Published in Huan Jing Ke Xue on December 01, 2009
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
Building the sequence map of the human pan-genome. Nat Biotechnol (2009) 5.53
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
Concurrent activation of striatal direct and indirect pathways during action initiation. Nature (2013) 4.87
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell (2012) 4.03
Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra. Nature (2008) 3.92
TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain (2010) 3.66
Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell (2013) 3.33
Sensing movement: microsensors for body motion measurement. Sensors (Basel) (2011) 3.27
NONCODE: an integrated knowledge database of non-coding RNAs. Nucleic Acids Res (2005) 3.16
Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Ann Neurol (2008) 2.95
Topological structure analysis of the protein-protein interaction network in budding yeast. Nucleic Acids Res (2003) 2.90
Identification of a novel risk variant in the FUS gene in essential tremor. Neurology (2013) 2.84
NONCODE v3.0: integrative annotation of long noncoding RNAs. Nucleic Acids Res (2011) 2.82
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A (2009) 2.68
Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network. Nucleic Acids Res (2011) 2.55
Exome sequencing identifies ZNF644 mutations in high myopia. PLoS Genet (2011) 2.52
Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am J Hum Genet (2013) 2.47
NONCODEv4: exploring the world of long non-coding RNA genes. Nucleic Acids Res (2013) 2.37
Diaphyseal bone formation in murine tibiae in response to knee loading. J Appl Physiol (1985) (2006) 2.32
Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18
PlantTFDB 2.0: update and improvement of the comprehensive plant transcription factor database. Nucleic Acids Res (2010) 2.09
Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A (2011) 2.03
Ribosome assembly factors prevent premature translation initiation by 40S assembly intermediates. Science (2011) 2.01
IMP-4 and OXA beta-lactamases in Acinetobacter baumannii from Singapore. J Antimicrob Chemother (2007) 1.98
Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. Nature (2012) 1.98
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80
Organization of the Caenorhabditis elegans small non-coding transcriptome: genomic features, biogenesis, and expression. Genome Res (2005) 1.77
Human movement training with a cable driven ARm EXoskeleton (CAREX). IEEE Trans Neural Syst Rehabil Eng (2014) 1.74
NONCODE v2.0: decoding the non-coding. Nucleic Acids Res (2007) 1.69
US-guided percutaneous microwave coagulation of small breast cancers: a clinical study. Radiology (2012) 1.66
Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts. Nucleic Acids Res (2013) 1.64
Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer. J Urol (2013) 1.64
SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects. Neurology (2013) 1.61
Conformational flexibility facilitates self-assembly of complex DNA nanostructures. Proc Natl Acad Sci U S A (2008) 1.60
Glucocerebrosidase mutations and risk of Parkinson disease in Chinese patients. Arch Neurol (2007) 1.58
Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study. Hum Mutat (2010) 1.57
High dietary taurine reduces apoptosis and atherosclerosis in the left main coronary artery: association with reduced CCAAT/enhancer binding protein homologous protein and total plasma homocysteine but not lipidemia. Hypertension (2009) 1.56
Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J (2005) 1.54
Wild-type and 'a' epitope variants in chronic hepatitis B virus carriers positive for hepatitis B surface antigen and antibody. J Gastroenterol Hepatol (2002) 1.50
Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack. Cancer Biol Ther (2011) 1.50
Quantum chemical 13C(alpha) chemical shift calculations for protein NMR structure determination, refinement, and validation. Proc Natl Acad Sci U S A (2008) 1.50
Methylene blue protects against paraquat-induced acute lung injury in rats. Int Immunopharmacol (2013) 1.47
Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks. Nucleic Acids Res (2012) 1.46
ncFANs: a web server for functional annotation of long non-coding RNAs. Nucleic Acids Res (2011) 1.46
Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation. Am J Physiol Cell Physiol (2009) 1.46
Road Traffic Injury Prevention Initiatives: A Systematic Review and Metasummary of Effectiveness in Low and Middle Income Countries. PLoS One (2016) 1.46
Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells. Cancer Biol Ther (2009) 1.45
Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. J Biol Chem (2003) 1.43
Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey. Clin Rheumatol (2014) 1.41
Intratumor injection of oncolytic adenovirus expressing HSP70 prolonged survival in melanoma B16 bearing mice by enhanced immune response. Cancer Biol Ther (2007) 1.40
Knee loading dynamically alters intramedullary pressure in mouse femora. Bone (2006) 1.40
Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect. Hum Mutat (2009) 1.39
Effects of platelet-rich plasma and recombinant human bone morphogenetic protein-2 on suture distraction osteogenesis. J Craniofac Surg (2013) 1.39
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet (2011) 1.38
Gene expression profile of murine long-term reconstituting vs. short-term reconstituting hematopoietic stem cells. Proc Natl Acad Sci U S A (2005) 1.32
Clustered microRNAs' coordination in regulating protein-protein interaction network. BMC Syst Biol (2009) 1.28
NPInter: the noncoding RNAs and protein related biomacromolecules interaction database. Nucleic Acids Res (2006) 1.24
Extensive X-linked adaptive evolution in central chimpanzees. Proc Natl Acad Sci U S A (2012) 1.23
miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2. Mol Med Rep (2011) 1.23
Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation. Blood (2002) 1.21
dbDEMC: a database of differentially expressed miRNAs in human cancers. BMC Genomics (2010) 1.20
Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis. Anal Chim Acta (2012) 1.20
PPAR-gamma: therapeutic target for ischemic stroke. Trends Pharmacol Sci (2007) 1.20
The bright side of JNKs-Multitalented mediators in neuronal sprouting, brain development and nerve fiber regeneration. Prog Neurobiol (2006) 1.20
Validity of two self-report measures of sitting time. J Phys Act Health (2011) 1.18
Location of modulatory beta subunits in BK potassium channels. J Gen Physiol (2010) 1.17
Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Autophagy (2013) 1.16
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. Hum Mutat (2011) 1.16
Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells. FASEB J (2010) 1.14
LC-MS based serum metabolomics for identification of hepatocellular carcinoma biomarkers in Egyptian cohort. J Proteome Res (2012) 1.14
NPInter v2.0: an updated database of ncRNA interactions. Nucleic Acids Res (2013) 1.13
Prevalence of coal workers' pneumoconiosis in China: a systematic analysis of 2001-2011 studies. Int J Hyg Environ Health (2013) 1.13
Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing. Rheumatology (Oxford) (2011) 1.12
Royal jelly ameliorates insulin resistance in fructose-drinking rats. Biol Pharm Bull (2008) 1.12
A dose-volume-based tool for evaluating and ranking IMRT treatment plans. J Appl Clin Med Phys (2004) 1.12
Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells. Cytokine (2012) 1.11
One-step microfluidic generation of pre-hatching embryo-like core-shell microcapsules for miniaturized 3D culture of pluripotent stem cells. Lab Chip (2013) 1.11
Systems genetics of susceptibility to obesity-induced diabetes in mice. Physiol Genomics (2011) 1.10
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. J Am Chem Soc (2012) 1.08
LC-MS profiling of N-Glycans derived from human serum samples for biomarker discovery in hepatocellular carcinoma. J Proteome Res (2014) 1.08
Detection and comparison of epidermal growth factor receptor mutations in cells and fluid of malignant pleural effusion in non-small cell lung cancer. Lung Cancer (2007) 1.08
Prevalence and significance of anti-peptidylarginine deiminase 4 antibodies in rheumatoid arthritis. J Rheumatol (2008) 1.07
Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am J Hum Genet (2013) 1.06
Knee loading stimulates cortical bone formation in murine femurs. BMC Musculoskelet Disord (2006) 1.05
Cyclic compressive loading facilitates recovery after eccentric exercise. Med Sci Sports Exerc (2008) 1.05
Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis. Hepatol Res (2009) 1.05
A limited-angle CT reconstruction method based on anisotropic TV minimization. Phys Med Biol (2013) 1.05
Bonding the foe - NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals. Front Immunol (2012) 1.04
Genes contributing to pain sensitivity in the normal population: an exome sequencing study. PLoS Genet (2012) 1.04
Biomechanical stability of a supra-acetabular pedicle screw internal fixation device (INFIX) vs external fixation and plates for vertically unstable pelvic fractures. J Orthop Surg Res (2012) 1.04
IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation. Exp Hematol (2007) 1.04
FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers. Am J Transplant (2005) 1.03
Development of a finite element human head model partially validated with thirty five experimental cases. J Biomech Eng (2013) 1.03
Comparison between early and delayed systemic treatment with candesartan of rats after ischaemic stroke. J Hypertens (2007) 1.03
Dissociable effects of dopamine on neuronal firing rate and synchrony in the dorsal striatum. Front Integr Neurosci (2009) 1.03
Symmetry controls the face geometry of DNA polyhedra. J Am Chem Soc (2009) 1.02
Sustained blockade of brain AT1 receptors before and after focal cerebral ischemia alleviates neurologic deficits and reduces neuronal injury, apoptosis, and inflammatory responses in the rat. J Cereb Blood Flow Metab (2004) 1.02
RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line. Cancer Genet Cytogenet (2010) 1.01