Published in J Cell Biol on March 15, 2010
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. Curr Biol (2011) 2.62
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol (2010) 2.18
The MIS12 complex is a protein interaction hub for outer kinetochore assembly. J Cell Biol (2010) 1.96
Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization. Proc Natl Acad Sci U S A (2010) 1.38
Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1. Mol Cell Biol (2011) 1.30
The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation. Mol Cancer Res (2011) 1.23
The KMN protein network--chief conductors of the kinetochore orchestra. J Cell Sci (2013) 1.16
Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex. J Mol Biol (2010) 1.15
Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. J Cell Biol (2012) 1.09
Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. Mol Biol Cell (2011) 1.09
Establishment of the vertebrate kinetochores. Chromosome Res (2012) 0.99
Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore. Open Biol (2012) 0.93
Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex. PLoS One (2012) 0.93
CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment. EMBO J (2010) 0.92
Insights from biochemical reconstitution into the architecture of human kinetochores. Nature (2016) 0.89
The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast. Genetics (2013) 0.88
Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation. J Cell Biol (2011) 0.86
Dynamic phosphorylation of HP1α regulates mitotic progression in human cells. Nat Commun (2014) 0.84
Structural basis of the chromodomain of Cbx3 bound to methylated peptides from histone h1 and G9a. PLoS One (2012) 0.84
Assembling pieces of the centromere epigenetics puzzle. Epigenetics (2012) 0.80
Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Open Biol (2016) 0.79
Phosphorylation-dephosphorylation cycle of HP1α governs accurate mitotic progression. Cell Cycle (2014) 0.77
The spatiotemporal dynamics of chromatin protein HP1α is essential for accurate chromosome segregation during cell division. J Biol Chem (2014) 0.77
Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells. Cell Div (2014) 0.75
Drosophila Nnf1 paralogs are partially redundant for somatic and germ line kinetochore function. Chromosoma (2016) 0.75
The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell (2003) 9.90
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
Heterochromatin revisited. Nat Rev Genet (2007) 8.70
Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol (2007) 6.83
Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma (1985) 6.17
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature (2002) 6.09
The vertebrate cell kinetochore and its roles during mitosis. Trends Cell Biol (1998) 5.87
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev (2004) 5.23
A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite. J Cell Biol (1989) 4.45
The HP1 protein family: getting a grip on chromatin. Curr Opin Genet Dev (2000) 4.34
Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast. Science (2000) 4.33
Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature (2006) 4.23
Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. J Cell Biol (1994) 3.99
A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere. Mol Biol Cell (1992) 3.94
CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. Cell (1992) 3.70
Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres. Cell (2004) 3.68
Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. Proc Natl Acad Sci U S A (2000) 3.53
The chromodomain protein Swi6: a key component at fission yeast centromeres. Science (1995) 3.40
Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. J Cell Biol (2006) 3.37
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science (2001) 3.35
Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. Dev Cell (2007) 3.25
The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J Cell Biol (2006) 3.23
Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. J Cell Biol (2003) 3.18
Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. Dev Cell (2007) 3.06
A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat Cell Biol (2004) 3.04
The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer. EMBO J (2000) 3.04
Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Genome Biol (2006) 2.99
Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation. Genes Dev (1999) 2.84
Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. J Cell Sci (2001) 2.82
Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. Chromosoma (1999) 2.79
Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin. EMBO J (2004) 2.79
Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J Cell Sci (2001) 2.76
Spreading of silent chromatin: inaction at a distance. Nat Rev Genet (2006) 2.64
CENP-B: a major human centromere protein located beneath the kinetochore. J Cell Biol (1990) 2.55
Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. Curr Biol (2005) 2.53
