Published in J Neurosci on March 03, 2010
Thalamic gating of corticostriatal signaling by cholinergic interneurons. Neuron (2010) 2.92
Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing. Cell Rep (2012) 1.91
Dopamine release in the basal ganglia. Neuroscience (2011) 1.67
α-Synuclein and dopamine at the crossroads of Parkinson's disease. Trends Neurosci (2010) 1.49
Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors. J Neurosci (2010) 1.41
Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis. Biol Sex Differ (2012) 1.27
Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100. Neuropsychopharmacology (2014) 1.25
Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons. Front Syst Neurosci (2011) 1.23
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. Proc Natl Acad Sci U S A (2013) 1.17
Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum. J Neurosci (2012) 1.17
Striatal cholinergic interneurons Drive GABA release from dopamine terminals. Neuron (2014) 1.14
Recent advances in Tourette syndrome. Curr Opin Neurol (2011) 1.13
Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders. Biochem Pharmacol (2011) 1.12
Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit. Neuron (2012) 1.05
Centrality of striatal cholinergic transmission in Basal Ganglia function. Front Neuroanat (2011) 1.04
M4 mAChR-mediated modulation of glutamatergic transmission at corticostriatal synapses. ACS Chem Neurosci (2014) 0.99
Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS Chem Neurosci (2013) 0.97
Local control of striatal dopamine release. Front Behav Neurosci (2014) 0.94
Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun (2015) 0.94
Regulation of striatal dopamine release by presynaptic auto- and heteroreceptors. Basal Ganglia (2012) 0.92
Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia. Prog Neurobiol (2015) 0.92
Dysregulation of striatal dopamine release in a mouse model of dystonia. J Neurochem (2010) 0.91
Striatal cholinergic interneuron regulation and circuit effects. Front Synaptic Neurosci (2014) 0.91
Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release. Neuron (2016) 0.90
Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits. Nat Commun (2012) 0.90
Cholinergic connectivity: it's implications for psychiatric disorders. Front Cell Neurosci (2013) 0.89
M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location. J Neurosci (2014) 0.87
Emerging approaches for treatment of schizophrenia: modulation of cholinergic signaling. Discov Med (2012) 0.86
An allosteric enhancer of M₄ muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine. Psychopharmacology (Berl) (2012) 0.86
Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice. PLoS One (2012) 0.84
Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions. Ann N Y Acad Sci (2015) 0.84
Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains. J Physiol (2015) 0.84
Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens. Neuropsychopharmacology (2011) 0.84
Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis. J Neurosci (2015) 0.84
Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. J Abnorm Child Psychol (2011) 0.83
Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice. Psychopharmacology (Berl) (2011) 0.82
Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. J Neurochem (2015) 0.81
B6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments. Brain Behav (2013) 0.81
Striatal dopamine neurotransmission: regulation of release and uptake. Basal Ganglia (2016) 0.79
Emerging Pharmacological Properties of Cholinergic Synaptic Transmission: Comparison between Mammalian and Insect Synaptic and Extrasynaptic Nicotinic Receptors. Curr Neuropharmacol (2011) 0.78
Heterogeneity in Dopamine Neuron Synaptic Actions Across the Striatum and Its Relevance for Schizophrenia. Biol Psychiatry (2016) 0.78
Optogenetic studies of nicotinic contributions to cholinergic signaling in the central nervous system. Rev Neurosci (2014) 0.78
Changes in sensitivity of reward and motor behavior to dopaminergic, glutamatergic, and cholinergic drugs in a mouse model of fragile X syndrome. PLoS One (2013) 0.78
Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons. PLoS One (2014) 0.78
Pharmacological and physiological characterization of the tremulous jaw movement model of parkinsonian tremor: potential insights into the pathophysiology of tremor. Front Syst Neurosci (2011) 0.78
Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cereb Cortex (2016) 0.78
Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias. Neurobiol Dis (2016) 0.77
