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1
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A genomics-guided approach for discovering and expressing cryptic metabolic pathways.
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Nat Biotechnol
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2003
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2.41
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2
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The calicheamicin gene cluster and its iterative type I enediyne PKS.
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Science
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2002
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2.40
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3
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Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.
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J Nat Prod
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2005
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1.88
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4
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The IsdG-family of haem oxygenases degrades haem to a novel chromophore.
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Mol Microbiol
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2010
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1.40
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5
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Benzodiazepine biosynthesis in Streptomyces refuineus.
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Chem Biol
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2007
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1.21
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6
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Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism.
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Proc Natl Acad Sci U S A
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2013
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1.07
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7
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The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots.
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Proc Natl Acad Sci U S A
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2002
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1.02
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8
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Lipophilic mediated assays for beta-hematin inhibitors.
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Comb Chem High Throughput Screen
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2010
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0.99
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9
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Biosynthetic origins of C-P bond containing tripeptide K-26.
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Org Lett
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2005
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0.97
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10
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A unifying nitrososynthase involved in nitrosugar biosynthesis.
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J Am Chem Soc
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2008
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0.96
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11
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Phenotypic mapping of metabolic profiles using self-organizing maps of high-dimensional mass spectrometry data.
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Anal Chem
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2014
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0.93
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12
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Combined chemical and biosynthetic route to access a new apoptolidin congener.
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Org Lett
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2009
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0.91
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13
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Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis.
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Future Med Chem
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2011
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0.90
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14
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Design and directed evolution of a dideoxy purine nucleoside phosphorylase.
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Protein Eng Des Sel
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2010
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0.89
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15
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Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster.
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Biochem Biophys Res Commun
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2010
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0.89
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16
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Bioactive oligosaccharide natural products.
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Nat Prod Rep
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2014
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0.89
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17
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Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40.
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Tetrahedron
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2011
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0.88
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18
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Structural mass spectrometry: rapid methods for separation and analysis of peptide natural products.
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J Nat Prod
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2012
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0.88
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19
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Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis.
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Chem Commun (Camb)
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2006
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0.87
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20
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Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis .
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Biochemistry
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2010
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0.87
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21
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Five-component cascade synthesis of nucleotide analogues in an engineered self-immobilized enzyme aggregate.
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Chembiochem
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2010
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0.86
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22
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Adenylation enzyme characterization using gamma -(18)O(4)-ATP pyrophosphate exchange.
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Chem Biol
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2009
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0.86
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23
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Reassembly of anthramycin biosynthetic gene cluster by using recombinogenic cassettes.
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Chembiochem
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2008
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0.83
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24
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Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26.
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Bioorg Med Chem Lett
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2007
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0.83
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25
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Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle.
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J Biol Chem
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2010
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0.83
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26
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Fluorescent probes of the apoptolidins and their utility in cellular localization studies.
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Angew Chem Int Ed Engl
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2014
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0.81
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27
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Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase.
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Org Lett
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2007
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0.80
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28
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Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus.
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Acta Crystallogr Sect F Struct Biol Cryst Commun
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2010
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0.80
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29
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Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis.
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J Am Chem Soc
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2013
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0.79
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30
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Biocatalysis in pharmaceutical preparation and alteration.
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Curr Opin Chem Biol
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2006
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0.77
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31
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Molecular differences between a mutase and a phosphatase: investigations of the activation step in Bacillus cereus phosphopentomutase.
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Biochemistry
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2012
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0.77
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32
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Decoding chemical structures from genomes.
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Nat Chem Biol
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2005
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0.76
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33
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Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener.
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Appl Environ Microbiol
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2010
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0.75
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34
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Distance geometry protocol to generate conformations of natural products to structurally interpret ion mobility-mass spectrometry collision cross sections.
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J Phys Chem B
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2014
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0.75
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35
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Designing a curriculum that goes beyond a list of topics.
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ACS Chem Biol
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2006
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0.75
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