bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.

PubWeight™: 1.40‹?› | Rank: Top 5%

🔗 View Article (PMC 41932)

Published in Proc Natl Acad Sci U S A on May 09, 1995

Authors

M González-García1, I García, L Ding, S O'Shea, L H Boise, C B Thompson, G Núñez

Author Affiliations

1: Department of Pathology and Anatomy, University of Michigan Medical School, Ann Arbor 48109, USA.

Articles citing this

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J Exp Med (1996) 1.79

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nat Rev Neurosci (2012) 1.69

Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult. J Cell Biol (2002) 1.69

Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol Cell Biol (1998) 1.41

p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors. J Cell Biol (1998) 1.36

Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. Proc Natl Acad Sci U S A (2004) 1.27

Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis. Mol Cell Biol (1998) 1.24

A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity (1997) 1.19

Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain. J Neurosci (2006) 1.19

Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha. J Cell Biol (2001) 1.16

SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. J Cell Biol (2003) 1.12

Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J Neurosci (2008) 1.06

Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons. EMBO J (2005) 1.05

GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway. J Cell Biol (2003) 1.03

BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina. Mol Neurodegener (2011) 1.02

Heat acclimation provides sustained improvement in functional recovery and attenuates apoptosis after traumatic brain injury. J Cereb Blood Flow Metab (2009) 1.00

Ontogeny of sex differences in the mammalian hypothalamus and preoptic area. Cell Mol Neurobiol (1997) 0.97

Expression of cellular oncogene Bcl-xL prevents coronavirus-induced cell death and converts acute infection to persistent infection in progenitor rat oligodendrocytes. J Virol (2005) 0.94

The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy (2014) 0.92

Bcl-xL protects adult septal cholinergic neurons from axotomized cell death. Proc Natl Acad Sci U S A (1998) 0.90

Interleukin 3 prevents delayed neuronal death in the hippocampal CA1 field. J Exp Med (1998) 0.90

Anti-apoptotic BCL-2 family proteins in acute neural injury. Front Cell Neurosci (2014) 0.90

The nuclear events guiding successful nerve regeneration. Front Mol Neurosci (2011) 0.89

A G-tract element in apoptotic agents-induced alternative splicing. Nucleic Acids Res (2008) 0.88

Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2. Mol Vis (2009) 0.88

In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XL. J Biol Chem (2010) 0.88

The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins. J Virol (2003) 0.88

Regulation of synaptic transmission by mitochondrial ion channels. J Bioenerg Biomembr (2004) 0.88

Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Exp Eye Res (2010) 0.87

The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L). Mol Cell Biol (1999) 0.86

Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons. J Cell Biol (2001) 0.86

Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL. J Biomed Sci (2011) 0.86

Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat. J Neurotrauma (2003) 0.85

Anti-apoptotic therapy with a Tat fusion protein protects against excitotoxic insults in vitro and in vivo. Exp Neurol (2007) 0.83

ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage. J Neurosci (2014) 0.81

A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death. Am J Pathol (1996) 0.81

Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells. Graefes Arch Clin Exp Ophthalmol (2005) 0.81

Muller cell expression of glutamate cycle related proteins and anti-apoptotic proteins in early human retinal development. Br J Ophthalmol (2006) 0.80

A high soy diet reduces programmed cell death and enhances bcl-xL expression in experimental stroke. Neuroscience (2007) 0.79

Detrimental effects of antiapoptotic treatments in spinal cord injury. Exp Neurol (2007) 0.79

Defining the role of the Bcl-2 family proteins in Huntington's disease. Cell Death Dis (2013) 0.78

The roles of Bcl-xL in modulating apoptosis during development of Xenopus laevis. BMC Dev Biol (2005) 0.77

Axotomized neonatal motoneurons overexpressing the bcl2 proto-oncogene retain functional electrophysiological properties. Proc Natl Acad Sci U S A (1996) 0.77

Increased expression of the anti-apoptotic protein Bcl-xL in the brain is associated with resilience to stress-induced depression-like behavior. Cell Mol Neurobiol (2012) 0.77

microRNA Expression Profiling of Propofol-Treated Developing Rat Hippocampal Astrocytes. DNA Cell Biol (2015) 0.77

Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors. J Neurosci (2016) 0.75

Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma. Mol Vis (2016) 0.75

Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins. Neurochem Int (2017) 0.75

Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Cell Death Differ (2017) 0.75

Articles cited by this

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39

Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (1993) 10.83

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell (1993) 7.25

Cell death during development of the nervous system. Annu Rev Neurosci (1991) 6.37

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res (1993) 5.83

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci U S A (1991) 5.50

Programmed cell death and the control of cell survival: lessons from the nervous system. Science (1993) 4.63

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science (1993) 4.53

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J Cell Biol (1988) 4.06

Trophic factors and neuronal survival. Neuron (1989) 3.66

bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development (1994) 3.34

Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron (1993) 2.83

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci U S A (1994) 2.66

Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science (1992) 2.60

Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci U S A (1994) 2.58

Ultrastructural localization of bcl-2 protein. J Histochem Cytochem (1992) 2.48

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J (1994) 2.16

Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol (1993) 2.16

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell (1993) 2.01

Long-term culture of dissociated sympathetic neurons. Methods Enzymol (1979) 1.89

