Published in BMJ on March 12, 2010
Carboplatin and paclitaxel with vs without bevacizumab in older patients with advanced non-small cell lung cancer. JAMA (2012) 2.56
Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study. BMJ (2014) 1.79
Stroke in relation to use of raloxifene and other drugs against osteoporosis. Osteoporos Int (2010) 1.42
Neuraminidase Inhibitors and Hospital Mortality in British Patients with H1N1 Influenza A: A Re-Analysis of Observational Data. PLoS One (2016) 1.41
Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality. J Am Med Inform Assoc (2014) 1.25
Survival after shock requiring high-dose vasopressor therapy. Chest (2013) 1.15
The CEA Second-Look Trial: a randomised controlled trial of carcinoembryonic antigen prompted reoperation for recurrent colorectal cancer. BMJ Open (2014) 1.15
Association between statins given in hospital and mortality in pneumonia patients. J Gen Intern Med (2011) 1.08
A questionnaire to assess the relevance and credibility of observational studies to inform health care decision making: an ISPOR-AMCP-NPC Good Practice Task Force report. Value Health (2014) 1.05
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Selection bias in rheumatic disease research. Nat Rev Rheumatol (2014) 1.02
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Post-operative acute kidney injury and five-year risk of death, myocardial infarction, and stroke among elective cardiac surgical patients: a cohort study. Crit Care (2013) 0.97
Immortal time bias in retrospective analysis: comment on 'Efficacy and safety of long-term treatment with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma'. Blood Cancer J (2015) 0.95
Statins and the Risk of Cirrhosis in Chronic Hepatitis B Patients. Am J Gastroenterol (2016) 0.95
Pulmonary metastasectomy: what is the practice and where is the evidence for effectiveness? Thorax (2014) 0.95
Six-month mortality among HIV-infected adults presenting for antiretroviral therapy with unexplained weight loss, chronic fever or chronic diarrhea in Malawi. PLoS One (2012) 0.93
Mortality of patients infected with HIV in the intensive care unit (2005 through 2010): significant role of chronic hepatitis C and severe sepsis. Crit Care (2014) 0.91
Blood pressure variability and cardiovascular disease: systematic review and meta-analysis. BMJ (2016) 0.91
Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: a retrospective cohort analysis. PLoS One (2014) 0.90
Prognostic value of chemotherapy-induced hematological toxicity in metastatic colorectal cancer patients. World J Gastroenterol (2014) 0.89
Decreased risk of stroke in patients with traumatic brain injury receiving acupuncture treatment: a population-based retrospective cohort study. PLoS One (2014) 0.88
Impact of chemotherapy delay on short- and long-term survival in younger and older AML patients: a Danish population-based cohort study. Leukemia (2014) 0.88
Validation of methods to control for immortal time bias in a pharmacoepidemiologic analysis of renin-angiotensin system inhibitors in type 2 diabetes. J Epidemiol (2014) 0.85
Statin use and breast cancer survival: a nationwide cohort study in Scotland. BMC Cancer (2016) 0.83
Increased risk of affective disorders in type 2 diabetes is minimized by sulfonylurea and metformin combination: a population-based cohort study. BMC Med (2012) 0.83
Bevacizumab efficacy in metastatic colorectal cancer is dependent on primary tumor resection. Ann Surg Oncol (2014) 0.82
Randomized Trials Built on Sand: Examples from COPD, Hormone Therapy, and Cancer. Rambam Maimonides Med J (2012) 0.82
Additive effects of blood glucose lowering drugs, statins and renin-angiotensin system blockers on all-site cancer risk in patients with type 2 diabetes. BMC Med (2014) 0.82
Natural history of pT3-4 or node positive bladder cancer treated with radical cystectomy and no neoadjuvant chemotherapy in a contemporary North-American multi-institutional cohort. Can Urol Assoc J (2012) 0.82
