Published in Proc Natl Acad Sci U S A on March 15, 1992
Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc Natl Acad Sci U S A (1998) 2.15
A new vector for recombination-based cloning of large DNA fragments from yeast artificial chromosomes. Nucleic Acids Res (1995) 1.80
Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus. Genetics (1995) 1.72
Expression of Cre recombinase in dopaminoceptive neurons. BMC Neurosci (2007) 1.19
Recombination during transformation as a source of chimeric mammalian artificial chromosomes in yeast (YACs). Nucleic Acids Res (1994) 1.19
Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis. EMBO J (1997) 1.04
Fine structure mapping and deletion analysis of the murine piebald locus. Genetics (1994) 1.01
Systematic screening of an arrayed cDNA library by PCR. Proc Natl Acad Sci U S A (1995) 0.92
Vector-hexamer PCR isolation of all insert ends from a YAC contig of the mouse Igh locus. Genome Res (1998) 0.80
The role of recombination and RAD52 in mutation of chromosomal DNA transformed into yeast. Nucleic Acids Res (1994) 0.78
Genetic and physical mapping of the mouse Ulnaless locus. Genetics (1996) 0.77
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Genomic sequencing. Proc Natl Acad Sci U S A (1984) 92.36
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem (1984) 66.58
Separation of large DNA molecules by contour-clamped homogeneous electric fields. Science (1986) 21.33
Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science (1987) 17.15
An electrophoretic karyotype for yeast. Proc Natl Acad Sci U S A (1985) 11.84
Germ-line transformation of mice. Annu Rev Genet (1986) 8.67
A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones. Nucleic Acids Res (1990) 8.52
Systematic screening of yeast artificial-chromosome libraries by use of the polymerase chain reaction. Proc Natl Acad Sci U S A (1990) 6.20
Isolation of single-copy human genes from a library of yeast artificial chromosome clones. Science (1989) 5.29
The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics (1937) 4.70
Production of single-stranded DNA templates by exonuclease digestion following the polymerase chain reaction. Nucleic Acids Res (1989) 4.70
Transformation of yeast spheroplasts without cell fusion. Anal Biochem (1987) 4.64
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature (1986) 3.30
Yeast artificial chromosome libraries containing large inserts from mouse and human DNA. Proc Natl Acad Sci U S A (1991) 2.89
Genetic analysis of the mouse using interspecific crosses. Trends Genet (1988) 2.64
Dispersion of alpha-like globin genes of the mouse to three different chromosomes. Nature (1981) 2.44
A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis. Cell (1978) 1.54
Preparation of clone libraries in yeast artificial-chromosome vectors. Methods Enzymol (1991) 1.51
Rescue of end fragments of yeast artificial chromosomes by homologous recombination in yeast. Nucleic Acids Res (1991) 1.30
Knobbly, a new dominant mutation in the mouse that affects embryonic ectoderm organization. Genet Res (1984) 1.22
A mouse genomic library of yeast artificial chromosome clones. Mamm Genome (1991) 1.07
An alpha globin pseudogene is located within the mouse t complex. Immunogenetics (1984) 1.02
Genetic analysis of mutations at the fused locus in the mouse. Proc Natl Acad Sci U S A (1986) 0.96
The use of interspecific mouse crosses for gene localization: present status and future perspectives. Curr Top Microbiol Immunol (1988) 0.83
Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science (1987) 17.15
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature (1996) 16.92
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature (2004) 16.76
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature (2000) 12.97
Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the U.S. Diabetes Care (2001) 9.76
The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites. Cell (1978) 9.73
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res (1997) 7.95
Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia. Proc Natl Acad Sci U S A (2005) 7.12
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature (1995) 6.18
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell (1997) 6.10
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci U S A (1995) 5.92
Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature (1995) 5.91
Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia? J Virol (2005) 5.78
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell (1998) 5.78
The product of the H19 gene may function as an RNA. Mol Cell Biol (1990) 5.61
An integrated nanoliter DNA analysis device. Science (1998) 5.40
Genetic diversity and disease control in rice. Nature (2000) 5.34
Isolation of single-copy human genes from a library of yeast artificial chromosome clones. Science (1989) 5.29
Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A (1977) 5.28
Parental imprinting of the mouse H19 gene. Nature (1991) 5.13
Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels. Cell (2000) 5.08
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell (1999) 5.07
Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature (1995) 4.93
NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol (2000) 4.75
Emergence and predominance of an H5N1 influenza variant in China. Proc Natl Acad Sci U S A (2006) 4.49
A transcriptional switch mediated by cofactor methylation. Science (2001) 4.32
Genomic imprinting in mammals. Annu Rev Genet (1997) 4.21
A paternal-specific methylation imprint marks the alleles of the mouse H19 gene. Nat Genet (1995) 4.12
Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proc Natl Acad Sci U S A (1978) 4.02
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis. Proc Natl Acad Sci U S A (1978) 3.88
