChIP-on-chip. Methods 2006 1.06
58 Genomic views of chromatin. Curr Opin Genet Dev 2005 1.05
59 Rpd3p relocation mediates a transcriptional response to rapamycin in yeast. Chem Biol 2004 1.04
60 Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol 2010 1.00
61 Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): II. Second-Strand Synthesis and In Vitro Transcription. CSH Protoc 2008 0.96
62 A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force. Cancer Res 2012 0.87
63 DNA-protein interactions in high definition. Genome Biol 2012 0.79
64 A tell-tail sign of chromatin: histone mutations drive pediatric glioblastoma. Cancer Cell 2012 0.79
65 Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): Overview. CSH Protoc 2008 0.78
66 RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. J Clin Invest 2016 0.77
67 Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease. Proc Natl Acad Sci U S A 2014 0.76
68 Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): I. CIP Treatment of Samples and Tailing Reaction with Terminal Transferase. CSH Protoc 2008 0.75
69 Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): III. Sample Purification. CSH Protoc 2008 0.75