Published in Biochemistry on November 28, 2006
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J Am Chem Soc (2010) 1.49
Structural insights into nonribosomal peptide enzymatic assembly lines. Nat Prod Rep (2009) 1.40
Biosynthesis of aromatic polyketides in bacteria. Acc Chem Res (2009) 1.34
Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase. Proc Natl Acad Sci U S A (2009) 1.30
Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase. Biochemistry (2008) 0.99
Biochemical and genetic insights into asukamycin biosynthesis. J Biol Chem (2010) 0.88
Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase. Biochemistry (2011) 0.88
The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase. Chem Biol (2013) 0.83
Retrobiosynthetic approach delineates the biosynthetic pathway and the structure of the acyl chain of mycobacterial glycopeptidolipids. J Biol Chem (2012) 0.79
Crystallization and preliminary X-ray diffraction analysis of FabG from Yersinia pestis. Acta Crystallogr F Struct Biol Commun (2013) 0.79
Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae. J Bacteriol (2015) 0.78
Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe. Proteins (2013) 0.77
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Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.75
Comparative Transcriptome Analysis of Penicillium citrinum Cultured with Different Carbon Sources Identifies Genes Involved in Citrinin Biosynthesis. Toxins (Basel) (2017) 0.75
Structural basis for gluten intolerance in celiac sprue. Science (2002) 8.16
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection. Acta Crystallogr D Biol Crystallogr (2008) 2.79
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A (2006) 2.63
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Transglutaminase 2 undergoes a large conformational change upon activation. PLoS Biol (2007) 2.53
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc Natl Acad Sci U S A (2004) 2.33
Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science (2013) 2.31
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chem Biol (2007) 2.02
Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chem Biol (2005) 2.00
Overproduction of free fatty acids in E. coli: implications for biodiesel production. Metab Eng (2008) 1.97
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol (2002) 1.87
An antibiotic factory caught in action. Nat Struct Mol Biol (2004) 1.81
Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase. Chem Biol (2003) 1.81
Evolution of polyketide synthases in bacteria. Proc Natl Acad Sci U S A (2008) 1.78
Tgf-Beta signaling in development. Sci STKE (2007) 1.70
Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase. Protein Sci (2007) 1.68
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (2003) 1.67
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. PLoS One (2008) 1.67
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases. Biochemistry (2002) 1.66
Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. J Proteome Res (2005) 1.63
Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. J Am Chem Soc (2006) 1.63
Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue. Biochem J (2004) 1.63
Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacol Ther (2007) 1.60
Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology (2007) 1.58
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. J Am Chem Soc (2007) 1.56
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology (2005) 1.55
Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. Metab Eng (2010) 1.55
Endotracheal intubation using a levering laryngoscope in a pediatric patient with Turner syndrome. Paediatr Anaesth (2008) 1.54
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A (2008) 1.54
Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol (2010) 1.51
Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension (2004) 1.50
High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue. Biochemistry (2002) 1.49
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol (2005) 1.48
Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry (2004) 1.47
Structure-based dissociation of a type I polyketide synthase module. Chem Biol (2007) 1.46
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry (2002) 1.45
In living color: bacterial pigments as an untapped resource in the classroom and beyond. PLoS Biol (2010) 1.44
Tailoring nanocarriers for intracellular protein delivery. Chem Soc Rev (2011) 1.42
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41
Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc (2010) 1.41
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nat Med (2012) 1.40
Magnetic sensors for protease assays. Angew Chem Int Ed Engl (2003) 1.39
The biochemical basis for stereochemical control in polyketide biosynthesis. J Am Chem Soc (2009) 1.39
Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. Clin Gastroenterol Hepatol (2005) 1.38
Redox regulation of transglutaminase 2 activity. J Biol Chem (2010) 1.38
Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease. Proc Natl Acad Sci U S A (2013) 1.36
Navigating the fungal polyketide chemical space: from genes to molecules. J Org Chem (2012) 1.36
Polyketide chain length control by chain length factor. J Am Chem Soc (2003) 1.35
The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene (2005) 1.35
Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. Appl Environ Microbiol (2002) 1.35
Biosynthesis of aromatic polyketides in bacteria. Acc Chem Res (2009) 1.34
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc Natl Acad Sci U S A (2008) 1.34
Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein. Biochemistry (2003) 1.34
Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33
Future therapeutic options for celiac disease. Nat Clin Pract Gastroenterol Hepatol (2005) 1.33
Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. J Am Chem Soc (2005) 1.33
Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide. PLoS One (2008) 1.32
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther (2006) 1.32
Redirecting the cyclization steps of fungal polyketide synthase. J Am Chem Soc (2007) 1.32
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
Rational design of combination enzyme therapy for celiac sprue. Chem Biol (2006) 1.28
Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proc Natl Acad Sci U S A (2005) 1.27
Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. Biochemistry (2003) 1.27
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J (2011) 1.27
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells. J Virol (2004) 1.27
Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A (2010) 1.27
Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. J Am Chem Soc (2003) 1.24
Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2). J Biol Chem (2002) 1.24
In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli. Proc Natl Acad Sci U S A (2011) 1.23
Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. J Immunol (2004) 1.23
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem (2010) 1.23
Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation. Nat Immunol (2009) 1.22
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng (2011) 1.22
A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem (2006) 1.22
Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. J Am Chem Soc (2008) 1.22
Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (2002) 1.21
Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Mol Cancer Ther (2005) 1.20
Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr (2003) 1.19
Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo. J Pharmacol Exp Ther (2004) 1.19
Combinatorial biosynthesis of polyketides--a perspective. Curr Opin Chem Biol (2012) 1.19