Published in Biochemistry on May 14, 1991
Mechanism and regulation of eukaryotic protein synthesis. Microbiol Rev (1992) 6.27
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J (1992) 6.16
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex. J Cell Biol (1992) 4.34
Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proc Natl Acad Sci U S A (1991) 3.70
Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments. J Cell Biol (1994) 2.75
Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J Cell Biol (1994) 2.74
Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal (2010) 2.56
Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J Cell Biol (1994) 2.50
Genetic analysis of lysosomal trafficking in Caenorhabditis elegans. Mol Biol Cell (2005) 2.44
The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. J Carcinog (2011) 2.30
Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A (1992) 2.23
Two GTPase isoforms, Ypt31p and Ypt32p, are essential for Golgi function in yeast. EMBO J (1996) 2.16
A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Proc Natl Acad Sci U S A (1994) 2.07
Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog (2009) 2.06
Mutations affecting G-protein subunit α11 in hypercalcemia and hypocalcemia. N Engl J Med (2013) 2.05
The small GTP-binding protein rab6 functions in intra-Golgi transport. J Cell Biol (1994) 2.02
Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol Cell Biol (1996) 2.00
Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc Natl Acad Sci U S A (2001) 1.99
Rho GTPases: functions and association with cancer. Clin Exp Metastasis (2007) 1.98
Ras-catalyzed hydrolysis of GTP: a new perspective from model studies. Proc Natl Acad Sci U S A (1996) 1.97
Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. J Cell Biol (1993) 1.86
A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. J Cell Biol (1994) 1.80
Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins. Mol Cell Biol (1993) 1.78
Distinct structural elements of rab5 define its functional specificity. EMBO J (1994) 1.72
Classification of fungal chitin synthases. Proc Natl Acad Sci U S A (1992) 1.70
Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. Genetics (2000) 1.67
Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast. Mol Biol Cell (2000) 1.64
Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc Natl Acad Sci U S A (2010) 1.62
Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras. Mol Cell Biol (1994) 1.60
Growth-regulated expression of rhoG, a new member of the ras homolog gene family. Mol Cell Biol (1992) 1.58
Towards complete sets of farnesylated and geranylgeranylated proteins. PLoS Comput Biol (2007) 1.57
Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms. Mol Biol Cell (2000) 1.52
Structural basis for recruitment of RILP by small GTPase Rab7. EMBO J (2005) 1.50
Evolution of the Ras-like small GTPases and their regulators. Small GTPases (2011) 1.48
Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. EMBO J (2008) 1.48
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. Biochem J (2000) 1.45
Functions and functional domains of the GTPase Cdc42p. Mol Biol Cell (2000) 1.45
Thousands of rab GTPases for the cell biologist. PLoS Comput Biol (2011) 1.44
The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol (1999) 1.43
A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication. J Virol (2004) 1.41
Mitogenic and oncogenic properties of the small G protein Rap1b. Proc Natl Acad Sci U S A (1998) 1.40
Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc Natl Acad Sci U S A (1997) 1.38
Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling. Pharmacol Ther (2006) 1.38
Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation. Mol Cell Biol (1999) 1.38
Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. Proc Natl Acad Sci U S A (1994) 1.37
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc Natl Acad Sci U S A (2010) 1.35
X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis. Proc Natl Acad Sci U S A (1992) 1.34
Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation. Genetics (1997) 1.33
The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans. J Cell Biol (2008) 1.23
Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors. Mol Cell Biol (1994) 1.21
Polarity proteins and cell-cell interactions in the testis. Int Rev Cell Mol Biol (2009) 1.21
Ran's C-terminal, basic patch, and nucleotide exchange mechanisms in light of a canonical structure for Rab, Rho, Ras, and Ran GTPases. Genome Res (2003) 1.20
