Published in Proc Natl Acad Sci U S A on April 15, 1991
Functional homologs of fungal metallothionein genes from Arabidopsis. Plant Cell (1994) 2.62
The rice metallothionein gene promoter does not direct foreign gene expression in seed endosperm. Plant Cell Rep (2004) 0.78
Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III. Biochem J (2002) 0.78
The role of Thr5 in human neuron growth inhibitory factor. J Biol Inorg Chem (2006) 0.78
Phylogenetic Analysis of Molluscan Metallothioneins: Evolutionary Insight from Crassostrea virginica. J Mol Evol (2016) 0.76
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Transformation of intact yeast cells treated with alkali cations. J Bacteriol (1983) 100.26
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol (1980) 61.16
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell (1986) 42.45
Metallothionein. Annu Rev Biochem (1986) 8.12
Zinc coordination, function, and structure of zinc enzymes and other proteins. Biochemistry (1990) 6.41
Biochemical effects of mercury, cadmium, and lead. Annu Rev Biochem (1972) 4.35
Spectrophotometric quantitation of silver grains eluted from autoradiograms. Anal Biochem (1983) 3.73
Biochemistry of metallothionein. Biochemistry (1988) 2.93
Structure of the metal clusters in rabbit liver metallothionein. Proc Natl Acad Sci U S A (1980) 2.40
Yeast metallothionein. Sequence and metal-binding properties. J Biol Chem (1985) 2.09
Domain nature of metallothionein. J Biol Chem (1982) 1.79
Sea urchin metallothionein sequence: key to an evolutionary diversity. Proc Natl Acad Sci U S A (1985) 1.37
Mammalian metallothionein is functional in yeast. Science (1986) 1.31
Yeast metallothionein function in metal ion detoxification. J Biol Chem (1986) 1.28
Conformation of [Cd7]-metallothionein-2 from rat liver in aqueous solution determined by nuclear magnetic resonance spectroscopy. J Mol Biol (1988) 1.24
113Cd NMR study of a metallothionein fragment. Evidence for a two-domain structure. J Biol Chem (1982) 1.14
A mechanism for cadmium- and zinc-induced tolerance to cadmium toxicity: involvement of metallothionein. Toxicol Appl Pharmacol (1976) 1.00
Cadmium binding to metallothioneins. Domain specificity in reactions of alpha and beta fragments, apometallothionein, and zinc metallothionein with Cd2+. J Biol Chem (1987) 0.99
Interprotein metal exchange reactions of metallothionein. Experientia Suppl (1987) 0.98
Non-metallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat. Toxicol Appl Pharmacol (1989) 0.98
Cadmium binding and metal cluster formation in metallothionein: a differential modification study. Biochemistry (1986) 0.95
Comparative 113Cd-n.m.r. studies on rabbit 113Cd7-, (Zn1,Cd6)- and partially metal-depleted 113Cd6-metallothionein-2a. Biochem J (1988) 0.91
Independence of the domains of metallothionein in metal binding. J Biol Chem (1985) 0.89
Overexpression of metallothionein in CHO cells and its effect on cell killing by ionizing radiation and alkylating agents. Carcinogenesis (1989) 0.83
Role of metallothionein in detoxification and tolerance to transition metals. Experientia Suppl (1987) 0.82
Domain-specificity of Cd2+ and Zn2+ binding to rabbit liver metallothionein 2. Metal ion mobility in the formation of Cd4-metallothionein alpha-fragment. Biochem J (1989) 0.79
Construction and characterization of a library of metallothionein coding sequence mutants. DNA (1985) 0.79
Effect of cadmium on F-actin and microtubules of Madin-Darby canine kidney cells. Toxicol Appl Pharmacol (1989) 0.78
Metallothioneins with interdomain hinges expanded by insertion mutagenesis. Protein Eng (1990) 0.78
Recognition of ribosomal RNA sites in DNA. I. Analysis of the E. coli system. Proc Natl Acad Sci U S A (1965) 2.05
Recognition of ribosomal RNA sites in DNA. II. The HeLa cell system. Proc Natl Acad Sci U S A (1965) 1.54
Effect of protein-bound RNA associated with chick embryo chromatin on template specificity of the chromatin. J Mol Biol (1969) 1.53
The complete nucleotide sequence of the Crossostoma lacustre mitochondrial genome: conservation and variations among vertebrates. Nucleic Acids Res (1992) 1.47
