Published in Adv Drug Deliv Rev on March 01, 2011
Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Res (2011) 1.47
Induced pluripotent stem cells as a disease modeling and drug screening platform. J Cardiovasc Pharmacol (2012) 1.09
Developing microRNA screening as a functional genomics tool for disease research. Front Physiol (2013) 0.92
Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility. Prog Biophys Mol Biol (2012) 0.89
Perspectives of induced pluripotent stem cells for cardiovascular system regeneration. Exp Biol Med (Maywood) (2015) 0.76
Diabetes mellitus and cellular replacement therapy: Expected clinical potential and perspectives. World J Diabetes (2014) 0.76
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
Embryonic stem cell lines derived from human blastocysts. Science (1998) 65.53
Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 18.96
Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov (2004) 15.57
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (2008) 14.26
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature (2009) 11.27
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell (2006) 7.21
Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res (2009) 7.09
Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol (2009) 6.39
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
Producing primate embryonic stem cells by somatic cell nuclear transfer. Nature (2007) 5.56
Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature (1963) 5.23
Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90
Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J (2007) 4.32
Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood (2009) 4.22
Adult mice generated from induced pluripotent stem cells. Nature (2009) 4.21
Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts. J Am Coll Cardiol (2007) 4.05
Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. Development (1998) 3.94
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study. Lancet Oncol (2009) 3.89
Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science (1997) 3.32
Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation (2008) 3.11
Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation (2009) 2.93
Cardiomyocyte differentiation of human induced pluripotent stem cells. Circulation (2009) 2.86
Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One (2010) 2.86
Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Circulation (2005) 2.12
Phenotypic correction of murine hemophilia A using an iPS cell-based therapy. Proc Natl Acad Sci U S A (2009) 2.02
Cardiopoietic programming of embryonic stem cells for tumor-free heart repair. J Exp Med (2007) 1.97
Cell-based therapy for myocardial ischemia and infarction: pathophysiological mechanisms. Annu Rev Pathol (2007) 1.86
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells (2008) 1.83
iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. Circ Res (2009) 1.77
Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs. Stem Cell Res (2010) 1.58
Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells. J Thorac Cardiovasc Surg (2003) 1.51
2008 FDA drug approvals. Nat Rev Drug Discov (2009) 1.46
Nuclear reprogramming and stem cell creation. Proc Natl Acad Sci U S A (2003) 1.44
Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types. J Mol Cell Cardiol (2005) 1.39
Stem cell therapy for heart failure: are arrhythmias a real safety concern? Circulation (2009) 1.28
Principles of safety pharmacology. Br J Pharmacol (2008) 1.27
Generation of a human embryonic stem cell line encoding the cystic fibrosis mutation deltaF508, using preimplantation genetic diagnosis. Reprod Biomed Online (2005) 1.20
Comparison of benefits on myocardial performance of cellular cardiomyoplasty with skeletal myoblasts and fibroblasts. Cell Transplant (2000) 1.13
Mesoangioblasts, vessel-associated multipotent stem cells, repair the infarcted heart by multiple cellular mechanisms: a comparison with bone marrow progenitors, fibroblasts, and endothelial cells. Arterioscler Thromb Vasc Biol (2005) 1.10
Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. J Biol Chem (2010) 1.06
Induced pluripotent stem cells from swine (Sus scrofa): why they may prove to be important. Cell Cycle (2009) 0.92
Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates. Mol Ther (2009) 0.85
Human stem cell models for predictive cardiac safety pharmacology. Stem Cell Res (2010) 0.83
World's first clinical trial of human embryonic stem cell therapy cleared. Regen Med (2009) 0.83
Preimplantation genetic diagnosis as a source of human embryonic stem cells for disease research and drug discovery. BJOG (2009) 0.79
Stem cells and ethics: current issues. J Cardiovasc Transl Res (2009) 0.78
The significance of induced pluripotent stem cells for basic research and clinical therapy. J Med Ethics (2008) 0.78
Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev (2007) 3.41
Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol (2002) 2.97
Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure. Circulation (2003) 1.90
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells (2008) 1.83
Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A (2010) 1.74
Regulation of the mammalian cell cycle: a model of the G1-to-S transition. Am J Physiol Cell Physiol (2002) 1.58
Dynamics of the cell cycle: checkpoints, sizers, and timers. Biophys J (2003) 1.47
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J Mol Cell Cardiol (2008) 1.44
Regulation of RNA polymerase III transcription during hypertrophic growth. EMBO J (2006) 1.42
Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure. J Am Coll Cardiol (2004) 1.41
Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway. EMBO J (2006) 1.41
Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. J Neurosci (2011) 1.36
Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year follow-up. Circulation (2005) 1.32
Human adipose stem cells: a potential cell source for cardiovascular tissue engineering. Cells Tissues Organs (2008) 1.20
Effects of a home-based exercise program on clinical outcomes in heart failure. Am Heart J (2007) 1.18
Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability. Ann Thorac Surg (2007) 1.15
"Good enough solutions" and the genetics of complex diseases. Circ Res (2012) 1.13
Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle. Biophys J (2004) 1.12
Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue. Biotechnol Bioeng (2007) 1.08
Quantitative second harmonic generation imaging of cartilage damage. Cell Tissue Bank (2008) 1.07
Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model. Arterioscler Thromb Vasc Biol (2011) 1.02
Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways. Proc Natl Acad Sci U S A (2002) 1.02
Coordination of cell growth and cell division: a mathematical modeling study. J Cell Sci (2004) 0.99
A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Circ Res (2008) 0.98
Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome. Matrix Biol (2007) 0.97
Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One (2012) 0.95
Influence of systematically varied nano-scale topography on cell morphology and adhesion. Cell Commun Adhes (2007) 0.94
Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease. Circulation (2003) 0.92
Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha. PLoS One (2013) 0.90
EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD. Gene (2003) 0.87
Hysteresis and cell cycle transitions: how crucial is it? Biophys J (2004) 0.83
Feasibility and safety of autologous myoblast transplantation in patients with ischemic cardiomyopathy. Cell Transplant (2005) 0.83
Cardiopoietry in motion: primed mesenchymal stem cells for ischemic cardiomyopathy. J Am Coll Cardiol (2013) 0.81
Atorvastatin and statins in the treatment of heart failure. Expert Opin Pharmacother (2007) 0.80
Relative roles of heart transplantation and long-term mechanical circulatory support in contemporary management of advanced heart failure - a critical appraisal 10 years after REMATCH. Eur J Cardiothorac Surg (2011) 0.80
Regeneration potential of adult cardiac myocytes. Cell Res (2013) 0.79
Risk stratification in patients with advanced heart failure requiring biventricular assist device support as a bridge to cardiac transplantation. J Heart Lung Transplant (2012) 0.78
Induced pluripotent stem cells: it's like déjà vu all over again. Circulation (2009) 0.76
Dilated cardiomyopathy: learning to live with yourself. Nat Med (2003) 0.76
Outcomes of biventricular mechanical support patients discharged to home to await heart transplantation. J Cardiovasc Nurs (2015) 0.76
Heart disease leaves its mark: proteomics-based biosignatures in acute coronary syndromes. J Am Coll Cardiol (2004) 0.76
Corrigendum: Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells. Sci Rep (2017) 0.75
Microenvironment influences vascular differentiation of murine cardiovascular progenitor cells. J Biomed Mater Res B Appl Biomater (2014) 0.75