Published in Science on February 04, 2010
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol (2011) 2.68
Sorting nexins provide diversity for retromer-dependent trafficking events. Nat Cell Biol (2011) 2.32
The retromer complex - endosomal protein recycling and beyond. J Cell Sci (2012) 2.08
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol (2011) 1.50
Retromer: a master conductor of endosome sorting. Cold Spring Harb Perspect Biol (2014) 1.46
Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. J Cell Sci (2011) 1.29
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron (2013) 1.26
The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans. Autophagy (2011) 1.26
mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell (2013) 1.22
LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science (2012) 1.18
SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. Cell Res (2011) 1.13
Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling. Mol Biol Cell (2011) 1.02
Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling. J Cell Biol (2013) 0.97
Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease. Int J Hypertens (2010) 0.95
VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1. Biol Open (2012) 0.91
A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration. Neurogenetics (2015) 0.91
Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genet (2013) 0.91
The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers. Mol Biol Cell (2012) 0.88
Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87
Membrane trafficking and phagosome maturation during the clearance of apoptotic cells. Int Rev Cell Mol Biol (2012) 0.86
Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus. Pathogens (2015) 0.85
C. elegans as a model for membrane traffic. WormBook (2014) 0.84
Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response. EBioMedicine (2016) 0.82
Biogenesis of endosome-derived transport carriers. Cell Mol Life Sci (2015) 0.82
Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome. Mol Biol Cell (2013) 0.82
Programmed Cell Death During Caenorhabditis elegans Development. Genetics (2016) 0.81
Retromer contributes to immunity-associated cell death in Arabidopsis. Plant Cell (2015) 0.80
Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. Elife (2015) 0.79
Retromer promotes immune quiescence by suppressing Spätzle-Toll pathway in Drosophila. J Cell Physiol (2014) 0.79
TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation. Proc Natl Acad Sci U S A (2014) 0.78
MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells. Cell Res (2012) 0.78
The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans. Mol Biol Cell (2014) 0.77
The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages. Sci Rep (2016) 0.77
High-Throughput All-Optical Analysis of Synaptic Transmission and Synaptic Vesicle Recycling in Caenorhabditis elegans. PLoS One (2015) 0.77
Sorting through the roles of beclin 1 in microglia and neurodegeneration. J Neuroimmune Pharmacol (2014) 0.77
The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells. PLoS Genet (2015) 0.76
Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology. Mol Biochem Parasitol (2016) 0.76
C. elegans midbodies are released, phagocytosed and undergo LC3-dependent degradation independent of macroautophagy. J Cell Sci (2016) 0.75
Rab17 mediates differential antigen sorting following efferocytosis and phagocytosis. Cell Death Dis (2016) 0.75
Quantitative analysis of retromer complex-related genes during embryo development in the mouse. Mol Cells (2011) 0.75
The giardial VPS35 retromer subunit is necessary for multimeric complex assembly and interaction with the vacuolar protein sorting receptor. Biochim Biophys Acta (2013) 0.75
Role of the Retromer Complex in Neurodegenerative Diseases. Front Aging Neurosci (2016) 0.75
WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors. Proc Natl Acad Sci U S A (2016) 0.75
Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs. Curr Biol (2016) 0.75
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62
Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One (2007) 5.60
Pyogenic bacterial infections in humans with MyD88 deficiency. Science (2008) 4.92
The shared antibiotic resistome of soil bacteria and human pathogens. Science (2012) 3.98
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature (2008) 3.67
Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol (2006) 3.19
Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol (2008) 3.13
The deepest divergences in land plants inferred from phylogenomic evidence. Proc Natl Acad Sci U S A (2006) 3.10
Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol (2009) 3.03
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86
NONCODE v3.0: integrative annotation of long noncoding RNAs. Nucleic Acids Res (2011) 2.82
Whole proteome prokaryote phylogeny without sequence alignment: a K-string composition approach. J Mol Evol (2004) 2.78
Selective amygdalohippocampectomy versus anterior temporal lobectomy in the management of mesial temporal lobe epilepsy: a meta-analysis of comparative studies. J Neurosurg (2013) 2.71
Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1. Cell (2008) 2.60
Tau reduction prevents Abeta-induced defects in axonal transport. Science (2010) 2.57
Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network. Nucleic Acids Res (2011) 2.55
Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients. J Infect Dis (2012) 2.49
Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science (2002) 2.36
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans. Cell (2009) 2.35
Tracing the origin and history of the HIV-2 epidemic. Proc Natl Acad Sci U S A (2003) 2.31
Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem (2005) 2.28
Nonracemic Betti base as a new chiral auxiliary: application to total syntheses of enantiopure (2S,6R)-dihydropinidine and (2S,6R)-isosolenopsins. J Org Chem (2005) 2.19
Structure and ubiquitin binding of the ubiquitin-interacting motif. J Biol Chem (2003) 2.19
External validation and prediction employing the predictive squared correlation coefficient test set activity mean vs training set activity mean. J Chem Inf Model (2008) 2.18
Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem (2003) 2.03
A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med (2007) 2.03
Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med (2013) 2.00
Mechanical assessment of two different methods of tripling hamstring tendons when using suspensory fixation. Knee Surg Sports Traumatol Arthrosc (2011) 1.99
Synthesis of few-layer hexagonal boron nitride thin film by chemical vapor deposition. Nano Lett (2010) 1.97
