Published in Proc Natl Acad Sci U S A on December 16, 2005
110 years of the Meyer-Overton rule: predicting membrane permeability of gases and other small compounds. Chemphyschem (2009) 2.31
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Proc Natl Acad Sci U S A (2009) 2.28
Subangstrom resolution X-ray structure details aquaporin-water interactions. Science (2013) 1.97
Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum. Nat Struct Mol Biol (2008) 1.68
High-resolution x-ray structure of human aquaporin 5. Proc Natl Acad Sci U S A (2008) 1.66
FRET imaging in living maize cells reveals that plasma membrane aquaporins interact to regulate their subcellular localization. Proc Natl Acad Sci U S A (2007) 1.65
No facilitator required for membrane transport of hydrogen sulfide. Proc Natl Acad Sci U S A (2009) 1.63
Unexpected complexity of the aquaporin gene family in the moss Physcomitrella patens. BMC Plant Biol (2008) 1.61
Hydrogen sulfide is a signaling molecule and a cytoprotectant. Antioxid Redox Signal (2012) 1.55
Crystal structure of a yeast aquaporin at 1.15 angstrom reveals a novel gating mechanism. PLoS Biol (2009) 1.41
Structural basis of aquaporin inhibition by mercury. J Mol Biol (2007) 1.35
Noncanonical binding of calmodulin to aquaporin-0: implications for channel regulation. Structure (2008) 1.32
Genome-wide analysis of major intrinsic proteins in the tree plant Populus trichocarpa: characterization of XIP subfamily of aquaporins from evolutionary perspective. BMC Plant Biol (2009) 1.23
A general protocol for the crystallization of membrane proteins for X-ray structural investigation. Nat Protoc (2009) 1.21
Identification and characterization of a bacterial hydrosulphide ion channel. Nature (2012) 1.20
Interactions of lipids with aquaporin-0 and other membrane proteins. Pflugers Arch (2007) 1.14
Structures of membrane proteins. Q Rev Biophys (2010) 1.11
Boron toxicity tolerance in barley through reduced expression of the multifunctional aquaporin HvNIP2;1. Plant Physiol (2010) 1.09
Homology modeling of major intrinsic proteins in rice, maize and Arabidopsis: comparative analysis of transmembrane helix association and aromatic/arginine selectivity filters. BMC Struct Biol (2007) 1.04
2007 annual progress report synopsis of the Center for Structures of Membrane Proteins. J Struct Funct Genomics (2009) 1.03
Annotation of Selaginella moellendorffii Major Intrinsic Proteins and the Evolution of the Protein Family in Terrestrial Plants. Front Plant Sci (2012) 0.98
Nitric oxide conduction by the brain aquaporin AQP4. Proteins (2010) 0.96
Expression and functional characterization of four aquaporin water channels from the European eel (Anguilla anguilla). J Exp Biol (2009) 0.91
Structural information, resolution, and noise in high-resolution atomic force microscopy topographs. Biophys J (2009) 0.89
Genome-wide identification and characterization of aquaporin genes (AQPs) in Chinese cabbage (Brassica rapa ssp. pekinensis). Mol Genet Genomics (2014) 0.88
TMPad: an integrated structural database for helix-packing folds in transmembrane proteins. Nucleic Acids Res (2011) 0.87
Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity. Proc Natl Acad Sci U S A (2010) 0.86
Projection map of aquaporin-9 at 7 A resolution. J Mol Biol (2006) 0.86
MIPModDB: a central resource for the superfamily of major intrinsic proteins. Nucleic Acids Res (2011) 0.86
Algal MIPs, high diversity and conserved motifs. BMC Evol Biol (2011) 0.85
Exploring transmembrane diffusion pathways with molecular dynamics. Physiology (Bethesda) (2010) 0.85
Cloning and characterization of a zebrafish homologue of human AQP1: a bifunctional water and gas channel. Am J Physiol Regul Integr Comp Physiol (2010) 0.83
Detecting Aquaporin Function and Regulation. Front Chem (2016) 0.83
Genome-wide identification, characterization, and expression profile of aquaporin gene family in flax (Linum usitatissimum). Sci Rep (2017) 0.82
Identification of a residue in helix 2 of rice plasma membrane intrinsic proteins that influences water permeability. J Biol Chem (2010) 0.82
Ion selectivity and gating mechanisms of FNT channels. Curr Opin Struct Biol (2013) 0.81
A functional BH3 domain in an aquaporin from Leishmania infantum. Cell Death Discov (2016) 0.80
The Aquaporin Splice Variant NbXIP1;1α Is Permeable to Boric Acid and Is Phosphorylated in the N-terminal Domain. Front Plant Sci (2016) 0.78
Molecular dynamics of water in the neighborhood of aquaporins. Eur Biophys J (2012) 0.77
New subfamilies of major intrinsic proteins in fungi suggest novel transport properties in fungal channels: implications for the host-fungal interactions. BMC Evol Biol (2014) 0.77
Driving forces for transmembrane alpha-helix oligomerization. Biophys J (2010) 0.77
Molecular dynamics study of the archaeal aquaporin AqpM. BMC Genomics (2011) 0.76
Fragment Screening of Human Aquaporin 1. Int J Mol Sci (2016) 0.75
Can Stabilization and Inhibition of Aquaporins Contribute to Future Development of Biomimetic Membranes? Membranes (Basel) (2015) 0.75
Profile of Robert M. Stroud. Proc Natl Acad Sci U S A (2006) 0.75