Invited Commentary: Influenza, Influenza Immunization, and Pregnancy-It's About Time. Am J Epidemiol (2016) 0.81
Drugs affecting the renin-angiotensin system and survival from cancer: a population based study of breast, colorectal and prostate cancer patient cohorts. BMC Med (2014) 0.80
Comparative-effectiveness of revascularization versus routine medical therapy for stable ischemic heart disease: a population-based study. J Gen Intern Med (2014) 0.79
Long term outcome of Aldosteronism after target treatments. Sci Rep (2016) 0.79
Increased risk of active tuberculosis following acute kidney injury: a nationwide, population-based study. PLoS One (2013) 0.79
Early Invasive Strategy and In-Hospital Survival Among Diabetics With Non-ST-Elevation Acute Coronary Syndromes: A Contemporary National Insight. J Am Heart Assoc (2017) 0.78
Transient detectable viremia and the risk of viral rebound in patients from the Swiss HIV Cohort Study. BMC Infect Dis (2015) 0.78
Patients started on hemodialysis with tunneled dialysis catheter have similar survival after arteriovenous fistula and arteriovenous graft creation. J Vasc Surg (2015) 0.78
Nebulised amphotericin B to eradicate Candida colonisation from the respiratory tract in critically ill patients receiving selective digestive decontamination: a cohort study. Crit Care (2013) 0.78
Post-diagnostic prescriptions for low-dose aspirin and breast cancer-specific survival: a nested case-control study in a breast cancer cohort from the UK Clinical Practice Research Datalink. Breast Cancer Res (2014) 0.77
Dipeptidyl Peptidase-4 Inhibitors and the Risk of Acute Pancreatitis in Patients With Type 2 Diabetes in Taiwan: A Population-Based Cohort Study. Medicine (Baltimore) (2015) 0.77
Prediction of individual combined benefit and harm for patients with atrial fibrillation considering warfarin therapy: a study protocol. BMJ Open (2015) 0.77
Effects of generic substitution on refill adherence to statin therapy: a nationwide population-based study. BMC Health Serv Res (2014) 0.77
Effect of isoniazid preventive therapy on tuberculosis or death in persons with HIV: a retrospective cohort study. BMC Infect Dis (2015) 0.77
Cardiovascular disease after Escherichia coli O157:H7 gastroenteritis. CMAJ (2012) 0.76
Willie Sutton and the future of acute respiratory distress syndrome research. Am J Respir Crit Care Med (2015) 0.76
Association of Oseltamivir Treatment With Virus Shedding, Illness, and Household Transmission of Influenza Viruses. J Infect Dis (2015) 0.76
Metformin effects on biochemical recurrence and metabolic signaling in the prostate. Prostate (2015) 0.76
Determinants of Quality Care and Mortality for Patients With Locally Advanced Cervical Cancer in Virginia. Medicine (Baltimore) (2016) 0.75
Post-diagnostic oral bisphosphonate use and colorectal cancer mortality: a population-based cohort study within the UK Clinical Practice Research Datalink. Br J Cancer (2015) 0.75
Natural history of diseases: Statistical designs and issues. Clin Pharmacol Ther (2016) 0.75
Post-ischemic stroke rehabilitation is associated with a higher risk of fractures in older women: A population-based cohort study. PLoS One (2017) 0.75
Pulmonary Metastasectomy for Colorectal Cancer: Recent Reports Prompt a Review of the Available Evidence. Curr Colorectal Cancer Rep (2014) 0.75
Does Higher Spending Improve Survival Outcomes for Myocardial Infarction? Examining the Cost-Outcomes Relationship Using Time-Varying Covariates. Health Serv Res (2015) 0.75
Associations of statins and antiretroviral drugs with the onset of type 2 diabetes among HIV-1-infected patients. BMC Infect Dis (2017) 0.75
Increased cancer risk with drug use among patients with diabetes: Are the biased methods the culprit? J Diabetes Investig (2012) 0.75
Metformin and the risk of cancer in type 2 diabetes: methodological challenges and perspectives. Ann Transl Med (2014) 0.75
Risk of Cerebrovascular Diseases After Uvulopalatopharyngoplasty in Patients With Obstructive Sleep Apnea: A Nationwide Cohort Study. Medicine (Baltimore) (2015) 0.75
