Membrane curvature in synaptic vesicle fusion and beyond.

PubWeight™: 2.09‹?› | Rank: Top 2%

🔗 View Article (PMID 20211126)

Published in Cell on March 05, 2010

Authors

Harvey T McMahon1, Michael M Kozlov, Sascha Martens

Author Affiliations

1: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB0 2QH, UK. hmm@mrc-lmb.cam.ac.uk

Articles citing this

Molecular machines governing exocytosis of synaptic vesicles. Nature (2012) 3.66

Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L). Proc Natl Acad Sci U S A (2011) 2.46

Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol (2012) 2.18

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. Elife (2012) 2.04

Protein-driven membrane stresses in fusion and fission. Trends Biochem Sci (2010) 1.69

Interplay of proteins and lipids in generating membrane curvature. Curr Opin Cell Biol (2010) 1.64

GLUT4 exocytosis. J Cell Sci (2011) 1.50

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nat Struct Mol Biol (2013) 1.38

Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody. Proc Natl Acad Sci U S A (2010) 1.38

A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol (2011) 1.37

Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism. Neuron (2011) 1.33

The rheostat in the membrane: BCL-2 family proteins and apoptosis. Cell Death Differ (2013) 1.29

Monomeric synucleins generate membrane curvature. J Biol Chem (2012) 1.27

Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes. PLoS Biol (2012) 1.26

Role of the synaptobrevin C terminus in fusion pore formation. Proc Natl Acad Sci U S A (2010) 1.20

Membrane curvature at a glance. J Cell Sci (2015) 1.19

α-Synuclein induces both positive mean curvature and negative Gaussian curvature in membranes. J Am Chem Soc (2012) 1.13

The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles. EMBO J (2011) 1.12

Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together. Biochemistry (2011) 1.06

Cis- and trans-membrane interactions of synaptotagmin-1. Proc Natl Acad Sci U S A (2012) 1.04

The induction of stromule formation by a plant DNA-virus in epidermal leaf tissues suggests a novel intra- and intercellular macromolecular trafficking route. Front Plant Sci (2012) 1.00

Membrane sculpting by F-BAR domains studied by molecular dynamics simulations. PLoS Comput Biol (2013) 1.00

Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine. J Biol Chem (2011) 0.95

The diverse and dynamic nature of Leishmania parasitophorous vacuoles studied by multidimensional imaging. PLoS Negl Trop Dis (2012) 0.93

Membrane curvature generation by a C-terminal amphipathic helix in peripherin-2/rds, a tetraspanin required for photoreceptor sensory cilium morphogenesis. J Cell Sci (2013) 0.93

Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper. Proc Natl Acad Sci U S A (2010) 0.92

Resolving single membrane fusion events on planar pore-spanning membranes. Sci Rep (2015) 0.91

Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner. Mol Biol Cell (2013) 0.91

Lumenal protein within secretory granules affects fusion pore expansion. Biophys J (2014) 0.90

Synaptotagmin SYTA forms ER-plasma membrane junctions that are recruited to plasmodesmata for plant virus movement. Curr Biol (2015) 0.88

Membrane tension and membrane fusion. Curr Opin Struct Biol (2015) 0.88

Expansion of the fusion stalk and its implication for biological membrane fusion. Proc Natl Acad Sci U S A (2014) 0.88

DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer. J Biol Chem (2014) 0.87

Adhesion and merging of lipid bilayers: a method for measuring the free energy of adhesion and hemifusion. Biophys J (2011) 0.87

Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength. Nat Struct Mol Biol (2015) 0.87

Mechanism for calcium ion sensing by the C2A domain of synaptotagmin I. Biophys J (2012) 0.86

A PLA1-2 punch regulates the Golgi complex. Trends Cell Biol (2011) 0.86

How could SNARE proteins open a fusion pore? Physiology (Bethesda) (2014) 0.86

A simple guide to biochemical approaches for analyzing protein-lipid interactions. Mol Biol Cell (2012) 0.85

Hepatocytes internalize trophic receptors at large endocytic "Hot Spots". Hepatology (2011) 0.85

The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses. Front Plant Sci (2014) 0.84

A comparison of coarse-grained and continuum models for membrane bending in lipid bilayer fusion pores. Biophys J (2013) 0.84