Molecular cloning and expression analysis of the aqp1aa gene in half-smooth tongue sole (Cynoglossus semilaevis). PLoS One (2017) 0.75
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Raster3D: photorealistic molecular graphics. Methods Enzymol (1997) 27.30
Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics. J Bacteriol (1997) 12.21
Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science (1992) 9.09
Structural determinants of water permeation through aquaporin-1. Nature (2000) 7.66
Structure of a glycerol-conducting channel and the basis for its selectivity. Science (2000) 6.64
Structural basis of water-specific transport through the AQP1 water channel. Nature (2002) 6.23
The pore dimensions of gramicidin A. Biophys J (1993) 5.58
Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature (2004) 2.94
The channel architecture of aquaporin 0 at a 2.2-A resolution. Proc Natl Acad Sci U S A (2004) 2.69
The tobacco aquaporin NtAQP1 is a membrane CO2 pore with physiological functions. Nature (2003) 2.37
MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry. J Comput Aided Mol Des (1995) 2.34
Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli. Proc Natl Acad Sci U S A (2001) 2.28
Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. J Mol Biol (1999) 1.99
Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem (2000) 1.70
Reconstituted aquaporin 1 water channels transport CO2 across membranes. J Biol Chem (1998) 1.47
Functional expression and characterization of an archaeal aquaporin. AqpM from methanothermobacter marburgensis. J Biol Chem (2003) 1.22
Osmoadaptation and osmoregulation in archaea. Front Biosci (2000) 1.15
Oligomerization state of water channels and glycerol facilitators. Involvement of loop E. J Biol Chem (1998) 1.12
Sugar transport through maltoporin of Escherichia coli: role of the greasy slide. J Bacteriol (2002) 1.04
Does aquaporin-1 pass gas? An opposing view. J Physiol (2002) 1.03
Oligomerization state of MIP proteins expressed in Xenopus oocytes as revealed by freeze-fracture electron-microscopy analysis. J Struct Biol (1999) 0.99
Rapid amplification of a water channel-like gene and its flanking sequences from the Methanothermobacter marburgensis genome using a single primer PCR strategy. J Biosci Bioeng (2001) 0.81
Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science (2002) 5.78
Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A. Science (2004) 5.42
Aquaporins in the kidney: from molecules to medicine. Physiol Rev (2002) 5.14
On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2005) 4.25
From structure to disease: the evolving tale of aquaporin biology. Nat Rev Mol Cell Biol (2004) 4.01
The unfolded protein response signals through high-order assembly of Ire1. Nature (2008) 3.87
Substrate twinning activates the signal recognition particle and its receptor. Nature (2004) 2.91
The channel architecture of aquaporin 0 at a 2.2-A resolution. Proc Natl Acad Sci U S A (2004) 2.69
Aquaporin water channels: molecular mechanisms for human diseases. FEBS Lett (2003) 2.47
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. Structure (2006) 2.40
An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci U S A (2003) 2.37
Aquaporin-4 square array assembly: opposing actions of M1 and M23 isoforms. Proc Natl Acad Sci U S A (2003) 2.37
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Proc Natl Acad Sci U S A (2009) 2.28
Targeting proteins to membranes: structure of the signal recognition particle. Curr Opin Struct Biol (2005) 2.18
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci U S A (2002) 2.16
Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z. PLoS Biol (2003) 2.11
A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy. J Natl Cancer Inst (2012) 2.07
Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice. Proc Natl Acad Sci U S A (2003) 2.06
Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice. Proc Natl Acad Sci U S A (2002) 1.97
Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A. Proc Natl Acad Sci U S A (2006) 1.85
An antibiotic factory caught in action. Nat Struct Mol Biol (2004) 1.81
Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. Proc Natl Acad Sci U S A (2003) 1.81
Discovery of the aquaporins and development of the field. Handb Exp Pharmacol (2009) 1.80
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science (2007) 1.77
Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci U S A (2007) 1.76
Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter. Ann Neurol (2012) 1.75
Mechanism of association and reciprocal activation of two GTPases. PLoS Biol (2004) 1.72
Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum. Nat Struct Mol Biol (2008) 1.68
Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry (2003) 1.67
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (2003) 1.67
Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. Proc Natl Acad Sci U S A (2003) 1.65
A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. Cell (2005) 1.63
Crystal structure of a eukaryotic phosphate transporter. Nature (2013) 1.60
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc Natl Acad Sci U S A (2010) 1.57
