Published in Free Radic Biol Med on February 26, 2010
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Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages. Free Radic Biol Med (2011) 0.92
A review of therapies for diabetic macular oedema and rationale for combination therapy. Eye (Lond) (2015) 0.92
Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med (2011) 0.83
Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia. PLoS One (2015) 0.80
The nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide affects stress response and fate of lipopolysaccharide-primed RAW 264.7 macrophage cells. Inflammation (2013) 0.76
Thiamine Deficiency Increases Ca(2+) Current and CaV1.2 L-type Ca(2+) Channel Levels in Cerebellum Granular Neurons. Cell Mol Neurobiol (2016) 0.75
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 13.15
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature (2000) 12.33
LPS induction of gene expression in human monocytes. Cell Signal (2001) 7.61
NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol (2006) 5.25
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes (2000) 4.55
NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol (2006) 3.15
Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci (2001) 3.03
Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol (2004) 2.89
The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol (1997) 2.89
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med (2003) 2.61
Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiology (1993) 2.28
Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci U S A (1996) 2.26
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes (2003) 1.99
Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc Natl Acad Sci U S A (2007) 1.95
Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells (1998) 1.94
Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase. J Am Soc Nephrol (2003) 1.89
Transcriptional profiling of the LPS induced NF-kappaB response in macrophages. BMC Immunol (2007) 1.71
Early lipopolysaccharide-induced reactive oxygen species production evokes necrotic cell death in human umbilical vein endothelial cells. J Hypertens (2009) 1.56
Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J Biol Chem (2006) 1.46
Cellular mechanisms in sepsis. J Intensive Care Med (2007) 1.39
Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. J Biol Chem (2005) 1.33
Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways. Eur J Pharmacol (2006) 1.33
Anti-inflammatory properties of alpha- and gamma-tocopherol. Mol Aspects Med (2007) 1.31
Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Diabetes Care (2006) 1.31
Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways. Int Immunopharmacol (2007) 1.20
The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev (2005) 1.19
Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7 macrophages. Biochem Biophys Res Commun (2009) 1.16
Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. J Immunol (2004) 1.15
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. J Biol Chem (2006) 1.13
The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. Am J Respir Crit Care Med (2000) 1.13
Activation of p38 mitogen-activated protein kinase/cytosolic phospholipase A2 cascade in hydroperoxide-stressed platelets. Free Radic Biol Med (2003) 1.11
6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macrophages. Biochem Biophys Res Commun (2009) 1.10
Focus on molecules: nuclear factor-kappaB. Exp Eye Res (2008) 1.08
Antioxidant supplementation in sepsis and systemic inflammatory response syndrome. Crit Care Med (2007) 1.08
Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages. Cytokine (2006) 1.05
Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. Diabetes Metab Res Rev (2008) 1.05
N-acetylcysteine protects mice from lethal endotoxemia by regulating the redox state of immune cells. Free Radic Res (2003) 1.04
Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells. Exp Eye Res (2007) 1.03
Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium. Biofactors (2009) 1.02
Characteristics of thiamin and its relevance to the management of heart failure. Nutr Clin Pract (2008) 1.01
Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells. Invest Ophthalmol Vis Sci (2006) 1.01
p38 Mitogen-activated protein kinase up-regulates LPS-induced NF-kappaB activation in the development of lung injury and RAW 264.7 macrophages. Toxicology (2006) 0.99
Molecular biology of septic shock. New Horiz (1998) 0.98
Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation. Eur J Pharmacol (2008) 0.97
Protective effects of N-acetyl-L-cysteine in endotoxemia. Am J Physiol (1994) 0.96
Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury. J Surg Res (2007) 0.96
Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci (2009) 0.96
The role of bacteriolysis in the pathophysiology of inflammation, infection and post-infectious sequelae. APMIS (2002) 0.96
Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice. J Immunol (2009) 0.95
Thiamine and benfotiamine prevent increased apoptosis in endothelial cells and pericytes cultured in high glucose. Diabetes Metab Res Rev (2004) 0.93
Bcl-2 protein family: implications in vascular apoptosis and atherosclerosis. Apoptosis (2006) 0.93
Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther (1996) 0.87
Curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in mice. Eur J Pharmacol (2009) 0.85
Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications. Acta Diabetol (2008) 0.85
Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes (2001) 0.85
Ascorbic acid and N-acetylcysteine improve in vitro the function of lymphocytes from mice with endotoxin-induced oxidative stress. Free Radic Res (2001) 0.84
Protective effect of resveratrol in endotoxemia-induced acute phase response in rats. Arch Toxicol (2008) 0.83
trans-10,cis-12 Conjugated linoleic acid induces depolarization of mitochondrial membranes in HT-29 human colon cancer cells: a possible mechanism for induction of apoptosis. J Med Food (2009) 0.82
Ascorbic acid modulates in vitro the function of macrophages from mice with endotoxic shock. Immunopharmacology (2000) 0.82
Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. Acta Diabetol (2001) 0.81