Case-crossover study to examine the change in postpartum risk of pulmonary embolism over time. BMC Pregnancy Childbirth (2017) 0.75
Does the association between adherence to statin medications and mortality depend on measurement approach? A retrospective cohort study. BMC Med Res Methodol (2017) 0.75
Methodological challenges to control for immortal time bias in addressing drug effects in type 2 diabetes. World J Methodol (2015) 0.75
Can We Predict Individual Combined Benefit and Harm of Therapy? Warfarin Therapy for Atrial Fibrillation as a Test Case. PLoS One (2016) 0.75
Propensity score matching and persistence correction to reduce bias in comparative effectiveness: the effect of cinacalcet use on all-cause mortality. Pharmacoepidemiol Drug Saf (2015) 0.75
A SEER Database Analysis of the Survival Advantage of Transarterial Chemoembolization for Hepatocellular Carcinoma: An Underutilized Therapy. J Vasc Interv Radiol (2016) 0.75
Meta-analysis of studies using statins as a reducer for primary liver cancer risk. Sci Rep (2016) 0.75
Propranolol and survival from breast cancer: a pooled analysis of European breast cancer cohorts. Breast Cancer Res (2016) 0.75
Comparison of Statistical Approaches for Dealing With Immortal Time Bias in Drug Effectiveness Studies. Am J Epidemiol (2016) 0.75
Incident Coronary Heart Disease After Preeclampsia: Role of Reduced Fetal Growth, Preterm Delivery, and Parity. J Am Heart Assoc (2017) 0.75
Commonly used medications and endometrial cancer survival: a population-based cohort study. Br J Cancer (2017) 0.75
Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study. Clin Transl Gastroenterol (2017) 0.75
Impact of Inferior Vena Cava Filter Placement on Short-Term Outcomes in Patients with Acute Pulmonary Embolism. Ann Vasc Surg (2017) 0.75
Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Pravastatin Added to First-Line Standard Chemotherapy in Small-Cell Lung Cancer (LUNGSTAR). J Clin Oncol (2017) 0.75
20-year outcomes following conservative management of clinically localized prostate cancer. JAMA (2005) 12.25
Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA (2005) 6.87
Renal and retinal effects of enalapril and losartan in type 1 diabetes. N Engl J Med (2009) 6.75
Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med (2007) 6.23
Statistical practice in high-throughput screening data analysis. Nat Biotechnol (2006) 5.85
Use of statins and the risk of death in patients with prostate cancer. J Clin Oncol (2013) 5.28
Prostate cancer and the Will Rogers phenomenon. J Natl Cancer Inst (2005) 5.10
Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia. Am J Respir Crit Care Med (2007) 3.94
The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study. BMJ (2012) 3.82
Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus. Am J Psychiatry (2009) 3.33
Physician scores on a national clinical skills examination as predictors of complaints to medical regulatory authorities. JAMA (2007) 3.27
Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapy. CMAJ (2006) 3.18
Androgen deprivation therapy and risk of acute kidney injury in patients with prostate cancer. JAMA (2013) 3.16
A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis. Arthritis Res Ther (2008) 2.87
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood. Neurology (2008) 2.87
Bronchodilator use and the risk of arrhythmia in COPD: part 1: Saskatchewan cohort study. Chest (2012) 2.65
ACE-I and ARBs in early diabetic nephropathy. J Renin Angiotensin Aldosterone Syst (2002) 2.64
The risk of hospitalized infection in patients with rheumatoid arthritis. J Rheumatol (2008) 2.60
Identification in administrative databases of women dying of breast cancer. J Clin Oncol (2006) 2.47
Do OSCAR winners live longer than less successful peers? A reanalysis of the evidence. Ann Intern Med (2006) 2.46
Association between licensure examination scores and practice in primary care. JAMA (2002) 2.44
Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study. BMJ (2010) 2.40
Use of first- and second-generation cyclooxygenase-2-selective nonsteroidal antiinflammatory drugs and risk of acute myocardial infarction. Circulation (2006) 2.34
Antirheumatic drugs and the risk of tuberculosis. Clin Infect Dis (2006) 2.29
Random measurement error and regression dilution bias. BMJ (2010) 2.20
Fluoroquinolones and the risk of serious arrhythmia: a population-based study. Clin Infect Dis (2012) 2.17
The risk of herpes zoster in patients with rheumatoid arthritis in the United States and the United Kingdom. Arthritis Rheum (2007) 2.16
Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding. CMAJ (2007) 2.02
Cardiovascular morbidity and mortality in COPD. Chest (2005) 2.01
Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs. Pharmacoepidemiol Drug Saf (2007) 1.98
Hepatitis B vaccination and the risk of childhood-onset multiple sclerosis. Arch Pediatr Adolesc Med (2007) 1.96
Discontinuation of statin therapy following an acute myocardial infarction: a population-based study. Eur Heart J (2008) 1.94
Patterns of antibiotic use and risk of hospital admission because of Clostridium difficile infection. CMAJ (2008) 1.91
Natural history of multiple sclerosis with childhood onset. N Engl J Med (2007) 1.89
Association between age and graft failure rates in young kidney transplant recipients. Transplantation (2011) 1.85
The nested case-control study in cardiology. Am Heart J (2003) 1.84
Drug, patient, and physician characteristics associated with off-label prescribing in primary care. Arch Intern Med (2012) 1.78
Gender differences in survival following hospitalisation for COPD. Thorax (2010) 1.73
Validation of increasing prostate specific antigen as a predictor of prostate cancer death after treatment of localized prostate cancer with surgery or radiation. J Urol (2004) 1.68
The early natural history of nephropathy in Type 1 Diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients. Diabetes (2005) 1.67
The use of inhaled corticosteroids and the risk of adrenal insufficiency. Eur Respir J (2012) 1.67
Inhaled corticosteroids and the risks of diabetes onset and progression. Am J Med (2010) 1.66
Use of warfarin and risk of urogenital cancer: a population-based, nested case-control study. Lancet Oncol (2007) 1.57
The concurrent use of antithrombotic therapies and the risk of bleeding in patients with atrial fibrillation. Thromb Haemost (2013) 1.53
Acute disseminated encephalomyelitis cohort study: prognostic factors for relapse. Eur J Paediatr Neurol (2006) 1.49
First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disability. J Pediatr (2004) 1.48
The structural equation modeling technique did not show a response shift, contrary to the results of the then test and the individualized approaches. J Clin Epidemiol (2005) 1.46
The utility of the Health Plan Employer Data and Information Set (HEDIS) asthma measure to predict asthma-related outcomes. Ann Allergy Asthma Immunol (2004) 1.44
Use of lithium and the risk of injurious motor vehicle crash in elderly adults: case-control study nested within a cohort. BMJ (2004) 1.44
Discordance between cross-sectional and longitudinal studies for the effect of dust on COPD: why? COPD (2005) 1.43
Immediate and delayed impact of oral glucocorticoid therapy on risk of serious infection in older patients with rheumatoid arthritis: a nested case-control analysis. Ann Rheum Dis (2012) 1.43
The use of metformin and the incidence of lung cancer in patients with type 2 diabetes. Diabetes Care (2012) 1.42
Bronchodilator use and the risk of arrhythmia in COPD: part 2: reassessment in the larger Quebec cohort. Chest (2012) 1.42
The relationship of diabetic retinopathy to preclinical diabetic glomerulopathy lesions in type 1 diabetic patients: the Renin-Angiotensin System Study. Diabetes (2005) 1.40
Risk of Lymphoma, Colorectal and Skin Cancer in Patients with IBD Treated with Immunomodulators and Biologics: A Quebec Claims Database Study. Inflamm Bowel Dis (2015) 1.40
