Published in Nat Struct Mol Biol on July 24, 2011
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. Elife (2012) 2.04
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity. J Neurosci (2012) 1.36
Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol (2011) 1.26
Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms. Elife (2014) 1.20
Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A (2013) 1.10
Synaptic vesicles position complexin to block spontaneous fusion. Neuron (2013) 1.08
Re-examining how complexin inhibits neurotransmitter release. Elife (2014) 1.07
A half-zippered SNARE complex represents a functional intermediate in membrane fusion. J Am Chem Soc (2014) 1.00
Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse. PLoS One (2012) 0.96
Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. J Neurosci (2013) 0.96
Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis. Elife (2015) 0.96
Membrane curvature sensing by the C-terminal domain of complexin. Nat Commun (2014) 0.95
Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo. Proc Natl Acad Sci U S A (2014) 0.94
Calcium sensitive ring-like oligomers formed by synaptotagmin. Proc Natl Acad Sci U S A (2014) 0.92
The SNARE complex in neuronal and sensory cells. Mol Cell Neurosci (2012) 0.92
Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics. J Cell Biol (2014) 0.89
Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin. Biophys J (2013) 0.89
Re-visiting the trans insertion model for complexin clamping. Elife (2015) 0.87
How could SNARE proteins open a fusion pore? Physiology (Bethesda) (2014) 0.86
The accessory helix of complexin functions by stabilizing central helix secondary structure. Elife (2014) 0.85
Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis. PLoS One (2012) 0.83
Complexins: small but capable. Cell Mol Life Sci (2015) 0.82
A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion. PLoS Comput Biol (2013) 0.82
Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex. Elife (2016) 0.82
Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity. J Biol Chem (2013) 0.79
Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening. Sci Rep (2015) 0.79
Three steps forward, two steps back: mechanistic insights into the assembly and disassembly of the SNARE complex. Curr Opin Chem Biol (2015) 0.79
A Chemical Controller of SNARE-Driven Membrane Fusion That Primes Vesicles for Ca(2+)-Triggered Millisecond Exocytosis. J Am Chem Soc (2016) 0.78
Complexin arrests a neighbor. Nat Struct Mol Biol (2011) 0.78
Nanodisc-cell fusion: control of fusion pore nucleation and lifetimes by SNARE protein transmembrane domains. Sci Rep (2016) 0.78
Genome-wide association study revealed genomic regions related to white/red earlobe color trait in the Rhode Island Red chickens. BMC Genet (2016) 0.78
The Multifaceted Role of SNARE Proteins in Membrane Fusion. Front Physiol (2017) 0.77
Accelerating SNARE-Mediated Membrane Fusion by DNA-Lipid Tethers. Angew Chem Int Ed Engl (2015) 0.77
Crystallization and preliminary X-ray diffraction analysis of Gos1p, a yeast SNARE protein. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Dilation of fusion pores by crowding of SNARE proteins. Elife (2017) 0.75
Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses. Cell Rep (2016) 0.75
Ring-like oligomers of Synaptotagmins and related C2 domain proteins. Elife (2016) 0.75
Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function. Front Mol Neurosci (2017) 0.75
SNAP receptors implicated in vesicle targeting and fusion. Nature (1993) 18.57
SNAREpins: minimal machinery for membrane fusion. Cell (1998) 16.97
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature (1998) 15.80
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell (1994) 7.43
Probing the relation between force--lifetime--and chemistry in single molecular bonds. Annu Rev Biophys Biomol Struct (2001) 7.19
Synaptotagmin I functions as a calcium regulator of release probability. Nature (2001) 5.96
Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Science (1992) 5.00
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature (1990) 4.68
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature (2000) 4.67
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
A clamping mechanism involved in SNARE-dependent exocytosis. Science (2006) 3.74
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Cell (2001) 3.49
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
Complexins: cytosolic proteins that regulate SNAP receptor function. Cell (1995) 3.04
PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane. Nat Struct Mol Biol (2003) 2.95
Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol (2007) 2.63
Fusion of cells by flipped SNAREs. Science (2003) 2.60
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Timing of neurotransmission at fast synapses in the mammalian brain. Nature (1996) 2.38
Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain? EMBO J (1998) 2.31
Alternative zippering as an on-off switch for SNARE-mediated fusion. Science (2009) 2.30
Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron (2009) 2.26
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion. Nat Struct Mol Biol (2008) 2.25
Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers. J Biol Chem (1998) 2.15
Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change? Biochemistry (1998) 2.11
Membrane curvature in synaptic vesicle fusion and beyond. Cell (2010) 2.09
X-ray structure of a neuronal complexin-SNARE complex from squid. J Biol Chem (2002) 1.82
A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis. J Neurosci (2006) 1.82
Activity-dependent changes in partial VAMP complexes during neurotransmitter release. Nat Neurosci (1999) 1.71
A fast, single-vesicle fusion assay mimics physiological SNARE requirements. Proc Natl Acad Sci U S A (2010) 1.68
Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion. Nat Struct Mol Biol (2010) 1.64
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol (2010) 1.63
Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem (2008) 1.59
Liposome fusion assay to monitor intracellular membrane fusion machines. Methods Enzymol (2003) 1.49
The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2009) 1.38
Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals. Biochem Biophys Res Commun (1995) 1.34
Protein determinants of SNARE-mediated lipid mixing. Biophys J (2010) 1.05
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell (2010) 7.94
The c-Myc target gene network. Semin Cancer Biol (2006) 5.98
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49
HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell (2007) 4.81
MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell (2009) 4.47
Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell (2007) 4.26
Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc Natl Acad Sci U S A (2004) 3.85
A clamping mechanism involved in SNARE-dependent exocytosis. Science (2006) 3.74
Energetics and dynamics of SNAREpin folding across lipid bilayers. Nat Struct Mol Biol (2007) 3.39
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23
Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42. J Cell Biol (2004) 3.06
Advanced materials for energy storage. Adv Mater (2010) 3.04
Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science (2012) 2.98
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95
Genetic evidence supports demic diffusion of Han culture. Nature (2004) 2.92
Fatty liver and the metabolic syndrome among Shanghai adults. J Gastroenterol Hepatol (2005) 2.67
The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cell (2008) 2.61
Fusion of cells by flipped SNAREs. Science (2003) 2.60
Mechanism of induction and suppression of antiviral immunity directed by virus-derived small RNAs in Drosophila. Cell Host Microbe (2008) 2.48
Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer. Immunity (2009) 2.46
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol (2002) 2.45
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol (2006) 2.45
Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAs. Plant Cell (2007) 2.43
Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity. Cell (2005) 2.40
Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A (2003) 2.32
Journeys through the Golgi--taking stock in a new era. J Cell Biol (2009) 2.30
Alternative zippering as an on-off switch for SNARE-mediated fusion. Science (2009) 2.30
Global surveillance of emerging Influenza virus genotypes by mass spectrometry. PLoS One (2007) 2.29
Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology. Nano Lett (2005) 2.22
Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J Hepatol (2005) 2.21
Johnson-Kendall-Roberts theory applied to living cells. Phys Rev Lett (2005) 2.13
Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins. J Cell Biol (2002) 2.13
Global regulation of nucleotide biosynthetic genes by c-Myc. PLoS One (2008) 2.12
Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc Natl Acad Sci U S A (2002) 2.07
Imaging single membrane fusion events mediated by SNARE proteins. Proc Natl Acad Sci U S A (2004) 1.99
GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem (2004) 1.99
Myo4p and She3p are required for cortical ER inheritance in Saccharomyces cerevisiae. J Cell Biol (2003) 1.92
SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science (2012) 1.89
Rtn1p is involved in structuring the cortical endoplasmic reticulum. Mol Biol Cell (2006) 1.85
Vectors for co-expression of an unrestricted number of proteins. Nucleic Acids Res (2007) 1.85
Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses. PLoS Pathog (2013) 1.83
High-energy MnO2 nanowire/graphene and graphene asymmetric electrochemical capacitors. ACS Nano (2010) 1.81
