Published in J Immunol on March 19, 2010
The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol (2011) 2.33
Premature menopause or early menopause and risk of ischemic stroke. Menopause (2012) 1.84
Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol (2014) 1.23
The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function. Vascul Pharmacol (2011) 1.18
IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke. Metab Brain Dis (2013) 1.11
A novel hypothesis: regulatory B lymphocytes shape outcome from experimental stroke. Transl Stroke Res (2012) 1.10
Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice. Metab Brain Dis (2013) 1.04
G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation. PLoS One (2012) 1.03
Phenotypic changes in immune cell subsets reflect increased infarct volume in male vs. female mice. Transl Stroke Res (2013) 1.03
Estrogen neuroprotection and the critical period hypothesis. Front Neuroendocrinol (2011) 1.03
Differential effects of aging and sex on stroke induced inflammation across the lifespan. Exp Neurol (2013) 1.03
Sex, stroke, and inflammation: the potential for estrogen-mediated immunoprotection in stroke. Horm Behav (2012) 0.99
PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1. J Neuroinflammation (2013) 0.99
Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury. Prog Neurobiol (2016) 0.90
Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system. Brain Behav Immun (2014) 0.88
International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators. Pharmacol Rev (2015) 0.87
Regulatory CD8(+)CD122 (+) T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells. Metab Brain Dis (2014) 0.84
Role of dihydrotestosterone in post-stroke peripheral immunosuppression after cerebral ischemia. Brain Behav Immun (2011) 0.84
Oestrogen signalling and neuroprotection in cerebral ischaemia. J Neuroendocrinol (2012) 0.83
GPER1/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res (2012) 0.83
2014 Thomas Willis Award Lecture: sex, stroke, and innovation. Stroke (2014) 0.83
The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions. J Immunother (2013) 0.82
Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats. PLoS One (2012) 0.82
What have we learned about GPER function in physiology and disease from knockout mice? J Steroid Biochem Mol Biol (2015) 0.81
Estrogen-mediated renoprotection following cardiac arrest and cardiopulmonary resuscitation is robust to GPR30 gene deletion. PLoS One (2014) 0.81
Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke. Front Cell Neurosci (2014) 0.81
Experimental pediatric arterial ischemic stroke model reveals sex-specific estrogen signaling. Stroke (2013) 0.79
Estradiol meets notch signaling in developing neurons. Front Endocrinol (Lausanne) (2011) 0.79
Neuroprotective action of acute estrogens: animal models of brain ischemia and clinical implications. Steroids (2013) 0.78
The battle of the sexes for stroke therapy: female- versus male-derived stem cells. CNS Neurol Disord Drug Targets (2013) 0.78
Adult stem cell transplantation: is gender a factor in stemness? Int J Mol Sci (2014) 0.78
Method parameters' impact on mortality and variability in mouse stroke experiments: a meta-analysis. Sci Rep (2016) 0.77
GPR30 FORMS AN INTEGRAL PART OF E2-PROTECTIVE PATHWAY IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. Immunol Endocr Metab Agents Med Chem (2011) 0.77
Inhibition of glycogen synthase kinase-3β enhances cognitive recovery after stroke: the role of TAK1. Learn Mem (2015) 0.77
The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats. J Neuroinflammation (2016) 0.76
G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease. World J Cardiol (2014) 0.76
GPER1 stimulation alters posttranslational modification of RGSz1 and induces desensitization of 5-HT1A receptor signaling in the rat hypothalamus. Neuroendocrinology (2014) 0.75
Recent Advances on the Role of G Protein-Coupled Receptors in Hypoxia-Mediated Signaling. AAPS J (2016) 0.75
Sex-specific effects of N-acetylcysteine in neonatal rats treated with hypothermia after severe hypoxia-ischemia. Neurosci Res (2016) 0.75
Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA. PLoS One (2017) 0.75
Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following ischemic stroke. Sci Rep (2017) 0.75
GPER modulators: Opportunity Nox on the heels of a class Akt. J Steroid Biochem Mol Biol (2017) 0.75
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (1999) 34.47
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature (2002) 11.79
A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (2005) 9.80
Regulatory T cells in autoimmmunity*. Annu Rev Immunol (2000) 9.36
Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol (1999) 7.60
Regulatory T cells in the control of immune pathology. Nat Immunol (2001) 6.98
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology (2004) 5.20
Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol (2006) 5.20
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med (2009) 4.87
Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation (2006) 4.61
The complex role of estrogens in inflammation. Endocr Rev (2007) 4.07
Experimental stroke induces massive, rapid activation of the peripheral immune system. J Cereb Blood Flow Metab (2006) 3.91
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med (2003) 3.89
Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab (1999) 3.48
Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci (2005) 3.45
Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages. J Immunol (2006) 3.28
Changes in proinflammatory cytokine activity after menopause. Endocr Rev (2002) 3.24
Infection after acute ischemic stroke: a manifestation of brain-induced immunodepression. Stroke (2007) 2.87
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev (2005) 2.78
Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke (2007) 2.76
T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation. J Cereb Blood Flow Metab (2007) 2.75
Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. J Neurosci (2003) 2.73
Control of immune pathology by regulatory T cells. Curr Opin Immunol (1998) 2.42
CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. J Exp Med (2007) 2.39
Tumor necrosis factor-alpha expression in ischemic neurons. Stroke (1994) 2.37
Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues. Mol Immunol (2004) 2.30
Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression. Neuroscience (2008) 2.01
The spleen contributes to stroke-induced neurodegeneration. J Neurosci Res (2008) 2.01
Expression of CCR7 in multiple sclerosis: implications for CNS immunity. Ann Neurol (2004) 1.83
Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions. Proc Natl Acad Sci U S A (2007) 1.83
Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke (2000) 1.83
G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane. Biochem Biophys Res Commun (2006) 1.79
GPR30 contributes to estrogen-induced thymic atrophy. Mol Endocrinol (2007) 1.78
The use of flow cytometry to evaluate temporal changes in inflammatory cells following focal cerebral ischemia in mice. Brain Res (2002) 1.77
Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp Neurol (2006) 1.69
17beta-estradiol reduces stroke injury in estrogen-deficient female animals. Stroke (1999) 1.58
Regulatory T cells in immunologic self-tolerance and autoimmune disease. Int Rev Immunol (2005) 1.57
Blockade of adrenoreceptors inhibits the splenic response to stroke. Exp Neurol (2009) 1.53
Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J Immunol (2009) 1.46
Rapid estrogen signaling in the brain. Neurosignals (2008) 1.43
The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation. Stroke (2009) 1.38
Sex, sex steroids, and brain injury. Semin Reprod Med (2009) 1.35
Recombinant T cell receptor ligand treats experimental stroke. Stroke (2009) 1.33
Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat. J Neurochem (1998) 1.27
Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia. Mol Chem Neuropathol (1995) 1.26
Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain. J Steroid Biochem Mol Biol (2007) 1.24
Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases. Front Neuroendocrinol (2008) 1.23
Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Stroke (2005) 1.20
Estrogen regulates CCR gene expression and function in T lymphocytes. J Immunol (2005) 1.15
17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis. J Neurosci Res (2001) 1.14
Multiple pathways transmit neuroprotective effects of gonadal steroids. Endocrine (2006) 1.10
Gender and the injured brain. Anesth Analg (2008) 1.10
Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex. J Cereb Blood Flow Metab (1995) 1.08
Estrogen action in neuroprotection and brain inflammation. Ann N Y Acad Sci (2006) 0.99
Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis. Clin Immunol (2002) 0.94
Gender and estrogen manipulation do not affect traumatic brain injury in mice. J Neurotrauma (2007) 0.90
Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke (2009) 6.79
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature (2003) 5.04
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Experimental stroke induces massive, rapid activation of the peripheral immune system. J Cereb Blood Flow Metab (2006) 3.91
TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79
Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A (2006) 3.41
Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages. J Immunol (2006) 3.28
Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging. Radiology (2012) 2.90
T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation. J Cereb Blood Flow Metab (2007) 2.75
Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. J Cereb Blood Flow Metab (2005) 2.53
Decreased FOXP3 levels in multiple sclerosis patients. J Neurosci Res (2005) 2.39
An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci U S A (2003) 2.37
Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp Neurol (2004) 2.30
Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. Ann Neurol (2003) 2.22
Estrogen and ischemic neuroprotection: an integrated view. Trends Endocrinol Metab (2003) 1.90
GeneDB--an annotation database for pathogens. Nucleic Acids Res (2011) 1.82
GPR30 contributes to estrogen-induced thymic atrophy. Mol Endocrinol (2007) 1.78
Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment. J Immunol (2004) 1.77
Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions. J Leukoc Biol (2003) 1.65
Find duplicates among the PubMed, EMBASE, and Cochrane Library Databases in systematic review. PLoS One (2013) 1.63
Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke. J Neurosci (2011) 1.63
Ancient haplotypes of the HLA Class II region. Genome Res (2005) 1.62
Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. J Neurosci (2003) 1.62
Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1). Int Immunol (2007) 1.59
Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos (2010) 1.53
Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity. J Neurosci Res (2003) 1.53
Quantifying optical microangiography images obtained from a spectral domain optical coherence tomography system. Int J Biomed Imaging (2012) 1.50
The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha. Am J Pathol (2003) 1.49
Pain evaluation and response to buprenorphine in rats subjected to sham middle cerebral artery occlusion. Contemp Top Lab Anim Sci (2002) 1.48
Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J Immunol (2009) 1.46
Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway. J Neurosci Res (2006) 1.46
Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice. J Neurosci Methods (2004) 1.45
Parathyroid hormone-related protein induction in focal stroke: a neuroprotective vascular peptide. Am J Physiol Regul Integr Comp Physiol (2002) 1.43
Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain. J Cereb Blood Flow Metab (2006) 1.40
Gender-specific response to isoflurane preconditioning in focal cerebral ischemia. J Cereb Blood Flow Metab (2007) 1.38
Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation. J Immunol (2003) 1.37
Epoxyeicosanoid signaling in CNS function and disease. Prostaglandins Other Lipid Mediat (2009) 1.35
Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res (2010) 1.35
Sex, sex steroids, and brain injury. Semin Reprod Med (2009) 1.35
Deleterious effects of dihydrotestosterone on cerebral ischemic injury. J Cereb Blood Flow Metab (2007) 1.35
Recombinant T cell receptor ligand treats experimental stroke. Stroke (2009) 1.33
Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Science (2002) 1.33
CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke. Metab Brain Dis (2010) 1.33
Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right. J Immunol (2009) 1.32
Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch. J Immunol (2004) 1.30
Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection. J Infect Dis (2008) 1.29
Role of P450 aromatase in sex-specific astrocytic cell death. J Cereb Blood Flow Metab (2006) 1.29
Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE. J Neurochem (2006) 1.26
High resolution radiographic and fine immunologic definition of TB disease progression in the rhesus macaque. Microbes Infect (2006) 1.26
Oral feeding with ethinyl estradiol suppresses and treats experimental autoimmune encephalomyelitis in SJL mice and inhibits the recruitment of inflammatory cells into the central nervous system. J Immunol (2003) 1.26
Dose-dependent effects of androgens on outcome after focal cerebral ischemia in adult male mice. J Cereb Blood Flow Metab (2009) 1.25
Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice. J Neuroimmunol (2005) 1.24
Mechanisms of gender-linked ischemic brain injury. Restor Neurol Neurosci (2009) 1.24
Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection. Proc Natl Acad Sci U S A (2006) 1.24
Brain aromatization: classic roles and new perspectives. Semin Reprod Med (2009) 1.23
Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci U S A (2011) 1.22
Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Stroke (2005) 1.20
Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. Stroke (2002) 1.19
Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single recombinant T-cell receptor ligand. J Neurosci (2009) 1.18
Optical microangiography of retina and choroid and measurement of total retinal blood flow in mice. Biomed Opt Express (2012) 1.18
Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis. J Neuroimmunol (2009) 1.17