Published in Proc Natl Acad Sci U S A on May 15, 1991
Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79
Construction and characterization of a bacterial artificial chromosome library of Sorghum bicolor. Nucleic Acids Res (1994) 3.94
The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med (1998) 2.56
Forward and reverse genetic approaches to behavior in the mouse. Science (1994) 2.20
Molecular definition of the 22q11 deletions in velo-cardio-facial syndrome. Am J Hum Genet (1995) 2.19
Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc Natl Acad Sci U S A (1998) 2.15
Dissection of the fusarium I2 gene cluster in tomato reveals six homologs and one active gene copy. Plant Cell (1998) 1.76
Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice. Proc Natl Acad Sci U S A (2000) 1.57
Marked improvement of PAC and BAC cloning is achieved using electroelution of pulsed-field gel-separated partial digests of genomic DNA. Nucleic Acids Res (1997) 1.51
Generating transgenic mice from bacterial artificial chromosomes: transgenesis efficiency, integration and expression outcomes. Transgenic Res (2009) 1.43
A method for the generation of YAC transgenic mice by pronuclear microinjection. Nucleic Acids Res (1993) 1.40
Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism. Mol Med (1995) 1.32
Transgenic mice generated by pronuclear injection of a yeast artificial chromosome. Nucleic Acids Res (1992) 1.24
Recombination during transformation as a source of chimeric mammalian artificial chromosomes in yeast (YACs). Nucleic Acids Res (1994) 1.19
Evi-5, a common site of retroviral integration in AKXD T-cell lymphomas, maps near Gfi-1 on mouse chromosome 5. J Virol (1995) 1.14
Isolation and characterization of a MAGE gene family in the Xp21.3 region. Proc Natl Acad Sci U S A (1995) 1.13
Identification of mutations in the Wiskott-Aldrich syndrome gene and characterization of a polymorphic dinucleotide repeat at DXS6940, adjacent to the disease gene. Proc Natl Acad Sci U S A (1995) 1.13
Fluorescence in situ hybridisation of multiple probes on a single microscope slide. Nucleic Acids Res (1994) 1.13
Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc Natl Acad Sci U S A (1995) 1.13
A sea urchin genome project: sequence scan, virtual map, and additional resources. Proc Natl Acad Sci U S A (2000) 1.10
Mapping the mouse genome: current status and future prospects. Proc Natl Acad Sci U S A (1995) 1.08
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem J (1997) 1.08
Small marker X chromosomes lack the X inactivation center: implications for karyotype/phenotype correlations. Am J Hum Genet (1994) 1.08
Genomic analysis using a yeast artificial chromosome library with mouse DNA inserts. Proc Natl Acad Sci U S A (1992) 1.07
Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus. BMC Genomics (2005) 1.07
The direct screening of cosmid libraries with YAC clones. Nucleic Acids Res (1991) 1.04
Meiotic transmission of an in vitro-assembled autonomous maize minichromosome. PLoS Genet (2007) 1.02
Creation of a deletion series of mouse YACs covering a 500 kb region around Xist. Nucleic Acids Res (1994) 0.98
High-resolution genetic map around the spinal muscular atrophy (SMA) locus on chromosome 5. Am J Hum Genet (1992) 0.97
Structure and expression of the mouse casein gene locus. Mamm Genome (1997) 0.95
Structural analysis of chromosomal rearrangements associated with the developmental mutations Ph, W19H, and Rw on mouse chromosome 5. Proc Natl Acad Sci U S A (1994) 0.94
Delineation of the dystonia-parkinsonism syndrome locus in Xq13. Proc Natl Acad Sci U S A (1992) 0.92
A giant novel gene undergoing extensive alternative splicing is severed by a Cornelia de Lange-associated translocation breakpoint at 3q26.3. Hum Genet (2004) 0.92
Rapid restriction analysis of YAC clones. Nucleic Acids Res (1994) 0.92
Isolation of candidate hybrid sterility 1 genes by cDNA selection in a 1.1 megabase pair region on mouse chromosome 17. Mamm Genome (1997) 0.92
Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. Genetics (2002) 0.86
Assembly of eukaryotic algal chromosomes in yeast. J Biol Eng (2013) 0.84
The structure of DXF34, a human X-linked sequence family with homology to a transcribed mouse Y-linked repeat. Mamm Genome (1997) 0.84
Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation. Mamm Genome (1997) 0.84
