Published in Blood on November 04, 2004
Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med (2007) 3.35
Activated protein C modulates cardiac metabolism and augments autophagy in the ischemic heart. J Thromb Haemost (2012) 1.63
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nat Med (2012) 1.58
Regulation of the protein C anticoagulant and antiinflammatory pathways. Curr Med Chem (2010) 1.48
Protein C anticoagulant system--anti-inflammatory effects. Semin Immunopathol (2011) 1.45
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest (2010) 1.41
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood (2006) 1.38
Retracted Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood (2009) 1.36
Ovarian cancer, the coagulation pathway, and inflammation. J Transl Med (2005) 1.33
Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. J Clin Invest (2007) 1.32
Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood (2011) 1.22
Endothelial cell protein C receptor: a multiliganded and multifunctional receptor. Blood (2014) 1.20
Activated protein C protects against myocardial ischemic/reperfusion injury through AMP-activated protein kinase signaling. J Thromb Haemost (2011) 1.18
Activated protein C protects against ventilator-induced pulmonary capillary leak. Am J Physiol Lung Cell Mol Physiol (2009) 1.09
Activation of endothelial intrinsic NF-{kappa}B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice. Blood (2009) 1.07
Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. Blood (2006) 1.04
The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases. IUBMB Life (2011) 0.95
Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor. Arterioscler Thromb Vasc Biol (2013) 0.93
Coagulation factor Xa modulates airway remodeling in a murine model of asthma. Am J Respir Crit Care Med (2006) 0.88
Activated protein C: a potential cardioprotective factor against ischemic injury during ischemia/reperfusion. Am J Transl Res (2009) 0.88
Angiotensin II facilitates fibrogenic effect of TGF-β1 through enhancing the down-regulation of BAMBI caused by LPS: a new pro-fibrotic mechanism of angiotensin II. PLoS One (2013) 0.81
Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates. Exp Mol Med (2013) 0.80
Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Ann Rheum Dis (2007) 0.80
Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice. J Pathol (2009) 0.80
Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis). PLoS Negl Trop Dis (2013) 0.78
A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice. J Thromb Haemost (2008) 0.77
Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med (2007) 3.35
Total synthesis of a functional designer eukaryotic chromosome. Science (2014) 3.31
Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood (2007) 2.92
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86
The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med (2005) 1.66
Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood (2009) 1.59
A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis. J Am Soc Nephrol (2008) 1.51
FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse. Thromb Haemost (2002) 1.49
Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. Blood (2007) 1.48
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest (2010) 1.41
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood (2006) 1.38
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo. Cancer Res (2009) 1.37
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest (2010) 1.36
Plasminogen receptors: the sine qua non of cell surface plasminogen activation. Front Biosci (2005) 1.36
Retracted Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood (2009) 1.36
Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg (2012) 1.35
Rapid selection of Drosophila S2 cells with the puromycin resistance gene. Biotechniques (2003) 1.35
Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. Physiol Genomics (2003) 1.26
Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge. Thromb Haemost (2002) 1.23
Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thromb Haemost (2006) 1.21
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications. Blood (2009) 1.21
A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins. Cytotechnology (2008) 1.21
Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest (2005) 1.17
A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. Am J Pathol (2004) 1.11
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab (2008) 1.10
Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice. J Biol Chem (2003) 1.08
A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate. J Am Chem Soc (2004) 1.05
A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells. J Biol Chem (2006) 1.05
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis (2003) 1.04
Plasminogen inhibits TNFalpha-induced apoptosis in monocytes. Blood (2006) 1.04
Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers. Biophys J (2004) 1.04
Conservation of critical functional domains in murine plasminogen activator inhibitor-1. J Biol Chem (2004) 1.02
Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. J Extra Corpor Technol (2011) 1.02
Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination. J Biomed Biotechnol (2012) 1.01
Generation of genetically-altered mice producing very low levels of coagulation factorVII. Thromb Haemost (2005) 1.00
The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif. J Am Chem Soc (2007) 0.99
Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. Am J Pathol (2002) 0.96
Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase. J Biol Chem (2012) 0.96
Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy. Neurocrit Care (2013) 0.96
Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proc Natl Acad Sci U S A (2011) 0.96
A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes. J Biol Chem (2013) 0.95
Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides. Neuropharmacology (2007) 0.94
The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. Am J Pathol (2003) 0.93
A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide. Biochemistry (2004) 0.93
Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. PLoS One (2010) 0.93
The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin. J Mol Biol (2002) 0.90
Plasminogen enhances neuritogenesis on laminin-1. J Neurosci (2009) 0.90
Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen. J Invest Dermatol (2008) 0.90
A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues. J Mol Biol (2004) 0.90
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage. Blood (2011) 0.89
Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives. J Biol Chem (2007) 0.89
Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation. Dev Biol (2006) 0.89
Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice. Neurosci Lett (2006) 0.88
Coagulation factor Xa modulates airway remodeling in a murine model of asthma. Am J Respir Crit Care Med (2006) 0.88
Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Carcinogenesis (2008) 0.88
alpha Domain deletion converts streptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator. J Biol Chem (2004) 0.87
Gene targeting of components of the fibrinolytic system. Thromb Haemost (2002) 0.87
Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. J Neurotrauma (2013) 0.87
Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces. Trends Cardiovasc Med (2003) 0.87
Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system. J Biol Chem (2013) 0.86
N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein. Neuropharmacology (2008) 0.86
Structure-function analysis of the streptokinase amino terminus (residues 1-59). J Biol Chem (2003) 0.86
Functional dissection of Streptococcus pyogenes M5 protein: the hypervariable region is essential for virulence. PLoS One (2009) 0.86
X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM. Biochemistry (2006) 0.85
Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen. Blood (2011) 0.85
NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins. Neuropeptides (2008) 0.85
A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. Am J Physiol Lung Cell Mol Physiol (2009) 0.85
A deficiency of uPAR alters endothelial angiogenic function and cell morphology. Vasc Cell (2011) 0.84
The molecular basis of conantokin antagonism of NMDA receptor function. Curr Drug Targets (2007) 0.84
The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain. J Biol Chem (2007) 0.84
Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains. FEBS Lett (2013) 0.84
Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex. J Biol Inorg Chem (2010) 0.84
Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation. Mol Cell Neurosci (2010) 0.83
Solution structure of the complex of VEK-30 and plasminogen kringle 2. J Struct Biol (2009) 0.82
Binding and orientation of conantokins in PL vesicles and aligned PL multilayers. Biochemistry (2003) 0.82
A fast-acting, modular-structured staphylokinase fusion with Kringle-1 from human plasminogen as the fibrin-targeting domain offers improved clot lysis efficacy. J Biol Chem (2003) 0.82
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Neuropharmacology (2009) 0.81
Fibrinogen has chaperone-like activity. Biochem Biophys Res Commun (2008) 0.81
A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. PLoS Pathog (2013) 0.80
Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties. Biochemistry (2005) 0.80
Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues. J Inorg Biochem (2010) 0.79
Cathepsin E is a specific marker of dysplasia in APC mouse intestine. Tumour Biol (2005) 0.79
The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine. Thromb Haemost (2012) 0.79
Factor VII deficiency impairs cutaneous wound healing in mice. Mol Med (2010) 0.79
Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine. Biochemistry (2015) 0.78
Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation. J Biol Chem (2013) 0.78
Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. Neuropharmacology (2012) 0.78
Synthetic conantokin peptides potently inhibit N-methyl-D-aspartate receptor-mediated currents of retinal ganglion cells. J Neurosci Res (2014) 0.78
Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM). Biochim Biophys Acta (2010) 0.77
Solution structure and functional characterization of human plasminogen kringle 5. Biochemistry (2009) 0.77
Tissue distribution of fetal liver cells following in utero transplantation in mice. Exp Biol Med (Maywood) (2005) 0.77
Maternal fibrinogen is necessary for embryonic development. Curr Drug Targets (2005) 0.77
Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling. PLoS One (2013) 0.77
Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury. J Neurotrauma (2014) 0.77
The crystal structure of the calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer. J Biol Inorg Chem (2010) 0.77
The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice. Cancer Lett (2004) 0.76