Published in Stem Cell Res on February 06, 2010
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation (2013) 2.57
Present state and future perspectives of using pluripotent stem cells in toxicology research. Arch Toxicol (2011) 1.69
Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation (2013) 1.54
Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes. Stem Cells (2013) 1.28
Induced pluripotent stem cells in cardiovascular drug discovery. Circ Res (2013) 1.22
Induced regeneration--the progress and promise of direct reprogramming for heart repair. Nat Med (2013) 1.17
Induced pluripotent stem cells as a disease modeling and drug screening platform. J Cardiovasc Pharmacol (2012) 1.09
Cardiac differentiation of pluripotent stem cells. Stem Cells Int (2011) 1.09
Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry. J Physiol (2011) 1.08
Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells. Prog Biophys Mol Biol (2012) 1.00
Current status of drug screening and disease modelling in human pluripotent stem cells. Bioessays (2012) 0.98
Modeling Timothy syndrome with iPS cells. J Cardiovasc Transl Res (2013) 0.95
Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes. Assay Drug Dev Technol (2011) 0.93
Programming and isolation of highly pure physiologically and pharmacologically functional sinus-nodal bodies from pluripotent stem cells. Stem Cell Reports (2014) 0.91
Stem cells and stem cell-derived tissues and their use in safety assessment. J Biol Chem (2013) 0.88
Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair. Adv Drug Deliv Rev (2015) 0.83
Human pluripotent stem cell-derived cardiomyocytes: response to TTX and lidocain reveals strong cell to cell variability. PLoS One (2012) 0.83
Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century. J Physiol (2016) 0.83
Human stem cell models for predictive cardiac safety pharmacology. Stem Cell Res (2010) 0.83
Induced pluripotent stem cells for regenerative cardiovascular therapies and biomedical discovery. Adv Drug Deliv Rev (2011) 0.81
Stoichiometry of the slow I(ks) potassium channel in human embryonic stem cell-derived myocytes. Pediatr Cardiol (2012) 0.80
Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes. PLoS One (2012) 0.80
Differentiation of Cardiomyocytes from Human Pluripotent Stem Cells Using Monolayer Culture. Biomark Insights (2015) 0.80
A new system for profiling drug-induced calcium signal perturbation in human embryonic stem cell-derived cardiomyocytes. J Biomol Screen (2014) 0.78
Stem cells in pediatric cardiology. Eur J Pediatr (2013) 0.78
Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Tissue Eng Part A (2016) 0.77
A novel 3D label-free monitoring system of hES-derived cardiomyocyte clusters: a step forward to in vitro cardiotoxicity testing. PLoS One (2013) 0.77
Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp. BMC Pharmacol Toxicol (2015) 0.76
Variability of Action Potentials Within and Among Cardiac Cell Clusters Derived from Human Embryonic Stem Cells. Sci Rep (2016) 0.75
Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. Sci Rep (2017) 0.75
Three-Dimensional Human Cardiac Tissue Engineered by Centrifugation of Stacked Cell Sheets and Cross-Sectional Observation of Its Synchronous Beatings by Optical Coherence Tomography. Biomed Res Int (2017) 0.75
Bioengineering Approaches to Mature Human Pluripotent Stem Cell-Derived Cardiomyocytes. Front Cell Dev Biol (2017) 0.75
Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes. Stem Cells Int (2017) 0.75
Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs). J Vis Exp (2017) 0.75
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol (2005) 3.97
Association between sleep apnea, sleep duration, and serum lipid profile in an urban, male, working population in Japan. Chest (2013) 3.23
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell (2009) 2.96
Ethics. The ISSCR guidelines for human embryonic stem cell research. Science (2007) 2.62
Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage. Biochem Biophys Res Commun (2006) 2.52
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci U S A (2002) 2.34
Efficient multicistronic expression of a transgene in human embryonic stem cells. Stem Cells (2007) 2.27
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest (2005) 2.25
Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors. Proc Natl Acad Sci U S A (2008) 2.17
Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling. Development (2008) 2.14
Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Proc Natl Acad Sci U S A (2006) 2.09
Pluripotential competence of cells associated with Nanog activity. Mech Dev (2005) 2.01
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell Stem Cell (2008) 1.98
Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression. PLoS One (2011) 1.95
MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev Cell (2011) 1.94
Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.93
Nanog expression in mouse germ cell development. Gene Expr Patterns (2005) 1.86
MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev (2010) 1.84
Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells. In Vitro Cell Dev Biol Anim (2010) 1.70
Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells. Nat Commun (2012) 1.70
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol Cell Biol (2004) 1.67
Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration. Arterioscler Thromb Vasc Biol (2007) 1.63
HLA-haplotype banking and iPS cells. Nat Biotechnol (2008) 1.61
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep (2012) 1.60
Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Dev Biol (2006) 1.59
RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Development (2005) 1.58
Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells. Biochem Biophys Res Commun (2008) 1.55
Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid bodies/nuages in male germ cells and forms a complex with snRNPs. Mech Dev (2003) 1.54
In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells. Invest Ophthalmol Vis Sci (2004) 1.52
Ultrastructural characterization of spermatogenesis and its evolutionary conservation in the germline: germinal granules in mammals. Mol Cell Endocrinol (2008) 1.51
Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells. PLoS One (2009) 1.46
Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells. FEBS Lett (2009) 1.43
A method for the selection of human embryonic stem cell sublines with high replating efficiency after single-cell dissociation. Stem Cells (2006) 1.39
Establishment of novel embryonic stem cell lines derived from the common marmoset (Callithrix jacchus). Stem Cells (2005) 1.35
Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS One (2011) 1.33
Tissue-specific demethylation in CpG-poor promoters during cellular differentiation. Hum Mol Genet (2011) 1.31
Long-term culture of male germline stem cells from hamster testes. Biol Reprod (2007) 1.31
Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells. Genes Cells (2009) 1.27
PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells. Biochem Biophys Res Commun (2008) 1.24
Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Proc Natl Acad Sci U S A (2011) 1.21
Gene targeting in human pluripotent stem cells with adeno-associated virus vectors. Biochem Biophys Res Commun (2009) 1.20
Targeted chromosome elimination from ES-somatic hybrid cells. Nat Methods (2006) 1.20
Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells. Development (2009) 1.20
Role of SOX2 in maintaining pluripotency of human embryonic stem cells. Genes Cells (2010) 1.19
Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells. Dev Dyn (2003) 1.18
Human leukocyte antigen matching estimations in a hypothetical bank of human embryonic stem cell lines in the Japanese population for use in cell transplantation therapy. Stem Cells (2006) 1.16
Spermatogenesis from epiblast and primordial germ cells following transplantation into postnatal mouse testis. Development (2004) 1.14
NANOG maintains self-renewal of primate ES cells in the absence of a feeder layer. Genes Cells (2006) 1.13
A simple and efficient cryopreservation method for primate embryonic stem cells. Int J Dev Biol (2004) 1.12
Phenotypic plasticity of mouse spermatogonial stem cells. PLoS One (2009) 1.11
RNA interference during spermatogenesis in mice. Dev Biol (2005) 1.08
Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors. Mol Ther (2011) 1.06
Development of primitive and definitive hematopoiesis from nonhuman primate embryonic stem cells in vitro. Development (2004) 1.06
Efficient integration of transgenes into a defined locus in human embryonic stem cells. Nucleic Acids Res (2010) 1.06