The TIP30 protein complex, arachidonic acid and coenzyme A are required for vesicle membrane fusion. PLoS One (2011) 0.83

A novel phase of compressed bilayers that models the prestalk transition state of membrane fusion. Biophys J (2012) 0.83

Cholesterol induces uneven curvature of asymmetric lipid bilayers. ScientificWorldJournal (2013) 0.81

Tethering membrane fusion: common and different players in myoblasts and at the synapse. J Neurogenet (2014) 0.80

Analytical characterization of the role of phospholipids in platelet adhesion and secretion. Anal Chem (2014) 0.80

Placing and shaping liposomes with reconfigurable DNA nanocages. Nat Chem (2017) 0.80

Adhesion energy can regulate vesicle fusion and stabilize partially fused states. J R Soc Interface (2012) 0.79

Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein. Biochim Biophys Acta (2016) 0.78

DOC2B and Munc13-1 differentially regulate neuronal network activity. Cereb Cortex (2013) 0.78

Measuring Ca2+-induced structural changes in lipid monolayers: implications for synaptic vesicle exocytosis. Biophys J (2012) 0.78

The Multifaceted Role of SNARE Proteins in Membrane Fusion. Front Physiol (2017) 0.77

Size-dependent ultrafast structural dynamics inside phospholipid vesicle bilayers measured with 2D IR vibrational echoes. Proc Natl Acad Sci U S A (2014) 0.77

Apical vacuole formation by gastric parietal cells in primary culture: effect of low extracellular Ca2+. Am J Physiol Cell Physiol (2012) 0.77

Membranes in motion. EMBO Rep (2010) 0.77

Viscoelastic deformation of lipid bilayer vesicles. Soft Matter (2015) 0.77

Cytosol-dependent membrane fusion in ER, nuclear envelope and nuclear pore assembly: biological implications. Nucleus (2010) 0.77

In vitro systems for Atg8 lipidation. Methods (2014) 0.77

Drug Delivery via Cell Membrane Fusion Using Lipopeptide Modified Liposomes. ACS Cent Sci (2016) 0.76

Myoblast fusion: playing hard to get. Dev Cell (2015) 0.76

A membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes. Biochim Biophys Acta (2014) 0.75

Reovirus FAST Proteins Drive Pore Formation and Syncytiogenesis Using a Novel Helix-Loop-Helix Fusion-Inducing Lipid Packing Sensor. PLoS Pathog (2015) 0.75

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. Nature (2017) 0.75

Self-eating with your fingers. Cell Res (2012) 0.75

The Salmonella effector SseJ disrupts microtubule dynamics when ectopically expressed in normal rat kidney cells. PLoS One (2017) 0.75

Numerical simulation of endocytosis: Viscous flow driven by membranes with non-uniformly distributed curvature-inducing molecules. J Comput Phys (2016) 0.75

A Coiled-Coil Peptide Shaping Lipid Bilayers upon Fusion. Biophys J (2016) 0.75

A net-like structure with pores is observed during cell fusion induced by the receptor FGFRL1. Commun Integr Biol (2011) 0.75

Membrane tension increases fusion efficiency of model membranes in the presence of SNAREs. Sci Rep (2017) 0.75

Hydrodynamic flow in a synaptic cleft during exocytosis. Eur Biophys J (2011) 0.75

Vesicular transport system in myotubes: ultrastructural study and signposting with vesicle-associated membrane proteins. Histochem Cell Biol (2013) 0.75

Articles by these authors

How proteins produce cellular membrane curvature. Nat Rev Mol Cell Biol (2006) 6.90

Mechanics of membrane fusion. Nat Struct Mol Biol (2008) 4.79

Protein-lipid interplay in fusion and fission of biological membranes. Annu Rev Biochem (2003) 4.77

How synaptotagmin promotes membrane fusion. Science (2007) 4.46

Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science (2008) 3.60

Stalk model of membrane fusion: solution of energy crisis. Biophys J (2002) 3.51

Mechanisms determining the morphology of the peripheral ER. Cell (2010) 3.35

Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains. Cell (2012) 3.26

The hydrophobic insertion mechanism of membrane curvature generation by proteins. Biophys J (2008) 2.98

Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. Nature (2007) 2.96

Mechanisms shaping the membranes of cellular organelles. Annu Rev Cell Dev Biol (2009) 2.71

