1
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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
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Nature
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2007
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65.18
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2
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Model-based analysis of ChIP-Seq (MACS).
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Genome Biol
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2008
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51.63
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3
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.
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Nature
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2009
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35.48
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4
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Genome-scale DNA methylation maps of pluripotent and differentiated cells.
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Nature
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2008
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30.29
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5
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In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
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Nature
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2007
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28.24
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6
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Mapping and analysis of chromatin state dynamics in nine human cell types.
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Nature
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2011
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24.37
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7
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Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.
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Proc Natl Acad Sci U S A
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2009
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20.66
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8
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Initial genome sequencing and analysis of multiple myeloma.
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Nature
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2011
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17.28
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9
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Dissecting direct reprogramming through integrative genomic analysis.
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Nature
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2008
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16.47
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10
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Active genes are tri-methylated at K4 of histone H3.
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Nature
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2002
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15.68
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11
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Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.
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PLoS Genet
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2008
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11.17
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12
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ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.
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Genome Res
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2012
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9.13
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13
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Charting histone modifications and the functional organization of mammalian genomes.
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Nat Rev Genet
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2010
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7.39
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14
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Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications.
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Nat Biotechnol
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2010
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7.00
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15
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Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses.
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Science
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2009
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6.07
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16
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Charting a dynamic DNA methylation landscape of the human genome.
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Nature
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2013
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5.80
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17
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Signaling network model of chromatin.
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Cell
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2002
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4.87
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18
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Jarid2 and PRC2, partners in regulating gene expression.
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Genes Dev
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2010
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4.65
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19
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Genome-wide chromatin state transitions associated with developmental and environmental cues.
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Cell
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2013
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3.83
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20
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Locus-specific editing of histone modifications at endogenous enhancers.
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Nat Biotechnol
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2013
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3.82
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21
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Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes.
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Nat Struct Mol Biol
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2006
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3.54
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22
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Epigenetic reprogramming in cancer.
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Science
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2013
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3.47
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23
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Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin.
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Mol Cell
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2003
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3.47
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24
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Defining functional DNA elements in the human genome.
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Proc Natl Acad Sci U S A
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2014
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3.35
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25
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Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells.
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Cell
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2011
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3.20
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26
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Reprogramming factor expression initiates widespread targeted chromatin remodeling.
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Cell Stem Cell
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2011
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3.16
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27
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Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis.
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Mol Cell
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2009
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3.05
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28
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A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals.
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Mol Cell
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2012
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3.04
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29
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Genomic distribution and inter-sample variation of non-CpG methylation across human cell types.
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PLoS Genet
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2011
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2.98
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30
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Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.
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Nat Biotechnol
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2013
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2.89
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31
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GC-rich sequence elements recruit PRC2 in mammalian ES cells.
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PLoS Genet
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2010
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2.86
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32
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The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
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Cell
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2012
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2.78
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33
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Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors.
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Nat Methods
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2010
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2.71
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34
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Transcriptional and epigenetic dynamics during specification of human embryonic stem cells.
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Cell
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2013
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2.64
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35
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ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
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Cancer Cell
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2012
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2.42
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36
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Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains.
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Cell
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2011
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2.30
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37
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Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
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Nature
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2012
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2.28
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38
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Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA.
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Nat Methods
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2009
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2.26
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39
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Development and validation of a T7 based linear amplification for genomic DNA.
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BMC Genomics
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2003
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2.23
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40
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DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.
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Cell
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2012
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2.20
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41
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Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.
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Proc Natl Acad Sci U S A
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2011
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2.16
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42
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SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing.
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Dev Cell
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2013
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1.97
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43
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Digital transcriptome profiling from attomole-level RNA samples.
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Genome Res
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2010
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1.83
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44
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Chromatin state maps: new technologies, new insights.
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Curr Opin Genet Dev
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2008
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1.77
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45
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Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq.
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Nat Protoc
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2011
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1.74
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46
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Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.
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J Exp Med
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2013
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1.71
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47
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Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.
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Proc Natl Acad Sci U S A
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2011
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1.59
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48
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EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas.
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PLoS One
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2011
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1.49
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49
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In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.
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Nucleic Acids Res
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2013
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1.46
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50
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Molecular biology. Genetic events that shape the cancer epigenome.
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Science
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2012
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1.44
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51
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Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity.
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PLoS Genet
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2012
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1.40
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52
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An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma.
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Cell Rep
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2013
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1.35
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53
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Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.
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Cell Stem Cell
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2010
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1.34
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54
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H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions.
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Genome Biol
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2012
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1.33
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55
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Developmental biology. Pluripotent chromatin state.
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Science
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2009
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1.24
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56
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Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.
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Genes Dev
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2012
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1.24
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57
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Genome-wide analysis of histone modifications by ChIP-on-chip.
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Methods
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2006
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1.06
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58
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Genomic views of chromatin.
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Curr Opin Genet Dev
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2005
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1.05
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59
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Rpd3p relocation mediates a transcriptional response to rapamycin in yeast.
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Chem Biol
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2004
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1.04
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60
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Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.
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Mol Cell Biol
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2010
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1.00
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61
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Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): II. Second-Strand Synthesis and In Vitro Transcription.
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CSH Protoc
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2008
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0.96
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62
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A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.
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Cancer Res
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2012
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0.87
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63
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DNA-protein interactions in high definition.
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Genome Biol
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2012
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0.79
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64
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A tell-tail sign of chromatin: histone mutations drive pediatric glioblastoma.
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Cancer Cell
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2012
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0.79
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65
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Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): Overview.
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CSH Protoc
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2008
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0.78
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66
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RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation.
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J Clin Invest
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2016
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0.77
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67
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Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease.
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Proc Natl Acad Sci U S A
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2014
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0.76
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68
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Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): I. CIP Treatment of Samples and Tailing Reaction with Terminal Transferase.
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CSH Protoc
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2008
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0.75
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69
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Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): III. Sample Purification.
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CSH Protoc
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2008
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0.75
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