| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis.
|
J Biol Chem
|
2002
|
1.46
|
|
2
|
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.
|
ACS Synth Biol
|
2013
|
1.40
|
|
3
|
Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase.
|
Cancer Sci
|
2007
|
1.23
|
|
4
|
Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life.
|
J Control Release
|
2007
|
1.11
|
|
5
|
Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice.
|
Biomaterials
|
2006
|
1.07
|
|
6
|
Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models.
|
Cancer Sci
|
2008
|
1.06
|
|
7
|
A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis.
|
Nat Chem Biol
|
2012
|
0.97
|
|
8
|
Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products.
|
Environ Microbiol
|
2010
|
0.95
|
|
9
|
Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway.
|
J Nat Prod
|
2010
|
0.94
|
|
10
|
Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes.
|
ChemMedChem
|
2007
|
0.94
|
|
11
|
Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format.
|
J Biomol Screen
|
2009
|
0.94
|
|
12
|
Total synthesis of spiruchostatin B aided by an automated synthesizer.
|
Org Biomol Chem
|
2011
|
0.93
|
|
13
|
Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.
|
J Antibiot (Tokyo)
|
2012
|
0.93
|
|
14
|
Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
|
Acta Crystallogr D Biol Crystallogr
|
2002
|
0.92
|
|
15
|
JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus sp. fA75.
|
J Antibiot (Tokyo)
|
2012
|
0.90
|
|
16
|
Molecular determinants of microbial resistance to thiopeptide antibiotics.
|
J Am Chem Soc
|
2010
|
0.90
|
|
17
|
Novel GRP78 molecular chaperone expression down-regulators JBIR-04 and -05 isolated from Streptomyces violaceoniger.
|
J Antibiot (Tokyo)
|
2007
|
0.90
|
|
18
|
Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase.
|
Biol Pharm Bull
|
2007
|
0.90
|
|
19
|
Streptomyces tateyamensis sp. nov., Streptomyces marinus sp. nov. and Streptomyces haliclonae sp. nov., isolated from the marine sponge Haliclona sp.
|
Int J Syst Evol Microbiol
|
2010
|
0.90
|
|
20
|
Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria.
|
FEMS Microbiol Lett
|
2009
|
0.89
|
|
21
|
Isolation of 2 new naphthablin analogs, JBIR-79 and JBIR-80, from Streptomyces sp. RI24.
|
J Antibiot (Tokyo)
|
2010
|
0.89
|
|
22
|
Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2.
|
ACS Chem Biol
|
2013
|
0.89
|
|
23
|
Naphthoquinone-like polyketide isolated from Streptomyces sp. RI-77 and its predicted biosynthetic pathway.
|
J Nat Prod
|
2011
|
0.88
|
|
24
|
A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559.
|
J Antibiot (Tokyo)
|
2007
|
0.88
|
|
25
|
Aminocaprophenone- and pyrrolidine-type alkaloids from the leaves of Ficus septica.
|
J Nat Prod
|
2009
|
0.87
|
|
26
|
New angucycline C-glycosides from Streptomyces sp. RI33.
|
J Antibiot (Tokyo)
|
2011
|
0.87
|
|
27
|
New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6.
|
Org Biomol Chem
|
2009
|
0.87
|
|
28
|
Tetracenoquinocin and 5-iminoaranciamycin from a sponge-derived Streptomyces sp. Sp080513GE-26.
|
J Nat Prod
|
2010
|
0.86
|
|
29
|
JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp. NBRC 105896 isolated from a marine sponge.
|
J Antibiot (Tokyo)
|
2009
|
0.86
|
|
30
|
Three new depsipeptides, JBIR-113, JBIR-114 and JBIR-115, isolated from a marine sponge-derived Penicillium sp. fS36.
|
J Antibiot (Tokyo)
|
2011
|
0.85
|
|
31
|
New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1.
|
J Antibiot (Tokyo)
|
2009
|
0.84
|
|
32
|
Combinatorial synthesis of deoxyhexasaccharides related to the landomycin A sugar moiety, based on an orthogonal deprotection strategy.
|
Chem Asian J
|
2010
|
0.83
|
|
33
|
Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph.
|
FEMS Yeast Res
|
2012
|
0.83
|
|
34
|
JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27.
|
Org Lett
|
2009
|
0.83
|
|
35
|
Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571.
|
J Antibiot (Tokyo)
|
2009
|
0.83
|
|
36
|
Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.
|
Toxicon
|
2009
|
0.83
|
|
37
|
JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3.
|
J Nat Prod
|
2010
|
0.83
|
|
38
|
JBIR-56 and JBIR-57, 2(1H)-pyrazinones from a marine sponge-derived Streptomyces sp. SpD081030SC-03.
|
J Nat Prod
|
2011
|
0.82
|
|
39
|
JBIR-15, a new aspochracin derivative, isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04.