The large subunit of replication factor C (Rfc1p/Cdc44p) is required for DNA replication and DNA repair in Saccharomyces cerevisiae. Genetics (1996) 1.20
Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily. Proc Natl Acad Sci U S A (1995) 1.16
Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation. Mol Cell Biol (1994) 1.13
Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases. Biochem J (1998) 1.11
Evidence for a recycling role for Rab7 in regulating a late step in endocytosis and in retention of lysosomal enzymes in Dictyostelium discoideum. Mol Biol Cell (1997) 1.08
Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator. EMBO J (1992) 1.07
Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins. Biochem J (1993) 1.06
The N-terminal domain of a rab protein is involved in membrane-membrane recognition and/or fusion. EMBO J (1994) 1.05
Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS. EMBO J (1997) 1.05
On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b. Proc Natl Acad Sci U S A (2002) 1.01
Death pathways triggered by activated Ras in cancer cells. Front Biosci (Landmark Ed) (2011) 1.00
Role of proto-oncogene activation in carcinogenesis. Environ Health Perspect (1992) 0.99
RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP. EMBO J (1992) 0.99
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways. Cell Signal (2006) 0.95
Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development. Mol Cell Biol (1996) 0.93
Ras GTPase-activating protein regulation of actin cytoskeleton and hyphal polarity in Aspergillus nidulans. Eukaryot Cell (2007) 0.93
Cationic modulation of rho 1-type gamma-aminobutyrate receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A (1994) 0.93
Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP. Mol Biol Cell (1994) 0.91
Polylysine domain of K-ras 4B protein is crucial for malignant transformation. Proc Natl Acad Sci U S A (1994) 0.91
Pseudomonas fluorescens and Glomus mosseae trigger DMI3-dependent activation of genes related to a signal transduction pathway in roots of Medicago truncatula. Plant Physiol (2005) 0.90
Overexpression of a dominant-negative allele of SEC4 inhibits growth and protein secretion in Candida albicans. J Bacteriol (1999) 0.90
Lessons from computer simulations of Ras proteins in solution and in membrane. Biochim Biophys Acta (2013) 0.87
Ras and Nox: Linked signaling networks? Free Radic Biol Med (2009) 0.87
Properties of Rab5 N-terminal domain dictate prenylation of C-terminal cysteines. Mol Biol Cell (1995) 0.87
The Srp54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe. Mol Cell Biol (1994) 0.86
Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis. Proc Natl Acad Sci U S A (1994) 0.86
Identification and expression analysis of ras gene in silkworm, Bombyx mori. PLoS One (2009) 0.85
Oxygen-mediated endocytosis in cancer. J Cell Mol Med (2010) 0.84
Effects of site-directed mutagenesis of mglA on motility and swarming of Myxococcus xanthus. BMC Microbiol (2010) 0.84
Identification and characterization of Iporin as a novel interaction partner for rab1. BMC Cell Biol (2005) 0.83
The insert region of Rac1 is essential for membrane ruffling but not cellular transformation. Mol Cell Biol (2001) 0.83
Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformans. Fungal Genet Biol (2013) 0.82
Molecular cloning and DNA sequence of a Dictyostelium cDNA encoding a Ran/TC4 related GTP binding protein belonging to the ras superfamily. Nucleic Acids Res (1993) 0.81
Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate. J Biol Chem (2015) 0.80
The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein. Mol Biol Cell (1998) 0.80
Role of ARF4L in recycling between endosomes and the plasma membrane. Cell Mol Neurobiol (2004) 0.80
Regulation of Rab5 function during phagocytosis of live Pseudomonas aeruginosa in macrophages. Infect Immun (2013) 0.80
Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration. J Biol Chem (2014) 0.80
Global proteomics analysis of testis and ovary in adult zebrafish (Danio rerio). Fish Physiol Biochem (2011) 0.79
Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells. Biochem J (1996) 0.79
Mutant Rab24 GTPase is targeted to nuclear inclusions. BMC Cell Biol (2002) 0.79
The distribution of alpha-helix propensity along the polypeptide chain is not conserved in proteins from the same family. Protein Sci (1995) 0.78
Crystallization and preliminary X-ray analysis of RabX3, a tandem GTPase from Entamoeba histolytica. Acta Crystallogr F Struct Biol Commun (2014) 0.78
FragKB: structural and literature annotation resource of conserved peptide fragments and residues. PLoS One (2010) 0.77
