PubRank

David Ron

Author PubWeight™ 296.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002 16.52
2 The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011 15.71
3 An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 2003 15.12
4 CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 2004 9.24
5 Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 2011 8.75
6 A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 2005 7.98
7 Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol 2002 6.48
8 A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 2004 6.37
9 The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol 2003 6.34
10 Endoplasmic reticulum stress signaling in disease. Physiol Rev 2006 5.90
11 Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol 2004 5.44
12 GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 2005 4.53
13 Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol 2007 4.45
14 Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest 2008 4.30
15 ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 2005 3.79
16 Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J 2004 3.77
17 The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J 2010 3.76
18 Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol 2004 3.57
19 Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab 2009 3.51
20 Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab 2008 3.45
21 Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci 2004 3.31
22 Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 2011 3.29
23 Stress-induced gene expression requires programmed recovery from translational repression. EMBO J 2003 3.26
24 The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell 2010 3.26
25 The mitochondrial UPR - protecting organelle protein homeostasis. J Cell Sci 2010 3.06
26 Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol 2004 3.00
27 Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice. Neuron 2008 2.95
28 Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci U S A 2002 2.93
29 Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci 2002 2.83
30 Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes 2002 2.74
31 Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell 2010 2.74
32 A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. J Cell Biol 2002 2.72
33 Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol 2004 2.68
34 Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature 2005 2.67
35 Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol 2009 2.66
36 Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol 2002 2.62
37 ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell 2007 2.61
38 ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab 2006 2.55
39 Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell 2006 2.54
40 Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Mol Cell 2010 2.51
41 The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A 2012 2.45
42 Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol 2009 2.42
43 ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A 2009 2.37
44 Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One 2009 2.30
45 Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics 2006 2.29
46 Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A 2009 2.22
47 Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol Cell Biol 2006 2.16
48 Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol 2003 2.15
49 Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol 2004 2.10
50 CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem 2005 2.08
51 Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol 2002 2.02
52 The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe 2013 1.91
53 ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. J Cell Biol 2010 1.87
54 The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab 2005 1.83
55 Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. EMBO J 2006 1.79
56 Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain 2006 1.78
57 IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab 2008 1.75
58 The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J Clin Invest 2007 1.74
59 Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc Natl Acad Sci U S A 2013 1.73
60 Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J Cell Biol 2005 1.69
61 Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proc Natl Acad Sci U S A 2009 1.68
62 Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A 2008 1.54
63 Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Mol Cell Biol 2002 1.54
64 Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One 2010 1.52
65 Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. EMBO J 2008 1.51
66 An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Mol Cell 2006 1.46
67 Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis. Mol Cell Biol 2011 1.42
68 Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease. J Cell Biol 2002 1.33
69 Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma. Am J Pathol 2008 1.31
70 The dynamic ER: experimental approaches and current questions. Curr Opin Cell Biol 2005 1.30
71 Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. J Cell Biol 2006 1.29
72 Disulphide production by Ero1α-PDI relay is rapid and effectively regulated. EMBO J 2010 1.28
73 CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells. Mol Immunol 2009 1.26
74 Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A 2013 1.24
75 New insights into translational regulation in the endoplasmic reticulum unfolded protein response. Cold Spring Harb Perspect Biol 2012 1.24
76 Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell Metab 2005 1.23
77 Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate. J Biol Chem 2005 1.23
78 Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci 2013 1.22
79 ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load. J Cell Biol 2012 1.20
80 Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK. J Biol Chem 2012 1.16
81 Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes 2012 1.16
82 A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem 2010 1.15
83 Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation. J Biol Chem 2007 1.14
84 Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome. Hum Mol Genet 2010 1.13
85 Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice. J Exp Med 2013 1.13
86 Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients. Hum Genet 2005 1.12
87 Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice. Mol Cell 2012 1.11
88 Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux. J Cell Biol 2007 1.09
89 Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila. Cell Rep 2013 1.08
90 Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases. J Cell Biol 2013 1.07
91 An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation. RNA 2007 1.06
92 Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. J Biomol Screen 2011 1.05
93 Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. J Cell Biol 2013 1.05
94 SnapShot: The unfolded protein response. Cell 2010 1.04
95 Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Mol Biol Cell 2011 1.01
96 Negative feedback by IRE1β optimizes mucin production in goblet cells. Proc Natl Acad Sci U S A 2013 1.00
97 C/EBP homologous protein is necessary for normal osteoblastic function. J Cell Biochem 2006 0.99
98 ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice. J Cell Sci 2005 0.98
99 The structure of the PERK kinase domain suggests the mechanism for its activation. Acta Crystallogr D Biol Crystallogr 2011 0.98
100 Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism. J Biol Chem 2011 0.98
101 Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice. Circ Res 2012 0.91
102 Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle. J Biol Chem 2009 0.91
103 The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load. FASEB J 2011 0.91
104 GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Mol Cell Biol 2013 0.89
105 Novel function of PERK as a mediator of force-induced apoptosis. J Biol Chem 2008 0.88
106 Structural determinants of PERK inhibitor potency and selectivity. Chem Biol Drug Des 2010 0.88
107 Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR. J Mol Biol 2010 0.87
108 Oligodendrocytes are a major target of the toxicity of spongiogenic murine retroviruses. Am J Pathol 2006 0.86
109 Modeling the endoplasmic reticulum unfolded protein response. Nat Struct Mol Biol 2010 0.85
110 Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification. Mol Biosyst 2013 0.85
111 The unfolded protein response in lung disease. Proc Am Thorac Soc 2010 0.85
112 The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation. Cell Struct Funct 2013 0.83
113 A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma. J Neurosci Res 2011 0.82
114 Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells. J Biol Chem 2012 0.81
115 Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1. Cell Signal 2004 0.80
116 Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2. J Biol Chem 2011 0.80
117 Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate. Biochem J 2012 0.79
118 Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58(IPK) TPR fragment. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.79
119 Transmission of proteotoxicity across cellular compartments. Genes Dev 2002 0.78
120 Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds. Chemistry 2012 0.77
121 The amino acid sensor GCN2 biases macronutrient selection during aging. Eur J Nutr 2011 0.76
122 New twists in the unfolded protein response. Elife 2012 0.75
123 Toward the discovery of new antifungal agents: the design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p. Nucleic Acids Symp Ser (Oxf) 2008 0.75
124 [GCN2 regulates feeding behavior to maintain amino acid homeostasis in omnivores]. Med Sci (Paris) 2005 0.75