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity (2007) 1.92
The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics (2010) 1.91
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. J Biol Chem (2009) 1.91
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91
Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathway. J Immunol (2012) 1.86
Low-dose, simple, and fast grating-based X-ray phase-contrast imaging. Proc Natl Acad Sci U S A (2010) 1.82
China's primary health-care reform. Lancet (2011) 1.81
Bandgap engineering of strained monolayer and bilayer MoS2. Nano Lett (2013) 1.80
Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein. J Biol Chem (2003) 1.80
Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. EMBO J (2009) 1.76
Divergent global precipitation changes induced by natural versus anthropogenic forcing. Nature (2013) 1.75
Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem (2011) 1.75
Hematocrit is associated with fibrosis in patients with nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol (2014) 1.71
Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus, Australia. Emerg Infect Dis (2010) 1.70
Internet-based videoconferencing coder/decoders and tools for telemedicine. Telemed J E Health (2011) 1.69
Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter. Mol Pharmacol (2008) 1.69
Developing a performance measurement framework and indicators for community health service facilities in urban China. BMC Fam Pract (2010) 1.68
Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Proc Natl Acad Sci U S A (2005) 1.67
A role for conditioned ventral tegmental glutamate release in cocaine seeking. J Neurosci (2007) 1.65
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity (2010) 1.64
Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. Cancer Sci (2010) 1.63
C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nat Cell Biol (2007) 1.63
Crystal structure of group II chaperonin in the open state. Structure (2010) 1.62
Emission factors of particulate matter and elemental carbon for crop residues and coals burned in typical household stoves in China. Environ Sci Technol (2010) 1.61
Induction of regulatory T cells by physiological level estrogen. J Cell Physiol (2008) 1.59
TAO kinases mediate activation of p38 in response to DNA damage. EMBO J (2007) 1.59
Liver-directed neonatal gene therapy prevents cardiac, bone, ear, and eye disease in mucopolysaccharidosis I mice. Mol Ther (2005) 1.58
Taxonomy of breast cancer based on normal cell phenotype predicts outcome. J Clin Invest (2014) 1.58
DeltaNp73beta is active in transactivation and growth suppression. Mol Cell Biol (2004) 1.56
Null genotypes of GSTM1 and GSTT1 contribute to increased risk of diabetes mellitus: a meta-analysis. Gene (2013) 1.55
Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proc Natl Acad Sci U S A (2007) 1.54
Metabolic alterations in corpus callosum may compromise brain functional connectivity in MTBI patients: an 1H-MRS study. Neurosci Lett (2011) 1.51
Expression of PTEN and mTOR in sacral chordoma and association with poor prognosis. Med Oncol (2014) 1.50
Gaining confidence in biological interpretation of the microarray data: the functional consistence of the significant GO categories. Bioinformatics (2007) 1.50
The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun (2013) 1.50
Triggering receptor expressed on myeloid cells-2 protects against polymicrobial sepsis by enhancing bacterial clearance. Am J Respir Crit Care Med (2013) 1.49
Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification. J Biol Chem (2006) 1.48
NHERF-1 and the cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors. J Biol Chem (2007) 1.48
Overprescribing in China, driven by financial incentives, results in very high use of antibiotics, injections, and corticosteroids. Health Aff (Millwood) (2012) 1.48
Apparently low reproducibility of true differential expression discoveries in microarray studies. Bioinformatics (2008) 1.48
Alteration of brain default network in subacute phase of injury in concussed individuals: resting-state fMRI study. Neuroimage (2011) 1.48
Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release. PLoS One (2008) 1.47
Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks. Nucleic Acids Res (2012) 1.46
Discovery of ZIP transporters that participate in cadmium damage to testis and kidney. Toxicol Appl Pharmacol (2009) 1.46
Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin. J Mol Med (Berl) (2008) 1.46
ncFANs: a web server for functional annotation of long non-coding RNAs. Nucleic Acids Res (2011) 1.46
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J (2003) 1.45
Dexamethasone promotes tolerance in vivo by enriching CD11clo CD40lo tolerogenic macrophages. Eur J Immunol (2012) 1.45
Feasibility of biodegradable PLGA common bile duct stents: an in vitro and in vivo study. J Mater Sci Mater Med (2009) 1.44
Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection. Blood (2003) 1.44
Highly photoluminescent carbon dots for multicolor patterning, sensors, and bioimaging. Angew Chem Int Ed Engl (2013) 1.44
Combined hepatocellular carcinoma and cholangiocarcinoma: a case report and review of the literature. Hepatobiliary Pancreat Dis Int (2007) 1.42
Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control. J Biol Chem (2009) 1.42
Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS. Retrovirology (2007) 1.41
MicroRNAome of porcine pre- and postnatal development. PLoS One (2010) 1.40
NANOGP8 is a retrogene expressed in cancers. FEBS J (2006) 1.40
ac response of a carbon chain under a finite frequency bias. J Chem Phys (2007) 1.40
The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J Immunol (2004) 1.40
MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. Carcinogenesis (2011) 1.39
Antibacterial therapy improves the effectiveness of prostate cancer detection using prostate-specific antigen in patients with asymptomatic prostatitis. Int Urol Nephrol (2009) 1.39
Cigarette smoking and the risk of endometrial cancer: a meta-analysis. Am J Med (2008) 1.38
Black carbon emissions in China from 1949 to 2050. Environ Sci Technol (2012) 1.38
Effect of vapor lock on root canal debridement by using a side-vented needle for positive-pressure irrigant delivery. J Endod (2010) 1.37
Melanoma-associated antigen genes - an update. Cancer Lett (2010) 1.36
The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling. J Pathol (2011) 1.36
Solar water oxidation by composite catalyst/alpha-Fe(2)O(3) photoanodes. J Am Chem Soc (2009) 1.35
Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro. Chin Med J (Engl) (2007) 1.35