Kinetochore structure and function. Trends Cell Biol (2005) 2.50
The HP1 chromo shadow domain binds a consensus peptide pentamer. Curr Biol (2000) 2.47
Building the centromere: from foundation proteins to 3D organization. Trends Cell Biol (2004) 2.15
CENP-B controls centromere formation depending on the chromatin context. Cell (2007) 2.15
Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres. Genes Dev (2007) 2.06
Heterochromatin links to centromeric protection by recruiting shugoshin. Nature (2008) 1.97
A CAF-1 dependent pool of HP1 during heterochromatin duplication. EMBO J (2004) 1.88
Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster. PLoS One (2007) 1.64
Structural and functional dynamics of human centromeric chromatin. Annu Rev Genomics Hum Genet (2006) 1.55
Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase. J Cell Sci (2003) 1.49
Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast. Mol Cell Biol (2008) 1.45
Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance. Mol Biol Cell (2006) 1.43
Basic mechanism of eukaryotic chromosome segregation. Philos Trans R Soc Lond B Biol Sci (2005) 1.26
Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres. J Biol Chem (2000) 1.12
The Suv39h-HP1 histone methylation pathway is dispensable for enrichment and protection of cohesin at centromeres in mammalian cells. Chromosoma (2007) 1.11
Dynamics of chromosomes and microtubules visualized by multiple-wavelength fluorescence imaging in living mammalian cells: effects of mitotic inhibitors on cell cycle progression. Genes Cells (1997) 1.07
Molecular behavior in living mitotic cells of human centromere heterochromatin protein HPLalpha ectopically expressed as a fusion to red fluorescent protein. Cell Struct Funct (2001) 0.97
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres. Cell (2004) 3.68
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J (2006) 3.53
Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. Dev Cell (2007) 3.25
Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. J Cell Biol (2003) 3.18
Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. Dev Cell (2007) 3.06
A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat Cell Biol (2004) 3.04
Mapping of long-range associations throughout the fission yeast genome reveals global genome organization linked to transcriptional regulation. Nucleic Acids Res (2010) 2.96
alpha-Klotho as a regulator of calcium homeostasis. Science (2007) 2.71
Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells (2007) 2.53
Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin. Mol Cell (2009) 2.49
Cnd2 has dual roles in mitotic condensation and interphase. Nature (2002) 2.49
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature (2007) 2.48
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol (2010) 2.18
Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. Genes Cells (2006) 2.03
The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A (2009) 1.98
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell (2009) 1.96
Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation. Mol Cell (2012) 1.85
Active establishment of centromeric CENP-A chromatin by RSF complex. J Cell Biol (2009) 1.69
Condensin architecture and interaction with DNA: regulatory non-SMC subunits bind to the head of SMC heterodimer. Curr Biol (2002) 1.64
A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast. Mol Cell (2003) 1.64
Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeast. Curr Biol (2002) 1.50
Condensin but not cohesin SMC heterodimer induces DNA reannealing through protein-protein assembly. EMBO J (2003) 1.44
Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance. Mol Biol Cell (2006) 1.43
Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function. PLoS One (2007) 1.41
The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase. J Cell Biol (2006) 1.39
Mapping epigenetic mutations in fission yeast using whole-genome next-generation sequencing. Genome Res (2009) 1.36
Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. Cell (2005) 1.36
Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway. Nat Struct Mol Biol (2013) 1.33
Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair. EMBO J (2012) 1.30
Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC. Genes Cells (2002) 1.30
Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1. Mol Cell Biol (2011) 1.30
The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II. Genes Dev (2011) 1.27
Metabolic profiling of the fission yeast S. pombe: quantification of compounds under different temperatures and genetic perturbation. Mol Biosyst (2009) 1.26
Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis. J Cell Biol (2008) 1.24
Control of localization of a spindle checkpoint protein, Mad2, in fission yeast. J Cell Sci (2002) 1.22
Separase-mediated cleavage of cohesin at interphase is required for DNA repair. Nature (2004) 1.20
The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1. J Biol Chem (2003) 1.18
Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast. Proc Natl Acad Sci U S A (2010) 1.17
Specific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast. FEBS J (2011) 1.15
Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres. Genes Cells (2008) 1.15
Regulation of checkpoint kinases through dynamic interaction with Crb2. EMBO J (2004) 1.15
The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle. J Biol Chem (2003) 1.13
A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. J Biol Chem (2002) 1.12
Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2. J Cell Sci (2011) 1.12
Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor. Genes Cells (2009) 1.11
Two-step, extensive alterations in the transcriptome from G0 arrest to cell division in Schizosaccharomyces pombe. Genes Cells (2007) 1.10
The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe. Open Biol (2011) 1.08
Genetic control of cellular quiescence in S. pombe. J Cell Sci (2009) 1.07
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores. Structure (2009) 1.05
PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA. Genes Cells (2002) 1.04
An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation. Plant Cell (2012) 1.03
The reconstituted human Chl12-RFC complex functions as a second PCNA loader. Genes Cells (2004) 1.03
SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver. Mol Cell (2011) 1.03
Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA. J Biol Chem (2013) 1.02
CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast. Mol Biol Cell (2011) 1.00
Highly accurate chemical formula prediction tool utilizing high-resolution mass spectra, MS/MS fragmentation, heuristic rules, and isotope pattern matching. Anal Chem (2012) 1.00
Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J (2011) 1.00
An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation. Genes Cells (2004) 0.99
Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing. J Biol Chem (2010) 0.99
Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair function of condensin. Proc Natl Acad Sci U S A (2004) 0.98
Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J Biol Chem (2011) 0.98
The S. pombe mitotic regulator Cut12 promotes spindle pole body activation and integration into the nuclear envelope. J Cell Biol (2009) 0.97
Nucleosome formation activity of human somatic nuclear autoantigenic sperm protein (sNASP). J Biol Chem (2010) 0.96
Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses. Cell Cycle (2006) 0.96
Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites. Mol Biosyst (2014) 0.94
Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing. Open Biol (2011) 0.94
Histone H2B mutations in inner region affect ubiquitination, centromere function, silencing and chromosome segregation. EMBO J (2006) 0.93
Genetically encoded system to track histone modification in vivo. Sci Rep (2013) 0.93
CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation. Curr Biol (2006) 0.92
Distinct modes of DNA damage response in S. pombe G0 and vegetative cells. Genes Cells (2006) 0.92
The nucleolus is involved in mRNA export from the nucleus in fission yeast. J Cell Sci (2004) 0.92
The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore. EMBO J (2003) 0.92
Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1. Genes Cells (2010) 0.90
Polo boxes and Cut23 (Apc8) mediate an interaction between polo kinase and the anaphase-promoting complex for fission yeast mitosis. J Cell Biol (2002) 0.90
Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase. Genes Cells (2006) 0.88
Does a GATA factor make the bed for centromeric nucleosomes? Cell Cycle (2003) 0.88
Suppression of a mitotic mutant by tRNA-Ala anticodon mutations that produce a dominant defect in late mitosis. J Cell Sci (2004) 0.88
Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex. Genes Cells (2014) 0.87
Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo. Eur J Cancer (2012) 0.87
New vectors for epitope tagging and gene disruption in Schizosaccharomyces pombe. Biotechniques (2013) 0.87
Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. J Cell Sci (2008) 0.87
Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe. PLoS One (2011) 0.86
Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation. J Cell Biol (2011) 0.86
Cdc48 is required for the stability of Cut1/separase in mitotic anaphase. J Struct Biol (2006) 0.86
Centromeric motion facilitates the mobility of interphase genomic regions in fission yeast. J Cell Sci (2013) 0.85
Characterization of the interaction of influenza virus NS1 with Akt. Biochem Biophys Res Commun (2010) 0.85
A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids. Genes Cells (2003) 0.84
A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules. Exp Cell Res (2011) 0.84
Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response? Genes Cells (2007) 0.83
In quiescence of fission yeast, autophagy and the proteasome collaborate for mitochondrial maintenance and longevity. Autophagy (2010) 0.83