Metformin and the incidence of prostate cancer in patients with type 2 diabetes. Cancer Epidemiol Biomarkers Prev (2010) 1.39
Antibiotics in primary prevention of stroke in the elderly. Stroke (2003) 1.39
Cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugs and the risk of ischemic stroke: a nested case-control study. Stroke (2006) 1.38
Androgen-deprivation therapy and the risk of stroke in patients with prostate cancer. Eur Urol (2011) 1.37
Physician and practice characteristics associated with the early utilization of new prescription drugs. Med Care (2003) 1.37
13-year outcomes following treatment for clinically localized prostate cancer in a population based cohort. J Urol (2007) 1.36
Point: were industry-sponsored roflumilast trials appropriate? Yes. Chest (2014) 1.36
Transdermal and oral hormone replacement therapy and the risk of stroke: a nested case-control study. BMJ (2010) 1.32
MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood. Brain (2004) 1.31
The effect of a task-oriented walking intervention on improving balance self-efficacy poststroke: a randomized, controlled trial. J Am Geriatr Soc (2005) 1.28
Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study. BMJ (2014) 1.27
Blood pressure and adiposity in children and adolescents. Circulation (2004) 1.24
The impact of hepatitis C virus coinfection on HIV progression before and after highly active antiretroviral therapy. J Acquir Immune Defic Syndr (2003) 1.24
Nonsteroidal anti-inflammatory drug use and the risk of severe skin and soft tissue complications in patients with varicella or zoster disease. Br J Clin Pharmacol (2008) 1.23
Incidence of and mortality from venous thromboembolism in a real-world population: the Q-VTE Study Cohort. Am J Med (2013) 1.22
The case-crossover study design in pharmacoepidemiology. Stat Methods Med Res (2008) 1.21
Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis. JAMA Intern Med (2016) 1.21
C-reactive protein and features of the metabolic syndrome in a population-based sample of children and adolescents. Clin Chem (2004) 1.21
Trends in the prescription of anti-diabetic medications in the United Kingdom: a population-based analysis. Pharmacoepidemiol Drug Saf (2009) 1.19
Mortality after infection with methicillin-resistant Staphylococcus aureus (MRSA) diagnosed in the community. BMC Med (2008) 1.18
Evaluating the validity of multiple imputation for missing physiological data in the national trauma data bank. J Emerg Trauma Shock (2009) 1.15
Discordant secular trends in elevated blood pressure and obesity in children and adolescents in a rapidly developing country. Circulation (2009) 1.13
Lifestyle variables and the risk of myocardial infarction in the general practice research database. BMC Cardiovasc Disord (2007) 1.12
Risks of pneumonia in patients with asthma taking inhaled corticosteroids. Am J Respir Crit Care Med (2010) 1.12
A multiple imputation model for imputing missing physiologic data in the national trauma data bank. J Am Coll Surg (2009) 1.11
Rheumatoid arthritis, its treatments, and the risk of tuberculosis in Quebec, Canada. Arthritis Rheum (2009) 1.10
Balance self-efficacy and its relevance to physical function and perceived health status after stroke. Arch Phys Med Rehabil (2006) 1.10
Comparison of three methods for estimating the standard error of the area under the curve in ROC analysis of quantitative data. Acad Radiol (2002) 1.09
Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis. Arch Intern Med (2008) 1.09
Secular trends of antibacterial prescribing in UK paediatric primary care. J Antimicrob Chemother (2010) 1.08
Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. Clin Chem (2007) 1.06
Body mass index (BMI) and waist circumference (WC) as screening tools for cardiovascular risk factors in Guadeloupean women. J Clin Epidemiol (2002) 1.06
Distribution of LDL particle size in a population-based sample of children and adolescents and relationship with other cardiovascular risk factors. Clin Chem (2005) 1.06