Nucleus Accumbens Acetylcholine Receptors Modulate Dopamine and Motivation. Neuropsychopharmacology (2016) 0.77
Parkinsonism Driven by Antipsychotics Originates from Dopaminergic Control of Striatal Cholinergic Interneurons. Neuron (2016) 0.77
Somatodendritic targeting of M5 muscarinic receptor in the rat ventral tegmental area: implications for mesolimbic dopamine transmission. J Comp Neurol (2013) 0.77
Decreased cholinergic receptor expression in the striatum: motor function deficit in hypoglycemic and diabetic rats. Cell Mol Neurobiol (2011) 0.76
Effects of anticholinergic challenge on psychopathology and cognition in drug-free patients with schizophrenia and healthy volunteers. Psychopharmacology (Berl) (2014) 0.76
Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol. Neural Plast (2015) 0.76
Locomotor activating effects of cocaine and scopolamine combinations in rats: isobolographic analysis. Behav Pharmacol (2014) 0.75
Role of Nitric Oxide on Dopamine Release and Morphine-Dependency. Basic Clin Neurosci (2016) 0.75
Striatal cholinergic interneurons and D2 receptor-expressing GABAergic medium spiny neurons regulate tardive dyskinesia. Exp Neurol (2016) 0.75
Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders. Neuron (2017) 0.75
Effects of dopamine D1-like and D2-like antagonists on cocaine discrimination in muscarinic receptor knockout mice. Eur J Pharmacol (2016) 0.75
Striatal dopamine release regulation by the cholinergic properties of the smokeless tobacco, gutkha. ACS Chem Neurosci (2015) 0.75
Predictive reward signal of dopamine neurons. J Neurophysiol (1998) 15.02
Getting formal with dopamine and reward. Neuron (2002) 9.83
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron (2000) 6.92
Two types of dopamine neuron distinctly convey positive and negative motivational signals. Nature (2009) 6.35
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov (2007) 4.83
Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli. Proc Natl Acad Sci U S A (2009) 4.15
Firing modes of midbrain dopamine cells in the freely moving rat. Neuroscience (2002) 3.22
Nicotine amplifies reward-related dopamine signals in striatum. Nat Neurosci (2004) 3.20
Coincident but distinct messages of midbrain dopamine and striatal tonically active neurons. Neuron (2004) 3.10
Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci (1991) 2.73
Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Nat Neurosci (2001) 2.69
Cholinergic interneuron characteristics and nicotinic properties in the striatum. J Neurobiol (2002) 2.36
Frequency-dependent modulation of dopamine release by nicotine. Nat Neurosci (2004) 2.32
Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology (2007) 2.23
Re-emergence of striatal cholinergic interneurons in movement disorders. Trends Neurosci (2007) 2.19
Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 2.16
Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning. J Neurosci (1994) 2.14
Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies. J Neurosci (1994) 1.98
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 1.93
Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia. Proc Natl Acad Sci U S A (1990) 1.90
Dual cholinergic control of fast-spiking interneurons in the neostriatum. J Neurosci (2002) 1.88
Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.87
Spontaneous activity of neostriatal cholinergic interneurons in vitro. J Neurosci (1999) 1.80
Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochem Res (2003) 1.75
Acetylcholine-mediated modulation of striatal function. Trends Neurosci (2000) 1.69
Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission. Br J Pharmacol (2007) 1.69
Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey. J Neurophysiol (1986) 1.60
RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Nat Neurosci (2006) 1.58
Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. J Neurosci (2002) 1.53
Meaningful silences: how dopamine listens to the ACh pause. Trends Neurosci (2006) 1.52
Altered dopamine release and uptake kinetics in mice lacking D2 receptors. J Neurosci (2002) 1.50
Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. J Neurosci (2002) 1.47
Time window of autoreceptor-mediated inhibition of limbic and striatal dopamine release. Synapse (2002) 1.46
Muscarinic (m2/m4) receptors reduce N- and P-type Ca2+ currents in rat neostriatal cholinergic interneurons through a fast, membrane-delimited, G-protein pathway. J Neurosci (1996) 1.42
Differential autoreceptor control of somatodendritic and axon terminal dopamine release in substantia nigra, ventral tegmental area, and striatum. J Neurosci (1997) 1.41
