Published in J Biol Chem on February 10, 1978
A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes. Biochem J (1980) 2.14
Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes. Biochem J (1983) 1.82
Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A (1990) 1.23
Characterization of the phosphorylated form of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes. Biochem J (1981) 1.23
Protein degradation in hepatocyte monolayers. Effects of glucagon, adenosine 3':5'-cyclic monophosphate and insulin. Biochem J (1980) 1.18
Epidermal growth factor mimics insulin effects in rat hepatocytes. Biochem J (1986) 1.14
An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations. Biochem J (1984) 1.10
The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP. Proc Natl Acad Sci U S A (1989) 1.09
The insulin- and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity. Biochem J (1987) 1.05
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Activation and phosphorylation of the 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase. Biochem J (1989) 0.98
Acute change in the cyclic AMP content of rat mammary acini in vitro. Influence of physiological and pharmacological agents. Biochem J (1985) 0.96
Insulin activates the plasma-membrane and dense-vesicle cyclic AMP phosphodiesterase in hepatocytes by distinct routes. Biochem J (1983) 0.94
Theoretical analysis of the consequences of cyclic nucleotide phosphodiesterase negative co-operativity. Amplification and positive co-operativity of cyclic AMP accumulation. Biochem J (1980) 0.94
Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases. J Clin Invest (1995) 0.94
The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases. Mol Cell Biochem (1993) 0.90
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The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung. Biochem J (1992) 0.88
Submitochondrial localization and asymmetric disposition of two peripheral cyclic nucleotide phosphodiesterases. Biochem J (1982) 0.88
Proteolytic activation and solubilization of endoplasmic-reticulum cyclic AMP phosphodiesterase activity. Biochem J (1983) 0.84
Isolation of insulin-sensitive phosphatidylinositol-glycan from rat adipocytes. Its impaired breakdown in the streptozotocin-diabetic rat. Biochem J (1990) 0.83
Simulations of the roles of multiple cyclic nucleotide phosphodiesterases. Biochem J (1982) 0.81
The action of adenosine in relation to that of insulin on the low-Km cyclic AMP phosphodiesterase in rat adipocytes. Biochem J (1985) 0.80
Cross-talk between glucagon- and adenosine-mediated signalling systems in rat hepatocytes: effects on cyclic AMP-phosphodiesterase activity. Biochem J (1995) 0.79
Extracellular calcium modulates insulin's action on enzymes controlling cyclic AMP metabolism in intact hepatocytes. Biochem J (1993) 0.78
Effects of vanadate on protein kinases in rat hepatocytes. Biochem J (1989) 0.77
Insulin inhibition of hepatic cAMP-dependent protein kinase: decreased affinity of protein kinase for cAMP and possible differential regulation of intrachain sites 1 and 2. Proc Natl Acad Sci U S A (1987) 0.76
Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1993) 4.23
Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins. Nature (1991) 3.15
The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues. J Biol Chem (1975) 2.84
Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes. J Biol Chem (1983) 2.73
Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats. J Biol Chem (1967) 2.66
Control of gluconeogenesis from amino acids in the perfused rat liver. J Biol Chem (1969) 2.64
Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism. J Biol Chem (1987) 2.40
Control of gluconeogenesis in liver. II. Effects of glucagon, catecholamines, and adenosine 3',5'-monophosphate on gluconeogenesis in the perfused rat liver. J Biol Chem (1968) 2.40
Studies on alpha-adrenergic activation of hepatic glucose output. Studies on role of calcium in alpha-adrenergic activation of phosphorylase. J Biol Chem (1977) 2.38
A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes. Anal Biochem (1976) 2.36
Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium. J Biol Chem (1986) 2.32
Characterization of responses of isolated rat hepatocytes to ATP and ADP. J Biol Chem (1985) 2.27
Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats. Biochim Biophys Acta (1974) 2.19
Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator. Cell (1992) 2.17
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Molecular mechanisms involved in alpha-adrenergic responses. Mol Cell Endocrinol (1981) 2.12
Studies on alpha-adrenergic activation of hepatic glucose output. Relationship between alpha-adrenergic stimulation of calcium efflux and activation of phosphorylase in isolated rat liver parenchymal cells. J Biol Chem (1978) 2.08
An effect of insulin on adipose-tissue adenosine 3':5'-cyclic monophosphate phosphodiesterase. Biochem J (1970) 2.07
Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1. J Biol Chem (1992) 2.06
Exposing rats to a predator impairs spatial working memory in the radial arm water maze. Hippocampus (1999) 1.95
Vasopressin-, angiotensin II-, and alpha 1-adrenergic-induced inhibition of Ca2+ transport by rat liver plasma membrane vesicles. J Biol Chem (1984) 1.95
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Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II. J Biol Chem (1985) 1.89
Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism. J Biol Chem (1968) 1.88
Studies on the role of adenosine 3',5'-monophosphate in the hepatic actions of glucagon and catecholamines. J Biol Chem (1971) 1.85
Effects of glucagon on amino acid transport and utilization in the perfused rat liver. J Biol Chem (1969) 1.82
The hormonal control of hepatic gluconeogenesis. Recent Prog Horm Res (1970) 1.78
Studies on alpha-adrenergic activation of hepatic glucose output. The role of mitochondrial calcium release in alpha-adrenergic activation of phosphorylase in perfused rat liver. J Biol Chem (1979) 1.75
