Published in Mol Microbiol on February 17, 2010
Nutritional immunity: transition metals at the pathogen-host interface. Nat Rev Microbiol (2012) 3.55
Iron in infection and immunity. Cell Host Microbe (2013) 2.77
Specificity for human hemoglobin enhances Staphylococcus aureus infection. Cell Host Microbe (2010) 1.66
Protein secretion and surface display in Gram-positive bacteria. Philos Trans R Soc Lond B Biol Sci (2012) 1.61
Molecular mechanisms of Staphylococcus aureus iron acquisition. Annu Rev Microbiol (2011) 1.51
Chlorite dismutases, DyPs, and EfeB: 3 microbial heme enzyme families comprise the CDE structural superfamily. J Mol Biol (2011) 1.27
A new way to degrade heme: the Mycobacterium tuberculosis enzyme MhuD catalyzes heme degradation without generating CO. J Biol Chem (2013) 1.14
Metal limitation and toxicity at the interface between host and pathogen. FEMS Microbiol Rev (2014) 1.14
Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity. Semin Immunopathol (2011) 1.13
A battle for iron: host sequestration and Staphylococcus aureus acquisition. Microbes Infect (2011) 1.12
The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb) (2011) 1.03
Staphylococcus lugdunensis IsdG liberates iron from host heme. J Bacteriol (2011) 1.01
Heme degradation by Staphylococcus aureus IsdG and IsdI liberates formaldehyde rather than carbon monoxide. Biochemistry (2013) 1.00
IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus. J Infect Dis (2013) 0.99
Electronic properties of the highly ruffled heme bound to the heme degrading enzyme IsdI. Proc Natl Acad Sci U S A (2011) 0.97
Sequestration and scavenging of iron in infection. Infect Immun (2013) 0.95
Inactivation of the heme degrading enzyme IsdI by an active site substitution that diminishes heme ruffling. J Biol Chem (2012) 0.91
Recent advances in bacterial heme protein biochemistry. Curr Opin Chem Biol (2011) 0.90
Heme uptake in bacterial pathogens. Curr Opin Chem Biol (2014) 0.89
The Escherichia coli protein YfeX functions as a porphyrinogen oxidase, not a heme dechelatase. MBio (2011) 0.89
Bacillus subtilis Fur represses one of two paralogous haem-degrading monooxygenases. Microbiology (2011) 0.86
Heme utilization by pathogenic bacteria: not all pathways lead to biliverdin. Acc Chem Res (2014) 0.85
Heme Synthesis and Acquisition in Bacterial Pathogens. J Mol Biol (2016) 0.85
Crystallographic and spectroscopic insights into heme degradation by Mycobacterium tuberculosis MhuD. Inorg Chem (2014) 0.84
Substrate, product, and cofactor: The extraordinarily flexible relationship between the CDE superfamily and heme. Arch Biochem Biophys (2015) 0.84
The PRE-Derived NMR Model of the 38.8-kDa Tri-Domain IsdH Protein from Staphylococcus aureus Suggests That It Adaptively Recognizes Human Hemoglobin. J Mol Biol (2015) 0.83
Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence in Staphylococcus aureus. Mol Microbiol (2014) 0.83
Time-resolved Studies of IsdG Protein Identify Molecular Signposts along the Non-canonical Heme Oxygenase Pathway. J Biol Chem (2015) 0.81
The flexible loop of Staphylococcus aureus IsdG is required for its degradation in the absence of heme. Biochemistry (2011) 0.81
Structures of the substrate-free and product-bound forms of HmuO, a heme oxygenase from corynebacterium diphtheriae: x-ray crystallography and molecular dynamics investigation. J Biol Chem (2013) 0.79
Heme binding to the IsdE(M78A; H229A) double mutant: challenging unidirectional heme transfer in the iron-regulated surface determinant protein heme transfer pathway of Staphylococcus aureus. J Biol Inorg Chem (2012) 0.79
IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus. J Biol Chem (2013) 0.78
Formaldehyde Stress Responses in Bacterial Pathogens. Front Microbiol (2016) 0.78
Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation. Proc Natl Acad Sci U S A (2016) 0.77
Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis. Sci Rep (2015) 0.77
Hydrogen bond donation to the heme distal ligand of Staphylococcus aureus IsdG tunes the electronic structure. J Biol Inorg Chem (2015) 0.76
Evolutionary relationships between heme-binding ferredoxin α + β barrels. BMC Bioinformatics (2016) 0.75
In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis. Biochemistry (2016) 0.75
Radical new paradigm for heme degradation in Escherichia coli O157:H7. Proc Natl Acad Sci U S A (2016) 0.75
Antibacterial photosensitization through activation of coproporphyrinogen oxidase. Proc Natl Acad Sci U S A (2017) 0.75
Chlamydomonas reinhardtii LFO1 Is an IsdG Family Heme Oxygenase. mSphere (2017) 0.75
Tight binding of heme to Staphylococcus aureus IsdG and IsdI precludes design of a competitive inhibitor. Metallomics (2017) 0.75