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol (1997) 1.38
Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes. J Neurosci (1992) 1.37
M5 muscarinic receptors are required for prolonged accumbal dopamine release after electrical stimulation of the pons in mice. J Neurosci (2002) 1.35
Cholinergic interneurons control the excitatory input to the striatum. J Neurosci (2007) 1.34
Variable dopamine release probability and short-term plasticity between functional domains of the primate striatum. J Neurosci (2003) 1.34
Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition. Mol Pharmacol (1998) 1.34
Glutamate-dependent inhibition of dopamine release in striatum is mediated by a new diffusible messenger, H2O2. J Neurosci (2003) 1.33
Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes. Mol Pharmacol (1995) 1.30
Molecular frequency filters at central synapses. Prog Neurobiol (2000) 1.28
Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry. Neurosci Lett (1990) 1.27
M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB J (2004) 1.25
Presynaptic opioid and nicotinic receptor modulation of dopamine overflow in the nucleus accumbens. J Neurosci (2008) 1.22
Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain. J Pharmacol Exp Ther (1984) 1.22
Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. Neuroscientist (2003) 1.21
Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain. Proc Natl Acad Sci U S A (1991) 1.19
Muscarinic IPSPs in rat striatal cholinergic interneurones. J Physiol (1998) 1.11
Endogenous ACh enhances striatal NMDA-responses via M1-like muscarinic receptors and PKC activation. Eur J Neurosci (1998) 1.10
Presynaptic localisation of the nicotinic acetylcholine receptor beta2 subunit immunoreactivity in rat nigrostriatal dopaminergic neurones. J Comp Neurol (2001) 1.09
Dopamine, acetylcholine and nitric oxide systems interact to induce corticostriatal synaptic plasticity. Rev Neurosci (2003) 1.06
Nicotinic acetylcholine receptors interact with dopamine in induction of striatal long-term depression. J Neurosci (2002) 1.06
Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: anatomical evidence for cholinergic modulation of glutamatergic prefronto-striatal pathways. J Comp Neurol (2001) 1.06
Tonically active neurons in the primate striatum and their role in the processing of information about motivationally relevant events. Eur J Neurosci (2002) 1.05
Coordinated expression of muscarinic receptor messenger RNAs in striatal medium spiny neurons. Neuroscience (2001) 1.05
Responses of tonically active neurons in the monkey striatum discriminate between motivationally opposing stimuli. J Neurosci (2003) 1.04
Blockade of M2-like muscarinic receptors enhances long-term potentiation at corticostriatal synapses. Eur J Neurosci (1998) 1.02
Subcellular redistribution of m2 muscarinic acetylcholine receptors in striatal interneurons in vivo after acute cholinergic stimulation. J Neurosci (1998) 1.00
Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum. J Neurosci (2008) 0.99
Synaptic localization of GABA(A) receptor subunits in the striatum of the rat. J Comp Neurol (2000) 0.95
Rats self-administer carbachol directly into the nucleus accumbens. Physiol Behav (1998) 0.94
Distinct presynaptic control of dopamine release in striosomal and matrix areas of the cat caudate nucleus. Proc Natl Acad Sci U S A (1989) 0.94
Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors. Biochimie (2000) 0.93
Muscarinic receptors on dopamine terminals in the cat caudate nucleus: neuromodulation of [3H]dopamine release in vitro by endogenous acetylcholine. Brain Res (1982) 0.92
Role of tonically active neurons in primate caudate in reward-oriented saccadic eye movement. J Neurosci (2001) 0.92
Functional mu opioid receptors are expressed in cholinergic interneurons of the rat dorsal striatum: territorial specificity and diurnal variation. Eur J Neurosci (2005) 0.91
Differential effects of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism in freely moving rats. Brain Res (1989) 0.88
Effect of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism: an in vivo microdialysis study comparing normal and 6-hydroxydopamine-lesioned rats. Brain Res (1993) 0.87
Reward unpredictability inside and outside of a task context as a determinant of the responses of tonically active neurons in the monkey striatum. J Neurosci (2001) 0.86
Cholinergic modulation of dopamine overflow in the rat neostriatum: a fast cyclic voltammetric study in vitro. Neurosci Lett (1994) 0.86
Release-enhancing pre-synaptic muscarinic and nicotinic receptors co-exist and interact on dopaminergic nerve endings of rat nucleus accumbens. J Neurochem (2008) 0.86
Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors. Neuropharmacology (2003) 0.86
Age-related changes of muscarinic cholinergic receptor subtypes in the striatum of Fisher 344 rats. Exp Gerontol (2004) 0.82
Muscarine receptor-mediated modulation of [3H]dopamine and [14C]acetylcholine release from rat neostriatal slices: selective antagonism by gallamine but not pirenzepine. Eur J Pharmacol (1986) 0.80
Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83
Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron (2012) 3.33
Nicotine amplifies reward-related dopamine signals in striatum. Nat Neurosci (2004) 3.20
A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab (2006) 2.82
Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49
Engineering GPCR signaling pathways with RASSLs. Nat Methods (2008) 2.29
Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology (2007) 2.23
A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc Natl Acad Sci U S A (2009) 1.90
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol (2007) 1.83
Maintaining network activity in submerged hippocampal slices: importance of oxygen supply. Eur J Neurosci (2009) 1.78
Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochem Res (2003) 1.75
Dopamine spillover after quantal release: rethinking dopamine transmission in the nigrostriatal pathway. Brain Res Rev (2008) 1.75
Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron (2002) 1.71
Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation. J Biol Chem (2007) 1.65
A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology (2013) 1.62
Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J Neurosci (2011) 1.56
M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity. J Neurosci (2004) 1.53
Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. J Neurosci (2002) 1.53
Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice. J Neurosci (2005) 1.52
α-Synuclein and dopamine at the crossroads of Parkinson's disease. Trends Neurosci (2010) 1.49
Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.47
Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. J Neurosci (2002) 1.47
Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine. Proc Natl Acad Sci U S A (2011) 1.44
Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes (2004) 1.44
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur J Neurosci (2003) 1.41
Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice. Mol Pharmacol (2003) 1.40
Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. Eur J Neurosci (2008) 1.38
Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle. Proc Natl Acad Sci U S A (2009) 1.33
Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Res (2008) 1.29
Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium. Life Sci (2007) 1.29
Structural basis of G protein-coupled receptor-G protein interactions. Nat Chem Biol (2010) 1.27
Role for M5 muscarinic acetylcholine receptors in cocaine addiction. J Neurosci Res (2003) 1.26
Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice. Mol Pharmacol (2004) 1.25
RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo. Proc Natl Acad Sci U S A (2010) 1.25
Rapid identification of functionally critical amino acids in a G protein-coupled receptor. Nat Methods (2007) 1.24
Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiol Dis (2006) 1.23
Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease. ACS Chem Neurosci (2012) 1.22
Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency. Cell Metab (2006) 1.21
M(3)-receptor knockout mice: muscarinic receptor function in atria, stomach fundus, urinary bladder, and trachea. Am J Physiol Regul Integr Comp Physiol (2002) 1.21
A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. J Clin Invest (2009) 1.20
Aminoglycoside-mediated rescue of a disease-causing nonsense mutation in the V2 vasopressin receptor gene in vitro and in vivo. Hum Mol Genet (2004) 1.19
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. Proc Natl Acad Sci U S A (2013) 1.17
Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum. J Neurosci (2012) 1.17
A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology (2012) 1.17
Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor. J Biol Chem (2005) 1.17
Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice. Carcinogenesis (2011) 1.16
Design and functional characterization of a novel, arrestin-biased designer G protein-coupled receptor. Mol Pharmacol (2012) 1.16
The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A (2010) 1.15