|
Biosci Biotechnol Biochem
|
2009
|
0.82
|
|
40
|
Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator.
|
Org Lett
|
2007
|
0.82
|
|
41
|
A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil.
|
J Antibiot (Tokyo)
|
2011
|
0.82
|
|
42
|
JBIR-52, a new antimycin-like compound, from Streptomyces sp. ML55.
|
J Antibiot (Tokyo)
|
2009
|
0.81
|
|
43
|
Solid-phase total synthesis of (-)-apratoxin A and its analogues and their biological evaluation.
|
Chem Asian J
|
2011
|
0.81
|
|
44
|
A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.
|
Mol Cancer Ther
|
2010
|
0.81
|
|
45
|
Isolation of a novel macrocyclic dilactone-JBIR-101-from Promicromonospora sp. RL26.
|
J Antibiot (Tokyo)
|
2011
|
0.80
|
|
46
|
Novel siderophore, JBIR-16, isolated from Nocardia tenerifensis NBRC 101015.
|
J Antibiot (Tokyo)
|
2009
|
0.80
|
|
47
|
New aureothin derivative, alloaureothin, from Streptomyces sp. MM23.
|
J Antibiot (Tokyo)
|
2007
|
0.79
|
|
48
|
JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07.
|
J Nat Prod
|
2012
|
0.79
|
|
49
|
A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6.
|
J Antibiot (Tokyo)
|
2008
|
0.79
|
|
50
|
A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp.
|
J Antibiot (Tokyo)
|
2010
|
0.79
|
|
51
|
JBIR-59, a new sorbicillinoid, from a marine-derived fungus Penicillium citrinum SpI080624G1f01.
|
J Antibiot (Tokyo)
|
2010
|
0.79
|
|
52
|
JBIR-58, a new salicylamide derivative, isolated from a marine sponge-derived Streptomyces sp. SpD081030ME-02.
|
J Antibiot (Tokyo)
|
2010
|
0.79
|
|
53
|
Tetrapeptides possessing a unique skeleton, JBIR-34 and JBIR-35, isolated from a sponge-derived actinomycete, Streptomyces sp. Sp080513GE-23.
|
J Nat Prod
|
2010
|
0.78
|
|
54
|
Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72.
|
J Nat Prod
|
2012
|
0.78
|
|
55
|
JBIR-107, a new metabolite from the marine-sponge-derived actinomycete, Streptomyces tateyamensis NBRC 105047.
|
Biosci Biotechnol Biochem
|
2013
|
0.78
|
|
56
|
JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.
|
J Antibiot (Tokyo)
|
2009
|
0.78
|
|
57
|
Macrocyclic hexaoxazoles as sequence- and mode-selective G-quadruplex binders.
|
Angew Chem Int Ed Engl
|
2008
|
0.78
|
|
58
|
Novel 24-membered macrolides, JBIR-19 and -20 isolated from Metarhizium sp. fE61.
|
J Antibiot (Tokyo)
|
2009
|
0.77
|
|
59
|
Actinobacteria associated with the marine sponges Cinachyra sp., Petrosia sp., and Ulosa sp. and their culturability.
|
Microbes Environ
|
2011
|
0.77
|
|
60
|
Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A.
|
Eur J Med Chem
|
2013
|
0.77
|
|
61
|
Two novel benzastatin derivatives, JBIR-67 and JBIR-73, isolated from Streptomyces sp. RI18.
|
J Antibiot (Tokyo)
|
2011
|
0.77
|
|
62
|
Synthesis, structure determination, and biological evaluation of destruxin E.
|
Org Lett
|
2010
|
0.77
|
|
63
|
A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55.
|
J Antibiot (Tokyo)
|
2007
|
0.77
|
|
64
|
Synthesis of a potent G-quadruplex-binding macrocyclic heptaoxazole.
|
Chembiochem
|
2009
|
0.77
|
|
65
|
JBIR-25, a novel antioxidative agent from Hyphomycetes sp. CR28109.
|
J Antibiot (Tokyo)
|
2009
|
0.77
|
|
66
|
Paraoerskovia marina gen. nov., sp. nov., an actinobacterium isolated from marine sediment.
|
Int J Syst Evol Microbiol
|
2009
|
0.77
|
|
67
|
A novel antimycin-like compound, JBIR-06, from Streptomyces sp. ML55.
|
J Antibiot (Tokyo)
|
2008
|
0.77
|
|
68
|
Discovery of a pimaricin analog JBIR-13, from Streptomyces bicolor NBRC 12746 as predicted by sequence analysis of type I polyketide synthase gene.
|
Appl Microbiol Biotechnol
|
2009
|
0.77
|
|
69
|
Induction of tubulin polymerization and apoptosis in malignant mesothelioma cells by a new compound JBIR-23.