[Prophylactic and therapeutic application of thiamine (vitamin B1)--a new point of view]. Wiad Lek (2006) 0.80
Benfotiamine. Monograph. Altern Med Rev (2006) 0.79
LPS-induced synthesis and release of PGE2 in liver macrophages: regulation by CPLA2, COX-1, COX-2, and PGE2 synthase. Adv Exp Med Biol (2002) 0.78
[Thiamine treatment in psychiatry and neurology]. Fortschr Neurol Psychiatr (2000) 0.78
A novel water-soluble vitamin E derivative prevents acute lung injury by bacterial endotoxin. Clin Exp Pharmacol Physiol (2004) 0.77
An antioxidative nutrient-rich enteral diet attenuates lethal activity and oxidative stress induced by lipopolysaccharide in mice. JPEN J Parenter Enteral Nutr (2007) 0.76
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev (2005) 2.42
Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2007) 1.61
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem (2002) 1.51
Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J Biol Chem (2006) 1.46
Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase. Diabetes (2004) 1.33
Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Res (2006) 1.27
Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes (2005) 1.26
Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation (2006) 1.17
Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells. FASEB J (2002) 1.15
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells. Diabetes (2006) 1.13
Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice. PLoS One (2009) 1.11
Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis (2008) 1.10
Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders. Chem Biol Interact (2011) 1.09
Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells. FASEB J (2004) 1.09
Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells. Mol Cancer Ther (2010) 1.09
Focus on molecules: nuclear factor-kappaB. Exp Eye Res (2008) 1.08
Prevention of posterior capsular opacification through aldose reductase inhibition. Invest Ophthalmol Vis Sci (2008) 1.07
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. Diabetes (2002) 1.06
Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages. Cytokine (2006) 1.05
Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells. Exp Eye Res (2007) 1.03
Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells. Endocrinology (2008) 1.01
Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells. Invest Ophthalmol Vis Sci (2006) 1.01
Aldose reductase: a novel therapeutic target for inflammatory pathologies. Int J Biochem Cell Biol (2009) 1.00
Regulation of NF-κB-induced inflammatory signaling by lipid peroxidation-derived aldehydes. Oxid Med Cell Longev (2013) 1.00
Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages. Free Radic Biol Med (2007) 1.00
Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells. FEBS Lett (2004) 0.99
Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett (2007) 0.98
Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology (2007) 0.96
Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci (2009) 0.96
Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice. J Immunol (2009) 0.95
Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo. Angiogenesis (2011) 0.95
Measurement and identification of S-glutathiolated proteins. Methods Enzymol (2010) 0.94
Aldose reductase deficiency protects sugar-induced lens opacification in rats. Chem Biol Interact (2011) 0.93
Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis. Cytokine (2009) 0.93
Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages. Free Radic Biol Med (2011) 0.92
Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells. Toxicol Appl Pharmacol (2007) 0.92
Post-translational protein modification by carotenoid cleavage products. Biofactors (2011) 0.91
Metabolism of lipid derived aldehyde, 4-hydroxynonenal in human lens epithelial cells and rat lens. Invest Ophthalmol Vis Sci (2003) 0.90
Aldose reductase inhibition prevents metaplasia of airway epithelial cells. PLoS One (2010) 0.89
Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins (2006) 0.89
Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2012) 0.88
Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells. FASEB J (2003) 0.88
Inhibition of aldose reductase prevents colon cancer metastasis. Carcinogenesis (2011) 0.88
Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes. J Toxicol Environ Health A (2009) 0.88
4-Hydroxynonenal in the pathogenesis and progression of human diseases. Curr Med Chem (2014) 0.87
Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway. Exp Eye Res (2009) 0.87
L-Arginine prevents metabolic effects of high glucose in diabetic mice. FEBS Lett (2008) 0.87
Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2011) 0.87
Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. PLoS One (2013) 0.87
Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle. Endocrinology (2010) 0.86
Studies on the genotoxicity of endosulfan in different tissues of fresh water fish Mystus vittatus using the comet assay. Arch Environ Contam Toxicol (2007) 0.86
Acute toxicity bioassays of mercuric chloride and malathion on air-breathing fish Channa punctatus (Bloch). Ecotoxicol Environ Saf (2005) 0.85
Synthesis, quantification, characterization, and signaling properties of glutathionyl conjugates of enals. Methods Enzymol (2010) 0.85
Investigation of the genotoxicity of malathion to freshwater teleost fish Channa punctatus (Bloch) using the micronucleus test and comet assay. Arch Environ Contam Toxicol (2009) 0.85
Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone. Invest Ophthalmol Vis Sci (2010) 0.84
Endotoxin-induced uveitis in rodents. Methods Mol Biol (2013) 0.83
Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin. Invest Ophthalmol Vis Sci (2002) 0.83
Aldose reductase catalyzes reduction of the lipid peroxidation product 4-oxonon-2-enal. Chem Res Toxicol (2003) 0.83
Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med (2011) 0.83
A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases. Expert Opin Investig Drugs (2012) 0.83
Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a. Antioxid Redox Signal (2012) 0.83
Retracted Piceatannol suppresses endotoxin-induced ocular inflammation in rats. Int Immunopharmacol (2013) 0.83