Superconductivity at 43 K in SmFeAsO1-xFx. Nature (2008) 3.80
Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene (1977) 3.79
The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia (2008) 3.69
Generation of coated intermediates of clathrin-mediated endocytosis on protein-free liposomes. Cell (1998) 3.62
Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam. Virology (2006) 3.59
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome. Cell (2000) 3.59
Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions. Science (1997) 3.59
Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. J Virol (2005) 3.51
Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding. J Exp Med (1997) 3.48
Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44
Epigenetic mechanisms underlying the imprinting of the mouse H19 gene. Genes Dev (1993) 3.42
Prevalence and genetic diversity of coronaviruses in bats from China. J Virol (2006) 3.37
Transcriptional control of the murine albumin/alpha-fetoprotein locus during development. Proc Natl Acad Sci U S A (1982) 3.37
A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell (1999) 3.36
The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse. J Biol Chem (1981) 3.26
Genomic imprinting is disrupted in interspecific Peromyscus hybrids. Nat Genet (1998) 3.22
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature (1997) 3.14
The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000 to 2005. J Virol (2007) 3.12
An enhancer deletion affects both H19 and Igf2 expression. Genes Dev (1995) 3.09
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08
Plasma urate and risk of Parkinson's disease. Am J Epidemiol (2007) 3.06
Multiple regulatory elements in the intergenic region between the alpha-fetoprotein and albumin genes. Mol Cell Biol (1986) 2.83
The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem (1996) 2.75
The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev (2000) 2.68
Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat Med (1998) 2.64
The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol Cell Biol (1991) 2.63
The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev (1998) 2.58
Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Nature (2000) 2.57
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol (1997) 2.51
Phenotypes Associated with SHOX Deficiency. J Clin Endocrinol Metab (2001) 2.51
Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005. J Virol (2006) 2.47
Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet (1995) 2.46
The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature (1999) 2.42
Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179). J Biol Chem (2001) 2.42
Structure and emergence of specific olfactory glomeruli in the mouse. J Neurosci (2001) 2.40
Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene (2011) 2.36
Infection of immunocompromised patients by avian H9N2 influenza A virus. J Infect (2011) 2.29
An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature (1997) 2.29
Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1. J Biol Chem (1995) 2.28
Establishment of influenza A virus (H6N1) in minor poultry species in southern China. J Virol (2007) 2.26
Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev (1997) 2.25
Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol Cell Biol (1998) 2.23
Colloid cyst of the third ventricle: imaging-pathologic correlation. AJNR Am J Neuroradiol (2000) 2.23
Two-dimensional imaging through diffusing media using 150-fs gated electronic holography techniques. Opt Lett (1991) 2.21
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat Neurosci (2000) 2.20
A comparison of two cloned mouse beta-globin genes and their surrounding and intervening sequences. Cell (1978) 2.20
Nitrogen fixation ability of exopolysaccharide synthesis mutants of Rhizobium sp. strain NGR234 and Rhizobium trifolii is restored by the addition of homologous exopolysaccharides. J Bacteriol (1987) 2.17
Evolutionary insights into the ecology of coronaviruses. J Virol (2007) 2.16
Crystal structure of a human TATA box-binding protein/TATA element complex. Proc Natl Acad Sci U S A (1996) 2.15
Exploring genome space. Nature (2000) 2.15
Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells. J Biol Chem (1998) 2.13
Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell (2000) 2.11
Cloning human telomeric DNA fragments into Saccharomyces cerevisiae using a yeast-artificial-chromosome vector. Proc Natl Acad Sci U S A (1989) 2.10
Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector. Nat Med (1999) 2.07
Mapping the Drosophila genome with yeast artificial chromosomes. Science (1989) 2.04
Fine-structure mapping of the three mouse alpha-fetoprotein gene enhancers. Mol Cell Biol (1988) 2.04
Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell (1996) 2.04
The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. Virology (2008) 2.04
Tissue-specific activation of a cloned alpha-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line. Nature (1984) 2.02
Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum (1998) 2.00
Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr (1999) 1.99
Competitive edge at the imprinted Prader-Willi/Angelman region? Nat Genet (1998) 1.99
The structure and expression of a novel gene activated in early mouse embryogenesis. EMBO J (1988) 1.98
Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product. Ophthalmologica (1997) 1.98
Regulation of Akt/PKB activation by tyrosine phosphorylation. J Biol Chem (2001) 1.98
Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A (1997) 1.97
Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. Annu Rev Nutr (2005) 1.97
Prospective comparison treatment of 595-nm pulsed-dye lasers for virgin port-wine stain. Br J Dermatol (2015) 1.96