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
Ribosome dysfunction is an early event in Alzheimer's disease. J Neurosci (2005) 1.80
Integrating multiple 'omics' analysis for microbial biology: application and methodologies. Microbiology (2009) 1.79
The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif. Nat Struct Mol Biol (2005) 1.79
Rapid identification of emerging infectious agents using PCR and electrospray ionization mass spectrometry. Ann N Y Acad Sci (2007) 1.79
SNAREs can promote complete fusion and hemifusion as alternative outcomes. J Cell Biol (2005) 1.78
Graphene anchored with co(3)o(4) nanoparticles as anode of lithium ion batteries with enhanced reversible capacity and cyclic performance. ACS Nano (2010) 1.78
Characterization of a novel influenza virus in cattle and Swine: proposal for a new genus in the Orthomyxoviridae family. MBio (2014) 1.75
Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell Res (2011) 1.74
Genotypic variation and mixtures of Lyme Borrelia in Ixodes ticks from North America and Europe. PLoS One (2010) 1.73
In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat). J Virol (2006) 1.70
A fast, single-vesicle fusion assay mimics physiological SNARE requirements. Proc Natl Acad Sci U S A (2010) 1.68
Budding of equine infectious anemia virus is insensitive to proteasome inhibitors. J Virol (2002) 1.67
EUS and survival in patients with pancreatic cancer: a population-based study. Gastrointest Endosc (2010) 1.66
Lung cancer: performance of automated lung nodule detection applied to cancers missed in a CT screening program. Radiology (2002) 1.66
3D aperiodic hierarchical porous graphitic carbon material for high-rate electrochemical capacitive energy storage. Angew Chem Int Ed Engl (2008) 1.64
Computer-aided diagnosis in thoracic CT. Semin Ultrasound CT MR (2005) 1.63
Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA. Cell Res (2012) 1.63
Identification of miniature inverted-repeat transposable elements (MITEs) and biogenesis of their siRNAs in the Solanaceae: new functional implications for MITEs. Genome Res (2008) 1.63
Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression. Hepatology (2009) 1.62
Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function. PLoS Pathog (2009) 1.61
Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature (2014) 1.60
Crystal structure of the T315I mutant of AbI kinase. Chem Biol Drug Des (2007) 1.60
Digital image analysis of EUS images accurately differentiates pancreatic cancer from chronic pancreatitis and normal tissue. Gastrointest Endosc (2008) 1.59
FisB mediates membrane fission during sporulation in Bacillus subtilis. Genes Dev (2013) 1.59
Sequence characteristics of functional siRNAs. RNA (2005) 1.59
Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem (2008) 1.59
3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro. J Virol (2006) 1.58
p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). J Biol Chem (2012) 1.55
RNA silencing: a conserved antiviral immunity of plants and animals. Virus Res (2004) 1.54
Direct broad-range detection of alphaviruses in mosquito extracts. Virology (2007) 1.52
Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem (2007) 1.52
Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p. Dev Cell (2010) 1.52
Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat Struct Biol (2003) 1.50
SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes. Proc Natl Acad Sci U S A (2008) 1.48
A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p. Mol Cell (2007) 1.48
Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res (2011) 1.48
Stapled Golgi cisternae remain in place as cargo passes through the stack. Elife (2013) 1.47
Fabrication of Graphene/Polyaniline Composite Paper via In Situ Anodic Electropolymerization for High-Performance Flexible Electrode. ACS Nano (2009) 1.47
Efficacy of catheter ablation and surgical CryoMaze procedure in patients with long-lasting persistent atrial fibrillation and rheumatic heart disease: a randomized trial. Eur Heart J (2010) 1.47
Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem (2005) 1.43
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol (2010) 1.43
Doped graphene sheets as anode materials with superhigh rate and large capacity for lithium ion batteries. ACS Nano (2011) 1.43
Morphological and physiological responses to sediment type and light availability in roots of the submerged plant Myriophyllum spicatum. Ann Bot (2007) 1.42
Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci (2011) 1.41
Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo. Clin Cancer Res (2005) 1.40
A graphene-pure-sulfur sandwich structure for ultrafast, long-life lithium-sulfur batteries. Adv Mater (2013) 1.40
Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin. Cell Metab (2007) 1.39
Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol Biol Cell (2004) 1.39