Published in Prostate on June 15, 2010
Autophagy activation: a novel mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of rapamycin pathway. Stem Cells Dev (2012) 1.25
Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion. J Biol Chem (2013) 1.15
Mitophagy is required for acute cardioprotection by simvastatin. Antioxid Redox Signal (2013) 1.14
Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes. Cell Physiol Biochem (2013) 1.08
Androgen receptor (AR) positive vs negative roles in prostate cancer cell deaths including apoptosis, anoikis, entosis, necrosis and autophagic cell death. Cancer Treat Rev (2013) 1.05
KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Oncotarget (2015) 0.98
Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins. Am J Cancer Res (2011) 0.97
Autophagy: a potential therapeutic target in lung diseases. Am J Physiol Lung Cell Mol Physiol (2013) 0.92
Statins impair glucose uptake in tumor cells. Neoplasia (2012) 0.90
Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy. Cell Rep (2015) 0.89
The strategies to control prostate cancer by chemoprevention approaches. Mutat Res (2014) 0.87
Augmentation of autophagy by atorvastatin via Akt/mTOR pathway in spontaneously hypertensive rats. Hypertens Res (2015) 0.83
BIRC6 protein, an inhibitor of apoptosis: role in survival of human prostate cancer cells. PLoS One (2013) 0.83
Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS One (2012) 0.82
Impact of treatment with statins on prostate-specific antigen and prostate volume in patients with benign prostatic hyperplasia. Korean J Urol (2013) 0.81
Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats. Neuropsychopharmacology (2013) 0.81
Pleiotropic effects of the HMG-CoA reductase inhibitors. Int J Gen Med (2011) 0.80
Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. Oncotarget (2015) 0.79
Mevastatin blockade of autolysosome maturation stimulates LBH589-induced cell death in triple-negative breast cancer cells. Oncotarget (2017) 0.77
Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction. Autophagy (2015) 0.77
The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells. J Diabetes Res (2016) 0.75
Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma. J Cancer (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Best practice statement on cryosurgery for the treatment of localized prostate cancer. J Urol (2008) 2.85
Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol (2014) 2.40
Human adult germline stem cells in question. Nature (2010) 1.74
Arabidopsis relatives of the human lysine-specific Demethylase1 repress the expression of FWA and FLOWERING LOCUS C and thus promote the floral transition. Plant Cell (2007) 1.64
Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks. Aging (Albany NY) (2011) 1.58
Specific age-associated DNA methylation changes in human dermal fibroblasts. PLoS One (2011) 1.51
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol Biol Cell (2006) 1.37
Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. J Biol Chem (2001) 1.35
Pluripotent stem cells escape from senescence-associated DNA methylation changes. Genome Res (2012) 1.32
Cellular signaling for activation of Rho GTPase Cdc42. Cell Signal (2008) 1.32
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol (2011) 1.27
Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition. J Biol Chem (2010) 1.25
The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. J Biol Chem (2002) 1.23
Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation (2010) 1.22
Monitoring of cellular senescence by DNA-methylation at specific CpG sites. Aging Cell (2012) 1.22
RhoGDI is required for Cdc42-mediated cellular transformation. Curr Biol (2003) 1.17
Robotic-assisted laparoscopic retroperitoneal lymph node dissection. Urology (2006) 1.17
Priapism associated with routine use of quetiapine: case report and review of the literature. Urology (2005) 1.16
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol (2010) 1.13
Parthenogenetic stem cells for tissue-engineered heart repair. J Clin Invest (2013) 1.11
Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. J Biol Chem (2006) 1.09
Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles. Mol Ther (2012) 1.07
Hematopoietic stem and progenitor cells acquire distinct DNA-hypermethylation during in vitro culture. Sci Rep (2013) 1.04
