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The PINK1/Parkin pathway regulates mitochondrial morphology.
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2008
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Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.
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Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.
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Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.
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Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.
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Hum Mol Genet
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2005
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Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.
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Open Biol
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1.42
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The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
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Nat Neurosci
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How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?
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Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.
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1.03
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TRAP1 rescues PINK1 loss-of-function phenotypes.
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Hum Mol Genet
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2013
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Molecular mechanisms of PINK1-related neurodegeneration.
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Curr Neurol Neurosci Rep
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2011
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PLoS One
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