Stimulation of glycosylphosphatidylinositol biosynthesis in mammalian cell-free systems by GTP hydrolysis: evidence for the involvement of membrane fusion. Biochem J (1999) 0.77
Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes. Int J Cell Biol (2014) 0.76
A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor. J Biol Chem (2016) 0.76
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers (1983) 99.69
Protein structure comparison by alignment of distance matrices. J Mol Biol (1993) 34.74
Errors in protein structures. Nature (1996) 18.70
Touring protein fold space with Dali/FSSP. Nucleic Acids Res (1998) 18.00
Prediction of protein secondary structure at better than 70% accuracy. J Mol Biol (1993) 17.53
Selection of representative protein data sets. Protein Sci (1992) 15.62
The P-loop--a common motif in ATP- and GTP-binding proteins. Trends Biochem Sci (1990) 14.55
Dali: a network tool for protein structure comparison. Trends Biochem Sci (1995) 14.13
Automated genome sequence analysis and annotation. Bioinformatics (1999) 13.92
Mapping the protein universe. Science (1996) 13.72
Combining evolutionary information and neural networks to predict protein secondary structure. Proteins (1994) 9.97
The HSSP database of protein structure-sequence alignments and family profiles. Nucleic Acids Res (1998) 9.59
The guanine nucleotide-binding switch in three dimensions. Science (2001) 9.34
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature (1998) 9.30
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science (1997) 9.21
New structure--novel fold? Structure (1997) 9.19
Enlarged representative set of protein structures. Protein Sci (1994) 7.98
PHD--an automatic mail server for protein secondary structure prediction. Comput Appl Biosci (1994) 6.71
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO J (1990) 6.51
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature (1993) 6.38
An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins. Proc Natl Acad Sci U S A (1992) 6.18
Positioning hydrogen atoms by optimizing hydrogen-bond networks in protein structures. Proteins (1996) 5.83
Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library. Proc Natl Acad Sci U S A (1987) 5.80
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. Nature (1989) 5.38
Completeness in structural genomics. Nat Struct Biol (2001) 5.36
Correlated mutations and residue contacts in proteins. Proteins (1994) 5.20
A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product. Nature (1984) 5.19
Transmembrane helices predicted at 95% accuracy. Protein Sci (1995) 5.05
The FSSP database of structurally aligned protein fold families. Nucleic Acids Res (1994) 4.94
A database of protein structure families with common folding motifs. Protein Sci (1992) 4.77
The primary structure of transcription factor TFIIIA has 12 consecutive repeats. FEBS Lett (1985) 4.73
RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc Natl Acad Sci U S A (1994) 4.58
Protein normal-mode dynamics: trypsin inhibitor, crambin, ribonuclease and lysozyme. J Mol Biol (1985) 4.56
MView: a web-compatible database search or multiple alignment viewer. Bioinformatics (1998) 4.50
The immunoglobulin fold. Structural classification, sequence patterns and common core. J Mol Biol (1994) 4.43
An evolutionary treasure: unification of a broad set of amidohydrolases related to urease. Proteins (1997) 4.42
Conservation and prediction of solvent accessibility in protein families. Proteins (1994) 4.29
An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. Oncogene (2009) 4.10
On the use of sequence homologies to predict protein structure: identical pentapeptides can have completely different conformations. Proc Natl Acad Sci U S A (1984) 4.08
Improved prediction of protein secondary structure by use of sequence profiles and neural networks. Proc Natl Acad Sci U S A (1993) 3.92
Searching protein structure databases has come of age. Proteins (1994) 3.87
Database algorithm for generating protein backbone and side-chain co-ordinates from a C alpha trace application to model building and detection of co-ordinate errors. J Mol Biol (1991) 3.81
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. Nature (1995) 3.61
The ral gene: a new ras related gene isolated by the use of a synthetic probe. EMBO J (1986) 3.50
Removing near-neighbour redundancy from large protein sequence collections. Bioinformatics (1998) 3.47
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis. Nature (1990) 3.47
Bioinformatics: from genome data to biological knowledge. Curr Opin Biotechnol (1997) 3.44