Arabidopsis homologs of retinoblastoma-associated protein 46/48 associate with a histone deacetylase to act redundantly in chromatin silencing. PLoS Genet (2011) 1.04
TBX3 Directs Cell-Fate Decision toward Mesendoderm. Stem Cell Reports (2013) 0.98
Group consensus reports from the Consensus Conference on Focal Treatment of Prostatic Carcinoma, Celebration, Florida, February 24, 2006. Urology (2007) 0.98
TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells. J Immunol (2010) 0.97
Expression of S-100 protein in renal cell neoplasms. Hum Pathol (2006) 0.95
Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. Biochem J (2006) 0.93
Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex. Gastroenterology (2012) 0.93
Antiapoptotic Cdc42 mutants are potent activators of cellular transformation. Biochemistry (2002) 0.92
Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles. Oncology (2011) 0.91
Rat embryonic fibroblasts improve reprogramming of human keratinocytes into induced pluripotent stem cells. Stem Cells Dev (2011) 0.91
Atorvastatin induces autophagy in prostate cancer PC3 cells through activation of LC3 transcription. Cancer Biol Ther (2011) 0.91
Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells. J Biol Chem (2012) 0.89
The polycomb protein Ezh2 impacts on induced pluripotent stem cell generation. Stem Cells Dev (2014) 0.89
Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol (2013) 0.87
Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men. Stem Cell Rev (2012) 0.85
The impact of bioactive lipids on cardiovascular development. Stem Cells Int (2011) 0.85
Do age-associated DNA methylation changes increase the risk of malignant transformation? Bioessays (2014) 0.85
Dendritic cell lineage commitment is instructed by distinct cytokine signals. Eur J Cell Biol (2011) 0.84
The activation mechanism of ACK1 (activated Cdc42-associated tyrosine kinase 1). Biochem J (2012) 0.84
Polycomb protein EED is required for silencing of pluripotency genes upon ESC differentiation. Stem Cell Rev (2015) 0.83
Identification of the domain in ErbB2 that restricts ligand-induced degradation. Cell Signal (2008) 0.82
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein Cell (2012) 0.82
Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis. Mol Cancer (2014) 0.82
Keratinocyte growth factor and dexamethasone plus elevated cAMP levels synergistically support pluripotent stem cell differentiation into alveolar epithelial type II cells. Tissue Eng Part A (2013) 0.81
Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90. Biochem J (2004) 0.81
Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells. Stem Cells Dev (2011) 0.80
COX-2 inhibitors arrest prostate cancer cell cycle progression by down-regulation of kinetochore/centromere proteins. Prostate (2014) 0.80
TGF-β stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level. BMC Syst Biol (2014) 0.79
Preoperative aspirin is safe in patients undergoing urologic robot-assisted surgery. J Endourol (2012) 0.79
Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells. Stem Cells Dev (2014) 0.78
Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells. Biochim Biophys Acta (2013) 0.78
Measurement of epidermal growth factor receptor turnover and effects of Cdc42. Methods Enzymol (2006) 0.78
Transcriptome analysis of MSC and MSC-derived osteoblasts on Resomer® LT706 and PCL: impact of biomaterial substrate on osteogenic differentiation. PLoS One (2011) 0.77
[Effect of combined use of PDTC and paclitaxel on proliferation and invasion of human breast cancer cell line MCF-7]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi (2010) 0.77
Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny. Stem Cells Int (2013) 0.76
Detecting differential peaks in ChIP-seq signals with ODIN. Bioinformatics (2015) 0.75
[Desorption characteristics of inorganic nitrogen in vegetable garden soil and their effects on soil NO3- -N loss potential]. Ying Yong Sheng Tai Xue Bao (2007) 0.75
Coupling cellular mitogenesis to apoptosis by designed biomolecules. Cell Signal (2009) 0.75
Identification of the region in Cdc42 that confers the binding specificity to activated Cdc42-associated kinase. J Biol Chem (2004) 0.75
Basic approaches to gene expression analysis of stem cells by microarrays. Methods Mol Biol (2011) 0.75
TBX3 Directs Cell-Fate Decision toward Mesendoderm. Stem Cell Reports (2014) 0.75