PubRank

Benoit de Crombrugghe

Author PubWeight™ 112.74‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002 15.20
2 The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 2002 8.19
3 Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev 2004 4.78
4 Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A 2005 4.25
5 SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology 2007 4.17
6 NFAT and Osterix cooperatively regulate bone formation. Nat Med 2005 2.99
7 Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A 2003 2.64
8 Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet 2003 2.23
9 Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A 2010 2.20
10 Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev 2004 1.88
11 Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A 2008 1.86
12 Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev 2006 1.86
13 p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol 2005 1.86
14 Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A 2004 1.77
15 Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis. Am J Pathol 2002 1.68
16 Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum 2010 1.64
17 The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation. Cancer Res 2003 1.63
18 SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification. Development 2010 1.61
19 Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix. J Bone Miner Res 2009 1.56
20 Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J 2009 1.54
21 Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum 2007 1.51
22 Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development 2009 1.50
23 Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons. Genesis 2010 1.46
24 The postnatal role of Sox9 in cartilage. J Bone Miner Res 2012 1.31
25 Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage. Genesis 2009 1.31
26 Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice. J Biol Chem 2003 1.29
27 Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements. Nucleic Acids Res 2003 1.28
28 Genetic evidence for the vital function of Osterix in cementogenesis. J Bone Miner Res 2012 1.26
29 Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. Proc Natl Acad Sci U S A 2005 1.26
30 Identification of SOX9 interaction sites in the genome of chondrocytes. PLoS One 2010 1.26
31 β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis 2012 1.25
32 Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS One 2008 1.24
33 Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology 2003 1.24
34 Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res 2008 1.23
35 Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance. Bone 2009 1.23
36 Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes. J Biol Chem 2003 1.21
37 The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site. Matrix Biol 2004 1.15
38 Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification. Biochem Biophys Res Commun 2012 1.11
39 Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth. Am J Pathol 2004 1.11
40 Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9. J Biol Chem 2006 1.10
41 Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma. Cancer Res 2005 1.09
42 Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter. Matrix Biol 2008 1.08
43 Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biol 2006 1.06
44 SOX9 exerts a bifunctional effect on type II collagen gene (COL2A1) expression in chondrocytes depending on the differentiation state. DNA Cell Biol 2003 1.05
45 Dermal transforming growth factor-beta responsiveness mediates wound contraction and epithelial closure. Am J Pathol 2009 1.05
46 Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts. J Biol Chem 2011 1.03
47 Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro. J Cell Sci 2013 1.03
48 Sclerostin is a direct target of osteoblast-specific transcription factor osterix. Biochem Biophys Res Commun 2010 0.98
49 A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo. Matrix Biol 2004 0.96
50 Attenuation of fibrosis in vitro and in vivo with SPARC siRNA. Arthritis Res Ther 2010 0.95
51 Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix. PLoS One 2013 0.92
52 Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo. J Biol Chem 2006 0.89
53 BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter. Histochem Cell Biol 2006 0.88
54 The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res 2010 0.87
55 The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells. Mol Cancer Res 2008 0.86
56 E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein. J Biol Chem 2013 0.85
57 Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation. Biochem Biophys Res Commun 2007 0.84
58 Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx. Biochem Biophys Res Commun 2012 0.83
59 Downregulation of a rheumatoid arthritis-related antigen (RA-A47) by ra-a47 antisense oligonucleotides induces inflammatory factors in chondrocytes. J Cell Physiol 2003 0.81
60 Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors. Hum Pathol 2010 0.80
61 Structural insights into histone demethylase NO66 in interaction with osteoblast-specific transcription factor osterix and gene repression. J Biol Chem 2013 0.80
62 Downregulation of rheumatoid arthritis-related antigen RA-A47 (HSP47/colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9. J Cell Physiol 2005 0.79
63 Transforming growth factor-beta isoforms differently stimulate proalpha2 (I) collagen gene expression during wound healing process in transgenic mice. J Cell Physiol 2002 0.79
64 Sp7 and Runx2 molecular complex synergistically regulate expression of target genes. Connect Tissue Res 2014 0.77
65 Correction: SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters. PLoS One 2015 0.77
66 Osterix is required for cranial neural crest-derived craniofacial bone formation. Biochem Biophys Res Commun 2013 0.76
67 Joint formation requires muscle formation and contraction. Dev Cell 2009 0.76
68 Persistent low level of osterix accelerates interleukin-6 production and impairs regeneration after tissue injury. PLoS One 2013 0.75