Published in Annu Rev Immunol on January 01, 2000
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med (2004) 8.98
Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med (2001) 7.86
Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med (2001) 7.46
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest (2003) 6.42
Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med (2001) 6.22
Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A (2002) 6.19
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med (2003) 6.00
Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med (2001) 5.56
Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest (2006) 4.72
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proc Natl Acad Sci U S A (2004) 4.70
The tumor microenvironment and its role in promoting tumor growth. Oncogene (2008) 4.66
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med (2002) 4.56
Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood (2007) 4.50
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med (2003) 4.41
Interleukin 2 signaling is required for CD4(+) regulatory T cell function. J Exp Med (2002) 3.94
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J Virol (2004) 3.58
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity (2008) 3.56
CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med (2001) 3.51
Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J Exp Med (2002) 3.47
Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med (2001) 3.47
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol (2004) 3.43
Certified professionals: CD4(+)CD25(+) suppressor T cells. J Exp Med (2001) 3.39
An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity (2011) 3.11
Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum (2007) 3.06
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest (2005) 3.04
Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu Rev Immunol (2008) 2.86
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med (2013) 2.85
A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med (2001) 2.81
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76
Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood (2005) 2.60
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med (2004) 2.58
Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood (2006) 2.42
Differentiation of T regulatory cells by immature dendritic cells. J Exp Med (2001) 2.35
Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc Natl Acad Sci U S A (2002) 2.35
CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther (2004) 2.25
Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques. Mucosal Immunol (2008) 2.23
Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses. J Exp Med (2002) 2.20
T cell regulation as a side effect of homeostasis and competition. J Exp Med (2003) 2.15
Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol (2005) 2.14
Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. J Exp Med (2005) 2.12
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc Natl Acad Sci U S A (2001) 2.04
Transplantation tolerance from a historical perspective. Nat Rev Immunol (2001) 2.04
Therapeutic targeting of Janus kinases. Immunol Rev (2008) 2.03
Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest (2006) 2.02
The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age. Clin Exp Immunol (2005) 2.01
Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression. Neuroscience (2008) 2.01
Testing the NKT cell hypothesis of human IDDM pathogenesis. J Clin Invest (2002) 1.98
Selection of self-reactive T cells in the thymus. Annu Rev Immunol (2011) 1.98
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev (2007) 1.98
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells. Immunity (2014) 1.95
Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala). J Clin Invest (2003) 1.95
Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut (2005) 1.95
IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J Immunol (2008) 1.93
Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis. J Exp Med (2004) 1.89
CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med (2006) 1.88
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med (2009) 1.85
Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood. Immunology (2002) 1.81
Regulatory functions of CD8+CD28- T cells in an autoimmune disease model. J Clin Invest (2003) 1.76
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. J Immunol (2009) 1.75
The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery. J Clin Invest (2003) 1.75
Dysfunctional T regulatory cells in multiple myeloma. Blood (2005) 1.72
The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis. Shock (2007) 1.71
Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. Proc Natl Acad Sci U S A (2010) 1.71
Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes. Blood (2004) 1.69
An integrated view of suppressor T cell subsets in immunoregulation. J Clin Invest (2004) 1.69
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci U S A (2004) 1.69
Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer. Br J Cancer (2005) 1.69
LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med (2005) 1.65
CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism. J Clin Invest (2004) 1.63
Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc Natl Acad Sci U S A (2001) 1.62
Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Immunity (2015) 1.62
Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J Exp Med (2001) 1.59
Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med (2003) 1.59
Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc Natl Acad Sci U S A (2002) 1.58
How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A (2005) 1.55
TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol (2008) 1.49
CD4+CD25+ suppressor lymphocytes in the circulation of patients immunized against melanoma antigens. J Immunother (2003) 1.47
Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells. Proc Natl Acad Sci U S A (2003) 1.47
Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells. Proc Natl Acad Sci U S A (2006) 1.47
How diverse--CD4 effector T cells and their functions. J Mol Cell Biol (2009) 1.44
Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels. Clin Exp Immunol (2006) 1.43
Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment. Crit Rev Oncol Hematol (2008) 1.42
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. Nat Immunol (2013) 1.42
Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras. Proc Natl Acad Sci U S A (2007) 1.42
CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. Proc Natl Acad Sci U S A (2001) 1.41
Chronic stress and susceptibility to skin cancer. J Natl Cancer Inst (2005) 1.41
FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect (2009) 1.40
Molecular orchestration of differentiation and function of regulatory T cells. Genes Dev (2009) 1.38
Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol (2009) 1.37
Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice. Infect Immun (2007) 1.36
T cell homeostasis and systemic autoimmunity. J Clin Invest (2001) 1.35
CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1. J Virol (2004) 1.34
Stromal regulatory T-cells are associated with a favourable prognosis in gastric cancer of the cardia. BMC Gastroenterol (2009) 1.34
Increased CD4+ CD25+ T regulatory cell activity in trauma patients depresses protective Th1 immunity. Ann Surg (2006) 1.31
Transcriptional regulation of IL-2 in health and autoimmunity. Autoimmun Rev (2008) 1.31
CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer. J Exp Med (2002) 1.31
The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases. Arthritis Res (2002) 1.30