Dictionary of recurrent domains in protein structures. Proteins (1998) 3.40
Protein folds and families: sequence and structure alignments. Nucleic Acids Res (1999) 3.38
Dali/FSSP classification of three-dimensional protein folds. Nucleic Acids Res (1997) 3.34
A method to predict functional residues in proteins. Nat Struct Biol (1995) 3.33
Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine. Nature (1997) 3.31
Parser for protein folding units. Proteins (1994) 3.25
Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. Protein Sci (1993) 3.25
Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling. Mol Cell (2000) 2.95
Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Oncogene (1988) 2.94
Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1. Biochemistry (1995) 2.91
The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. J Biol Chem (1989) 2.87
A sequence property approach to searching protein databases. J Mol Biol (1995) 2.86
Yeast chromosome III: new gene functions. EMBO J (1994) 2.85
Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site. EMBO J (1986) 2.85
Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell (1990) 2.77
Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem (2000) 2.77
Fast and simple Monte Carlo algorithm for side chain optimization in proteins: application to model building by homology. Proteins (1992) 2.69
GTPase-activating proteins: helping hands to complement an active site. Trends Biochem Sci (1998) 2.64
Dipoles of the alpha-helix and beta-sheet: their role in protein folding. Nature (1981) 2.56
Kinetics of interaction of nucleotides with nucleotide-free H-ras p21. Biochemistry (1990) 2.55
Detection of common three-dimensional substructures in proteins. Proteins (1991) 2.53
Evaluation of protein models by atomic solvation preference. J Mol Biol (1992) 2.53
Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature (2005) 2.52
Ras/Rap effector specificity determined by charge reversal. Nat Struct Biol (1996) 2.52
Protein fold recognition by prediction-based threading. J Mol Biol (1997) 2.51
Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line. Mol Cell Biol (1990) 2.51
CAST: an iterative algorithm for the complexity analysis of sequence tracts. Complexity analysis of sequence tracts. Bioinformatics (2000) 2.50
N-terminal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchange. Biochemistry (1997) 2.50
The PDBFINDER database: a summary of PDB, DSSP and HSSP information with added value. Comput Appl Biosci (1996) 2.46
The HSSP database of protein structure-sequence alignments. Nucleic Acids Res (1997) 2.44
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nat Struct Biol (1997) 2.43
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. J Biol Chem (2000) 2.42
The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller. Nature (1998) 2.42
DNA polymerase beta belongs to an ancient nucleotidyltransferase superfamily. Trends Biochem Sci (1995) 2.41
A novel RNA-binding motif in omnipotent suppressors of translation termination, ribosomal proteins and a ribosome modification enzyme? Nucleic Acids Res (1994) 2.37
A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol (1998) 2.36
Progress in protein structure prediction? Trends Biochem Sci (1993) 2.34
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins. Nat Struct Biol (1995) 2.32
Can three-dimensional contacts in protein structures be predicted by analysis of correlated mutations? Protein Eng (1994) 2.30
GEFs: structural basis for their activation of small GTP-binding proteins. Trends Biochem Sci (1999) 2.29
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Cell (2001) 2.28
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. Nature (2000) 2.25
Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras. J Biol Chem (1993) 2.23
The kinetic mechanism of Ran--nucleotide exchange catalyzed by RCC1. Biochemistry (1995) 2.20
Predicting protein structure using hidden Markov models. Proteins (1997) 2.20
Structural view of the Ran-Importin beta interaction at 2.3 A resolution. Cell (1999) 2.15
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. J Biol Chem (1996) 2.14
The FSSP database: fold classification based on structure-structure alignment of proteins. Nucleic Acids Res (1996) 2.10
Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. Science (1990) 2.09
How good are predictions of protein secondary structure? FEBS Lett (1983) 2.08
The GeneQuiz web server: protein functional analysis through the Web. Trends Biochem Sci (2000) 2.07
The ten helical twist angles of B-DNA. Nucleic Acids Res (1982) 2.02