Published in Diabetes Care on August 24, 2012
Metformin and the risk of cancer: time-related biases in observational studies. Diabetes Care (2012) 3.11
Metformin use and lung cancer risk in patients with diabetes. Cancer Prev Res (Phila) (2015) 1.49
Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders. Cancer Prev Res (Phila) (2014) 1.38
Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates. Nat Rev Clin Oncol (2013) 1.20
Lung cancer chemoprevention: current status and future prospects. Nat Rev Clin Oncol (2013) 1.09
Metformin and erlotinib synergize to inhibit basal breast cancer. Oncotarget (2014) 0.98
Does chronic obstructive pulmonary disease with or without type 2 diabetes mellitus influence the risk of lung cancer? Result from a population-based cohort study. PLoS One (2014) 0.91
Survival of patients with stage IV lung cancer with diabetes treated with metformin. Am J Respir Crit Care Med (2015) 0.89
Comment on: Smiechowski et al. The use of metformin and the incidence of lung cancer in patients with type 2 diabetes. Diabetes Care 2013;36:124-129. Diabetes Care (2013) 0.83
Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta-analysis. Biomed Rep (2015) 0.81
Cancer risk in patients aged 30 years and above with type 2 diabetes receiving antidiabetic monotherapy: a cohort study using metformin as the comparator. Ther Clin Risk Manag (2015) 0.80
Metformin use and young age lung cancer: A case series report. Oncol Lett (2016) 0.80
Diabetes, metformin and incidence of and death from invasive cancer in postmenopausal women: Results from the women's health initiative. Int J Cancer (2015) 0.79
Chemoprevention of lung cancer: prospects and disappointments in human clinical trials. Cancers (Basel) (2013) 0.78
Association between diabetes or antidiabetic therapy and lung cancer: A meta-analysis. J Diabetes Investig (2013) 0.76
Association of the metformin with the risk of lung cancer: a meta-analysis. Transl Lung Cancer Res (2013) 0.76
Conventional hypoglycaemic agents and the risk of lung cancer in patients with diabetes: a meta-analysis. PLoS One (2014) 0.75
Response to comment on: Smiechowski et al. The use of metformin and the incidence of lung cancer in patients with type 2 diabetes. Diabetes Care 2013;36:124-129. Diabetes Care (2013) 0.75
Effect of Metformin on Different Non-Diabetes Related Conditions, a Special Focus on Malignant Conditions: Review of Literature. J Clin Med Res (2017) 0.75
Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients. Neoplasia (2017) 0.75
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42
Use of the UK General Practice Research Database for pharmacoepidemiology. Br J Clin Pharmacol (1998) 7.41
Validity of diagnostic coding within the General Practice Research Database: a systematic review. Br J Gen Pract (2010) 7.41
Immortal time bias in pharmaco-epidemiology. Am J Epidemiol (2007) 6.98
Validity of the general practice research database. Pharmacotherapy (2003) 6.78
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res (2009) 6.74
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care (2009) 6.17
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene (2008) 5.85
Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila) (2010) 4.36
Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest (2007) 4.29
Metformin prevents tobacco carcinogen--induced lung tumorigenesis. Cancer Prev Res (Phila) (2010) 3.86
Immortal time bias in observational studies of drug effects. Pharmacoepidemiol Drug Saf (2007) 3.66
Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs. Epidemiology (2001) 3.51
Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) (2010) 2.60
Metformin and cancer: new applications for an old drug. Med Oncol (2011) 2.03
Metformin in cancer: translational challenges. J Mol Endocrinol (2012) 1.94
Cohort study of pioglitazone and cancer incidence in patients with diabetes. Diabetes Care (2011) 1.83
Antidiabetes drugs correlate with decreased risk of lung cancer: a population-based observation in Taiwan. Clin Lung Cancer (2011) 1.70
Glucose-lowering agents and the patterns of risk for cancer: a study with the General Practice Research Database and secondary care data. Diabetologia (2011) 1.53
Diabetes and the risk of lung cancer. Diabetes Care (2005) 1.49
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene (2010) 1.47
Prostate cancer risk among men with diabetes mellitus (Spain). Cancer Causes Control (2005) 1.29
Metformin beyond diabetes: new life for an old drug. Curr Diabetes Rev (2006) 1.11
Insulin, insulin resistance, obesity, and cancer. Curr Diab Rep (2010) 1.07
Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA (2005) 6.87
Renal and retinal effects of enalapril and losartan in type 1 diabetes. N Engl J Med (2009) 6.75
Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med (2007) 6.23
Use of statins and the risk of death in patients with prostate cancer. J Clin Oncol (2013) 5.28
Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev (2006) 4.02
Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia. Am J Respir Crit Care Med (2007) 3.94
The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study. BMJ (2012) 3.82
Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus. Am J Psychiatry (2009) 3.33
Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapy. CMAJ (2006) 3.18
Androgen deprivation therapy and risk of acute kidney injury in patients with prostate cancer. JAMA (2013) 3.16
Metformin and the risk of cancer: time-related biases in observational studies. Diabetes Care (2012) 3.11
Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes. BMJ (2010) 3.09
A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis. Arthritis Res Ther (2008) 2.87
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood. Neurology (2008) 2.87
Bronchodilator use and the risk of arrhythmia in COPD: part 1: Saskatchewan cohort study. Chest (2012) 2.65
ACE-I and ARBs in early diabetic nephropathy. J Renin Angiotensin Aldosterone Syst (2002) 2.64
Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. J Clin Oncol (2008) 2.63
The risk of hospitalized infection in patients with rheumatoid arthritis. J Rheumatol (2008) 2.60
Randomized trial of tamoxifen versus combined tamoxifen and octreotide LAR Therapy in the adjuvant treatment of early-stage breast cancer in postmenopausal women: NCIC CTG MA.14. J Clin Oncol (2011) 2.58
Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study. BMJ (2010) 2.40
Use of first- and second-generation cyclooxygenase-2-selective nonsteroidal antiinflammatory drugs and risk of acute myocardial infarction. Circulation (2006) 2.34
Antirheumatic drugs and the risk of tuberculosis. Clin Infect Dis (2006) 2.29
The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prev Res (Phila) (2008) 2.23
Fluoroquinolones and the risk of serious arrhythmia: a population-based study. Clin Infect Dis (2012) 2.17
The risk of herpes zoster in patients with rheumatoid arthritis in the United States and the United Kingdom. Arthritis Rheum (2007) 2.16
A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev (2005) 2.15
Reproducibility of plasma steroid hormones, prolactin, and insulin-like growth factor levels among premenopausal women over a 2- to 3-year period. Cancer Epidemiol Biomarkers Prev (2006) 2.14
Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res (Phila) (2012) 2.10
Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding. CMAJ (2007) 2.02
A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer. Cancer Epidemiol Biomarkers Prev (2008) 2.01
Cardiovascular morbidity and mortality in COPD. Chest (2005) 2.01
Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs. Pharmacoepidemiol Drug Saf (2007) 1.98
Hepatitis B vaccination and the risk of childhood-onset multiple sclerosis. Arch Pediatr Adolesc Med (2007) 1.96
Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal women. Cancer Epidemiol Biomarkers Prev (2007) 1.95
Discontinuation of statin therapy following an acute myocardial infarction: a population-based study. Eur Heart J (2008) 1.94
Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev (2002) 1.91
Patterns of antibiotic use and risk of hospital admission because of Clostridium difficile infection. CMAJ (2008) 1.91
Natural history of multiple sclerosis with childhood onset. N Engl J Med (2007) 1.89
In vitro metformin anti-neoplastic activity in epithelial ovarian cancer. Gynecol Oncol (2008) 1.88
Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor. Clin Cancer Res (2007) 1.84
The nested case-control study in cardiology. Am Heart J (2003) 1.84
Hyperglycemia, insulin resistance, impaired pancreatic β-cell function, and risk of pancreatic cancer. J Natl Cancer Inst (2013) 1.80
Association of markers of insulin and glucose control with subsequent colorectal cancer risk. Cancer Epidemiol Biomarkers Prev (2003) 1.75
A prospective study of plasma adiponectin and pancreatic cancer risk in five US cohorts. J Natl Cancer Inst (2012) 1.74
Gender differences in survival following hospitalisation for COPD. Thorax (2010) 1.73
Incidence and risk factors of amniotic fluid embolisms: a population-based study on 3 million births in the United States. Am J Obstet Gynecol (2008) 1.71
The early natural history of nephropathy in Type 1 Diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients. Diabetes (2005) 1.67
The use of inhaled corticosteroids and the risk of adrenal insufficiency. Eur Respir J (2012) 1.67
Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res Treat (2010) 1.67
