Effector and regulatory B cells: modulators of CD4+ T cell immunity.

PubWeight™: 3.56‹?› | Rank: Top 1%

🔗 View Article (PMC 3038334)

Published in Nat Rev Immunol on March 12, 2010

Authors

Frances E Lund1, Troy D Randall

Author Affiliations

1: Department of Medicine, University of Rochester Medical Center, New York 14642, USA. frances_lund@urmc.rochester.edu

Articles citing this

(truncated to the top 100)

ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity (2011) 5.59

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood (2010) 4.28

Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations. Ann Rheum Dis (2014) 2.43

Macrophages and control of granulomatous inflammation in tuberculosis. Mucosal Immunol (2011) 1.98

Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors. Cancer Biol Ther (2010) 1.94

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood (2011) 1.84

A small CD11b(+) human B1 cell subpopulation stimulates T cells and is expanded in lupus. J Exp Med (2011) 1.78

Adenosine production by human B cells and B cell-mediated suppression of activated T cells. Blood (2013) 1.70

Cathelin-related antimicrobial peptide differentially regulates T- and B-cell function. Eur J Immunol (2011) 1.67

B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis. J Immunol (2011) 1.59

mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile. PLoS One (2016) 1.41

Advances in human B cell phenotypic profiling. Front Immunol (2012) 1.41

Targeting B cells and antibody in transplantation. Am J Transplant (2011) 1.34

B10 cell regulation of health and disease. Immunol Rev (2014) 1.21

Lipid-antigen presentation by CD1d(+) B cells is essential for the maintenance of invariant natural killer T cells. Immunity (2012) 1.21

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. J Clin Invest (2012) 1.17

Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial. Blood (2013) 1.14

B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response. PLoS Pathog (2013) 1.14

B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice. J Immunol (2011) 1.12

Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies. Diabetes (2011) 1.12

Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression. J Allergy Clin Immunol (2013) 1.11

Regulatory B cells and allergic diseases. Allergy Asthma Immunol Res (2011) 1.11

Role of type I interferons in the activation of autoreactive B cells. Immunol Cell Biol (2012) 1.10

Identification of IFN-γ-producing innate B cells. Cell Res (2013) 1.10

Immunologic human renal allograft injury associates with an altered IL-10/TNF-α expression ratio in regulatory B cells. J Am Soc Nephrol (2014) 1.10

A molecular mechanism for TNF-α-mediated downregulation of B cell responses. J Immunol (2011) 1.10

The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Adv Exp Med Biol (2013) 1.09

Mechanisms of allergen-specific immunotherapy. Clin Transl Allergy (2012) 1.06

TSP1-producing B cells show immune regulatory property and suppress allergy-related mucosal inflammation. Sci Rep (2013) 1.06

Fishing for mammalian paradigms in the teleost immune system. Nat Immunol (2013) 1.06

B cells and autoantibodies: complex roles in CNS injury. Trends Immunol (2010) 1.05

Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond. BMC Immunol (2012) 1.01

Efficacy and safety of rituximab in common variable immunodeficiency-associated immune cytopenias: a retrospective multicentre study on 33 patients. Br J Haematol (2011) 1.00

Inhibition of increased circulating Tfh cell by anti-CD20 monoclonal antibody in patients with type 1 diabetes. PLoS One (2013) 0.98

The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Semin Immunol (2014) 0.98

Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand. Nat Commun (2014) 0.97

B cells mediate chronic allograft rejection independently of antibody production. J Clin Invest (2014) 0.96

B effector cells in rheumatoid arthritis and experimental arthritis. Autoimmunity (2012) 0.95

B cell subsets in atherosclerosis. Front Immunol (2012) 0.95

IgG4-Related Fibrotic Diseases from an Immunological Perspective: Regulators out of Control? Int J Rheumatol (2012) 0.95

Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse. PLoS One (2013) 0.94

Emerging trends in the formation and function of tuberculosis granulomas. Front Immunol (2013) 0.93

B cell depletion curtails CD4+ T cell memory and reduces protection against disseminating virus infection. J Immunol (2014) 0.93

Functionally Distinct Subpopulations of CpG-Activated Memory B Cells. Sci Rep (2012) 0.93

TNF-α-secreting B cells contribute to myocardial fibrosis in dilated cardiomyopathy. J Clin Immunol (2013) 0.92

Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells. J Exp Med (2014) 0.91

Positive and negative regulation of T cell responses by fibroblastic reticular cells within paracortical regions of lymph nodes. Front Immunol (2012) 0.91

Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation. Front Immunol (2012) 0.91

B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses. J Immunol (2013) 0.91

Pancreatic ductal adenocarcinoma: a review of immunologic aspects. J Investig Med (2012) 0.91

CD23+ CD21(high) CD1d(high) B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential. J Immunol (2012) 0.90

B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection. J Immunol (2011) 0.90

The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice. J Immunol (2012) 0.89

Essential role for B cells in transplantation tolerance. Curr Opin Immunol (2011) 0.89

The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? J Immunol (2014) 0.88

Tolerance in clinical transplantation: progress, challenge or just a dream? Langenbecks Arch Surg (2011) 0.88

Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest (2011) 0.87

Origin and biology of the allogeneic response. Cold Spring Harb Perspect Med (2013) 0.87

Resident bacteria-stimulated IL-10-secreting B cells ameliorate T cell-mediated colitis by inducing Tr-1 cells that require IL-27-signaling. Cell Mol Gastroenterol Hepatol (2015) 0.86

Role of regulatory T cells in pathogenesis and biological therapy of multiple sclerosis. Mediators Inflamm (2013) 0.86

Gene Therapy for Duchenne muscular dystrophy. Expert Opin Orphan Drugs (2015) 0.86

New insights into B cell biology in systemic lupus erythematosus and Sjögren's syndrome. Curr Opin Rheumatol (2015) 0.86

B Cells, Antibodies, and More. Clin J Am Soc Nephrol (2015) 0.85

Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia. J Clin Immunol (2012) 0.85

Dendritic cell status modulates the outcome of HIV-related B cell disease progression. PLoS Pathog (2011) 0.85

Diverse phosphorylation patterns of B cell receptor-associated signaling in naïve and memory human B cells revealed by phosphoflow, a powerful technique to study signaling at the single cell level. Front Cell Infect Microbiol (2012) 0.85

Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma. Oncoimmunology (2015) 0.84

Role of microRNA-15a in autoantibody production in interferon-augmented murine model of lupus. Mol Immunol (2012) 0.84

Influence of dendritic cells on B-cell responses during HIV infection. Clin Dev Immunol (2012) 0.84

Antigen presenting B cells facilitate CD4 T cell cooperation resulting in enhanced generation of effector and memory CD4 T cells. PLoS One (2013) 0.84

High-anxious individuals show increased chronic stress burden, decreased protective immunity, and increased cancer progression in a mouse model of squamous cell carcinoma. PLoS One (2012) 0.84

Human effector B lymphocytes express ARID3a and secrete interferon alpha. J Autoimmun (2016) 0.84

Clinical transplantation tolerance. Semin Immunopathol (2011) 0.83

Ezrin tunes the magnitude of humoral immunity. J Immunol (2013) 0.83

MicroRNAs, Major Players in B Cells Homeostasis and Function. Front Immunol (2014) 0.83

Evolutionary and functional relationships of B cells from fish and mammals: insights into their novel roles in phagocytosis and presentation of particulate antigen. Infect Disord Drug Targets (2012) 0.83

B cells and progressive multifocal leukoencephalopathy: search for the missing link. Front Immunol (2015) 0.82

Reprogramming of B cells into regulatory cells with engineered fusokines. Infect Disord Drug Targets (2012) 0.81

Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the Children's Oncology Group Study ASCT0031. Biol Blood Marrow Transplant (2011) 0.81

CD19(+) B cells confer protection against experimental cerebral malaria in semi-immune rodent model. PLoS One (2013) 0.81

Aberrant frequency of IL-10-producing B cells and its association with Treg/Th17 in adult primary immune thrombocytopenia patients. Biomed Res Int (2014) 0.81

Interferon-alpha triggers B cell effector 1 (Be1) commitment. PLoS One (2011) 0.81

Update on the immunological pathway of negative regulation in acute insults and sepsis. J Interferon Cytokine Res (2012) 0.81

Quantitative activation suppression assay to evaluate human bone marrow-derived mesenchymal stromal cell potency. Cytotherapy (2015) 0.80

Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity. BMC Syst Biol (2013) 0.80

IL-10 and lymphotoxin-α expression profiles within marginal zone-like B-cell populations are associated with control of HIV-1 disease progression. PLoS One (2014) 0.80

Dendritic cells and B cells: unexpected partners in Th2 development. J Immunol (2014) 0.80

B cells play key roles in th2-type airway immune responses in mice exposed to natural airborne allergens. PLoS One (2015) 0.80