A Chlamydomonas genomic library in yeast artificial chromosomes. Genetics (1995) 0.84
A novel Ty1-mediated fragmentation method for native and artificial yeast chromosomes reveals that the mouse steel gene is a hotspot for Ty1 integration. Genetics (1996) 0.83
Rapid cloning of mouse DNA as yeast artificial chromosomes by transformation-associated recombination (TAR). Mamm Genome (1998) 0.83
Characterization and mapping of the human SOX4 gene. Mamm Genome (1993) 0.82
Physical and comparative mapping of distal mouse chromosome 16. 5 p5. Genome Res (1998) 0.82
Conserved sequence-tagged sites: a phylogenetic approach to genome mapping. Proc Natl Acad Sci U S A (1992) 0.82
Linkage disequilibrium and physical mapping of X-linked juvenile retinoschisis. Am J Hum Genet (1997) 0.81
Mouse chromosome 16. Mamm Genome (1992) 0.81
Integration of image analysis and robotics into a fully automated colony picking and plate handling system. Nucleic Acids Res (1992) 0.81
Chlorambucil-induced mutations in mice recovered in homozygotes. Proc Natl Acad Sci U S A (1992) 0.81
Vector-hexamer PCR isolation of all insert ends from a YAC contig of the mouse Igh locus. Genome Res (1998) 0.80
Linkage disequilibrium and physical mapping of Pas1 in mice. Genome Res (1999) 0.79
The role of recombination and RAD52 in mutation of chromosomal DNA transformed into yeast. Nucleic Acids Res (1994) 0.78
Yeast artificial chromosomes for the molecular analysis of the familial polyposis APC gene region. Proc Natl Acad Sci U S A (1992) 0.78
Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. Genome Res (1998) 0.77
Efficient size-independent chromosome delivery from yeast to cultured cell lines. Nucleic Acids Res (2016) 0.76
Construction and characterization of a large insert porcine YAC library. Mamm Genome (1997) 0.76
Transgenesis in the rat and larger mammals. J Clin Invest (1996) 0.76
Microsatellite markers for the cone-rod retinal dystrophy gene, CRX, on 19q13.3. J Med Genet (1998) 0.75
Centromeric and noncentromeric ADE2-selectable fragmentation vectors for yeast artificial chromosomes in AB1380. Genome Res (1997) 0.75
High-resolution landmark framework for the sequence-ready mapping of Xq23-q26.1. Genome Res (1999) 0.75
Comparison of YACs containing mouse centromeric satellite sequences cloned in rad52 and RAD52 host strains. Mamm Genome (1998) 0.75
Mouse X chromosome. Mamm Genome (1992) 0.75
Rapid mapping of markers applying vectorette technology to YAC fragmentation allows easy assembly of a high-density STS bacterial clone contig spanning the markers D6S1260-D6S1918. Mamm Genome (1998) 0.75
A yeast artificial chromosome (YAC) library containing 10 haploid chicken genome equivalents. Mamm Genome (1997) 0.75
Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science (1987) 17.15
Genome linking with yeast artificial chromosomes. Nature (1988) 7.39
Systematic screening of yeast artificial-chromosome libraries by use of the polymerase chain reaction. Proc Natl Acad Sci U S A (1990) 6.20
Transformation of yeast spheroplasts without cell fusion. Anal Biochem (1987) 4.64
Construction of yeast artificial chromosome libraries with large inserts using fractionation by pulsed-field gel electrophoresis. Nucleic Acids Res (1989) 2.90
A large inverted duplication allows homologous recombination between chromosomes heterozygous for the proximal t complex inversion. Cell (1987) 2.88
Mapping the Drosophila genome with yeast artificial chromosomes. Science (1989) 2.04
Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA X Fe(II). Proc Natl Acad Sci U S A (1983) 1.92
Construction of human chromosome 21-specific yeast artificial chromosomes. Proc Natl Acad Sci U S A (1989) 1.83
Transfer of a yeast artificial chromosome carrying human DNA from Saccharomyces cerevisiae into mammalian cells. Proc Natl Acad Sci U S A (1990) 1.60
Yeast artificial chromosomes: an alternative approach to the molecular analysis of mouse developmental mutations. Genet Res (1991) 1.05
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry (1977) 38.82
Lambda replacement vectors carrying polylinker sequences. J Mol Biol (1983) 32.76
Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals. Cell (1987) 16.01
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell (1996) 12.59
A physical map of the human genome. Nature (2001) 12.39