Structure and function of water channels. Curr Opin Struct Biol (2002) 1.55
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry (2002) 1.45
Function of human Rh based on structure of RhCG at 2.1 A. Proc Natl Acad Sci U S A (2010) 1.41
Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Chem Biol (2003) 1.40
Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine. J Clin Invest (2002) 1.38
Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proc Natl Acad Sci U S A (2006) 1.36
Structural basis of aquaporin inhibition by mercury. J Mol Biol (2007) 1.35
Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage. Proc Natl Acad Sci U S A (2008) 1.35
Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. J Biol Chem (2002) 1.35
Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis. Proc Natl Acad Sci U S A (2004) 1.34
Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus. Proc Natl Acad Sci U S A (2005) 1.33
The role of aquaporin RWC3 in drought avoidance in rice. Plant Cell Physiol (2004) 1.33
Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation. Proc Natl Acad Sci U S A (2008) 1.33
Glycerol facilitator GlpF and the associated aquaporin family of channels. Curr Opin Struct Biol (2003) 1.30
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry. Proc Natl Acad Sci U S A (2004) 1.30
Comparison of human solute carriers. Protein Sci (2010) 1.29
Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. PLoS One (2010) 1.27
Fabs enable single particle cryoEM studies of small proteins. Structure (2012) 1.25
Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. Proc Natl Acad Sci U S A (2014) 1.23
Structure of sugar-bound LacY. Proc Natl Acad Sci U S A (2014) 1.23
Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. Proc Natl Acad Sci U S A (2008) 1.22
Functional expression and characterization of an archaeal aquaporin. AqpM from methanothermobacter marburgensis. J Biol Chem (2003) 1.22
Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. J Biol Chem (2002) 1.22
A general protocol for the crystallization of membrane proteins for X-ray structural investigation. Nat Protoc (2009) 1.21
Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (2002) 1.21
Arsenic trioxide uptake by human and rat aquaglyceroporins. Biochem Biophys Res Commun (2004) 1.21
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. J Mol Biol (2002) 1.21
Functional analysis of the aquaporin gene family in Caenorhabditis elegans. Am J Physiol Cell Physiol (2007) 1.20
Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A. J Biol Chem (2005) 1.19
Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. BMC Biochem (2006) 1.19
Fast and selective ammonia transport by aquaporin-8. J Biol Chem (2006) 1.18
Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence. Proc Natl Acad Sci U S A (2007) 1.18
Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase. J Biol Chem (2003) 1.16
How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. Mol Cell (2007) 1.15
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol (2011) 1.14
Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs. Proc Natl Acad Sci U S A (2009) 1.14
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry (2006) 1.14
Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei. Proc Natl Acad Sci U S A (2007) 1.13
Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica. PLoS One (2010) 1.13
Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland. Am J Physiol Cell Physiol (2005) 1.13
Decreased pulmonary vascular permeability in aquaporin-1-null humans. Proc Natl Acad Sci U S A (2002) 1.13
Structural and functional basis for RNA cleavage by Ire1. BMC Biol (2011) 1.12
The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. Structure (2003) 1.11
Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget (2014) 1.11
Immunolocalization of AQP-5 in rat parotid and submandibular salivary glands after stimulation or inhibition of secretion in vivo. Am J Physiol Gastrointest Liver Physiol (2004) 1.08
A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. J Am Chem Soc (2012) 1.08
Ion permeation of AQP6 water channel protein. Single channel recordings after Hg2+ activation. J Biol Chem (2002) 1.06
Structural context shapes the aquaporin selectivity filter. Proc Natl Acad Sci U S A (2010) 1.06
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol (2013) 1.05
Cell-free complements in vivo expression of the E. coli membrane proteome. Protein Sci (2007) 1.05
Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase. Structure (2004) 1.04
The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction. Physiology (Bethesda) (2006) 1.03
Overexpressing human membrane proteins in stably transfected and clonal human embryonic kidney 293S cells. Nat Protoc (2012) 1.03
Structural basis for alternating access of a eukaryotic calcium/proton exchanger. Nature (2013) 1.03
Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. J Mol Biol (2003) 1.03
Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems. Proc Natl Acad Sci U S A (2010) 1.03
Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening. J Mol Biol (2008) 1.02
Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective. J Biol Chem (2006) 1.02