Published in Immunity on September 01, 2015
Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature (2016) 1.37
Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat Rev Immunol (2015) 1.10
The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent. PLoS Pathog (2016) 0.86
The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection. Semin Immunopathol (2016) 0.86
Diverse roles of endoplasmic reticulum stress sensors in bacterial infection. Mol Cell Pediatr (2016) 0.81
Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition. Hum Reprod Update (2016) 0.81
Homeostasis-altering molecular processes as mechanisms of inflammasome activation. Nat Rev Immunol (2017) 0.78
FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2. Mol Cell Biol (2016) 0.76
The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases. Front Immunol (2017) 0.76
The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome. Cell Mol Life Sci (2016) 0.76
Mitochondrial DNA in innate immune responses and inflammatory pathology. Nat Rev Immunol (2017) 0.75
Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin. Neural Regen Res (2017) 0.75
Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress. Sci Rep (2017) 0.75
Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases. Mediators Inflamm (2016) 0.75
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity. Proc Natl Acad Sci U S A (2016) 0.75
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5. Immunol Cell Biol (2016) 0.75
ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis. J Clin Cell Immunol (2016) 0.75
Unconventional Pathways of Secretion Contribute to Inflammation. Int J Mol Sci (2017) 0.75
Inositol-Requiring Enzyme 1-Dependent Activation of AMPK Promotes Brucella abortus Intracellular Growth. J Bacteriol (2016) 0.75
Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose. Cell Death Dis (2016) 0.75
Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria. Immunity (2015) 0.75
Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. PLoS One (2016) 0.75
NOD1 and NOD2: New Functions Linking Endoplasmic Reticulum Stress and Inflammation. DNA Cell Biol (2016) 0.75
Autophagy in Dendritic Cells and B Cells Is Critical for the Inflammatory State of TLR7-Mediated Autoimmunity. J Immunol (2016) 0.75
Endoplasmic Reticulum Proteostasis: A Key Checkpoint in Cancer. Am J Physiol Cell Physiol (2016) 0.75
Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3 mediated activation of Superoxide Dismutase 2. J Biol Chem (2017) 0.75
Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection. PLoS Pathog (2017) 0.75
Brucella Rough Mutant Induce Macrophage Death via Activating IRE1α Pathway of Endoplasmic Reticulum Stress by Enhanced T4SS Secretion. Front Cell Infect Microbiol (2017) 0.75
Correction of intermittent hypoxia reduces inflammation in obese subjects with obstructive sleep apnea. JCI Insight (2017) 0.75
Melatonin and mitochondrial function during ischemia/reperfusion injury. Cell Mol Life Sci (2017) 0.75
FDA-approved immunosuppressants targeting staphylococcal superantigens: mechanisms and insights. Immunotargets Ther (2017) 0.75
The inflammasomes. Cell (2010) 19.37
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68
A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77
Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02
How dying cells alert the immune system to danger. Nat Rev Immunol (2008) 8.63
The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol (2012) 8.52
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J (2006) 8.12
Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science (1984) 8.01
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol (2010) 7.47
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity (2007) 6.75
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature (1999) 6.37
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell (1997) 6.26
The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol (2011) 5.73
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56
The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ (2000) 4.34
K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity (2013) 3.96
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol (2004) 3.85
Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev (1998) 3.24
Role of carbohydrates in protein secretion and turnover: effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts. Cell (1978) 3.12
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab (2010) 3.07
Identification of novel stress-induced genes downstream of chop. EMBO J (1998) 2.93
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem (2002) 2.46
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A (2012) 2.45
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity (2013) 2.45
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science (2012) 2.25
Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes. J Immunol (2006) 2.21
Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. PLoS Pathog (2008) 2.16
Signaling by ROS drives inflammasome activation. Eur J Immunol (2010) 2.13
Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem (2009) 2.04
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell (2013) 1.93
Recognition of bacteria by inflammasomes. Annu Rev Immunol (2012) 1.81
Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis. J Exp Med (2000) 1.79
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol (2008) 1.75
Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis. Biochim Biophys Acta (2009) 1.66
ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis (2012) 1.60
Induction of ER stress in macrophages of tuberculosis granulomas. PLoS One (2010) 1.45
ER stress-induced inflammation: does it aid or impede disease progression? Trends Mol Med (2012) 1.41
The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol (2012) 1.35
Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Rep (2014) 1.33
Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus. PLoS One (2009) 1.20
Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome. Trends Immunol (2014) 1.17
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J (2013) 1.15
Activation of the unfolded protein response by Listeria monocytogenes. Cell Microbiol (2012) 1.09
The NLRP3 inflammasome in Alzheimer's disease. Mol Neurobiol (2013) 1.07
DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death. Autophagy (2013) 1.02
ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. Cell Death Differ (2013) 1.01
Mitochondrial DNA and inflammatory diseases. Hum Genet (2011) 1.01
Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection. J Immunol (2013) 0.97
Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. J Exp Med (2014) 0.87
Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis. Front Cell Infect Microbiol (2013) 0.85
Inflammasomes in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol (2013) 0.84
Caspase-2-dependent dendritic cell death, maturation, and priming of T cells in response to Brucella abortus infection. PLoS One (2012) 0.84
UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase is amplified in tunicamycin-resistant soybean cells. Eur J Biochem (1995) 0.79
Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis (2016) 0.75