The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein. Cell (1988) 10.75
The DNA sequence of human chromosome 21. Nature (2000) 10.66
A forkhead-domain gene is mutated in a severe speech and language disorder. Nature (2001) 9.25
Nucleotide sequence of cdna coding for Semliki Forest virus membrane glycoproteins. Nature (1980) 8.07
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell (1997) 7.59
Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene. Nature (1986) 6.45
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature (1986) 6.34
Rapid restriction mapping of DNA cloned in lambda phage vectors. Gene (1984) 6.25
An integrated and simplified approach to cloning into plasmids and single-stranded phages. Methods Enzymol (1983) 5.81
RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. EMBO J (2001) 5.70
Studies on heterologous anti-lymphocyte serum in mice. I. In vitro and in vivo properties. J Immunol (1966) 5.59
Specific cloning of DNA fragments absent from the DNA of a male patient with an X chromosome deletion. Proc Natl Acad Sci U S A (1985) 5.50
Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segment. Nature (1985) 4.62
Normalization strategies for cDNA microarrays. Nucleic Acids Res (2000) 4.61
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology. Proc Natl Acad Sci U S A (1999) 4.58
Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response. J Immunol (1966) 4.49
Cloning of the T gene required in mesoderm formation in the mouse. Nature (1990) 4.20
Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy. Nature (1986) 4.13
DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature (2004) 4.12
Selective isolation of cosmid clones by homologous recombination in Escherichia coli. Proc Natl Acad Sci U S A (1984) 4.11
A subcloning strategy for DNA sequence analysis. Nucleic Acids Res (1980) 4.06
Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein. Nat Genet (1993) 3.63
High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe. Cell (1993) 3.56
An improved method for isolation of mouse pancreatic islets. Transplantation (1985) 3.52
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry (2007) 3.49
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. Mol Biol Cell (2001) 3.41
Construction and characterization of a 2.5-kilobase procollagen clone. Proc Natl Acad Sci U S A (1978) 3.26
The capsid protein of Semliki Forest virus has clusters of basic amino acids and prolines in its amino-terminal region. Proc Natl Acad Sci U S A (1980) 3.26
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet (1999) 3.25
Derivation of clones close to met by preparative field inversion gel electrophoresis. Science (1987) 3.21
Analysis of cosmids using linearization by phage lambda terminase. Gene (1985) 2.98
Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2. Nat Genet (2000) 2.96
The UTX gene escapes X inactivation in mice and humans. Hum Mol Genet (1998) 2.91
A large inverted duplication allows homologous recombination between chromosomes heterozygous for the proximal t complex inversion. Cell (1987) 2.88
Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates. Methods Enzymol (1999) 2.65
Localization and cloning of Xp21 deletion breakpoints involved in muscular dystrophy. Hum Genet (1987) 2.64
Construction and use of human chromosome jumping libraries from NotI-digested DNA. Nature (1987) 2.58
Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes. Cell (1984) 2.55
Sequence interpretation. Functional annotation of mouse genome sequences. Science (2001) 2.54
A complete BAC-based physical map of the Arabidopsis thaliana genome. Nat Genet (1999) 2.47
Adult Thymectomy: Effect on Recovery from Immunologic Depression in Mice. Science (1965) 2.41
Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes. Cell (1986) 2.40
A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia. Am J Hum Genet (1999) 2.38
Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4. Science (1995) 2.38
Procollagen complementary DNA, a probe for messenger RNA purification and the number of type I collagen genes. Biochemistry (1978) 2.37
Deletions in immunoglobulin mu chains. EMBO J (1982) 2.35
Localisation of a gene implicated in a severe speech and language disorder. Nat Genet (1998) 2.33
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum Mol Genet (2001) 2.29