Effects of extracellular matrixes and growth factors on the hepatic differentiation of human embryonic stem cells. Am J Physiol Gastrointest Liver Physiol (2008) 1.00
Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Biol Reprod (2009) 0.99
Sleep-disordered breathing in the usual lifestyle setting as detected with home monitoring in a population of working men in Japan. Sleep (2008) 0.99
NBRP databases: databases of biological resources in Japan. Nucleic Acids Res (2009) 0.99
Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel. J Biol Chem (2003) 0.98
Genetically manipulated human embryonic stem cell-derived dendritic cells with immune regulatory function. Stem Cells (2007) 0.98
Associations between obstructive sleep apnea, metabolic syndrome, and sleep duration, as measured with an actigraph, in an urban male working population in Japan. Sleep (2010) 0.98
Mammalian BarH1 confers commissural neuron identity on dorsal cells in the spinal cord. J Neurosci (2003) 0.95
Haploinsufficiency of Bcl-x leads to male-specific defects in fetal germ cells: differential regulation of germ cell apoptosis between the sexes. Dev Biol (2003) 0.93
Trichostatin A induces myocardial differentiation of monkey ES cells. Biochem Biophys Res Commun (2007) 0.92
In vitro differentiation and maturation of mouse embryonic stem cells into hepatocytes. Exp Cell Res (2005) 0.92
Transplantation of embryonic stem cell-derived endodermal cells into mice with induced lethal liver damage. Stem Cells (2007) 0.91
Insulators prevent transcriptional interference between two promoters in a double gene construct for transgenesis. FEBS Lett (2002) 0.91
Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination. Proc Natl Acad Sci U S A (2006) 0.90
Identification and characterization of hemoangiogenic progenitors during cynomolgus monkey embryonic stem cell differentiation. Stem Cells (2006) 0.90
Induction of corneal epithelium-like cells from cynomolgus monkey embryonic stem cells and their experimental transplantation to damaged cornea. Cornea (2010) 0.89
Genomic imprinting of XX spermatogonia and XX oocytes recovered from XX<-->XY chimeric testes. Proc Natl Acad Sci U S A (2005) 0.88
Sequential analysis of alpha- and beta-globin gene expression during erythropoietic differentiation from primate embryonic stem cells. Stem Cells (2006) 0.88
Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells. Chromosome Res (2012) 0.88
Direct development of functionally mature tryptase/chymase double-positive connective tissue-type mast cells from primate embryonic stem cells. Stem Cells (2007) 0.88
Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med (2011) 0.87
Resetting of peripheral circadian clock by prostaglandin E2. EMBO Rep (2005) 0.86
Simple and highly efficient method for production of endothelial cells from human embryonic stem cells. Cell Transplant (2010) 0.86
Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets. Eur Heart J (2012) 0.86
Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma. Cancer Lett (2010) 0.86
Comparative study of transplantation of hepatocytes at various differentiation stages into mice with lethal liver damage. Cell Transplant (2012) 0.86
Transplantation of neural cells derived from retinoic acid-treated cynomolgus monkey embryonic stem cells successfully improved motor function of hemiplegic mice with experimental brain injury. Neurobiol Dis (2005) 0.86
Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells. Circ Cardiovasc Genet (2013) 0.86
In vitro germ cell differentiation from cynomolgus monkey embryonic stem cells. PLoS One (2009) 0.85
STAT3 is dispensable for maintenance of self-renewal in nonhuman primate embryonic stem cells. Stem Cells (2004) 0.85
X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9a. Genesis (2004) 0.85
Relationships of decreased lung function with metabolic syndrome and obstructive sleep apnea in Japanese males. Intern Med (2012) 0.84
Combination of functional cardiomyocytes derived from human stem cells and a highly-efficient microelectrode array system: an ideal hybrid model assay for drug development. Curr Stem Cell Res Ther (2010) 0.84
alpha4-Integrin(+) endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells. Blood (2006) 0.83
Electroporation of cynomolgus monkey embryonic stem cells. Genesis (2003) 0.83
Circadian clock-controlled diurnal oscillation of Ras/ERK signaling in mouse liver. Proc Jpn Acad Ser B Phys Biol Sci (2013) 0.82