Identification of competence-repressing factors during log-phase growth of Haemophilus influenzae. J Bacteriol (1972) 1.29
Photochemical studies of the carotenoid biosynthetic pathway in Neurospora crassa. Arch Biochem Biophys (1969) 1.21
Immunochemical detection of metallothionein in specific epithelial cells of rat organs. Proc Natl Acad Sci U S A (1982) 1.14
Replication of Bacillus subtilis DNA during germination in 5 bromouracil containing medium and marker mapping. Genetics (1968) 1.10
Decreased glutathione content of human erythrocytes produced by methyl phenylazoformate. Biochem Biophys Res Commun (1965) 1.10
Characterization of recognition sites on bacteriophage HP1c1 DNA which interact with the DNA uptake system of Haemophilus influenzae Rd. Gene (1984) 1.06
A novel stress-inducible metallothionein-like gene from rice. Plant Mol Biol (1995) 1.06
Nucleotide sequence and properties of the cohesive DNA termini from bacteriophage HP1c1 of Haemophilus influenzae Rd. Gene (1984) 1.05
Cadmium-induced accumulation of metallothionein messenger RNA in rat liver. J Biol Chem (1981) 1.05
New chromatographic form of phenylalanine transfer ribonucleic acid from Escherichia coli growing exponentially in a low-phosphate medium. J Bacteriol (1974) 1.01
RNA expression patterns of a type 2 metallothionein-like gene from rice. Plant Mol Biol (1996) 1.00
Behavior of chloramphenicol-induced phenylalanine transfer ribonucleic acid during recovery from chloramphenicol treatment in Escherichia coli. Biochemistry (1973) 1.00
Sources of triacylglycerol accumulation in livers of rats fed a cholesterol-supplemented diet. Lipids (1995) 0.98
Circadian variations in plasma and erythrocyte glutamate concentrations in adult men consuming a diet with and without added monosodium glutamate. J Nutr (2000) 0.98
Determination of DNA base composition via depurination. Anal Biochem (1966) 0.98
Assignment of the Nance-Horan syndrome to the distal short arm of the X chromosome. Hum Genet (1990) 0.95
Single strand breakage and repair in eukaryotic DNA as assayed by S1 nuclease. Nucleic Acids Res (1977) 0.95
Comparative fingerprint and composition analysis of the three forms of 32P-labeled phenylalanine tRNA from chloramphenicol-treated Escherichia coli. Biochemistry (1974) 0.95
A BASIC microcomputer program for plotting the secondary structure of proteins. Comput Programs Biomed (1982) 0.94
Redundant DNA of Neurospora crassa. Biochem Genet (1972) 0.93
The proportion of cells labeled with tritiated thymidine as a function of population doubling level in cultures of fetal, adult, mutant, and tumor origin. Exp Cell Res (1976) 0.93
An improved method to obtain a large number of mutants in a defined region of DNA. Methods Enzymol (1987) 0.92
Immunochemical localization of metallothionein in rat liver and kidney. J Histochem Cytochem (1982) 0.91
Endoscopic staple-assisted esophagodiverticulostomy: an excellent treatment of choice for Zenker's diverticulum. Laryngoscope (2000) 0.91
National Cancer Institute workshop on the possible roles of metallothionein in carcinogenesis. Cancer Res (1993) 0.90
Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum. Am J Chin Med (2000) 0.89
Nucleotide sequence of cloned DNA segments of the Haemophilus influenzae bacteriophage HP1c1. Gene (1984) 0.89
Approaching healthy body mass index norms for children and adolescents from health-related physical fitness. Obes Rev (2002) 0.87
Effect of cysteine replacements at positions 13 and 50 on metallothionein structure. Biochemistry (1991) 0.87
Intracellular metallothionein concentration and the rate of zinc or cadmium influx and MT mRNA accumulation in a CHO Cdr variant. Exp Cell Res (1989) 0.86
Effects of dietary monounsaturated fatty acids on plasma lipids in humans. J Lipid Res (1990) 0.86
Thymic hormone-containing cells. V. Immunohistological detection of metallothionein within the cells bearing thymulin (a zinc-containing hormone) in human and mouse thymuses. J Histochem Cytochem (1984) 0.86
