Published in Proc Natl Acad Sci U S A on February 10, 2010
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Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli. J Biol Chem (2003) 1.61
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Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Mol Syst Biol (2011) 1.32
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Gene3D: structural assignment for whole genes and genomes using the CATH domain structure database. Genome Res (2002) 1.29
Effective function annotation through catalytic residue conservation. Proc Natl Acad Sci U S A (2005) 1.28
A structure-based anatomy of the E.coli metabolome. J Mol Biol (2003) 1.27
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Molecular docking for substrate identification: the short-chain dehydrogenases/reductases. J Mol Biol (2007) 1.24
Metal-MACiE: a database of metals involved in biological catalysis. Bioinformatics (2009) 1.23
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Ligand selectivity and competition between enzymes in silico. Nat Biotechnol (2004) 1.22
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On the diversity of physicochemical environments experienced by identical ligands in binding pockets of unrelated proteins. Proteins (2010) 1.12
Correcting for sequence biases in present/absent calls. Genome Biol (2007) 1.12
Missing in action: enzyme functional annotations in biological databases. Nat Chem Biol (2009) 1.11
Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade. J Clin Endocrinol Metab (2011) 1.10
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Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies. PLoS Comput Biol (2012) 1.09
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Evolution of enzymes and pathways for the biosynthesis of cofactors. Nat Prod Rep (2007) 1.07
Gene3D: structural assignments for the biologist and bioinformaticist alike. Nucleic Acids Res (2003) 1.07
Estimation and correction of non-specific binding in a large-scale spike-in experiment. Genome Biol (2007) 1.07
Structural analysis of metal sites in proteins: non-heme iron sites as a case study. J Mol Biol (2009) 1.06
Target selection and determination of function in structural genomics. IUBMB Life (2003) 1.05
Inferring protein function from structure. Methods Biochem Anal (2003) 1.04
Structure and mechanism of drug efflux machinery in Gram negative bacteria. Curr Drug Targets (2008) 1.03
Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family. Bioinformatics (2007) 1.03
Unlocking the potential of survival data for model organisms through a new database and online analysis platform: SurvCurv. Aging Cell (2013) 1.02
Toward the detection and validation of repeats in protein structure. Proteins (2004) 1.02
The CoFactor database: organic cofactors in enzyme catalysis. Bioinformatics (2010) 1.01
Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. PLoS Genet (2010) 1.01
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