Published in Proc Natl Acad Sci U S A on June 18, 2012
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. Elife (2012) 2.04
Studying calcium-triggered vesicle fusion in a single vesicle-vesicle content and lipid-mixing system. Nat Protoc (2012) 1.10
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Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. PLoS One (2012) 0.75
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Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion. Nat Struct Mol Biol (2006) 2.74
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Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion. Cell (2009) 2.47
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Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1. Science (2010) 1.77
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Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1. Proc Natl Acad Sci U S A (2005) 1.71
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Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophys J (2006) 1.52
Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation. Nat Struct Mol Biol (2011) 1.41
The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2009) 1.38
Discrimination between docking and fusion of liposomes reconstituted with neuronal SNARE-proteins using FCS. Proc Natl Acad Sci U S A (2009) 1.36
Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1. J Biol Chem (2006) 1.34
Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. J Biol Chem (2008) 1.25
Mechanism and function of synaptotagmin-mediated membrane apposition. Nat Struct Mol Biol (2011) 1.19
Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs. EMBO J (2012) 1.16
The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. Biochem J (2012) 0.92
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis. Nature (2006) 6.54
Video-rate far-field optical nanoscopy dissects synaptic vesicle movement. Science (2008) 5.87
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Macromolecular-scale resolution in biological fluorescence microscopy. Proc Natl Acad Sci U S A (2006) 3.04
Helical extension of the neuronal SNARE complex into the membrane. Nature (2009) 2.92
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids. Nat Struct Mol Biol (2007) 2.63
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron (2012) 2.49
Two-color far-field fluorescence nanoscopy. Biophys J (2007) 2.44
SNARE assembly and disassembly exhibit a pronounced hysteresis. Nat Struct Biol (2002) 2.40
Membrane protein sequestering by ionic protein-lipid interactions. Nature (2011) 2.40
Determinants of liposome fusion mediated by synaptic SNARE proteins. Proc Natl Acad Sci U S A (2004) 2.28
A complete genetic analysis of neuronal Rab3 function. J Neurosci (2004) 2.21
Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Nat Struct Biol (2002) 2.21
Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes. PLoS Biol (2006) 2.17
One SNARE complex is sufficient for membrane fusion. Nat Struct Mol Biol (2010) 2.14
Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells. Proc Natl Acad Sci U S A (2002) 2.03
Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci (2013) 1.82
Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions. Methods (2012) 1.75
Long unfolded linkers facilitate membrane protein import through the nuclear pore complex. Science (2011) 1.73
Membrane fusion intermediates via directional and full assembly of the SNARE complex. Science (2012) 1.71
Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells. J Neurosci (2005) 1.71
SNAREs prefer liquid-disordered over "raft" (liquid-ordered) domains when reconstituted into giant unilamellar vesicles. J Biol Chem (2004) 1.65
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Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis. J Biol Chem (2001) 1.63
Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity. Proc Natl Acad Sci U S A (2006) 1.59
Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation. Proc Natl Acad Sci U S A (2009) 1.57
Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. J Biol Chem (2002) 1.56
The riddle of the Sec1/Munc-18 proteins - new twists added to their interactions with SNAREs. Trends Biochem Sci (2003) 1.50
SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs. J Cell Biol (2002) 1.45
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor. J Neurochem (2009) 1.44
Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation. Nat Struct Mol Biol (2011) 1.41
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nat Struct Mol Biol (2013) 1.38
The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis. J Biol Chem (2003) 1.38
The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2009) 1.38
Discrimination between docking and fusion of liposomes reconstituted with neuronal SNARE-proteins using FCS. Proc Natl Acad Sci U S A (2009) 1.36
Molecular cloning and functional characterization of human vesicular glutamate transporter 3. EMBO Rep (2002) 1.35
Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis. J Neurosci (2003) 1.32
Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein. J Neurosci (2010) 1.32
Synaptic vesicles are constitutively active fusion machines that function independently of Ca2+. Curr Biol (2008) 1.31
Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies. EMBO J (2006) 1.30
Distinct kinetic changes in neurotransmitter release after SNARE protein cleavage. Science (2005) 1.29
Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses. Proc Natl Acad Sci U S A (2011) 1.27
Evidence for early endosome-like fusion of recently endocytosed synaptic vesicles. Traffic (2006) 1.27
Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol (2002) 1.26
Distribution, lateral mobility and function of membrane proteins incorporated into giant unilamellar vesicles. Biophys J (2004) 1.26
3D reconstruction of high-resolution STED microscope images. Microsc Res Tech (2008) 1.26
Kiss-and-run, collapse and 'readily retrievable' vesicles. Traffic (2007) 1.26
The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly. J Biol Chem (2002) 1.25
Molecular sieving properties of the cytoplasm of Escherichia coli and consequences of osmotic stress. Mol Microbiol (2010) 1.22
Core proteins of the secretory machinery. Handb Exp Pharmacol (2008) 1.22
Determinants of synaptobrevin regulation in membranes. Mol Biol Cell (2007) 1.20
Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression. J Biol Chem (2006) 1.19
Unique luminal localization of VGAT-C terminus allows for selective labeling of active cortical GABAergic synapses. J Neurosci (2008) 1.14
Endosomal fusion upon SNARE knockdown is maintained by residual SNARE activity and enhanced docking. Traffic (2009) 1.11
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. EMBO J (2006) 1.11
Controlling synaptotagmin activity by electrostatic screening. Nat Struct Mol Biol (2012) 1.08
Methods for studying synaptosomal copper release. J Neurosci Methods (2003) 1.08
Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption. Mol Cell Biol (2005) 1.08
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Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold. J Biol Chem (2012) 1.06
A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion. Mol Biol Cell (2007) 1.04
Quaternary structure of SecA in solution and bound to SecYEG probed at the single molecule level. Structure (2011) 1.03
Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. J Neurosci (2010) 1.03
Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Neuron (2013) 1.02
The architecture of an excitatory synapse. J Cell Sci (2010) 1.02
Highly efficient blue-emitting iridium(III) carbene complexes and phosphorescent OLEDs. Angew Chem Int Ed Engl (2008) 1.02
The Habc domain and the SNARE core complex are connected by a highly flexible linker. Biochemistry (2003) 1.00
Reinvestigation of the role of snapin in neurotransmitter release. J Biol Chem (2004) 1.00
SNARE function is not involved in early endosome docking. Mol Biol Cell (2008) 0.99
A dual function for Munc-18 in exocytosis of PC12 cells. Eur J Neurosci (2005) 0.98
The specificity of SNARE pairing in biological membranes is mediated by both proof-reading and spatial segregation. EMBO J (2007) 0.98
A fluorescence-based in vitro assay for investigating early endosome dynamics. Nat Protoc (2010) 0.98
Synaptic and vesicular co-localization of the glutamate transporters VGLUT1 and VGLUT2 in the mouse hippocampus. J Neurochem (2006) 0.97
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Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol Pharmacol (2007) 0.95
Endobrevin/VAMP8 mediates exocytotic release of hexosaminidase from rat basophilic leukaemia cells. FEBS Lett (2007) 0.95
Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1β with the nucleosome. J Biol Chem (2012) 0.95
Synaptic PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter release. Neuron (2013) 0.95
Counting the SNAREs needed for membrane fusion. J Mol Cell Biol (2011) 0.94
Bartonella infection in shelter cats and dogs and their ectoparasites. Vector Borne Zoonotic Dis (2010) 0.94
VAMP3 is associated with endothelial weibel-palade bodies and participates in their Ca(2+)-dependent exocytosis. Biochim Biophys Acta (2010) 0.94
Distinct yet overlapping roles of Rab GTPases on synaptic vesicles. Small GTPases (2011) 0.93
Direct interaction of the major light-harvesting complex II and PsbS in nonphotochemical quenching. Proc Natl Acad Sci U S A (2013) 0.92
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Sorting in early endosomes reveals connections to docking- and fusion-associated factors. Proc Natl Acad Sci U S A (2009) 0.91
Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence. J Neurosci (2005) 0.91
Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. Mol Cell Biol (2002) 0.91
Probing receptor-translocator interactions in the oligopeptide ABC transporter by fluorescence correlation spectroscopy. Biophys J (2008) 0.89
Microdomains of SNARE proteins in the plasma membrane. Curr Top Membr (2013) 0.89
Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter. Proc Natl Acad Sci U S A (2012) 0.88
A tethering complex recruits SNAREs and grabs vesicles. Cell (2009) 0.87
Synaptic membrane proteins form stable microdomains in early endosomes. Microsc Res Tech (2010) 0.87
Transmembrane domain peptide/peptide nucleic acid hybrid as a model of a SNARE protein in vesicle fusion. Angew Chem Int Ed Engl (2011) 0.87