Effect of insulin on adenosine 3',5'-monophosphate in the rat epididymal fat pad. J Biol Chem (1966) 1.72
Mechanism of long chain fatty acid permeation in the isolated adipocyte. J Biol Chem (1981) 1.72
A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Science (1995) 1.70
Stereospecific transport of glucose in the perfused rat liver. Am J Physiol (1968) 1.67
Mechanisms involved in alpha-adrenergic phenomena. Am J Physiol (1985) 1.67
Purification and characterization of the zeta isoform of protein kinase C from bovine kidney. J Biol Chem (1992) 1.66
alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium. J Biol Chem (1982) 1.65
Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats. J Biol Chem (1975) 1.65
Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice. J Clin Invest (1976) 1.64
A method for deriving kinetic constants for two enzymes acting on the same substrate. Biochem J (1971) 1.63
Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists. J Biol Chem (1987) 1.62
Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate. J Biol Chem (1986) 1.61
Gluconeogenesis in the perfused liver. The effects of fasting, alloxan diabetes, glucagon, epinephrine, adenosine 3',5'-monophosphate and insulin. Am J Med (1966) 1.58
Activation of rat liver phospholipase D by the small GTP-binding protein RhoA. J Biol Chem (1994) 1.57
Control of gluconeogenesis in liver. V. Effects of fasting, diabetes, and glucagon on lactate and endogenous metabolism in the perfused rat liver. J Biol Chem (1972) 1.53
Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate. J Biol Chem (1985) 1.52
Regulation of fructose-2,6-bisphosphate content in rat hepatocytes, perfused hearts, and perfused hindlimbs. J Biol Chem (1982) 1.52
Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with alpha-adrenergic agonists and with glucagon. Biochem J (1980) 1.52
Early effects of 3',5'-adenosine monophosphate on the fluxes of calcium end potassium in the perfused liver of normal and adrenalectomized rats. Proc Natl Acad Sci U S A (1968) 1.51
Control of gluconeogenesis in liver. 3. Effects of L-lactate, pyruvate, fructose, glucagon, epinephrine, and adenosine 3',5'-monophosphate on gluconeogenic intermediates in the perfused rat liver. J Biol Chem (1969) 1.50
Interaction of glucocorticoids with glucagon and epinephrine in the control of gluconeogenesis and glycogenolysis in liver and of lipolysis in adipose tissue. J Biol Chem (1972) 1.49
Mechanisms involved in alpha-adrenergic phenomena: role of calcium ions in actions of catecholamines in liver and other tissues. Am J Physiol (1980) 1.49
Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. J Biol Chem (1984) 1.48
Factors affecting glucose transport in heart muscle and erythrocytes. Fed Proc (1966) 1.48
Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor. J Biol Chem (1996) 1.48
Evidence for a role of the microtubular system in the secretion of newly synthesized albumin and other proteins by the liver. J Clin Invest (1974) 1.44
Guanine-nucleotide and hormone regulation of polyphosphoinositide phospholipase C activity of rat liver plasma membranes. Bivalent-cation and phospholipid requirements. Biochem J (1987) 1.44
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Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. J Biol Chem (1997) 1.42
On the question of translocation of heart cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1975) 1.41
Phosphatidate-dependent protein phosphorylation. Proc Natl Acad Sci U S A (1991) 1.39
Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts. J Cell Biol (1993) 1.38
Regulation of adenosine 3',5'-monophosphate-dependent protein kinase. I. Preliminary characterization of the adipose tissue enzyme in crude extracts. J Biol Chem (1973) 1.38
Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation. J Biol Chem (1999) 1.38
The role of cyclic AMP in the interaction of glucagon and insulin in the control of liver metabolism. Ann N Y Acad Sci (1971) 1.36
Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in hepatocytes by vasopressin. J Biol Chem (1983) 1.36
Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits. J Biol Chem (1992) 1.34
Purification and characterization of two G-proteins that activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the Gq class. J Biol Chem (1991) 1.32
Modulation of the alpha 1-adrenergic control of hepatocyte calcium redistribution by increases in cyclic AMP. J Biol Chem (1983) 1.31
The role of cyclic AMP in the control of liver metabolism. Adv Enzyme Regul (1968) 1.29
The relationships between receptor binding capacity for norepinephrine, angiotensin II, and vasopressin and release of inositol trisphosphate, Ca2+ mobilization, and phosphorylase activation in rat liver. Mol Pharmacol (1985) 1.29
Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors. J Biol Chem (1999) 1.28
Phosphatidylinositol breakdown induced by vasopressin and epinephrine in hepatocytes is calcium-dependent. J Biol Chem (1982) 1.28
Control of gluconeogenesis in liver. IV. Differential effects of fatty acids and glucagon on ketogenesis and gluconeogenesis in the perfused rat liver. J Biol Chem (1969) 1.25
Ca2+-mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation. FEBS Lett (1987) 1.25
Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism. J Biol Chem (1992) 1.24
Fructose 2,6-bisphosphate. Hormonal regulation and mechanism of its formation in liver. J Biol Chem (1981) 1.24
The stimulation of gluconeogenesis from lactate by epinephrine, glucagon, cyclic 3',5'-adenylate in the perfused rat liver. Pharmacol Rev (1966) 1.23
Regulation of adenosine 3',5'-monophosphate-dependent protein kinase. II. Hormonal regulation of the adipose tissue enzyme. J Biol Chem (1973) 1.23
Effects of glucose on glycogen synthetase, phosphorylase, and glycogen deposition in the perfused rat liver. Proc Natl Acad Sci U S A (1970) 1.22
Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol. J Biol Chem (1993) 1.22