Huntington disease-linked locus D4S111 exposed as the alpha-L-iduronidase gene. Somat Cell Mol Genet (1991) 2.23
Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells. Nat Genet (2000) 2.22
Influence of rejection therapy on fungal and nocardial infections in renal-transplant recipients. Lancet (1973) 2.22
Construction, arraying, and high-density screening of large insert libraries of human chromosomes X and 21: their potential use as reference libraries. Proc Natl Acad Sci U S A (1991) 2.21
Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7. EMBO J (1986) 2.19
Construction of recombinant plasmids containing rat muscle actin and myosin light chain DNA sequences. Proc Natl Acad Sci U S A (1980) 2.17
Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation (1987) 2.14
A physical map of 4 million bp around the Duchenne muscular dystrophy gene on the human X-chromosome. Cell (1986) 2.12
Construction and characterization of pro alpha 1 collagen complementary deoxyribonucleic acid clones. Biochemistry (1979) 2.08
A 10-megabase physical map of human Xp21, including the Duchenne muscular dystrophy gene. Genomics (1988) 2.04
A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Nucleic Acids Res (1998) 2.01
Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. Hum Mol Genet (1994) 2.00
Hybridization fingerprinting of high-density cDNA-library arrays with cDNA pools derived from whole tissues. Mamm Genome (1992) 1.99
Molecular approaches to mammalian genetics. Cold Spring Harb Symp Quant Biol (1986) 1.99
Pulmonary nocardiosis. Therapy with minocycline and with erythromycin plus ampicillin. JAMA (1973) 1.94
Complete coverage of the Schizosaccharomyces pombe genome in yeast artificial chromosomes. Nat Genet (1992) 1.93
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system. Hum Mol Genet (1997) 1.90
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. Proc Natl Acad Sci U S A (2000) 1.88
Complex patterns of linkage disequilibrium in the Huntington disease region. Am J Hum Genet (1991) 1.84
Possible active enhancement of a human cadaver renal allograft with antilymphocyte serum (ALS) and donor bone marrow: case report of an initial attempt. Surgery (1976) 1.84
Antiserum to lymphocytes: prolonged survival of canine renal allografts. Science (1966) 1.81
Familial infantile convulsions and paroxysmal choreoathetosis: a new neurological syndrome linked to the pericentromeric region of human chromosome 16. Am J Hum Genet (1997) 1.79
Two hundred one consecutive living-donor nephrectomies. Arch Surg (1998) 1.75
Analysis of IMGSAC autism susceptibility loci: evidence for sex limited and parent of origin specific effects. J Med Genet (2005) 1.74
A conserved sorting-associated protein is mutant in chorea-acanthocytosis. Nat Genet (2001) 1.69
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum Mol Genet (1997) 1.69
Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects. Behav Genet (2010) 1.67
Hybridization analyses of arrayed cDNA libraries. Trends Genet (1991) 1.66
Automated image analysis for array hybridization experiments. Bioinformatics (2001) 1.66
Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat. Somat Cell Mol Genet (1994) 1.66
Conservation of the Duchenne muscular dystrophy gene in mice and humans. Science (1987) 1.66
Analysis of the human VPS13 gene family. Genomics (2004) 1.65
Miniature genome in the marine chordate Oikopleura dioica. Science (2001) 1.65
A missense mutation in connexin26, D66H, causes mutilating keratoderma with sensorineural deafness (Vohwinkel's syndrome) in three unrelated families. Hum Mol Genet (1999) 1.65
Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein. Cell (1994) 1.65
Molecular probes define different regions of the mouse t complex. Cell (1985) 1.65
Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP). Hum Mol Genet (1997) 1.64
SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. Mol Cell (1998) 1.64
Protein microarrays for gene expression and antibody screening. Anal Biochem (1999) 1.64
FOXP2 is not a major susceptibility gene for autism or specific language impairment. Am J Hum Genet (2002) 1.63
Some effects of purified heterologous antihuman lymphocyte serum in man. Transplantation (1967) 1.62
Effect of adult thymectomy on the recovery from immunological depression induced by anti-lymphocyte serum. Surg Forum (1965) 1.60