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Scaling and assessment of data quality. Acta Crystallogr D Biol Crystallogr (2005) 61.38
A graphical user interface to the CCP4 program suite. Acta Crystallogr D Biol Crystallogr (2003) 13.43
Bilirubin is an antioxidant of possible physiological importance. Science (1987) 11.26
Microsomal heme oxygenase. Characterization of the enzyme. J Biol Chem (1969) 5.35
Passage of heme-iron across the envelope of Staphylococcus aureus. Science (2003) 4.83
Crystal structure of human heme oxygenase-1. Nat Struct Biol (1999) 2.64
IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus. J Biol Chem (2003) 2.39
Iron-regulated surface determinants (Isd) of Staphylococcus aureus: stealing iron from heme. Microbes Infect (2004) 2.37
Utilization of host iron sources by Corynebacterium diphtheriae: identification of a gene whose product is homologous to eukaryotic heme oxygenases and is required for acquisition of iron from heme and hemoglobin. J Bacteriol (1997) 2.22
Expression and characterization of a heme oxygenase (Hmu O) from Corynebacterium diphtheriae. Iron acquisition requires oxidative cleavage of the heme macrocycle. J Biol Chem (1998) 2.06
The structure and properties of phycocyanobilin and related bilatrienes. Biochemistry (1968) 1.72
Intracellular metalloporphyrin metabolism in Staphylococcus aureus. Biometals (2007) 1.71
Heme oxygenase: evolution, structure, and mechanism. Antioxid Redox Signal (2002) 1.63
Products of heme oxygenase and their potential therapeutic applications. Am J Physiol Renal Physiol (2006) 1.58
Staphylococcus aureus IsdG and IsdI, heme-degrading enzymes with structural similarity to monooxygenases. J Biol Chem (2004) 1.58
Homologues of neisserial heme oxygenase in gram-negative bacteria: degradation of heme by the product of the pigA gene of Pseudomonas aeruginosa. J Bacteriol (2001) 1.55
Degradation of heme in gram-negative bacteria: the product of the hemO gene of Neisseriae is a heme oxygenase. J Bacteriol (2000) 1.53
Bacillus anthracis IsdG, a heme-degrading monooxygenase. J Bacteriol (2006) 1.51
Ruffling of metalloporphyrins bound to IsdG and IsdI, two heme-degrading enzymes in Staphylococcus aureus. J Biol Chem (2008) 1.46
Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem. Mol Microbiol (2008) 1.37
Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa. Biochemistry (2004) 1.36
Structure and catalytic mechanism of heme oxygenase. Nat Prod Rep (2007) 1.35
The heme oxygenase(s)-phytochrome system of Pseudomonas aeruginosa. J Biol Chem (2004) 1.35
Unusual diheme conformation of the heme-degrading protein from Mycobacterium tuberculosis. J Mol Biol (2009) 1.33
Crystal structure of the dioxygen-bound heme oxygenase from Corynebacterium diphtheriae: implications for heme oxygenase function. J Biol Chem (2004) 1.31
Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1. Biochemistry (2001) 1.27
Crystal structure of rat heme oxygenase-1 in complex with heme. FEBS Lett (2000) 1.25
The hmuQ and hmuD genes from Bradyrhizobium japonicum encode heme-degrading enzymes. J Bacteriol (2006) 1.21
Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation. J Biol Chem (2003) 1.09
Role of haem oxygenase-1 in microbial host defence. Cell Microbiol (2008) 1.03
A heme-degradation pathway in a blood-sucking insect. Proc Natl Acad Sci U S A (2006) 1.01
Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications. J Mol Biol (2003) 1.01
Roles of distal Asp in heme oxygenase from Corynebacterium diphtheriae, HmuO: A water-driven oxygen activation mechanism. J Biol Chem (2004) 0.96
Unique features of recombinant heme oxygenase of Drosophila melanogaster compared with those of other heme oxygenases studied. Eur J Biochem (2004) 0.87
Passage of heme-iron across the envelope of Staphylococcus aureus. Science (2003) 4.83
Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (2008) 4.55
Nutritional immunity: transition metals at the pathogen-host interface. Nat Rev Microbiol (2012) 3.55
Nonmydriatic ocular fundus photography among headache patients in an emergency department. Neurology (2013) 3.36
Nonmydriatic digital ocular fundus photography on the iPhone 3G: the FOTO-ED study. Arch Ophthalmol (2012) 3.12
Nonmydriatic ocular fundus photography in the emergency department. N Engl J Med (2011) 2.81
Iron in infection and immunity. Cell Host Microbe (2013) 2.77
Nutritional immunity beyond iron: a role for manganese and zinc. Curr Opin Chem Biol (2009) 2.69
Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell Host Microbe (2011) 2.66
Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe (2012) 2.66
A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence. Cell Host Microbe (2007) 2.55
Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization. J Bacteriol (2006) 2.54