Membrane hemifusion: crossing a chasm in two leaps. Cell (2005) 2.61

Focal adhesions as mechanosensors: a physical mechanism. Proc Natl Acad Sci U S A (2005) 2.43

Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions. PLoS Pathog (2010) 2.33

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science (2010) 2.12

Membranes of the world unite! J Cell Biol (2006) 2.06

Assembly and mechanosensory function of focal adhesions: experiments and models. Eur J Cell Biol (2005) 2.06

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii. EMBO J (2008) 2.00

Lipid intermediates in membrane fusion: formation, structure, and decay of hemifusion diaphragm. Biophys J (2002) 2.00

Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell (2013) 1.97

Membrane fission: model for intermediate structures. Biophys J (2003) 1.84

Computational model of membrane fission catalyzed by ESCRT-III. PLoS Comput Biol (2009) 1.78

Spontaneous curvature of phosphatidic acid and lysophosphatidic acid. Biochemistry (2005) 1.66

Interplay of proteins and lipids in generating membrane curvature. Curr Opin Cell Biol (2010) 1.64

Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion. Mol Biol Cell (2008) 1.42

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation. EMBO J (2012) 1.37

Mechanisms and regulation of autophagosome formation. Curr Opin Cell Biol (2012) 1.30

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. Nat Chem Biol (2009) 1.29

Stalk phase formation: effects of dehydration and saddle splay modulus. Biophys J (2004) 1.28

Prefission constriction of Golgi tubular carriers driven by local lipid metabolism: a theoretical model. Biophys J (2003) 1.21

Forming giant vesicles with controlled membrane composition, asymmetry, and contents. Proc Natl Acad Sci U S A (2011) 1.15

Early steps of HIV-1 fusion define the sensitivity to inhibitory peptides that block 6-helix bundle formation. PLoS Pathog (2009) 1.14

Role of focal adhesions and mechanical stresses in the formation and progression of the lamellipodium-lamellum interface [corrected]. Biophys J (2009) 1.14

How lipid flippases can modulate membrane structure. Biochim Biophys Acta (2008) 1.13

Extracellular annexins and dynamin are important for sequential steps in myoblast fusion. J Cell Biol (2012) 1.12

Modeling membrane shaping by proteins: focus on EHD2 and N-BAR domains. FEBS Lett (2009) 1.08

Computational model of cytokinetic abscission driven by ESCRT-III polymerization and remodeling. Biophys J (2012) 1.04

Physical model for self-organization of actin cytoskeleton and adhesion complexes at the cell front. Biophys J (2012) 1.03

Intracellular curvature-generating proteins in cell-to-cell fusion. Biochem J (2011) 1.02

A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox. J Cell Biol (2005) 1.01

Fusion-pore expansion during syncytium formation is restricted by an actin network. J Cell Sci (2008) 0.99

Point-like protrusion as a prestalk intermediate in membrane fusion pathway. Biophys J (2007) 0.98

Influenza hemagglutinins outside of the contact zone are necessary for fusion pore expansion. J Biol Chem (2004) 0.97

The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii. BMC Biol (2011) 0.95

Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells. PLoS One (2010) 0.95

Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation. Autophagy (2013) 0.93

Actin polymerization upon processive capping by formin: a model for slowing and acceleration. Biophys J (2006) 0.91

Orientation and interaction of oblique cylindrical inclusions embedded in a lipid monolayer: a theoretical model for viral fusion peptides. Biophys J (2004) 0.89

Biophysics: Joint effort bends membrane. Nature (2010) 0.87

Biophysics: bending over to attract. Nature (2007) 0.85

Crawling cell locomotion revisited. Proc Natl Acad Sci U S A (2011) 0.81

Force-driven polymerization in cells: actin filaments and focal adhesions. J Phys Condens Matter (2005) 0.79

Heat evolution of micelle formation, dependence of enthalpy, and heat capacity on the surfactant chain length and head group. J Colloid Interface Sci (2002) 0.78

Excluding the unwanted during autophagy. Cell Cycle (2014) 0.76

Model of T-cell nuclear deformation by the cortical actin layer. Biophys J (2013) 0.75

Cell boundary and intracellular space. Preface. Curr Top Membr (2011) 0.75