Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism.

PubWeight™: 2.25‹?› | Rank: Top 2%

🔗 View Article (PMC 3178410)

Published in Dev Cell on January 19, 2010

Authors

Ann C Zovein1, Alfonso Luque, Kirsten A Turlo, Jennifer J Hofmann, Kathleen M Yee, Michael S Becker, Reinhard Fassler, Ira Mellman, Timothy F Lane, M Luisa Iruela-Arispe

Author Affiliations

1: Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Articles citing this

Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol (2011) 3.25

Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events. Blood (2010) 1.98

Molecular regulation of lumen morphogenesis. Curr Biol (2011) 1.96

Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix. Blood (2011) 1.91

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development (2010) 1.78

Combinatorial and distinct roles of α₅ and α₄ integrins in stress erythropoiesis in mice. Blood (2010) 1.72

Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling. Dev Cell (2011) 1.55

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. Fluids Barriers CNS (2012) 1.44

Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development (2010) 1.42

An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium. Nat Cell Biol (2013) 1.38

Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO J (2010) 1.36

Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting. Int Rev Cell Mol Biol (2011) 1.36

Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice. J Exp Med (2011) 1.25

Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development (2012) 1.21

Tips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis. Cold Spring Harb Perspect Med (2012) 1.21

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc Cell (2011) 1.20

Mechanoinduction of lymph vessel expansion. EMBO J (2011) 1.19

Molecular mechanisms controlling vascular lumen formation in three-dimensional extracellular matrices. Cells Tissues Organs (2011) 1.19

Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. Mol Cell (2013) 1.17

Polarity in mammalian epithelial morphogenesis. Cold Spring Harb Perspect Biol (2013) 1.14

VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun (2013) 1.13

EGFL7 meets miRNA-126: an angiogenesis alliance. J Angiogenes Res (2010) 1.12

β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability. EMBO J (2011) 1.07

VEGF-directed blood vessel patterning: from cells to organism. Cold Spring Harb Perspect Med (2012) 1.05

Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood (2012) 1.05

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature (2015) 1.04

Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Nat Med (2014) 1.04

CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling. J Cell Biol (2013) 1.03

Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling. Blood (2013) 0.97

Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun (2015) 0.97

Rho GTPases in collective cell migration. Small GTPases (2014) 0.96

Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development (2014) 0.95

Tubulogenesis during blood vessel formation. Semin Cell Dev Biol (2011) 0.94

Tubulogenesis. Development (2013) 0.94

Amnion formation in the mouse embryo: the single amniochorionic fold model. BMC Dev Biol (2011) 0.94

Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol (2010) 0.94

The role of extracellular matrix in vascular branching morphogenesis. Cell Adh Migr (2012) 0.93

Integrin Beta 1 suppresses multilayering of a simple epithelium. PLoS One (2012) 0.93

Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev Biol (2011) 0.92

Integrins are required for cardioblast polarisation in Drosophila. BMC Dev Biol (2012) 0.92

"You Shall Not Pass"-tight junctions of the blood brain barrier. Front Neurosci (2014) 0.92

When Cre-mediated recombination in mice does not result in protein loss. Genetics (2010) 0.90

Recent advances in vascular development. Curr Opin Hematol (2012) 0.90

An anteroposterior wave of vascular inhibitor downregulation signals aortae fusion along the embryonic midline axis. Development (2010) 0.90

Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol (2013) 0.87

An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Dev Biol (2012) 0.87

The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells. J Cereb Blood Flow Metab (2013) 0.87

Cellular and molecular mechanisms underlying blood vessel lumen formation. Bioessays (2013) 0.87

Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1. PLoS One (2016) 0.85

Integrin signaling in vascular function. Curr Opin Hematol (2012) 0.85

The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling. Development (2015) 0.84

Single-cell analysis of endothelial morphogenesis in vivo. Development (2015) 0.83

Polarizing pathways: balancing endothelial polarity, permeability, and lumen formation. Exp Cell Res (2013) 0.82

Integrins and epithelial cell polarity. J Cell Sci (2014) 0.82

Differential sensitivity of epithelial cells to extracellular matrix in polarity establishment. PLoS One (2014) 0.82

Multiple endothelial cells constitute the tip of developing blood vessels and polarize to promote lumen formation. Development (2014) 0.81

LUMENating blood vessels. Dev Cell (2011) 0.80

β1-integrin/matrix interactions support blood-brain barrier integrity. J Cereb Blood Flow Metab (2011) 0.80

Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization. Circulation (2015) 0.79

Progenitor Epithelium: Sorting Out Pancreatic Lineages. J Histochem Cytochem (2015) 0.79

Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arterioscler Thromb Vasc Biol (2014) 0.79

Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation. J Oncol (2011) 0.79

Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis. Arterioscler Thromb Vasc Biol (2011) 0.79