In vivo uptake of [14C]leucine by skeletal muscle ribosomes after injury in rats fed two levels of protein. Br J Nutr (1969) 0.85
A simple method for the purification of the mitochondrial NADH dehydrogenase. Biochim Biophys Acta (1971) 0.85
Circadian variations in plasma neutral and basic amino acid concentrations in young men on an ordinary Taiwanese diet. J Formos Med Assoc (2000) 0.84
Effects of fat emulsions with different fatty acid composition on plasma and hepatic lipids in rats receiving total parenteral nutrition. Clin Nutr (1996) 0.84
Time-dependent effects of inosine on competence development in Haemophilus influenzae. J Bacteriol (1970) 0.84
Obligatory urinary and fecal nitrogen losses in young Chinese men. J Nutr (1972) 0.84
Why reversing the sequence of the alpha domain of human metallothionein-2 does not change its metal-binding and folding characteristics. Eur J Biochem (1999) 0.83
The effects of apolipoprotein E polymorphism on the distribution of lipids and lipoproteins in the Chinese population. Atherosclerosis (1995) 0.83
DNA strained breakage repair in ataxia telangiectasia fibroblast-like cells. Mutat Res (1975) 0.83
Foods predictive of nutrient intake in Chinese diet in Taiwan: I. Total calories, protein, fat and fatty acids. Int J Epidemiol (1992) 0.83
Term pregnancy in a noncommunicating rudimentary horn of an unicornuate uterus: a case report. Zhonghua Yi Xue Za Zhi (Taipei) (1999) 0.83
Feeding of infants with full-fat soya bean-rice foods. J Trop Pediatr Afr Child Health (1967) 0.82
Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition. Nutrition (1997) 0.82
Studies on interaction between histone V (f2c) and deoxyribonucleic acids. Biochemistry (1975) 0.82
Substitution of glutamic acids for the conserved lysines in the alpha domain affects metal binding in both the alpha and beta domains of mammalian metallothionein. Biochem Biophys Res Commun (1994) 0.81
Unscheduled DNA synthesis in cultured ataxia telangiectasia fibroblast-like cells. Mutat Res (1980) 0.81
Spectroscopic models related to coenzymes and base pairs. I. The basis for hypochromism in the ultraviolet spectra of model systems related to nicotinamide--adenine dinucleotide. J Am Chem Soc (1967) 0.81
LDL of Taiwanese vegetarians are less oxidizable than those of omnivores. J Nutr (2000) 0.81
Mutation of invariant cysteines of mammalian metallothionein alters metal binding capacity, cadmium resistance, and 113Cd NMR spectrum. J Biol Chem (1991) 0.81
Effects of the ratio of polyunsaturated and monounsaturated fatty acid to saturated fatty acid on rat plasma and liver lipid concentrations. Lipids (1998) 0.81
Apurinic and/or apyrimidinic endonuclease activity in ataxia telangiectasia cell extracts. Mutat Res (1978) 0.81
Foods predictive of nutrient intake in Chinese diet in Taiwan: II. Vitamin A, vitamin B1, vitamin B2, vitamin C and calcium. Int J Epidemiol (1992) 0.81
Function and sequence analyses of tumor suppressor gene p53 of CHO.K1 cells. DNA Cell Biol (1999) 0.80
Antioxidant and hepatoprotective effects of Acathopanax senticosus. Phytother Res (2000) 0.80
Radioiodination of chicken erythrocyte histones H4 and H5 in chromatin. J Biol Chem (1979) 0.80
Lack of mutagenicity of vinyl chloride in two strains of Neurospora crassa. Mutat Res (1977) 0.80
Construction and characterization of a library of metallothionein coding sequence mutants. DNA (1985) 0.79
Circadian variations in plasma and erythrocyte concentrations of glutamate, glutamine, and alanine in men on a diet without and with added monosodium glutamate. Metabolism (1999) 0.79
A high cholesterol, (n-3) polyunsaturated fatty acid diet induces hypercholesterolemia more than a high cholesterol (n-6) polyunsaturated fatty acid diet in hamsters. J Nutr (1996) 0.79
Metallothionein accumulation in CHO Cdr cells in response to lead treatment. Chem Biol Interact (1989) 0.79
Antibodies to Epstein-Barr virus thymidine kinase: a characteristic marker for the serological detection of nasopharyngeal carcinoma. Int J Cancer (2001) 0.79
Primary sequence of duck metallothionein. Biochim Biophys Acta (1990) 0.78
