Published in Science on August 01, 2008
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity (2010) 5.43
The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature (2010) 4.61
Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55
Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science (2009) 4.45
A prescription for human immunology. Immunity (2008) 4.09
The history of Toll-like receptors - redefining innate immunity. Nat Rev Immunol (2013) 3.59
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest (2010) 3.40
Variation in the human immune system is largely driven by non-heritable influences. Cell (2015) 3.07
From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol (2014) 2.82
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81
Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88. Gut (2011) 2.67
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat Immunol (2010) 2.55
Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity (2010) 2.47
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol (2012) 2.38
Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors. Nat Rev Microbiol (2010) 2.37
Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet (2009) 2.35
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol (2009) 2.27
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore) (2010) 2.26
Human genetic susceptibility to infectious disease. Nat Rev Genet (2012) 2.25
Genetic variation in Toll-like receptors and disease susceptibility. Nat Immunol (2012) 2.09
Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IκBα deficiency. Clin Microbiol Rev (2011) 2.08
Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol (2011) 2.04
Innate antifungal immunity: the key role of phagocytes. Annu Rev Immunol (2011) 1.98
Th17 cells in immunity to Candida albicans. Cell Host Microbe (2012) 1.97
C-type lectin receptors orchestrate antifungal immunity. Nat Immunol (2012) 1.89
Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. J Clin Invest (2011) 1.88
Pathogenesis and pathophysiology of pneumococcal meningitis. Clin Microbiol Rev (2011) 1.87
Human genetics of infectious diseases: between proof of principle and paradigm. J Clin Invest (2009) 1.84
Integration of B cell responses through Toll-like receptors and antigen receptors. Nat Rev Immunol (2012) 1.72
Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity. J Exp Med (2011) 1.71
Host innate immune responses to sepsis. Virulence (2013) 1.66
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc Natl Acad Sci U S A (2009) 1.65
IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients. Blood (2012) 1.65
Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunol (2012) 1.62
Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life. Clin Immunol (2009) 1.59
Toll-like receptor signaling pathways--therapeutic opportunities. Mediators Inflamm (2010) 1.58
Revisiting Crohn's disease as a primary immunodeficiency of macrophages. J Exp Med (2009) 1.54
A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4. Nat Immunol (2014) 1.54
Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infect Immun (2009) 1.52
IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly. Mol Cell (2014) 1.52
Toll-like receptors--sentries in the B-cell response. Immunology (2009) 1.52
Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog (2012) 1.52
Assembly and localization of Toll-like receptor signalling complexes. Nat Rev Immunol (2014) 1.48
Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep (2012) 1.45
Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity. Cell (2017) 1.41
Role of innate host defenses in susceptibility to early-onset neonatal sepsis. Clin Perinatol (2010) 1.39
Unleashing the therapeutic potential of NOD-like receptors. Nat Rev Drug Discov (2009) 1.39
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci U S A (2011) 1.38
Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells. PLoS One (2009) 1.35
Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS Pathog (2015) 1.35
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood. J Exp Med (2012) 1.35
Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010) 1.34
Developmental biology of the innate immune response: implications for neonatal and infant vaccine development. Pediatr Res (2009) 1.33
Overview of the immune response. J Allergy Clin Immunol (2010) 1.32
Inborn errors of anti-viral interferon immunity in humans. Curr Opin Virol (2011) 1.31
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J (2009) 1.30
Identification of potential pathway mediation targets in Toll-like receptor signaling. PLoS Comput Biol (2009) 1.30
A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients. EMBO Mol Med (2011) 1.29
Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans. Eur J Immunol (2012) 1.24
Innate immunity. J Allergy Clin Immunol (2009) 1.23
Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Nat Rev Immunol (2011) 1.23
Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J Infect Dis (2012) 1.23
TLR3 immunity to infection in mice and humans. Curr Opin Immunol (2013) 1.22
Innate control of B cell responses. Trends Immunol (2011) 1.21
TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures. J Cell Biol (2014) 1.17
Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases. J Biol Chem (2009) 1.17
The genetic theory of infectious diseases: a brief history and selected illustrations. Annu Rev Genomics Hum Genet (2013) 1.17
Pathophysiology and treatment of septic shock in neonates. Clin Perinatol (2010) 1.17
Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice. PLoS One (2010) 1.15
Innate responses to Toxoplasma gondii in mice and humans. Trends Parasitol (2011) 1.15
Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection. Infect Immun (2010) 1.12
Innate and adaptive immune responses against Staphylococcus aureus skin infections. Semin Immunopathol (2011) 1.12
Immunodeficiency and autoimmunity: lessons from systemic lupus erythematosus. Trends Mol Med (2011) 1.10
Laboratory evaluation of primary immunodeficiencies. J Allergy Clin Immunol (2009) 1.10
Targeting TLR/IL-1R signalling in human diseases. Mediators Inflamm (2010) 1.09
Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation. Mucosal Immunol (2012) 1.09
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J Biol Chem (2009) 1.09
Severe infectious diseases of childhood as monogenic inborn errors of immunity. Proc Natl Acad Sci U S A (2015) 1.09
Immunology taught by humans. Sci Transl Med (2012) 1.08
Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol (2011) 1.08
Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs. Proc Natl Acad Sci U S A (2009) 1.08
Protective role of IL-1β against post-arthroplasty Staphylococcus aureus infection. J Orthop Res (2011) 1.08
Population genetic tools for dissecting innate immunity in humans. Nat Rev Immunol (2013) 1.08