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nat Commun (2016) 0.78

An apical actin-rich domain drives the establishment of cell polarity during cell adhesion. Histochem Cell Biol (2012) 0.78

Actin remodeling by Nck regulates endothelial lumen formation. Mol Biol Cell (2015) 0.78

Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium. Cell Mol Life Sci (2015) 0.78

Synergy of cell-cell repulsion and vacuolation in a computational model of lumen formation. J R Soc Interface (2014) 0.78

Improved functionality of the vasculature during conventionally fractionated radiation therapy of prostate cancer. PLoS One (2013) 0.77

Molecular control of capillary morphogenesis and maturation by recognition and remodeling of the extracellular matrix: functional roles of endothelial cells and pericytes in health and disease. Connect Tissue Res (2015) 0.77

Enhanced assay of endothelial exocytosis using extracellular matrix components. Anal Biochem (2014) 0.77

Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth. Angiogenesis (2016) 0.77

Endothelial Cords Promote Tumor Initial Growth prior to Vascular Function through a Paracrine Mechanism. Sci Rep (2016) 0.77

Expression of polarity genes in human cancer. Cancer Inform (2015) 0.77

A VE-cadherin-PAR3-α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)α in endothelial cells. Mol Biol Cell (2012) 0.76

Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol (2017) 0.75

Diacylglycerol Kinases: Shaping Diacylglycerol and Phosphatidic Acid Gradients to Control Cell Polarity. Front Cell Dev Biol (2016) 0.75

Epithelial cell integrin β1 is required for developmental angiogenesis in the pituitary gland. Proc Natl Acad Sci U S A (2016) 0.75

Small Rho GTPase-mediated actin dynamics at endothelial adherens junctions. Small GTPases (2016) 0.75

Integrins in development and cancer. Biophys Rev (2013) 0.75

Endosomes derived from clathrin-independent endocytosis serve as precursors for endothelial lumen formation. PLoS One (2013) 0.75

Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity. JCI Insight (2016) 0.75

VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol Biol Cell (2016) 0.75

Apicobasal polarity of brain endothelial cells. J Cereb Blood Flow Metab (2015) 0.75

Endothelial cell hyperproliferation and stratification in uteroplacental blood vessels of the black mastiff bat, Molossus rufus. Placenta (2011) 0.75

Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. Biomed Res Int (2015) 0.75

Identification of Peptides Derived from the C-terminal Domain of Fibulin-7 Active for Endothelial Cell Adhesion and Tube Formation Disruption. Biopolymers (2015) 0.75

Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. Toxicology (2012) 0.75

Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus. J Biol Chem (2016) 0.75

AmotL2 integrates polarity and junctional cues to modulate cell shape. Sci Rep (2017) 0.75

Src- and Fyn-dependent apical membrane trafficking events control endothelial lumen formation during vascular tube morphogenesis. PLoS One (2017) 0.75

Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability. Nat Mater (2017) 0.75

Articles cited by this

Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63

Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol (2001) 31.56

Integrin signaling. Science (1999) 16.44

Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol (2009) 13.01

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09

Autocrine VEGF signaling is required for vascular homeostasis. Cell (2007) 7.37

PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell (2007) 5.84

The PAR-aPKC system: lessons in polarity. J Cell Sci (2006) 4.73

Tube morphogenesis: making and shaping biological tubes. Cell (2003) 4.54

Angiogenesis in vitro. Nature (1980) 4.46

Endothelial tubes assemble from intracellular vacuoles in vivo. Nature (2006) 4.46

Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev (2000) 3.86

Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev (1995) 3.80

Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol (2000) 3.38

VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn (2006) 3.38

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis. J Cell Biol (2008) 3.29

The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell (2009) 3.08

CD99 plays a major role in the migration of monocytes through endothelial junctions. Nat Immunol (2002) 3.01

Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow. Immunity (2000) 2.51

Cellular and molecular mechanisms of vascular lumen formation. Dev Cell (2009) 2.45

Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling. J Cell Sci (2008) 2.43

Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol (2003) 2.38

VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn (2006) 2.21

Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells. J Cell Biol (2005) 2.06

Cell polarity triggered by cell-cell adhesion via E-cadherin. J Cell Sci (2009) 2.04

Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation. J Cell Biol (2008) 1.85

Mechanisms controlling human endothelial lumen formation and tube assembly in three-dimensional extracellular matrices. Birth Defects Res C Embryo Today (2007) 1.84

Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis. Am J Physiol Cell Physiol (2008) 1.76

ECM remodeling regulates angiogenesis: endothelial integrins look for new ligands. Sci STKE (2002) 1.63

Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. J Cell Biol (2007) 1.51

Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. J Cell Sci (2009) 1.47

Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. Development (2008) 1.41

A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep (2006) 1.35

Antibodies to beta 1-integrins cause alterations of aortic vasculogenesis, in vivo. Dev Dyn (1992) 1.33

Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev Dyn (2008) 1.24

Endothelial expression of beta1 integrin is required for embryonic vascular patterning and postnatal vascular remodeling. Mol Cell Biol (2007) 1.19

Integrins in vascular development. Circ Res (2001) 1.05

Targeted mutations in integrins and their ligands: their implications for vascular biology. Thromb Haemost (1997) 0.99

Florence Sabin and the mechanism of blood vessel lumenization during vasculogenesis. Microcirculation (2003) 0.88

Articles by these authors

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature (2007) 8.88

Autocrine VEGF signaling is required for vascular homeostasis. Cell (2007) 7.37

The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res (2009) 6.83

Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell (2003) 6.38

Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol (2005) 5.97

Oncology meets immunology: the cancer-immunity cycle. Immunity (2013) 5.60

Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A (2005) 4.48

Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med (2004) 4.34

Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell (2008) 4.17

Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science (2005) 4.12

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol (2005) 4.03

Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02

Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells. J Cell Biol (2004) 3.82

Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity (2007) 3.58

Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature (2010) 3.52

VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn (2006) 3.38

Activation of lysosomal function during dendritic cell maturation. Science (2003) 3.22

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci U S A (2012) 3.21

Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature (2002) 3.21

Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol (2008) 2.82

The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains. J Cell Biol (2003) 2.78

Antibody therapeutics in cancer. Science (2013) 2.64

Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature (2006) 2.64

Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Nat Cell Biol (2004) 2.59

Toll-like receptors induce a phagocytic gene program through p38. J Exp Med (2003) 2.49

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature (2008) 2.47

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development (2002) 2.42

The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells. J Cell Biol (2003) 2.39

Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. J Clin Invest (2010) 2.38

Quantitative and dynamic assessment of the contribution of the ER to phagosome formation. Cell (2005) 2.35

Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation. J Cell Biol (2002) 2.34

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood (2009) 2.26

Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A (2003) 2.23

VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn (2006) 2.21

Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation. J Exp Med (2003) 2.16

The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J Cell Biol (2002) 2.14

Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell (2008) 2.13

Designing vaccines based on biology of human dendritic cell subsets. Immunity (2010) 2.04

The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell (2010) 2.01

Notch signaling in blood vessels: who is talking to whom about what? Circ Res (2007) 2.00

Immunotherapy: bewitched, bothered, and bewildered no more. Science (2004) 1.99

Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J (2008) 1.96

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol (2010) 1.92

Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging. Nat Med (2002) 1.86

ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem (2003) 1.84

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development (2010) 1.78

Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis. J Exp Med (2006) 1.77

Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res (2007) 1.77

The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol (2010) 1.77

ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Immunity (2002) 1.73

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine (2009) 1.72

A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes. Sci Signal (2014) 1.67

The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell (2012) 1.66

Transferrin receptor recycling in the absence of perinuclear recycling endosomes. J Cell Biol (2002) 1.62

Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells. Traffic (2006) 1.61

ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2. EMBO J (2006) 1.59

Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol (2008) 1.59

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J Exp Med (2013) 1.57

How the rich get richer. J Cell Biol (2007) 1.57

ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem Biophys Res Commun (2002) 1.55

PTH expands short-term murine hemopoietic stem cells through T cells. Blood (2012) 1.53

A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells. J Cell Biol (2011) 1.52

Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. J Cell Biol (2007) 1.51

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation. Cancer Res (2011) 1.50

Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A (2007) 1.50

Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell (2005) 1.47

ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells. J Biol Chem (2005) 1.45

Mature dendritic cells use endocytic receptors to capture and present antigens. Proc Natl Acad Sci U S A (2010) 1.45

Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res (2010) 1.45

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells. Blood (2012) 1.43

Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells. J Exp Med (2009) 1.42

Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations. Proc Natl Acad Sci U S A (2002) 1.38

How the rich get richer. J Exp Med (2007) 1.38

By the scientists, for the scientists. J Cell Biol (2009) 1.37

The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. Cancer Res (2005) 1.33

CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One (2012) 1.33

T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab (2009) 1.32

Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo. Circ Res (2003) 1.32

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors. J Neurooncol (2009) 1.32

Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. J Cell Biol (2009) 1.31

Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. J Bone Miner Res (2010) 1.29

Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem (2005) 1.28

The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression. Science (2010) 1.27

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev (2008) 1.27

A33 antigen displays persistent surface expression. Cancer Immunol Immunother (2008) 1.26

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation. J Exp Med (2013) 1.25

Notch signaling in vascular morphogenesis. Curr Opin Hematol (2004) 1.25

CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol (2006) 1.25