PubRank

R John Solaro

Author PubWeight™ 147.24‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Calcium, thin filaments, and the integrative biology of cardiac contractility. Annu Rev Physiol 2005 3.44
2 Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res 2005 2.79
3 At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. Circ Res 2004 2.06
4 Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol 2006 2.06
5 Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Circ Res 2007 2.05
6 Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. J Clin Invest 2008 2.02
7 Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T. J Biol Chem 2003 1.99
8 Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci U S A 2002 1.98
9 Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I. J Biol Chem 2006 1.89
10 Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J Biol Chem 2003 1.87
11 Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing. J Physiol 2003 1.85
12 Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. Am J Physiol Heart Circ Physiol 2007 1.84
13 Biology of the troponin complex in cardiac myocytes. Prog Cardiovasc Dis 2005 1.83
14 Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Circ Res 2003 1.82
15 Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem 2008 1.75
16 The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Circ Res 2007 1.74
17 Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophys J 2007 1.61
18 Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin. J Mol Biol 2007 1.60
19 Mechanisms and use of calcium-sensitizing agents in the failing heart. Circulation 2006 1.53
20 p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. Circ Res 2007 1.48
21 A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation. Physiology (Bethesda) 2007 1.48
22 A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol 2004 1.48
23 Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I. J Biol Chem 2008 1.46
24 Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments. J Mol Cell Cardiol 2009 1.46
25 Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res 2012 1.39
26 Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J 2005 1.38
27 Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I. Circ Res 2009 1.33
28 Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. Circ Res 2004 1.32
29 Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res 2007 1.29
30 FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol 2009 1.29
31 Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation 2010 1.29
32 The significance of regulatory light chain phosphorylation in cardiac physiology. Arch Biochem Biophys 2011 1.27
33 Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. J Biol Chem 2004 1.27
34 AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function. J Biol Chem 2012 1.27
35 Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells. Circ Res 2007 1.26
36 Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure. Am J Physiol Heart Circ Physiol 2006 1.25
37 Molecular and integrated biology of thin filament protein phosphorylation in heart muscle. Ann N Y Acad Sci 2004 1.22
38 PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation. Basic Res Cardiol 2010 1.21
39 Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts. Am J Physiol Heart Circ Physiol 2008 1.20
40 Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation 2011 1.18
41 Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation 2010 1.18
42 Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation 2008 1.17
43 Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes. Am J Physiol Cell Physiol 2008 1.16
44 Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle. J Biol Chem 2008 1.15
45 Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins. J Biol Chem 2007 1.14
46 Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties. J Mol Cell Cardiol 2012 1.14
47 Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin. Circ Res 2005 1.14
48 A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival. J Biol Chem 2012 1.12
49 Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function. Cardiovasc Res 2008 1.12
50 Troponin I serines 43/45 and regulation of cardiac myofilament function. Am J Physiol Heart Circ Physiol 2002 1.11
51 p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility. Am J Physiol Regul Integr Comp Physiol 2007 1.11
52 Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. Am J Physiol Heart Circ Physiol 2011 1.10
53 Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol 2011 1.09
54 Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically. J Physiol 2004 1.09
55 The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c. Mol Cell Biochem 2004 1.08
56 Specific enhancement of sarcomeric response to Ca2+ protects murine myocardium against ischemia-reperfusion dysfunction. Am J Physiol Heart Circ Physiol 2005 1.08
57 Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments. J Biol Chem 2010 1.08
58 Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice. J Biol Chem 2010 1.07
59 A novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain. Mol Cell Proteomics 2010 1.05
60 Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo. Am J Physiol Heart Circ Physiol 2004 1.04
61 PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo. Biochemistry 2007 1.04
62 Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy. Proteomics 2008 1.04
63 Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments. J Biol Chem 2006 1.04
64 Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation. Am J Physiol Heart Circ Physiol 2002 1.03
65 Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia. Circ Res 2005 1.03
66 Actin capping protein: an essential element in protein kinase signaling to the myofilaments. Circ Res 2002 1.02
67 alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI. Am J Physiol Heart Circ Physiol 2002 1.01
68 Retracted A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling. J Biol Chem 2013 1.00
69 Regulation of cardiac excitation and contraction by p21 activated kinase-1. Prog Biophys Mol Biol 2009 0.99
70 Expression of slow skeletal troponin I in hearts of phospholamban knockout mice alters the relaxant effect of beta-adrenergic stimulation. Circ Res 2002 0.99
71 The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium. Am J Physiol Heart Circ Physiol 2013 0.97
72 Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol 2010 0.97
73 Functional importance of the carboxyl-terminal region of striated muscle tropomyosin. J Biol Chem 2003 0.96
