Published in Nat Rev Mol Cell Biol on October 01, 2007
The life and miracles of kinetochores. EMBO J (2009) 4.59
Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov (2009) 4.16
Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science (2009) 4.10
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature (2008) 3.77
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol (2010) 3.50
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell (2010) 3.44
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science (2010) 3.13
Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B. Science (2010) 3.07
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends Cell Biol (2010) 2.88
Mechanics of cytokinesis in eukaryotes. Curr Opin Cell Biol (2009) 2.65
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol (2009) 2.61
Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol (2010) 2.51
Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nat Chem Biol (2007) 2.31
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol (2010) 2.18
A mechanism for chromosome segregation sensing by the NoCut checkpoint. Nat Cell Biol (2009) 2.04
Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell (2010) 2.00
Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell (2010) 1.89
Clearing the way for mitosis: is cohesin a target? Nat Rev Mol Cell Biol (2009) 1.88
Age-associated increase in aneuploidy and changes in gene expression in mouse eggs. Dev Biol (2008) 1.85
Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view. Curr Opin Cell Biol (2009) 1.83
Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. Mol Cell Biol (2010) 1.81
Kinetochore-microtubule interactions: the means to the end. Curr Opin Cell Biol (2008) 1.80
Dual role of topoisomerase II in centromere resolution and aurora B activity. PLoS Biol (2008) 1.79
Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. Nature (2010) 1.73
Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J Cell Biol (2009) 1.73
Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors. Dev Cell (2011) 1.68
Spindle assembly checkpoint: the third decade. Philos Trans R Soc Lond B Biol Sci (2011) 1.68
Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A (2012) 1.66
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase. Proc Natl Acad Sci U S A (2010) 1.65
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun (2011) 1.59
Geometry and force behind kinetochore orientation: lessons from meiosis. Nat Rev Mol Cell Biol (2012) 1.55
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line. J Cell Biol (2008) 1.54
The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly. J Cell Biol (2012) 1.50
Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. PLoS One (2010) 1.50
Emerging roles of the SUMO pathway in mitosis. Cell Div (2008) 1.48
Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro. Cell Cycle (2011) 1.48
Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen. PLoS Genet (2012) 1.47
Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nat Chem Biol (2016) 1.45
Targeting survivin in cancer. Cancer Lett (2012) 1.44
Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One (2008) 1.43
Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell (2011) 1.43
Aurora B kinase activation requires survivin priming phosphorylation by PLK1. J Mol Cell Biol (2010) 1.43
Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores. J Cell Biol (2010) 1.42
When 2+2=5: the origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta (2008) 1.42
Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. J Exp Med (2011) 1.37
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol (2012) 1.36
Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. Curr Biol (2010) 1.36
Contrasting roles of condensin I and condensin II in mitotic chromosome formation. J Cell Sci (2012) 1.35
Aurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in mice. Mol Biol Cell (2010) 1.35
Dual detection of chromosomes and microtubules by the chromosomal passenger complex drives spindle assembly. Dev Cell (2010) 1.34
Aurora kinase inhibitors as anticancer molecules. Biochim Biophys Acta (2010) 1.33
The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol (2012) 1.33
Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase. J Cell Biol (2010) 1.32
Pericentromeric sister chromatid cohesion promotes kinetochore biorientation. Mol Biol Cell (2009) 1.31
Kinetochore-microtubule interactions: steps towards bi-orientation. EMBO J (2010) 1.30
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J Cell Biol (2009) 1.29
Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol (2011) 1.29
EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A. Proc Natl Acad Sci U S A (2008) 1.28
The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J (2010) 1.28
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nat Commun (2012) 1.27
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol (2012) 1.27
Identification of a novel chromosomal passenger complex and its unique localization during cytokinesis in Trypanosoma brucei. PLoS One (2008) 1.26
The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly. J Cell Biol (2011) 1.26
Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase. J Cell Biol (2009) 1.26