MyD88: a central player in innate immune signaling. F1000Prime Rep (2014) 1.08
Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system. Dis Model Mech (2013) 1.07
Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. J Exp Med (2015) 1.07
Regulation of B-cell responses by Toll-like receptors. Immunology (2012) 1.07
Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia. Crit Care (2010) 1.06
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J Clin Invest (2010) 1.06
New insights into innate immune control of systemic candidiasis. Med Mycol (2014) 1.05
IgM memory B cells: a mouse/human paradox. Cell Mol Life Sci (2012) 1.03
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly. J Biol Chem (2010) 1.03
Immunological loss-of-function due to genetic gain-of-function in humans: autosomal dominance of the third kind. Curr Opin Immunol (2015) 1.03
Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against Staphylococcus aureus and USA300 MRSA skin infections. J Invest Dermatol (2010) 1.02
Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection. PLoS Pathog (2014) 1.02
Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans. Mamm Genome (2010) 1.01
ISG15: leading a double life as a secreted molecule. Exp Mol Med (2013) 1.01
Innate immune recognition. Annu Rev Immunol (2001) 26.65
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature (2003) 10.97
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol (2000) 6.61
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science (2006) 6.47
TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 5.86
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol (2006) 5.35
Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science (2003) 4.80
MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity (2006) 4.28
Herpes simplex virus encephalitis in human UNC-93B deficiency. Science (2006) 4.26
Macrophages and age-dependent resistance to Herpes simplex virus in mice. J Immunol (1970) 4.15
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74
Primary immunodeficiencies: a field in its infancy. Science (2007) 3.67
Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature (2000) 3.61
A specific primed immune response in Drosophila is dependent on phagocytes. PLoS Pathog (2007) 3.17
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A (2004) 2.74
Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J Immunol (2004) 2.26
Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity (2005) 2.16
Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases. Nat Immunol (2007) 1.96
B cell intrinsic TLR signals amplify but are not required for humoral immunity. J Exp Med (2007) 1.89
Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol (2006) 1.89
Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway. J Biol Chem (2005) 1.70
Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo. J Immunol (2006) 1.69
Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice. Cell Microbiol (2005) 1.59
The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice. J Biol Chem (2004) 1.58
Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2. Infect Immun (2005) 1.44
The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice. Clin Exp Immunol (2006) 0.98
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity (2005) 14.95
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Taking dendritic cells into medicine. Nature (2007) 11.82
Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med (2003) 11.23
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature (2010) 10.37
Genetic dissection of immunity to mycobacteria: the human model. Annu Rev Immunol (2001) 6.92
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science (2011) 6.19
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity (2011) 5.98
A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity (2008) 5.89
TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 5.86
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity (2010) 5.43
Cancer immunotherapy via dendritic cells. Nat Rev Cancer (2012) 5.37
The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol (2007) 5.33
Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood (2004) 5.10
Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood (2006) 5.05
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity (2003) 4.93
Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science (2003) 4.80
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med (2005) 4.79
Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med (2011) 4.51
Herpes simplex virus encephalitis in human UNC-93B deficiency. Science (2006) 4.26
The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood (2007) 4.14
Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J Exp Med (2010) 3.98
Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency. Nat Genet (2003) 3.95
Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity (2008) 3.94
Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J Exp Med (2008) 3.85
Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol (2009) 3.70
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol (2003) 3.69
Primary immunodeficiencies: a field in its infancy. Science (2007) 3.67
B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen. Nat Immunol (2011) 3.66
Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years. J Allergy Clin Immunol (2010) 3.65
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med (2011) 3.63
Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity (2007) 3.58
Efficacy of gene therapy for X-linked severe combined immunodeficiency. N Engl J Med (2010) 3.54
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J Exp Med (2007) 3.51
Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features. Semin Immunol (2006) 3.41
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science (2013) 3.33
Canadian 2003 International Consensus Algorithm For the Diagnosis, Therapy, and Management of Hereditary Angioedema. J Allergy Clin Immunol (2004) 3.30
IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med (2011) 3.29
Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol (2008) 3.13
Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. Immunity (2009) 3.13
Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation. J Exp Med (2011) 3.12
Stem-cell gene therapy for the Wiskott-Aldrich syndrome. N Engl J Med (2010) 3.09
Susceptibility to leprosy is associated with PARK2 and PACRG. Nature (2004) 3.07
Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol (2011) 3.05
Systemic lupus erythematosus: all roads lead to type I interferons. Curr Opin Immunol (2006) 2.99
Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol (2007) 2.98
Prevalence of fabry disease in a cohort of 508 unrelated patients with hypertrophic cardiomyopathy. J Am Coll Cardiol (2007) 2.95
Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med (2011) 2.93