B-lymphocytes as key players in chemical-induced asthma. PLoS One (2013) 0.79

The Centenary of Immune Thrombocytopenia - Part 1: Revising Nomenclature and Pathogenesis. Front Pediatr (2016) 0.79

Effect of B-cell depletion on coreceptor switching in R5 simian-human immunodeficiency virus infection of rhesus macaques. J Virol (2011) 0.79

Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response. Nat Commun (2016) 0.79

Epithelial cell-derived micro RNA-146a generates interleukin-10-producing monocytes to inhibit nasal allergy. Sci Rep (2015) 0.79

Infections in patients taking Rituximab for hematologic malignancies: two-year cohort study. BMC Infect Dis (2013) 0.79

Inducible IL10(+) suppressor B cells inhibit CNS inflammation and T helper 17 polarization. Mol Ther (2012) 0.79

B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms. Biologics (2012) 0.79

Control of dichotomic innate and adaptive immune responses by artery tertiary lymphoid organs in atherosclerosis. Front Physiol (2012) 0.79

Timing of Toll-like receptor 9 agonist administration in pneumococcal vaccination impacts both humoral and cellular immune responses as well as nasopharyngeal colonization in mice. Infect Immun (2012) 0.78

Renal Transplant Recipients Treated with Calcineurin-Inhibitors Lack Circulating Immature Transitional CD19+CD24hiCD38hi Regulatory B-Lymphocytes. PLoS One (2016) 0.78

Enhanced renewal of regulatory T cells in relation to CD4(+) conventional T lymphocytes in the peripheral compartment. Immunology (2015) 0.78

Articles cited by this

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med (2008) 12.90

Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum (2006) 8.78

Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med (2009) 6.89

A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity (2008) 6.73

Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest (2008) 5.85

Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol (2000) 4.73

Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity (2002) 4.60

Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med (2003) 4.35

Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat Rev Immunol (2007) 3.99

A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med (1999) 3.74

Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev (2008) 3.67

Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol (2008) 3.40

Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu Rev Immunol (1990) 3.29

Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial. Arthritis Rheum (2005) 3.25

Novel suppressive function of transitional 2 B cells in experimental arthritis. J Immunol (2007) 3.09

Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy. J Immunol (2005) 3.00

Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity (2005) 2.97

The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol (2009) 2.87

Cytokine-producing B lymphocytes-key regulators of immunity. Curr Opin Immunol (2008) 2.84

Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proc Natl Acad Sci U S A (2007) 2.81

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest (2007) 2.81

B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol (1998) 2.63

B-cell-depleting induction therapy and acute cellular rejection. N Engl J Med (2009) 2.56

Successful T cell priming in B cell-deficient mice. J Exp Med (1995) 2.52

Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity (2009) 2.45

B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis. J Immunol (2007) 2.43

Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J Immunol (2006) 2.40

The 'short' history of regulatory B cells. Trends Immunol (2007) 2.38

Splenic T zone development is B cell dependent. J Exp Med (2001) 2.35

B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med (1998) 2.32

B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo. J Immunol (1995) 2.29

Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. J Exp Med (2003) 2.27

Depletion of B cells in murine lupus: efficacy and resistance. J Immunol (2007) 2.25

Organogenic role of B lymphocytes in mucosal immunity. Science (1999) 2.23

Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med (1999) 2.11

B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity. J Immunol (2007) 2.05

Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura. Blood (2007) 2.01

CD8 T cell memory in B cell-deficient mice. J Exp Med (1996) 1.97

A critical role for B cells in the development of memory CD4 cells. J Immunol (2000) 1.97

B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol (2008) 1.96

Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. Blood (2008) 1.94

Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. J Immunol (2009) 1.87

Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT/muMT mice. J Virol (1998) 1.86

Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus. J Exp Med (2008) 1.86

B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection. J Immunol (2006) 1.86

B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice. J Immunol (1998) 1.81

Maintenance of the plasma cell pool is independent of memory B cells. Proc Natl Acad Sci U S A (2008) 1.75

Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis. J Immunol (2005) 1.74

A role for B cells in the development of T cell helper function in a malaria infection in mice. Proc Natl Acad Sci U S A (1998) 1.73

Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci U S A (2005) 1.71

Importance of B cells, but not specific antibodies, in primary and secondary protective immunity to the intracellular bacterium Francisella tularensis live vaccine strain. Infect Immun (1999) 1.70

Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity. J Immunol (2008) 1.69

Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. Thromb Haemost (2008) 1.68