Tension sensing by Aurora B kinase is independent of survivin-based centromere localization. Nature (2013) 1.24
INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol (2009) 1.23
Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis. Trends Cell Biol (2012) 1.22
Interplay between synaptonemal complex, homologous recombination, and centromeres during mammalian meiosis. PLoS Genet (2012) 1.22
Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. Dev Cell (2008) 1.21
The central element protein ZEP1 of the synaptonemal complex regulates the number of crossovers during meiosis in rice. Plant Cell (2010) 1.21
Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes. J Cell Biol (2010) 1.21
Coordinating cohesion, co-orientation, and congression during meiosis: lessons from holocentric chromosomes. Genes Dev (2010) 1.20
Bi-orienting chromosomes: acrobatics on the mitotic spindle. Chromosoma (2008) 1.19
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. Mol Biol Cell (2008) 1.19
Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. J Cell Biol (2010) 1.18
Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J Biol Chem (2010) 1.18
Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice. PLoS One (2010) 1.17
Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem (2008) 1.17
Cytokinesis microtubule organisers at a glance. J Cell Sci (2012) 1.17
The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol (2012) 1.17
The Aurora Kinase in Trypanosoma brucei plays distinctive roles in metaphase-anaphase transition and cytokinetic initiation. PLoS Pathog (2009) 1.16
Polar body emission requires a RhoA contractile ring and Cdc42-mediated membrane protrusion. Dev Cell (2008) 1.16
The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly. Cell (2011) 1.16
The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell (2009) 1.15
Arabidopsis α Aurora kinases function in formative cell division plane orientation. Plant Cell (2011) 1.14
Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J Cell Biol (2012) 1.14
Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC. BMC Cancer (2010) 1.13
Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target. Oncotarget (2011) 1.13
CtBPs promote cell survival through the maintenance of mitotic fidelity. Mol Cell Biol (2009) 1.12
The Ndc80 complex: integrating the kinetochore's many movements. Chromosome Res (2011) 1.11
Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis. Development (2008) 1.10
The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression. Mol Biol Cell (2010) 1.10
SUMOylation modulates the function of Aurora-B kinase. J Cell Sci (2010) 1.10
Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle. Open Biol (2013) 1.09
Making the cut: the chemical biology of cytokinesis. ACS Chem Biol (2010) 1.09
DNA topoisomerase II is a determinant of the tensile properties of yeast centromeric chromatin and the tension checkpoint. Mol Biol Cell (2008) 1.09
Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. Mol Biol Cell (2011) 1.09
Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase. Nucleic Acids Res (2009) 1.09
The cellular geography of aurora kinases. Nat Rev Mol Cell Biol (2003) 6.40
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13
The dynamic kinetochore-microtubule interface. J Cell Sci (2004) 4.07
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49
The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Cell (2010) 3.26
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet (2007) 3.08
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
Chromosomal passengers: the four-dimensional regulation of mitotic events. Chromosoma (2004) 2.94
Chk1 is required for spindle checkpoint function. Dev Cell (2007) 2.90
Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes. Dev Cell (2003) 2.62
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol (2009) 2.61
Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. EMBO J (2004) 2.60
Inactivation of a human kinetochore by specific targeting of chromatin modifiers. Dev Cell (2008) 2.50
Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J Cell Sci (2003) 2.48
A super-resolution map of the vertebrate kinetochore. Proc Natl Acad Sci U S A (2010) 2.36
Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. Cell (2003) 2.20
Trashing the genome: the role of nucleases during apoptosis. Nat Rev Mol Cell Biol (2005) 2.19
Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO J (2010) 2.17
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. Nat Cell Biol (2006) 2.16
Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα. J Cell Biol (2012) 1.94
CENP-I is essential for centromere function in vertebrate cells. Dev Cell (2002) 1.94
Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J (2004) 1.89
Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J (2002) 1.82
Condensin regulates the stiffness of vertebrate centromeres. Mol Biol Cell (2009) 1.81
MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity. J Cell Biol (2002) 1.81
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Dev Cell (2006) 1.71
Condensin: Architect of mitotic chromosomes. Chromosome Res (2009) 1.67
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis. J Cell Sci (2002) 1.61
Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton (2004) 1.59
Co-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X alpha-satellite array. EMBO J (2002) 1.58