Metallothioneins with interdomain hinges expanded by insertion mutagenesis. Protein Eng (1990) 0.78
Transcripts of metallothionein genes in Arabidopsis thaliana. DNA Seq (1995) 0.78
Proliferative capacity of cell cultures derived from the human placenta. In Vitro (1976) 0.78
Maternal transmission of mitochondrial DNA in ducks. Biochem Biophys Res Commun (1990) 0.78
Transition metal-binding proteins from three Chesapeake Bay fish species. Environ Health Perspect (1986) 0.77
Assessment of intragastric pH value changes after early nasogastric feeding. Nutrition (2000) 0.77
Lipoprotein responses to fish, coconut and soybean oil diets with and without cholesterol in the Syrian hamster. J Formos Med Assoc (1995) 0.77
Effect of L-glutamine on hepatic lipids at different energy levels in rats receiving total parenteral nutrition. JPEN J Parenter Enteral Nutr (1994) 0.77
Quinazolines. 12. 1,3-Diaminobenzo(f)quinazolines containing long-chain alkyl or chloro substituents on the central ring. Synthesis and biological evaluation as candidate antifolate and antimalarial agents. J Med Chem (1974) 0.77
Metallothionein detoxification function is impaired by replacement of both conserved lysines with glutamines in the hinge between the two domains. Biochemistry (1993) 0.77
Multiple isoforms of metallothionein are expressed in the porcine liver. Gene (1998) 0.77
Glial immunoreactivity for metallothionein in the rat brain. Glia (1991) 0.77
Pigeon metallothionein consists of two species. Biochim Biophys Acta (1990) 0.77
Effects of L-glutamine on induced hepatosteatosis in rats receiving total parenteral nutrition. J Formos Med Assoc (1995) 0.77
Excess energy and nitrogen balance at protein intakes above the requirement level in young men. Am J Clin Nutr (1988) 0.77
Actual nitrogen deposition in mature adult rats fed moderate to high protein diets. J Nutr (1982) 0.77
Superoxide dismutase and catalase activities in Ataxia telangiectasia and normal fibroblast cell extracts. Mutat Res (1979) 0.77
Type 2 rice metallothionein-like gene has two introns. DNA Seq (1998) 0.76
Effects of fish oil and safflower oil emulsions on diet-induced hepatic steatosis in rats receiving total parenteral nutrition. Clin Nutr (1996) 0.76
Replacement of all alpha-domain lysines with glutamates reduces metallothionein detoxification function. Biochem Biophys Res Commun (1994) 0.76
Further resolution of adult chick hemoglobins by isoelectric focusing in polyacrylamide gel. Biochim Biophys Acta (1976) 0.76
Comparative effects of polyunsaturated- to saturated fatty acid ratio versus polyunsaturated- and monounsaturated fatty acids to saturated fatty acid ratio on lipid metabolism in rats. Atherosclerosis (1999) 0.76
Semi-empirical simulation of Zn/Cd binding site preference in the metal binding domains of mammalian metallothionein. Protein Eng (1996) 0.76
Purification and properties of the cathepsin D types proteinase from beef and rabbit lung and its identification in macrophages. Infect Immun (1973) 0.76
[Study of patients with polycholorinated biphenyls poisoning. I. Blood analyses of patients (author's transl)]. Taiwan Yi Xue Hui Za Zhi (1980) 0.76
Effects of dietary supplementation with fish oil on prostanoid metabolism during acute coronary occlusion with or without reperfusion in diet-induced hypercholesterolemic rabbits. Int J Cardiol (1992) 0.76
Differential effect of adrenalectomy on rat liver metallothionein mRNA levels in basal and stress conditions. Horm Metab Res (1992) 0.76
Regional neurochemical studies on the effect of beta, beta'-iminodipropionitrile (IDPN) in the rat. J Neurosci Res (1975) 0.76
Age-dependent variation for inducibility of metallothionein genes in mouse liver by cadmium. Dev Genet (1988) 0.76
Molecular cloning of Chinese hamster metallothionein II gene and its 5' flanking region. Biochim Biophys Acta (1991) 0.75
Transient response of amplified metallothionein genes in CHO cells to induction by alpha interferon. Mol Cell Biol (1987) 0.75
The involvement of monoaminergic mechanisms in a chemically induced hyperkinetic syndrome in the rat. Psychopharmacol Bull (1975) 0.75