Feasibility of nonmydriatic ocular fundus photography in the emergency department: Phase I of the FOTO-ED study. Acad Emerg Med (2011) 2.46
A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat Biotechnol (2003) 2.41
The calicheamicin gene cluster and its iterative type I enediyne PKS. Science (2002) 2.40
Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation. J Neurotrauma (2007) 2.39
Clinical policy: neuroimaging and decisionmaking in adult mild traumatic brain injury in the acute setting. Ann Emerg Med (2008) 2.32
Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring. J Neurotrauma (2007) 2.15
Position statement: definition of traumatic brain injury. Arch Phys Med Rehabil (2010) 2.03
Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus. J Immunol (2008) 1.97
Quality of nonmydriatic digital fundus photography obtained by nurse practitioners in the emergency department: the FOTO-ED study. Ophthalmology (2012) 1.95
Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example. J Nat Prod (2005) 1.88
Staphylococcus aureus redirects central metabolism to increase iron availability. PLoS Pathog (2006) 1.81
Guidelines for prehospital management of traumatic brain injury 2nd edition. Prehosp Emerg Care (2008) 1.75
Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens. Infect Immun (2010) 1.74
Intracellular metalloporphyrin metabolism in Staphylococcus aureus. Biometals (2007) 1.71
Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholds. J Neurotrauma (2007) 1.67
Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds. J Neurotrauma (2007) 1.67
Specificity for human hemoglobin enhances Staphylococcus aureus infection. Cell Host Microbe (2010) 1.66
Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens. Proc Natl Acad Sci U S A (2013) 1.64
Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia. Infect Immun (2010) 1.59
Monitoring the inflammatory response to infection through the integration of MALDI IMS and MRI. Cell Host Microbe (2012) 1.58
Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis. Infect Immun (2010) 1.54
Molecular mechanisms of Staphylococcus aureus iron acquisition. Annu Rev Microbiol (2011) 1.51
Recombination, repair and replication in the pathogenic Neisseriae: the 3 R's of molecular genetics of two human-specific bacterial pathogens. Mol Microbiol (2003) 1.48
Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration. PLoS Pathog (2012) 1.47
Ruffling of metalloporphyrins bound to IsdG and IsdI, two heme-degrading enzymes in Staphylococcus aureus. J Biol Chem (2008) 1.46
Patients' perspectives of enrollment in research without consent: the patients' experiences in emergency research-progesterone for the treatment of traumatic brain injury study. Crit Care Med (2015) 1.43
Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury. Brain Res (2005) 1.40
Development of a low-resource RNA extraction cassette based on surface tension valves. ACS Appl Mater Interfaces (2011) 1.38
Common data elements for traumatic brain injury: recommendations from the interagency working group on demographics and clinical assessment. Arch Phys Med Rehabil (2010) 1.38
Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem. Mol Microbiol (2008) 1.37
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proc Natl Acad Sci U S A (2010) 1.35
Standardizing data collection in traumatic brain injury. J Neurotrauma (2011) 1.35
Diagnostic accuracy and use of nonmydriatic ocular fundus photography by emergency physicians: phase II of the FOTO-ED study. Ann Emerg Med (2013) 1.35
Guidelines for the management of severe traumatic brain injury. XIII. Antiseizure prophylaxis. J Neurotrauma (2007) 1.34
Signaling and DNA-binding activities of the Staphylococcus aureus HssR-HssS two-component system required for heme sensing. J Biol Chem (2007) 1.34
Does progesterone have neuroprotective properties? Ann Emerg Med (2007) 1.33
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 19. The role of anti-seizure prophylaxis following severe pediatric traumatic brain injury. Pediatr Crit Care Med (2003) 1.32
Progesterone in the clinical treatment of acute traumatic brain injury. Expert Opin Investig Drugs (2010) 1.32
Progesterone's role in neuroprotection, a review of the evidence. Brain Res (2013) 1.31
A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host Microbe (2013) 1.31
Guidelines for the management of severe traumatic brain injury. XIV. Hyperventilation. J Neurotrauma (2007) 1.29
Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapy. J Neurotrauma (2007) 1.26
Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds. J Neurotrauma (2007) 1.24
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 1: Introduction. Pediatr Crit Care Med (2003) 1.24
Benzodiazepine biosynthesis in Streptomyces refuineus. Chem Biol (2007) 1.21
