Published in Eur J Immunol on March 01, 2010
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov (2011) 3.08
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity (2013) 2.45
The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis. PLoS Pathog (2015) 2.04
Critical functions of priming and lysosomal damage for NLRP3 activation. Eur J Immunol (2010) 1.87
Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors? Front Cell Infect Microbiol (2012) 1.84
Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity (2015) 1.74
The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol (2011) 1.56
Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci (2014) 1.54
A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans. PLoS Pathog (2011) 1.47
The Overexpression of NALP3 Inflammasome in Knee Osteoarthritis Is Associated with Synovial Membrane Prolidase and NADPH Oxidase 2. Oxid Med Cell Longev (2016) 1.40
Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? Int J Inflam (2011) 1.30
Innate immune sensing of DNA viruses. Virology (2011) 1.30
Inflammasomes in neuroinflammation and changes in brain function: a focused review. Front Neurosci (2014) 1.26
Dysregulated relationship of inflammation and oxidative stress in major depression. Brain Behav Immun (2012) 1.18
Sterile inflammatory responses mediated by the NLRP3 inflammasome. Eur J Immunol (2010) 1.14
Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death. Cell Cycle (2013) 1.14
Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome. J Biol Chem (2011) 1.14
Reactive oxygen species at the crossroads of inflammasome and inflammation. Front Physiol (2014) 1.12
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease. Nat Rev Immunol (2015) 1.10
The rate of interleukin-1beta secretion in different myeloid cells varies with the extent of redox response to Toll-like receptor triggering. J Biol Chem (2011) 1.09
The role of reactive-oxygen-species in microbial persistence and inflammation. Int J Mol Sci (2011) 1.08
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? Antioxid Redox Signal (2015) 1.07
Lipid raft redox signaling: molecular mechanisms in health and disease. Antioxid Redox Signal (2011) 1.06
Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One (2011) 1.03
Manganese superoxide dismutase: guardian of the powerhouse. Int J Mol Sci (2011) 1.02
Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets. Antioxid Redox Signal (2013) 0.99
NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model. PLoS One (2014) 0.97
An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucoma. Invest Ophthalmol Vis Sci (2012) 0.97
Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection. PLoS One (2012) 0.95
NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys. Oxid Med Cell Longev (2013) 0.95
Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome. Antioxid Redox Signal (2013) 0.93
Immune regulation toward immunomodulation for neuroprotection in glaucoma. Curr Opin Pharmacol (2012) 0.93
Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: a novel mechanism of albumin-induced tubulointerstitial inflammation. Int J Biochem Cell Biol (2014) 0.93
Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea. EMBO Mol Med (2012) 0.93
Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages. Eur J Immunol (2011) 0.92
Mitoxosome: a mitochondrial platform for cross-talk between cellular stress and antiviral signaling. Immunol Rev (2011) 0.92
Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit. Antioxid Redox Signal (2014) 0.92
NLRP3 Inflammasome and MS/EAE. Autoimmune Dis (2013) 0.92
Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1. J Neurosci (2012) 0.91
Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice. Mediators Inflamm (2014) 0.91
Epithelial, dendritic, and CD4(+) T cell regulation of and by reactive oxygen and nitrogen species in allergic sensitization. Biochim Biophys Acta (2011) 0.90
Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence. Biomed Res Int (2013) 0.90
Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-κB/NLRP3 pathway. PLoS One (2013) 0.89
Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood-brain barrier: protection by the antioxidant N-acetylcysteine. Brain Behav Immun (2012) 0.89
Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome. PLoS One (2012) 0.89
Activation of the NLRP3 inflammasome in association with calcium oxalate crystal induced reactive oxygen species in kidneys. J Urol (2014) 0.89
NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair? Free Radic Biol Med (2014) 0.89
Critical role for the AIM2 inflammasome during acute CNS bacterial infection. J Neurochem (2014) 0.88
Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. J Exp Med (2014) 0.87
Genome integrity, stem cells and hyaluronan. Aging (Albany NY) (2012) 0.87
ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury. Oxid Med Cell Longev (2016) 0.84
Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice. Dig Dis Sci (2012) 0.84
Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol (2012) 0.84
Emerging role of antioxidants in the protection of uveitis complications. Curr Med Chem (2011) 0.84