|
Cancer Lett
|
2010
|
0.76
|
|
70
|
JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634.
|
J Antibiot (Tokyo)
|
2009
|
0.76
|
|
71
|
New xanthoquinodin-like compounds, JBIR-97, -98 and -99, obtained from marine sponge-derived fungus Tritirachium sp. SpB081112MEf2.
|
J Antibiot (Tokyo)
|
2010
|
0.76
|
|
72
|
A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species.
|
J Antibiot (Tokyo)
|
2010
|
0.76
|
|
73
|
JBIR-12, a novel antioxidative agent from Penicillium sp. NBRC 103941.
|
J Antibiot (Tokyo)
|
2009
|
0.75
|
|
74
|
JBIR-124: a novel antioxidative agent from a marine sponge-derived fungus Penicillium citrinum SpI080624G1f01.
|
J Antibiot (Tokyo)
|
2011
|
0.75
|
|
75
|
Isolation and structure elucidation of tumescenamides A and B, two peptides produced by Streptomyces tumescens YM23-260.
|
J Antibiot (Tokyo)
|
2010
|
0.75
|
|
76
|
(S)-stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor.
|
Org Biomol Chem
|
2010
|
0.75
|
|
77
|
Efficient synthesis of the deoxysugar part of versipelostatin by direct and stereoselective glycosylation and revision of the structure of the trisaccharide unit.
|
Chem Asian J
|
2009
|
0.75
|
|
78
|
Isolation of two new terpeptin analogs-JBIR-81 and JBIR-82-from a seaweed-derived fungus, Aspergillus sp. SpD081030G1f1.
|
J Antibiot (Tokyo)
|
2010
|
0.75
|
|
79
|
JBIR-14, a highly oxygenated ergostane, from Isaria sp. NBRC 104353.
|
J Antibiot (Tokyo)
|
2010
|
0.75
|
|
80
|
JBIR-37 and -38, novel glycosyl benzenediols, isolated from the sponge-derived fungus, Acremonium sp. SpF080624G1f01.
|
Biosci Biotechnol Biochem
|
2009
|
0.75
|
|
81
|
Two novel decanedienamide derivatives, JBIR-07 and -08, from Streptomyces versipellis 4083-SVS6.
|
Nat Prod Res
|
2009
|
0.75
|
|
82
|
JBIR-120: a new growth inhibitor of hormone-refractory prostate cancer cells.
|
J Antibiot (Tokyo)
|
2012
|
0.75
|
|
83
|
Stawamycin analog, JBIR-11 from Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830.
|
J Antibiot (Tokyo)
|
2008
|
0.75
|
|
84
|
A new furaquinocin derivative, JBIR-136, from Streptomyces sp. 4963H2.
|
J Antibiot (Tokyo)
|
2012
|
0.75
|
|
85
|
Flaviogeranin, a new neuroprotective compound from Streptomyces sp.
|
J Antibiot (Tokyo)
|
2010
|
0.75
|
|
86
|
JBIR-26, a novel natural compound from Streptomyces sp. AK-AH76, regulates mammalian circadian clock.
|
J Antibiot (Tokyo)
|
2008
|
0.75
|
|
87
|
JBIR-69, a new metabolite from Streptomyces sp. OG05.
|
J Antibiot (Tokyo)
|
2010
|
0.75
|
|
88
|
Streptomyces aomiensis sp. nov., isolated from a soil sample using the membrane-filter method.
|
Int J Syst Evol Microbiol
|
2010
|
0.75
|
|
89
|
JBIR-54, a new 4-pyridinone derivative isolated from Penicillium daleae Zaleski fE50.
|
J Antibiot (Tokyo)
|
2009
|
0.75
|
|
90
|
JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin.
|
J Nat Prod
|
2012
|
0.75
|
|
91
|
Screening and evaluation of new inhibitors of hepatic glucose production.
|
J Antibiot (Tokyo)
|
2009
|
0.75
|
|
92
|
Total synthesis and structure elucidation of JBIR-39: a linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues.
|
Chemistry
|
2014
|
0.75
|
|
93
|
Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces sp. RK74.
|
Org Lett
|
2012
|
0.75
|
|
94
|
A phenylacetylated peptide, JBIR-96, isolated from Streptomyces sp. RI051-SDHV6.
|
J Nat Prod
|
2011
|
0.75
|
|
95
|
JBIR-78 and JBIR-95: phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56.
|
J Nat Prod
|
2012
|
0.75
|
|
96
|
New pyridone alkaloids JBIR-130, JBIR-131 and JBIR-132 from Isaria sp. NBRC 104353.
|
J Antibiot (Tokyo)
|
2012
|
0.75
|
|
97
|
Surgical bedside master console for neurosurgical robotic system.
|
Int J Comput Assist Radiol Surg
|
2012
|
0.75
|