PubRank

David J Mangelsdorf

Author PubWeight™ 214.72‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007 9.62
2 Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005 9.14
3 Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 2003 6.21
4 Nuclear receptor expression links the circadian clock to metabolism. Cell 2006 5.43
5 Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004 4.65
6 Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 2006 4.64
7 FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A 2009 3.99
8 Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell 2006 3.82
9 Vitamin D receptor as an intestinal bile acid sensor. Science 2002 3.64
10 Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol 2003 3.59
11 Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem 2002 3.52
12 Structural determinants of allosteric ligand activation in RXR heterodimers. Cell 2004 3.36
13 Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med 2004 3.17
14 FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 2011 3.16
15 Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nucl Recept Signal 2003 3.14
16 Retinoid x receptor heterodimers in the metabolic syndrome. N Engl J Med 2005 3.12
17 LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol 2006 3.11
18 Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell 2012 3.07
19 Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 2006 3.05
20 Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev 2012 2.91
21 Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc Natl Acad Sci U S A 2004 2.89
22 Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab 2008 2.76
23 LXRs regulate the balance between fat storage and oxidation. Cell Metab 2005 2.75
24 Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol 2010 2.67
25 Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A 2002 2.56
26 Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab 2007 2.51
27 A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc Natl Acad Sci U S A 2007 2.50
28 Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A 2003 2.50
29 A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab 2005 2.42
30 High-throughput real-time quantitative reverse transcription PCR. Curr Protoc Mol Biol 2006 2.41
31 Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc Natl Acad Sci U S A 2012 2.38
32 Fibroblast growth factor 21: from pharmacology to physiology. Am J Clin Nutr 2009 2.35
33 βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab 2012 2.27
34 Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol 2003 2.26
35 The liver X receptor gene team: potential new players in atherosclerosis. Nat Med 2002 2.24
36 International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev 2006 2.22
37 FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med 2013 2.20
38 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med 2007 2.18
39 A Nuclear Receptor Atlas: macrophage activation. Mol Endocrinol 2005 2.13
40 Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Dev Cell 2006 2.11
41 A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol Endocrinol 2005 2.06
42 International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev 2006 2.04
43 Identification of a hormonal basis for gallbladder filling. Nat Med 2006 2.03
44 A natural product that lowers cholesterol as an antagonist ligand for FXR. Science 2002 1.99
45 FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway. Cell Metab 2011 1.97
46 Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem 2003 1.92
47 FGF21 contributes to neuroendocrine control of female reproduction. Nat Med 2013 1.89
48 De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J Biol Chem 2003 1.89
49 Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Mol Endocrinol 2008 1.85
50 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol 2007 1.75
51 Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem 2006 1.72
52 MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol 2009 1.71
53 The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife 2012 1.69
54 Nuclear hormone receptor regulation of microRNAs controls developmental progression. Science 2009 1.69
55 Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. J Biol Chem 2004 1.57
56 Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol 2009 1.49
57 Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J Biol Chem 2002 1.48
58 Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol 2008 1.47
59 The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression. J Biol Chem 2003 1.46
60 Liver X receptors regulate adrenal cholesterol balance. J Clin Invest 2006 1.45
61 The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell 2003 1.44
62 Regulation of bile acid synthesis by fat-soluble vitamins A and D. J Biol Chem 2010 1.40
63 The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Mol Endocrinol 2011 1.39
64 Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest 2012 1.38
65 Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. Cardiovasc Res 2007 1.32
66 FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. J Lipid Res 2007 1.31
67 Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function. Mol Cell Endocrinol 2003 1.28
68 Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci U S A 2002 1.28
69 Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc Natl Acad Sci U S A 2009 1.26
70 Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism. Diabetes 2008 1.21
71 Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology 2007 1.20
72 Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer. PLoS Med 2010 1.19
73 Expression profiling of nuclear receptors in human and mouse embryonic stem cells. Mol Endocrinol 2009 1.16
74 Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions. Mol Endocrinol 2010 1.15
75 Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo. J Biol Chem 2012 1.13
76 Pregnane X receptor is a target of farnesoid X receptor. J Biol Chem 2006 1.13
77 Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol 2012 1.12
78 LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes Dev 2011 1.10
79 International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacol Rev 2006 1.08
80 The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). J Atheroscler Thromb 2002 1.08
81 LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. J Clin Invest 2010 1.06
82 Nuclear receptor regulation of stemness and stem cell differentiation. Exp Mol Med 2009 1.03
83 The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell 2011 1.03
84 In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. Mol Endocrinol 2007 1.03
85 Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer. Mol Endocrinol 2012 1.01
86 Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. J Med Chem 2007 0.99
87 Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Mol Endocrinol 2004 0.97
88 Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Mol Endocrinol 2009 0.96
89 Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells. J Biol Chem 2002 0.92
90 Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Gastroenterology 2002 0.92
91 Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release. Clin Gastroenterol Hepatol 2009 0.92
92 Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. Mol Endocrinol 2003 0.91
93 AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids. J Biol Chem 2010 0.91
94 Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. J Invest Dermatol 2002 0.91
95 Nuclear receptors of the enteric tract: guarding the frontier. Nutr Rev 2008 0.88
96 Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development. Anat Rec A Discov Mol Cell Evol Biol 2005 0.87
97 Bile Acids as Hormones: The FXR-FGF15/19 Pathway. Dig Dis 2015 0.86
98 Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Mol Endocrinol 2004 0.85
99 Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis. Chem Biol 2003 0.85
100 Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes. J Biol Chem 2011 0.85
101 Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. Mol Endocrinol 2014 0.83
102 Structural insights into gene repression by the orphan nuclear receptor SHP. Proc Natl Acad Sci U S A 2013 0.83
103 LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing. Mol Interv 2002 0.82
104 Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE. Exp Cell Res 2012 0.82
105 Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Genes Dev 2007 0.79
106 Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus. Mol Endocrinol 2013 0.78
107 Nuclear receptors: emerging drug targets for parasitic diseases. J Clin Invest 2017 0.75
108 Establishment of a monoclonal antibody for human LXRalpha: Detection of LXRalpha protein expression in human macrophages. Nucl Recept 2003 0.75
109 Reflections on the field of metabolism. Cell Metab 2015 0.75