Published in J Biol Inorg Chem on March 02, 2010
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MagicWand: a single, designed peptide that assembles to stable, ordered alpha-helical fibers. Biochemistry (2008) 0.98
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Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry (2009) 0.92
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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86
Tuning the electronic absorption of protein-embedded all-trans-retinal. Science (2012) 1.70
The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med (2005) 1.66
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Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest (2010) 1.41
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood (2006) 1.38
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The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest (2010) 1.36
Plasminogen receptors: the sine qua non of cell surface plasminogen activation. Front Biosci (2005) 1.36
Retracted Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood (2009) 1.36
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A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. Blood (2004) 1.35
Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. Physiol Genomics (2003) 1.26
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Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thromb Haemost (2006) 1.21
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications. Blood (2009) 1.21
A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins. Cytotechnology (2008) 1.21
The crystal structures of the open and catalytically competent closed conformation of Escherichia coli glycogen synthase. J Biol Chem (2009) 1.18
Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest (2005) 1.17
A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. Am J Pathol (2004) 1.11
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab (2008) 1.10
Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic. J Am Chem Soc (2007) 1.10
Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice. J Biol Chem (2003) 1.08
The X-ray crystallographic structure of Escherichia coli branching enzyme. J Biol Chem (2002) 1.07
A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate. J Am Chem Soc (2004) 1.05
A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells. J Biol Chem (2006) 1.05
Plasminogen inhibits TNFalpha-induced apoptosis in monocytes. Blood (2006) 1.04
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis (2003) 1.04
Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers. Biophys J (2004) 1.04
Conservation of critical functional domains in murine plasminogen activator inhibitor-1. J Biol Chem (2004) 1.02
Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. J Extra Corpor Technol (2011) 1.02
Protein purification with polymeric affinity membranes containing functionalized poly(acid) brushes. Biomacromolecules (2010) 1.02
Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination. J Biomed Biotechnol (2012) 1.01
Generation of genetically-altered mice producing very low levels of coagulation factorVII. Thromb Haemost (2005) 1.00
The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif. J Am Chem Soc (2007) 0.99
Oligosaccharide binding in Escherichia coli glycogen synthase. Biochemistry (2009) 0.97
Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. Am J Pathol (2002) 0.96
Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase. J Biol Chem (2012) 0.96
Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proc Natl Acad Sci U S A (2011) 0.96
Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy. Neurocrit Care (2013) 0.96
A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes. J Biol Chem (2013) 0.95
Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus. Biochemistry (2010) 0.95
Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides. Neuropharmacology (2007) 0.94
The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. Am J Pathol (2003) 0.93
The structure of Apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation. J Mol Biol (2006) 0.93
A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide. Biochemistry (2004) 0.93
Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. PLoS One (2010) 0.93
The crystal structure and mechanism of 1-L-myo-inositol- 1-phosphate synthase. J Biol Chem (2002) 0.92
The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNAPC. J Biol Chem (2006) 0.90
The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin. J Mol Biol (2002) 0.90
Plasminogen enhances neuritogenesis on laminin-1. J Neurosci (2009) 0.90
Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen. J Invest Dermatol (2008) 0.90
A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues. J Mol Biol (2004) 0.90
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage. Blood (2011) 0.89
Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation. Dev Biol (2006) 0.89
Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives. J Biol Chem (2007) 0.89
Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice. Neurosci Lett (2006) 0.88
The structure of the 1L-myo-inositol-1-phosphate synthase-NAD+-2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate complex demands a revision of the enzyme mechanism. J Biol Chem (2003) 0.88
Coagulation factor Xa modulates airway remodeling in a murine model of asthma. Am J Respir Crit Care Med (2006) 0.88
Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Carcinogenesis (2008) 0.88
Genetic perturbation of glycolysis results in inhibition of de novo inositol biosynthesis. J Biol Chem (2005) 0.88
alpha Domain deletion converts streptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator. J Biol Chem (2004) 0.87
Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. J Neurotrauma (2013) 0.87
Engineering a rhodopsin protein mimic. J Am Chem Soc (2006) 0.87
Gene targeting of components of the fibrinolytic system. Thromb Haemost (2002) 0.87
Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces. Trends Cardiovasc Med (2003) 0.87
Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system. J Biol Chem (2013) 0.86
N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein. Neuropharmacology (2008) 0.86
Functional dissection of Streptococcus pyogenes M5 protein: the hypervariable region is essential for virulence. PLoS One (2009) 0.86
Structure-function analysis of the streptokinase amino terminus (residues 1-59). J Biol Chem (2003) 0.86
An all-aqueous route to polymer brush-modified membranes with remarkable permeabilites and protein capture rates. J Memb Sci (2012) 0.86
X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM. Biochemistry (2006) 0.85
NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins. Neuropeptides (2008) 0.85
Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen. Blood (2011) 0.85
A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. Am J Physiol Lung Cell Mol Physiol (2009) 0.85
The molecular basis of conantokin antagonism of NMDA receptor function. Curr Drug Targets (2007) 0.84