M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1. Proc Natl Acad Sci U S A (2010) 1.15
A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neurosci (2010) 1.14
Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata. J Neurosci (2004) 1.14
Chronic activation of a designer G(q)-coupled receptor improves β cell function. J Clin Invest (2013) 1.13
Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol (2002) 1.09
Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation. Proc Natl Acad Sci U S A (2013) 1.07
Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. ACS Chem Neurosci (2014) 1.06
Structural basis of M3 muscarinic receptor dimer/oligomer formation. J Biol Chem (2011) 1.06
Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors. Biochem Pharmacol (2009) 1.06
Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress. Am J Physiol Heart Circ Physiol (2007) 1.05
Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J (2004) 1.05
M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice. Br J Pharmacol (2005) 1.05
Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice. Psychopharmacology (Berl) (2007) 1.03
Direct-pathway striatal neurons regulate the retention of decision-making strategies. J Neurosci (2013) 1.03
Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy. J Biol Chem (2001) 1.03
Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice. Diabetes (2009) 1.03
Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands. J Biol Chem (2007) 1.02
M1 muscarinic receptor signaling in mouse hippocampus and cortex. Brain Res (2002) 1.02
Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo. J Neurosci (2010) 1.01
Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor. J Biol Chem (2005) 1.01
Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab (2013) 1.00
Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction. J Immunol (2009) 1.00
Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors. J Cell Biol (2004) 0.99
Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum. J Neurosci (2008) 0.99
Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway. J Neuroimmunol (2005) 0.99
Intact attentional processing but abnormal responding in M1 muscarinic receptor-deficient mice using an automated touchscreen method. Neuropharmacology (2011) 0.98
Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline. J Neurosci (2011) 0.98
Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex. J Physiol (2006) 0.98
Muscarinic (M) receptors in coronary circulation: gene-targeted mice define the role of M2 and M3 receptors in response to acetylcholine. Arterioscler Thromb Vasc Biol (2004) 0.97
Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity. Cell Metab (2010) 0.96
Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses. J Neurosci (2009) 0.96
Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir Res (2006) 0.96
Cholinergic stimulation of amylase secretion from pancreatic acinar cells studied with muscarinic acetylcholine receptor mutant mice. J Pharmacol Exp Ther (2005) 0.96
In vivo ethanol experience increases D(2) autoinhibition in the ventral tegmental area. Neuropsychopharmacology (2011) 0.95
Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.95
Structural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation. FASEB J (2011) 0.95
Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice. Psychopharmacology (Berl) (2011) 0.95
Beneficial metabolic effects caused by persistent activation of beta-cell M3 muscarinic acetylcholine receptors in transgenic mice. Endocrinology (2010) 0.95
Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review. J Recept Signal Transduct Res (2008) 0.94
M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes. J Mol Neurosci (2006) 0.93
Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. Respir Res (2005) 0.93
Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proc Natl Acad Sci U S A (2009) 0.93
Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor. J Biol Chem (2004) 0.92
Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice. J Physiol (2005) 0.91
V2 vasopressin receptor deficiency causes changes in expression and function of renal and hypothalamic components involved in electrolyte and water homeostasis. Am J Physiol Renal Physiol (2008) 0.91
Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse. J Mol Neurosci (2006) 0.91
Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors. Am J Physiol Gastrointest Liver Physiol (2005) 0.91
Learning and memory impairments in a congenic C57BL/6 strain of mice that lacks the M2 muscarinic acetylcholine receptor subtype. Behav Brain Res (2008) 0.90