Zinc depletion regulates the processing and secretion of IL-1β. Cell Death Dis (2014) 0.83
Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression. Sci Rep (2015) 0.83
Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages. Eur J Immunol (2014) 0.82
Mycoplasma hyorhinis activates the NLRP3 inflammasome and promotes migration and invasion of gastric cancer cells. PLoS One (2013) 0.82
Porphyromonas gingivalis-induced reactive oxygen species activate JAK2 and regulate production of inflammatory cytokines through c-Jun. Infect Immun (2014) 0.81
Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease. World J Gastroenterol (2015) 0.81
Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells. Cell Mol Immunol (2014) 0.81
Silica nanoparticles induce oxidative stress and inflammation of human peripheral blood mononuclear cells. Cell Stress Chaperones (2014) 0.81
K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells. Cell Death Dis (2015) 0.80
Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes. J Immunol (2013) 0.80
Damage control: management of cellular stress by the NLRP3 inflammasome. Eur J Immunol (2013) 0.80
Intra-city Differences in Cardiac Expression of Inflammatory Genes and Inflammasomes in Young Urbanites: A Pilot Study. J Toxicol Pathol (2012) 0.80
The mechanisms of action of vaccines containing aluminum adjuvants: an in vitro vs in vivo paradigm. Springerplus (2015) 0.80
Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells. Chem Cent J (2012) 0.79
NLRP3 Inflammasome Activation by Viroporins of Animal Viruses. Viruses (2015) 0.79
Ragweed pollen extract intensifies lipopolysaccharide-induced priming of NLRP3 inflammasome in human macrophages. Immunology (2013) 0.79
Activation of the NLRP3/caspase-1 inflammasome in human dental pulp tissue and human dental pulp fibroblasts. Cell Tissue Res (2015) 0.79
Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. Mol Oral Microbiol (2015) 0.79
Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88/NF-κB pathway. J Cell Mol Med (2016) 0.79
Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages. J Transl Med (2016) 0.78
Macrophages and Uveitis in Experimental Animal Models. Mediators Inflamm (2015) 0.78
Advances in biomimetic regeneration of elastic matrix structures. Drug Deliv Transl Res (2012) 0.78
Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors. Curr Pharm Biotechnol (2013) 0.78
Serum amyloid A induces interleukin-1β secretion from keratinocytes via the NACHT, LRR and PYD domains-containing protein 3 inflammasome. Clin Exp Immunol (2015) 0.78
Targeting the inflammasome in rheumatic diseases. Transl Res (2015) 0.77
Asbestos and multi-walled carbon nanotubes generate distinct oxidative responses in inflammatory cells. J Clin Biochem Nutr (2014) 0.77
Extracellular adenosine generation in the regulation of pro-inflammatory responses and pathogen colonization. Biomolecules (2015) 0.77
Inflammasome Activity in Non-Microbial Lung Inflammation. J Environ Immunol Toxicol (2014) 0.77
Dangerous Liaisons: Caspase-11 and Reactive Oxygen Species Crosstalk in Pathogen Elimination. Int J Mol Sci (2015) 0.76
Redox distress and genetic defects conspire in systemic autoinflammatory diseases. Nat Rev Rheumatol (2015) 0.76
Chlamydial plasmid-encoded protein pORF5 induces production of IL-1β and IL-18 via NALP3 inflammasome activation and p38 MAPK pathway. Int J Clin Exp Med (2015) 0.76
Identification of Novel Therapeutic Targets in COPD. Tanaffos (2011) 0.76
Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death. Int J Mol Sci (2016) 0.75
Effective suppression of pro-inflammatory molecules by DHCA via IKK-NF-κB pathway, in vitro and in vivo. Br J Pharmacol (2015) 0.75
Up-regulation of mRNA ventricular PRNP prion protein gene expression in air pollution highly exposed young urbanites: endoplasmic reticulum stress, glucose regulated protein 78, and nanosized particles. Int J Mol Sci (2013) 0.75
Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression. Int J Neuropsychopharmacol (2016) 0.75
Recent advances in understanding and managing gout. F1000Res (2017) 0.75
Anti-inflammatory potential of total saponins derived from the roots of Panax ginseng in lipopolysaccharide-activated RAW 264.7 macrophages. Exp Ther Med (2015) 0.75
Oxidative stress contributes to the impaired sonic hedgehog pathway in type 1 diabetic mice with myocardial infarction. Exp Ther Med (2015) 0.75
Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation. Int J Mol Med (2017) 0.75
Association of the serum uric acid level with liver histology in biopsy-proven non-alcoholic fatty liver disease. Biomed Rep (2016) 0.75
Toll-Like Receptor-Mediated Free Radical Generation in Clonorchis sinensis Excretory-Secretory Product-Treated Cholangiocarcinoma Cells. Korean J Parasitol (2016) 0.75
The Relationship between NALP3 and Autoinflammatory Syndromes. Int J Mol Sci (2016) 0.75
NALP inflammasomes: a central role in innate immunity. Semin Immunopathol (2007) 1.91
Mechanisms of uric acid crystal-mediated autoinflammation. Immunol Rev (2010) 1.28