74 Novel control of cardiac myofilament response to calcium by S-glutathionylation at specific sites of myosin binding protein C. Front Physiol 2013 0.95
75 Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43. Cardiovasc Res 2011 0.94
76 Sites of intra- and intermolecular cross-linking of the N-terminal extension of troponin I in human cardiac whole troponin complex. J Biol Chem 2009 0.94
77 Structural basis for the in situ Ca(2+) sensitization of cardiac troponin C by positive feedback from force-generating myosin cross-bridges. Arch Biochem Biophys 2013 0.93
78 Ca(2+) activation and tension cost in myofilaments from mouse hearts ectopically expressing enteric gamma-actin. Am J Physiol Heart Circ Physiol 2002 0.93
79 Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K. J Cardiovasc Pharmacol 2015 0.92
80 CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms. Am J Physiol Cell Physiol 2009 0.92
81 Effects of protein kinase C dependent phosphorylation and a familial hypertrophic cardiomyopathy-related mutation of cardiac troponin I on structural transition of troponin C and myofilament activation. Biochemistry 2004 0.91
82 A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin. Circ Heart Fail 2013 0.91
83 Myocardial infarction in mice alters sarcomeric function via post-translational protein modification. Mol Cell Biochem 2011 0.91
84 H2O2 alters rat cardiac sarcomere function and protein phosphorylation through redox signaling. Am J Physiol Heart Circ Physiol 2010 0.91
85 Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation. Arch Biochem Biophys 2012 0.90
86 Sub-proteomic fractionation, iTRAQ, and OFFGEL-LC-MS/MS approaches to cardiac proteomics. J Proteomics 2010 0.90
87 Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ. J Mol Cell Cardiol 2006 0.90
88 Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation. J Muscle Res Cell Motil 2011 0.89
89 Enhanced ionization of phosphorylated peptides during MALDI TOF mass spectrometry. Anal Chem 2004 0.89
90 p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. Am J Physiol Heart Circ Physiol 2011 0.89
91 Novel bradykinin signaling in adult rat cardiac myocytes through activation of p21-activated kinase. Am J Physiol Heart Circ Physiol 2010 0.88
92 Myofilament proteins: From cardiac disorders to proteomic changes. Proteomics Clin Appl 2008 0.87
93 Correlations between alterations in length-dependent Ca2+ activation of cardiac myofilaments and the end-systolic pressure-volume relation. J Muscle Res Cell Motil 2008 0.87
94 Interventricular differences in myofilament function in experimental congestive heart failure. Pflugers Arch 2011 0.87
95 Molecular actions of drugs that sensitize cardiac myofilaments to Ca2+. Ann Med 2002 0.87
96 Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1. J Mol Cell Cardiol 2013 0.87
97 Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis. J Mol Cell Cardiol 2010 0.86
98 Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A. J Muscle Res Cell Motil 2012 0.84
99 Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathy. J Mol Cell Cardiol 2003 0.84
100 Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling. Prog Biophys Mol Biol 2010 0.84
101 Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L. J Biol Chem 2013 0.84
102 Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia. J Mol Cell Cardiol 2011 0.83
103 Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity. J Muscle Res Cell Motil 2010 0.83
104 Decreasing tropomyosin phosphorylation rescues tropomyosin-induced familial hypertrophic cardiomyopathy. J Biol Chem 2013 0.83
105 New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I. Biochim Biophys Acta 2012 0.83
106 Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium. Arch Biochem Biophys 2012 0.83
107 Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation. Biologics 2008 0.83
108 Physiological significance of troponin T binding domains in striated muscle tropomyosin. Am J Physiol Heart Circ Physiol 2004 0.82
109 Inhibition of endothelial barrier dysfunction by P21-activated kinase-1. Can J Physiol Pharmacol 2007 0.82
110 An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. Am J Physiol Heart Circ Physiol 2009 0.82
111 Maladaptive modifications in myofilament proteins and triggers in the progression to heart failure and sudden death. Pflugers Arch 2014 0.81
112 Tropomyosin dephosphorylation results in compensated cardiac hypertrophy. J Biol Chem 2012 0.81
113 Maintenance of adult cardiac function requires the chromatin factor Asxl2. J Mol Cell Cardiol 2012 0.80
114 Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins. J Biomol NMR 2009 0.80
115 Novel roles of PAK1 in the heart. Cell Logist 2012 0.79
116 Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit. Pediatr Res 2006 0.79
117 Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation. Basic Res Cardiol 2014 0.78
118 PAK1 is a novel cardiac protective signaling molecule. Front Med 2014 0.78
119 Genetics of dilated cardiomyopathy: more genes that kill. J Am Coll Cardiol 2004 0.78
120 When hearts fail so does skeletal muscle: breaking a vicious cycle. Circ Res 2006 0.78
121 Myofilament calcium sensitization delays decompensated hypertrophy differently between the sexes following myocardial infarction. Am J Physiol Regul Integr Comp Physiol 2010 0.78
122 Pak1: steps towards understanding the regulatory mechanisms of pacemaker function of the heart. Future Cardiol 2007 0.77
123 Functional defects in troponin and the systems biology of heart failure. J Mol Cell Cardiol 2002 0.77
124 Translational medicine with a capital T, troponin T, that is. Circ Res 2007 0.77
125 Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling. Front Pharmacol 2013 0.76
126 Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1). J Biol Chem 2002 0.76
127 Why is it important to analyze the cardiac sarcomere subproteome? Expert Rev Proteomics 2010 0.76
128 Reversal of effects of acidosis on contraction of rat heart myocytes by CGP-48506. Front Biosci 2008 0.75
129 A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling. J Biol Chem 2017 0.75
130 The activity of cardiac myocytes reflects a confluence of a multitude of electrical and chemical signals that promote and control the ability of the myocytes to shorten and develop force. J Mol Cell Cardiol 2010 0.75
131 Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor β (TGFβ1)-dependent paracrine mechanism. J Biol Chem 2017 0.75
132 Conference report: fifth international conference on muscle energetics, July 2001. J Muscle Res Cell Motil 2004 0.75
133 Kate Bárány: a life of science, teaching, and service. J Muscle Res Cell Motil 2012 0.75