Published in Nucleic Acids Res on March 01, 2003
L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol (2008) 2.07
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis (2008) 1.82
SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters. PLoS One (2014) 1.58
Unraveling the transcriptional regulatory machinery in chondrogenesis. J Bone Miner Metab (2011) 1.34
Reduced sox9 function promotes heart valve calcification phenotypes in vivo. Circ Res (2010) 1.30
The new collagen gene COL27A1 contains SOX9-responsive enhancer elements. Matrix Biol (2005) 1.25
Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes. Exp Cell Res (2009) 1.21
Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site. Arthritis Rheum (2008) 1.20
Morphogenetic and regulatory mechanisms during developmental chondrogenesis: new paradigms for cartilage tissue engineering. Tissue Eng Part B Rev (2009) 1.17
Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol (2009) 1.11
A Col9a1 enhancer element activated by two interdependent SOX9 dimers. Nucleic Acids Res (2007) 1.11
A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration. Nucleic Acids Res (2013) 1.03
Highly conserved proximal promoter element harbouring paired Sox9-binding sites contributes to the tissue- and developmental stage-specific activity of the matrilin-1 gene. Biochem J (2005) 1.02
Computational identification and functional validation of regulatory motifs in cartilage-expressed genes. Genome Res (2007) 1.01
L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. J Biol Chem (2012) 0.99
The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. Nucleic Acids Res (2015) 0.99
A homozygous nonsense mutation in SOX9 in the dominant disorder campomelic dysplasia: a case of mitotic gene conversion. Hum Genet (2005) 0.96
Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte. Cell Rep (2015) 0.95
SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. J Biol Chem (2010) 0.95
Transcriptional control of mesenchymal stem cell differentiation. Transfus Med Hemother (2008) 0.90
SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells. Am J Pathol (2007) 0.90
The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res (2010) 0.87
The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation. Exp Cell Res (2009) 0.85
Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage. Matrix Biol (2012) 0.83
A novel retinoic acid-response element requires an enhancer element mediator for transcriptional activation. Biochem J (2004) 0.80
SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc. Sci Rep (2016) 0.75
An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos. Biomed Res Int (2017) 0.75
ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity. Connect Tissue Res (2016) 0.75
Poly(γ-Glutamic Acid) as an Exogenous Promoter of Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells. Tissue Eng Part A (2015) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Sox9 is required for cartilage formation. Nat Genet (1999) 7.89
SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol (1997) 5.72
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J (1998) 5.15
SOX9 directly regulates the type-II collagen gene. Nat Genet (1997) 4.88
From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res (1999) 4.64
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A (2001) 4.13
Pairing SOX off: with partners in the regulation of embryonic development. Trends Genet (2000) 3.82
Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus. Cell (1995) 3.72
A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis. Cell (1995) 3.59
Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis. Dev Dyn (1997) 3.35
Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites. Mol Cell Biol (1997) 3.34
Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J Cell Biol (1995) 3.16
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol (1999) 2.70
Definition of a consensus DNA binding site for SRY. Nucleic Acids Res (1994) 2.34
Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. J Biol Chem (1998) 2.21
L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis Cartilage (2001) 1.96
The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences. Nucleic Acids Res (2000) 1.91
A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice. J Cell Sci (1995) 1.90
Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1(II) collagen gene. J Biol Chem (1995) 1.85
An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes. Mol Cell Biol (1996) 1.64
Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Mol Cell Biol (1999) 1.62
Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo. J Biol Chem (1998) 1.61
Collagen XI nucleates self-assembly and limits lateral growth of cartilage fibrils. J Biol Chem (2000) 1.58
Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha2(XI) collagen gene. J Biol Chem (2000) 1.34
Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts. Proc Natl Acad Sci U S A (1996) 1.31
Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage. J Cell Biol (1996) 1.17
Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition. Mol Endocrinol (2001) 1.13
Structural organization of distinct domains within the non-collagenous N-terminal region of collagen type XI. J Biol Chem (2000) 1.11
High conservation of cis-regulatory elements between quail and human for the Pax-6 gene. Dev Genes Evol (1999) 1.05
Autosomal recessive disorder otospondylomegaepiphyseal dysplasia is associated with loss-of-function mutations in the COL11A2 gene. Am J Hum Genet (2000) 1.04
Oto- spondylo-megaepiphyseal dysplasia (OSMED): clinical description of three patients homozygous for a missense mutation in the COL11A2 gene. Am J Med Genet (1997) 1.04
Axial structure of the heterotypic collagen fibrils of vitreous humour and cartilage. J Mol Biol (2001) 0.92
Identification of an interaction between SOX9 and HSP70. FEBS Lett (2001) 0.87
Cell type-specific regulatory sequences control expression of the Drosophila FMRF-NH2 neuropeptide gene. J Neurobiol (1999) 0.82
Hopkins Memorial Medal lecture. Pleasant surprises en route from the biochemistry of collagen to attempts at gene therapy. Biochem Soc Trans (1999) 0.80
Heritable osteoarthritis. Diagnosis and possible modes of cell and gene therapy. Osteoarthritis Cartilage (1999) 0.78
Genes and gene expression. Clin Orthop Relat Res (2000) 0.78
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell (2002) 15.20
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev (2002) 8.19
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A (2005) 4.25
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17
NFAT and Osterix cooperatively regulate bone formation. Nat Med (2005) 2.99
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A (2003) 2.64
Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet (2003) 2.23
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A (2010) 2.20
Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev (2004) 1.88
Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A (2008) 1.86
Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev (2006) 1.86
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol (2005) 1.86