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line. J Cell Biol (2008) 1.54
Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair. Mol Cell (2006) 1.54
Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J Biol Chem (2003) 1.50
Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell (2011) 1.43
Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly. EMBO J (2012) 1.41
Contrasting roles of condensin I and condensin II in mitotic chromosome formation. J Cell Sci (2012) 1.35
The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol (2012) 1.33
Chromosome engineering allows the efficient isolation of vertebrate neocentromeres. Dev Cell (2013) 1.30
Sgt1 is required for human kinetochore assembly. EMBO Rep (2004) 1.30
Human artificial chromosome with a conditional centromere for gene delivery and gene expression. DNA Res (2010) 1.29
Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Mol Biol Cell (2006) 1.26
Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology. Expert Opin Drug Deliv (2014) 1.26
CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains. J Cell Sci (2002) 1.25
INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol (2009) 1.23
The chromosomal passenger complex: one for all and all for one. Cell (2007) 1.22
Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc Natl Acad Sci U S A (2011) 1.21
RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate. J Cell Sci (2003) 1.20
Efficiency of de novo centromere formation in human artificial chromosomes. Genomics (2002) 1.19
Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier. Mol Biol Cell (2009) 1.19
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res (2002) 1.15
In vivo functional dissection of human inner kinetochore protein CENP-C. J Struct Biol (2002) 1.14
Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores. EMBO Rep (2004) 1.11
Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis. Development (2008) 1.10
Three distinct stages of apoptotic nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis. Exp Cell Res (2007) 1.10
SUMOylation modulates the function of Aurora-B kinase. J Cell Sci (2010) 1.10
Reverse genetics of essential genes in tissue-culture cells: 'dead cells talking'. Trends Cell Biol (2002) 1.10
Mitotic chromosome formation and the condensin paradox. Exp Cell Res (2004) 1.07
A new generation of human artificial chromosomes for functional genomics and gene therapy. Cell Mol Life Sci (2012) 1.06
Novel components of human mitotic chromosomes identified by proteomic analysis of the chromosome scaffold fraction. Chromosoma (2004) 1.06
Molecular and genetic analysis of condensin function in vertebrate cells. Mol Biol Cell (2008) 1.06
Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle. Exp Cell Res (2005) 1.05
Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function. J Cell Sci (2012) 1.03
Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes. Nat Commun (2013) 1.02
HACking the centromere chromatin code: insights from human artificial chromosomes. Chromosome Res (2012) 1.02
A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes. Proc Natl Acad Sci U S A (2008) 1.01
Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere. ACS Synth Biol (2012) 0.99
Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis. J Cell Sci (2003) 0.99
Apoptosis-associated caspase activation assays. Methods (2008) 0.98
Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis. J Biol Chem (2010) 0.96
Building mitotic chromosomes. Curr Opin Cell Biol (2010) 0.95
Polo-like kinase-activating kinases: Aurora A, Aurora B and what else? Cell Cycle (2012) 0.94
How do kinetochores CLASP dynamic microtubules? Cell Cycle (2003) 0.94
Super-resolution fluorescence microscopy as a tool to study the nanoscale organization of chromosomes. Curr Opin Chem Biol (2011) 0.93
A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells. BMC Cancer (2013) 0.92
CENP-V is required for centromere organization, chromosome alignment and cytokinesis. EMBO J (2008) 0.91
Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells. J Biol Chem (2001) 0.91
Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis. J Biol Chem (2003) 0.89
Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. Nucleus (2012) 0.85
Genetic analysis of the short splice variant of the inhibitor of caspase-activated DNase (ICAD-S) in chicken DT40 cells. J Biol Chem (2007) 0.85
INCENP at the kinase crossroads. Nat Cell Biol (2006) 0.82
Protecting a transgene expression from the HAC-based vector by different chromatin insulators. Cell Mol Life Sci (2013) 0.82
Nap1 regulates proper CENP-B binding to nucleosomes. Nucleic Acids Res (2013) 0.82
Shugoshin: a centromeric guardian senses tension. Bioessays (2005) 0.81
Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system. J Cell Sci (2006) 0.81
A mitosis-specific AMPK trimer? Cell Cycle (2012) 0.80
Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells. Exp Cell Res (2010) 0.80
Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function. Nucleic Acids Res (2013) 0.80
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. Mol Biol Cell (2007) 0.80
A perfect funeral with no corpse. J Cell Biol (2003) 0.79
Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex. Biochemistry (2009) 0.79