Guidelines for the management of severe traumatic brain injury. VII. Intracranial pressure monitoring technology. J Neurotrauma (2007) 1.21
Metabolic discrimination of select list agents by monitoring cellular responses in a multianalyte microphysiometer. Sensors (Basel) (2009) 1.19
Subcellular localization of the Staphylococcus aureus heme iron transport components IsdA and IsdB. Infect Immun (2009) 1.18
Two heme-dependent terminal oxidases power Staphylococcus aureus organ-specific colonization of the vertebrate host. MBio (2013) 1.17
MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Infect Immun (2013) 1.17
Crystallization of synthetic haemozoin (beta-haematin) nucleated at the surface of lipid particles. Dalton Trans (2009) 1.17
Metal limitation and toxicity at the interface between host and pathogen. FEMS Microbiol Rev (2014) 1.14
Staphylococcus aureus HrtA is an ATPase required for protection against heme toxicity and prevention of a transcriptional heme stress response. J Bacteriol (2008) 1.13
Integrin alphavbeta1 promotes infection by human metapneumovirus. Proc Natl Acad Sci U S A (2009) 1.13
Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity. Semin Immunopathol (2011) 1.13
A battle for iron: host sequestration and Staphylococcus aureus acquisition. Microbes Infect (2011) 1.12
Control of copper resistance and inorganic sulfur metabolism by paralogous regulators in Staphylococcus aureus. J Biol Chem (2011) 1.12
Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120. Proc Natl Acad Sci U S A (2007) 1.12
Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH. J Biol Chem (2011) 1.11
Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. PLoS Pathog (2011) 1.10
Human metapneumovirus fusion protein vaccines that are immunogenic and protective in cotton rats. J Virol (2006) 1.10
Bacillus anthracis HssRS signalling to HrtAB regulates haem resistance during infection. Mol Microbiol (2009) 1.10
Depression and poverty among rural women: a relationship of social causation or social selection? J Rural Health (2008) 1.10
Balancing ethical goals in challenging individual participant scenarios occurring in a trial conducted with exception from informed consent. Acad Emerg Med (2015) 1.09
Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. Antimicrob Agents Chemother (2009) 1.08
The heme sensor system of Staphylococcus aureus. Contrib Microbiol (2009) 1.08
Guidelines for the management of severe traumatic brain injury. III. Prophylactic hypothermia. J Neurotrauma (2007) 1.08
A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III). Int J Stroke (2013) 1.08
Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism. Proc Natl Acad Sci U S A (2013) 1.07
Host-microbe interactions that shape the pathogenesis of Acinetobacter baumannii infection. Cell Microbiol (2012) 1.05
The neutral lipid composition present in the digestive vacuole of Plasmodium falciparum concentrates heme and mediates β-hematin formation with an unusually low activation energy. Biochemistry (2010) 1.05
Membrane damage elicits an immunomodulatory program in Staphylococcus aureus. PLoS Pathog (2010) 1.05
Hairpin DNA-functionalized gold colloids for the imaging of mRNA in live cells. J Am Chem Soc (2010) 1.04
Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization. Antimicrob Agents Chemother (2011) 1.04
Guidelines for the management of severe traumatic brain injury. XI. Anesthetics, analgesics, and sedatives. J Neurotrauma (2007) 1.02
A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo. J Virol (2007) 1.02
Guidelines for the management of severe traumatic brain injury. XV. Steroids. J Neurotrauma (2007) 1.02
The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots. Proc Natl Acad Sci U S A (2002) 1.02
Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes. Nano Lett (2005) 1.02
The epidemiology of childhood injury in Maputo, Mozambique. Int J Emerg Med (2010) 1.01
Menaquinone biosynthesis potentiates haem toxicity in Staphylococcus aureus. Mol Microbiol (2012) 1.01
Staphylococcus lugdunensis IsdG liberates iron from host heme. J Bacteriol (2011) 1.01
Low-resource method for extracting the malarial biomarker histidine-rich protein II to enhance diagnostic test performance. Anal Chem (2012) 1.00
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 5. Indications for intracranial pressure monitoring in pediatric patients with severe traumatic brain injury. Pediatr Crit Care Med (2003) 1.00
The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype. J Biol Chem (2013) 1.00
Genomic and functional analysis of the type VI secretion system in Acinetobacter. PLoS One (2013) 0.99
Lipophilic mediated assays for beta-hematin inhibitors. Comb Chem High Throughput Screen (2010) 0.99