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ. Mol Microbiol (2005) 1.80
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A (2004) 1.77
Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis. Am J Pathol (2002) 1.68
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum (2010) 1.64
The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation. Cancer Res (2003) 1.63
SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification. Development (2010) 1.61
Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix. J Bone Miner Res (2009) 1.56
Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J (2009) 1.54
Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum (2007) 1.51
Subclavian flap aortoplasty: still a safe, reproducible, and effective treatment for infant coarctation. Eur J Cardiothorac Surg (2007) 1.51
Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development (2009) 1.50
Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons. Genesis (2010) 1.46
Generation of viable male and female mice from two fathers. Biol Reprod (2010) 1.46
Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8. Arterioscler Thromb Vasc Biol (2006) 1.45
Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage. Genesis (2009) 1.31
The postnatal role of Sox9 in cartilage. J Bone Miner Res (2012) 1.31
Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice. J Biol Chem (2003) 1.29
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun (2011) 1.27
Identification of SOX9 interaction sites in the genome of chondrocytes. PLoS One (2010) 1.26
Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. Proc Natl Acad Sci U S A (2005) 1.26
Genetic evidence for the vital function of Osterix in cementogenesis. J Bone Miner Res (2012) 1.26
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis (2012) 1.25
Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate. Am J Surg Pathol (2013) 1.25
Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS One (2008) 1.24
Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology (2003) 1.24
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res (2008) 1.23
Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance. Bone (2009) 1.23
Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes. J Biol Chem (2003) 1.21
Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma. Oncol Rep (2008) 1.16
The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site. Matrix Biol (2004) 1.15
Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification. Biochem Biophys Res Commun (2012) 1.11
Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth. Am J Pathol (2004) 1.11
Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9. J Biol Chem (2006) 1.10
Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma. Cancer Res (2005) 1.09
Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter. Matrix Biol (2008) 1.08
Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biol (2006) 1.06
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Mod Pathol (2012) 1.06
SOX9 exerts a bifunctional effect on type II collagen gene (COL2A1) expression in chondrocytes depending on the differentiation state. DNA Cell Biol (2003) 1.05
Dermal transforming growth factor-beta responsiveness mediates wound contraction and epithelial closure. Am J Pathol (2009) 1.05
Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts. J Biol Chem (2011) 1.03
Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro. J Cell Sci (2013) 1.03
Sclerostin is a direct target of osteoblast-specific transcription factor osterix. Biochem Biophys Res Commun (2010) 0.98
A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo. Matrix Biol (2004) 0.96
Cystic pancreatic neuroendocrine tumors: a clinicopathologic study. Am J Surg Pathol (2012) 0.95
Attenuation of fibrosis in vitro and in vivo with SPARC siRNA. Arthritis Res Ther (2010) 0.95
Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix. PLoS One (2013) 0.92
The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice. Dig Dis Sci (2011) 0.90
Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo. J Biol Chem (2006) 0.89
BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter. Histochem Cell Biol (2006) 0.88
Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. Hum Pathol (2012) 0.87
The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res (2010) 0.87
Preoperative radiation therapy in the management of recurrent orbital hemangiopericytoma. Ophthal Plast Reconstr Surg (2011) 0.86
The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells. Mol Cancer Res (2008) 0.86
Significance of overexpression of alpha methylacyl-coenzyme A racemase in hepatocellular carcinoma. J Exp Clin Cancer Res (2008) 0.86
E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein. J Biol Chem (2013) 0.85
Cloning and expression of 21.1-kDa tegumental protein of Clonorchis sinensis and human antibody response to it as a trematode-nematode pan-specific serodiagnosis antigen. Parasitol Res (2010) 0.84
Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation. Biochem Biophys Res Commun (2007) 0.84
Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx. Biochem Biophys Res Commun (2012) 0.83
Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo. J Lipid Res (2007) 0.81
Downregulation of a rheumatoid arthritis-related antigen (RA-A47) by ra-a47 antisense oligonucleotides induces inflammatory factors in chondrocytes. J Cell Physiol (2003) 0.81
Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors. Hum Pathol (2010) 0.80
A novel retinoic acid-response element requires an enhancer element mediator for transcriptional activation. Biochem J (2004) 0.80
Structural insights into histone demethylase NO66 in interaction with osteoblast-specific transcription factor osterix and gene repression. J Biol Chem (2013) 0.80
Molecular cloning, expression, and characterization of cyclophilin A from Clonorchis sinensis. Parasitol Res (2011) 0.79
Schistosoma japonicum tegumental protein 20.8, role in reproduction through its calcium binding ability. Parasitol Res (2013) 0.79
Transforming growth factor-beta isoforms differently stimulate proalpha2 (I) collagen gene expression during wound healing process in transgenic mice. J Cell Physiol (2002) 0.79
Downregulation of rheumatoid arthritis-related antigen RA-A47 (HSP47/colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9. J Cell Physiol (2005) 0.79
The topological structure and function of Echinococcus granulosus lactate dehydrogenase, a tegumental transmembrane protein. Mol Biochem Parasitol (2012) 0.78
Choosing the order of deceased donor and living donor kidney transplantation in pediatric recipients: a Markov decision process model. Transplantation (2015) 0.77
Sp7 and Runx2 molecular complex synergistically regulate expression of target genes. Connect Tissue Res (2014) 0.77
Correction: SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters. PLoS One (2015) 0.77
Osterix is required for cranial neural crest-derived craniofacial bone formation. Biochem Biophys Res Commun (2013) 0.76
Joint formation requires muscle formation and contraction. Dev Cell (2009) 0.76
Persistent low level of osterix accelerates interleukin-6 production and impairs regeneration after tissue injury. PLoS One (2013) 0.75