Vitamin D status in patients with stage IV colorectal cancer: findings from Intergroup trial N9741. J Clin Oncol (2011) 1.64
Diabetes mellitus and cancer risk in a population-based case-control study among men from Montreal, Canada. Int J Cancer (2006) 1.58
The concurrent use of antithrombotic therapies and the risk of bleeding in patients with atrial fibrillation. Thromb Haemost (2013) 1.53
When and by whom is concern first expressed for children with neuromotor problems? Arch Pediatr Adolesc Med (2005) 1.51
Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2005) 1.50
Acute effects of exercise in patients with previous deep venous thrombosis: impact of the postthrombotic syndrome. Chest (2003) 1.49
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res (2013) 1.49
Acute disseminated encephalomyelitis cohort study: prognostic factors for relapse. Eur J Paediatr Neurol (2006) 1.49
First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disability. J Pediatr (2004) 1.48
Racial differences in premenopausal endogenous hormones. Cancer Epidemiol Biomarkers Prev (2005) 1.45
Use of lithium and the risk of injurious motor vehicle crash in elderly adults: case-control study nested within a cohort. BMJ (2004) 1.44
The utility of the Health Plan Employer Data and Information Set (HEDIS) asthma measure to predict asthma-related outcomes. Ann Allergy Asthma Immunol (2004) 1.44
Prediagnostic plasma C-peptide and pancreatic cancer risk in men and women. Cancer Epidemiol Biomarkers Prev (2007) 1.44
Body shape throughout life and correlations with IGFs and GH. Endocr Relat Cancer (2007) 1.43
Immediate and delayed impact of oral glucocorticoid therapy on risk of serious infection in older patients with rheumatoid arthritis: a nested case-control analysis. Ann Rheum Dis (2012) 1.43
Bronchodilator use and the risk of arrhythmia in COPD: part 2: reassessment in the larger Quebec cohort. Chest (2012) 1.42
The relationship of diabetic retinopathy to preclinical diabetic glomerulopathy lesions in type 1 diabetic patients: the Renin-Angiotensin System Study. Diabetes (2005) 1.40
Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II. Endocr Relat Cancer (2006) 1.40
Metformin and the incidence of prostate cancer in patients with type 2 diabetes. Cancer Epidemiol Biomarkers Prev (2010) 1.39
Antibiotics in primary prevention of stroke in the elderly. Stroke (2003) 1.39
Cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugs and the risk of ischemic stroke: a nested case-control study. Stroke (2006) 1.38
Androgen-deprivation therapy and the risk of stroke in patients with prostate cancer. Eur Urol (2011) 1.37
Point: were industry-sponsored roflumilast trials appropriate? Yes. Chest (2014) 1.36
Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era. Cancer Causes Control (2005) 1.33
Transdermal and oral hormone replacement therapy and the risk of stroke: a nested case-control study. BMJ (2010) 1.32
Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev (2002) 1.31
MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood. Brain (2004) 1.31
Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. Carcinogenesis (2007) 1.29
Centralized blood processing for the selenium and vitamin E cancer prevention trial: effects of delayed processing on carotenoids, tocopherols, insulin-like growth factor-I, insulin-like growth factor binding protein 3, steroid hormones, and lymphocyte viability. Cancer Epidemiol Biomarkers Prev (2005) 1.28
C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women. Cancer Epidemiol Biomarkers Prev (2006) 1.27
Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study. BMJ (2014) 1.27
Hormonal profile of diabetic men and the potential link to prostate cancer. Cancer Causes Control (2008) 1.26
Soy isoflavones in the treatment of prostate cancer. Nutr Cancer (2003) 1.24
The impact of hepatitis C virus coinfection on HIV progression before and after highly active antiretroviral therapy. J Acquir Immune Defic Syndr (2003) 1.24
Effect of fear of litigation on obstetric care: a nationwide analysis on obstetric practice. Am J Perinatol (2011) 1.23
Nonsteroidal anti-inflammatory drug use and the risk of severe skin and soft tissue complications in patients with varicella or zoster disease. Br J Clin Pharmacol (2008) 1.23
Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res (2007) 1.22
Incidence of and mortality from venous thromboembolism in a real-world population: the Q-VTE Study Cohort. Am J Med (2013) 1.22
The case-crossover study design in pharmacoepidemiology. Stat Methods Med Res (2008) 1.21
Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis. JAMA Intern Med (2016) 1.21
Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Cancer Res (2007) 1.21