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc Natl Acad Sci U S A (1994) 1.76

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development (1994) 1.40

Bcl-2 protein expression during murine development. Am J Pathol (1994) 1.23

Bcl-2 affects survival but not neuronal differentiation of PC12 cells. J Neurosci (1993) 1.02

Thrombospondin 3 is a developmentally regulated heparin binding protein. J Biol Chem (1994) 0.96

Articles by these authors

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39

CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 9.80

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 9.73

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell (1997) 8.61

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35

Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science (1989) 7.78

Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93

The B7 and CD28 receptor families. Immunol Today (1994) 6.38

Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. Ann Neurol (1999) 5.83

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev (2001) 5.66

Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol (2001) 5.10

Role of the CD28 receptor in T-cell activation. Immunol Today (1990) 4.89

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol Cell Biol (1987) 4.76

Epidemiological evidence of the spread of a Mycobacterium tuberculosis strain of the Beijing genotype on Gran Canaria Island. Am J Respir Crit Care Med (2001) 4.75

Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature (1997) 4.55

Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol Cell (1999) 4.55

Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature (1985) 4.35

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia (2011) 4.28

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A (1995) 4.22

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell (2000) 4.10

Bax-independent inhibition of apoptosis by Bcl-XL. Nature (1996) 3.82

Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem (1999) 3.81

Barrel-stave model or toroidal model? A case study on melittin pores. Biophys J (2001) 3.80

c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells. Nature (1985) 3.72

T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol (2001) 3.59

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J (1996) 3.57

Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science (1987) 3.49

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA. Mol Cell Biol (1991) 3.48

Expression of the c-myb proto-oncogene during cellular proliferation. Nature (1986) 3.45

An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem (2000) 3.44

IL-7 enhances the survival and maintains the size of naive T cells. J Immunol (2001) 3.39

bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development (1994) 3.34

Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. Genes Dev (1998) 3.33

Characterization of XIAP-deficient mice. Mol Cell Biol (2001) 3.32

Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol (1998) 3.32

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci U S A (1994) 3.26

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J Biol Chem (2001) 3.22

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol (1999) 3.17

Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00

Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells. J Immunol (1997) 2.98

Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med (1995) 2.94

Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia (2013) 2.85

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes. J Immunol (1990) 2.84

Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. J Biol Chem (2001) 2.76

Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer. Science (1990) 2.76

Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol (1996) 2.69

Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science (1991) 2.65

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med (1993) 2.62

Novel fluorescent protein from Discosoma coral and its mutants possesses a unique far-red fluorescence. FEBS Lett (2000) 2.61

Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J Immunol (1993) 2.55

Measuring nicotine dependence among high-risk adolescent smokers. Addict Behav (1996) 2.54

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proc Natl Acad Sci U S A (2000) 2.46

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J (1999) 2.45

CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J (1998) 2.44

Detection of the plasmid-mediated quinolone resistance determinant qnr among clinical isolates of Klebsiella pneumoniae producing AmpC-type beta-lactamase. J Antimicrob Chemother (2003) 2.37

Guidelines for the management of HIV infection in pregnant women and the prevention of mother-to-child transmission. HIV Med (2001) 2.33

Absence of B7-dependent responses in CD28-deficient mice. Immunity (1994) 2.32

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev (1996) 2.30

The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ (2000) 2.29

AU RNA-binding factors differ in their binding specificities and affinities. J Biol Chem (1992) 2.25

Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2000) 2.24

CD28 ligation in T-cell activation: evidence for two signal transduction pathways. Blood (1990) 2.21

Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function. Proc Natl Acad Sci U S A (1999) 2.18

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J (1994) 2.16

Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol Cell Biol (1997) 2.15

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment. Cell (1987) 2.15

Expression of bcl-xL can confer a multidrug resistance phenotype. Blood (1995) 2.11

CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity (1996) 2.09

Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins. Mol Cell Biol (1995) 2.07

Viremia, virus excretion, and antibody responses after challenge in volunteers with low levels of antibody to rubella virus. J Infect Dis (1983) 2.07

Estimation of the cortical functional connectivity with the multimodal integration of high-resolution EEG and fMRI data by directed transfer function. Neuroimage (2005) 2.06

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci U S A (1998) 2.04

Evolutionarily conserved Ets family members display distinct DNA binding specificities. J Exp Med (1992) 2.04

Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ (2003) 2.01

Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci U S A (1995) 2.00

New mutations associated with resistance not detected following zidovudine monotherapy in pregnancy when used in accordance with British HIV Association guidelines. HIV Med (2008) 1.99

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). EMBO J (1997) 1.97

Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. Proc Natl Acad Sci U S A (1990) 1.96

Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol (1982) 1.96

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci U S A (1998) 1.95