Igh-6(-/-) (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens. Infect Immun (2000) 1.67

Production of cytokines by human B cells in health and disease. Immunol Today (1997) 1.66

Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. Blood (2008) 1.64

Targeting CD22 reprograms B-cells and reverses autoimmune diabetes. Diabetes (2008) 1.63

Requirement of B cells for generating CD4+ T cell memory. J Immunol (2009) 1.60

Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE. Clin Immunol (2006) 1.60

A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J Immunol (2003) 1.59

Immunotherapeutic mechanisms of anti-CD20 monoclonal antibodies. Curr Opin Immunol (2008) 1.58

Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. Curr Dir Autoimmun (2005) 1.56

Rituximab exerts a dual effect in pemphigus vulgaris. J Invest Dermatol (2008) 1.54

Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25- CD4+ regulatory T cells. J Immunol (2006) 1.52

"To B or not to B?" B-cells and graft rejection. Transplantation (2008) 1.51

Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells. J Exp Med (1996) 1.50

Rituximab-induced B cell depletion in autoimmune diseases: potential effects on T cells. Clin Immunol (2008) 1.49

Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis. Clin Immunol (2007) 1.44

Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study. Arthritis Res Ther (2006) 1.42

B cell-directed therapies for autoimmune disease and correlates of disease response and relapse. J Allergy Clin Immunol (2008) 1.40

IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA. J Immunol (2004) 1.40

CD4+ T cell activation and tolerance induction in B cell knockout mice. J Exp Med (1996) 1.32

Impaired T cell immunity in B cell-deficient mice following viral central nervous system infection. J Immunol (2001) 1.31

Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis. J Immunol (2007) 1.28

Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol (2005) 1.26

The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response. J Immunol (2007) 1.25

B lymphocytes promote expansion of regulatory T cells in oral tolerance: powerful induction by antigen coupled to cholera toxin B subunit. J Immunol (2008) 1.25

CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells. Diabetes (2009) 1.24

Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells. J Immunol (2005) 1.22

Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo. J Exp Med (1998) 1.21

B cell-dependent TCR diversification. J Immunol (2004) 1.18

Antigen-specific B cells efficiently present low doses of antigen for induction of T cell proliferation. J Immunol (1985) 1.18

Resting B cells expand a CD4+CD25+Foxp3+ Treg population via TGF-beta3. Eur J Immunol (2008) 1.17

B cells amplify IFN-gamma production by T cells via a TNF-alpha-mediated mechanism. J Immunol (2007) 1.17

Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signals CD40 ligand, interferon gamma, and IL-10: role of B cells in the maintenance of T cell responses. J Exp Med (1999) 1.13

Direct expansion of human allospecific FoxP3+CD4+ regulatory T cells with allogeneic B cells for therapeutic application. J Immunol (2009) 1.11

Priming of CD4+ T cells and development of CD4+ T cell memory; lessons for malaria. Parasite Immunol (2006) 1.09

Translational Mini-Review Series on B Cell-Directed Therapies: Recent advances in B cell-directed biological therapies for autoimmune disorders. Clin Exp Immunol (2009) 1.07

B cell depletion inhibits spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J Immunol (2008) 1.07

A dose-escalation study of rituximab for treatment of systemic lupus erythematosus and Evans' syndrome: immunological analysis of B cells, T cells and cytokines. Rheumatology (Oxford) (2008) 1.04

Lupus resistance is associated with marginal zone abnormalities in an NZM murine model. Lab Invest (2006) 1.04

Current status on B-cell depletion therapy in autoimmune diseases other than rheumatoid arthritis. Autoimmun Rev (2009) 1.03

Impaired CD4 T cell activation due to reliance upon B cell-mediated costimulation in nonobese diabetic (NOD) mice. J Immunol (2000) 1.03

Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation. Gastroenterology (2007) 1.03

Deficient CD4+ T cell priming and regression of CD8+ T cell functionality in virus-infected mice lacking a normal B cell compartment. J Immunol (2003) 0.98

Germinal centers regulate human Th2 development. J Immunol (2003) 0.96

The emerging role of rituximab in organ transplantation. Transpl Int (2006) 0.96

The pathophysiology of HCV induced B-cell clonal disorders. Autoimmun Rev (2007) 0.94

Cell intrinsic TGF-beta 1 regulation of B cells. J Immunol (2008) 0.87

Articles by these authors

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol (2007) 10.71

Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat Med (2004) 5.22

Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity (2009) 3.33

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med (2008) 3.15

The development of inducible bronchus-associated lymphoid tissue depends on IL-17. Nat Immunol (2011) 3.13

Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity (2012) 2.87

Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens. Immunity (2009) 2.68

Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. J Clin Invest (2006) 2.56

Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza. Nat Immunol (2010) 2.27

Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J Exp Med (2004) 2.23

Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity. Immunity (2004) 2.23

Ectopic lymphoid tissues and local immunity. Semin Immunol (2008) 2.18

A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus. J Immunol (2008) 2.10

Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med (2010) 2.10

Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs. Immunity (2006) 1.95

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci U S A (2003) 1.89

B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection. J Immunol (2006) 1.86

CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection. J Immunol (2005) 1.77

Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virus. J Immunol (2011) 1.74

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat Immunol (2009) 1.71

Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen. J Exp Med (2005) 1.59

Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. Curr Dir Autoimmun (2005) 1.56

Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza. Proc Natl Acad Sci U S A (2007) 1.56

CXCR5⁺ T helper cells mediate protective immunity against tuberculosis. J Clin Invest (2013) 1.55

Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization. Vaccine (2010) 1.43

Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells. Nat Immunol (2012) 1.40

The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12. J Exp Med (2002) 1.40

IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung. J Immunol (2011) 1.40

In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity. J Immunol (2009) 1.38

Profiling early lung immune responses in the mouse model of tuberculosis. PLoS One (2011) 1.36

B cells promote resistance to heterosubtypic strains of influenza via multiple mechanisms. J Immunol (2008) 1.35

Regulation of antinucleoprotein IgG by systemic vaccination and its effect on influenza virus clearance. J Virol (2011) 1.35

Uneven distribution of MHC class II epitopes within the influenza virus. Vaccine (2005) 1.31

Simultaneous detection of EGFP and cell surface markers by fluorescence microscopy in lymphoid tissues. J Histochem Cytochem (2003) 1.30

Adaptive immunity and adipose tissue biology. Trends Immunol (2010) 1.29

Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza. J Immunol (2002) 1.29

Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P carinii-specific antibody. J Immunol (2003) 1.29

CD40-deficient, influenza-specific CD8 memory T cells develop and function normally in a CD40-sufficient environment. J Exp Med (2003) 1.27

Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent. J Immunol (2002) 1.26

Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets. Immunol Res (2009) 1.24

Inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses. PLoS One (2009) 1.23

Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13. J Immunol (2004) 1.22

Role of CXC chemokine ligand 13, CC chemokine ligand (CCL) 19, and CCL21 in the organization and function of nasal-associated lymphoid tissue. J Immunol (2005) 1.20

Maintenance of long term gamma-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cells. J Immunol (2003) 1.06

Anatomical features of anti-viral immunity in the respiratory tract. Semin Immunol (2004) 1.06

Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b. J Exp Med (2010) 1.05

Suppressed insulin signaling and increased apoptosis in CD38-null islets. Diabetes (2006) 1.02

Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect. J Immunol (2011) 0.99

Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections. J Immunol (2012) 0.97

CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responses. J Immunol (2003) 0.95

Innate immunity is regulated by CD38, an ecto-enzyme with ADP-ribosyl cyclase activity. Microbes Infect (2003) 0.94

Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni. Biochemistry (2005) 0.92

G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity. J Exp Med (2010) 0.89

Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia. PLoS One (2010) 0.86

CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J Exp Med (2013) 0.86

Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections. PLoS One (2012) 0.84

Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL-6 in OSM-driven pulmonary inflammation. J Immunol (2013) 0.82

Generation of a dual-functioning antitumor immune response in the peritoneal cavity. Am J Pathol (2013) 0.80

The function of local lymphoid tissues in pulmonary immune responses. Adv Exp Med Biol (2007) 0.80

Role of lymphotoxin and homeostatic chemokines in the development and function of local lymphoid tissues in the respiratory tract. Inmunologia (2007) 0.80

Memory: the incomplete unhappening of differentiation. Immunity (2011) 0.79

Neonatal irradiation sensitizes mice to delayed pulmonary challenge. Radiat Res (2012) 0.78

Stromal cells put the brakes on T-cell responses. Immunol Cell Biol (2011) 0.78

CD28 and inducible costimulator (ICOS) signalling can sustain CD154 expression on activated T cells. Immunology (2008) 0.78

Role of CCL19/21 and its possible signaling through CXCR3 in development of metallophilic macrophages in the mouse thymus. Histochem Cell Biol (2011) 0.75